Cited by 1,332Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysCalcium signaling and nucleotide metabolism

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

The role for autophagy in cancer

Open access

White, Eileen·2015·Journal of Clinical Investigation

DOI 10.1172/jci73941PMC PMC4382247

Open this paper in CoChat — free account Open PDF

Abstract

Autophagy is a survival-promoting pathway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes. Autophagy preserves organelle function, prevents the toxic buildup of cellular waste products, and provides substrates to sustain metabolism in starvation. Although in some contexts autophagy suppresses tumorigenesis, in most contexts autophagy facilitates tumorigenesis. Cancers can upregulate autophagy to survive microenvironmental stress and to increase growth and aggressiveness. Mechanisms by which autophagy promotes cancer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic function of mitochondria. Efforts to inhibit autophagy to improve cancer therapy have thereby attracted great interest.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci73941

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Cancer Genome Landscapes
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Discovery and saturation analysis of cancer genes across 21 tumour types
Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · cited 1×
“Note that large-scale genomic analysis of human cancers to date has failed to identify recurrent mutations in BECN1 or other essential autophagy genes (21, 22).”
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583

Flagged first, then by citations

Show all 58 references

Sorted by citations

Items 501–600 of 1,000

Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors
Huang, S., Adhikari, S., Brownell, J. E., Calderwood, E. F., Chouitar, J., D’Amore, N. R., England, D. B., Foley, K., Harrison, S. J., Leroy, P. J., et al. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115681 · Cited by 32
LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation
Liang, L., Huan, L., Wang, J., Wu, Y., Huang, S., & He, X. (2021) · Cell Discovery · doi:10.1038/s41421-021-00339-1 · Cited by 34
RETRACTED ARTICLE: lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p
Wang, G., Lin, X., Han, H., Zhang, H., Li, X., Feng, M., & Jiang, C. (2022) · Bioengineered · doi:10.1080/21655979.2022.2065947 · Cited by 33
Retracted
Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer
Ranjan, A., German, N., Mikelis, C. M., Srivenugopal, K. S., & Srivastava, S. (2017) · Tumor Biology · doi:10.1177/1010428317705517 · Cited by 33
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK)
Draz, H. M., Goldberg, A. A., Titorenko, V. I., Guns, E. S. T., Safe, S. H., & Sanderson, J. T. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.09.006 · Cited by 33
Autophagy promotes escape from phosphatidylinositol 3‐kinase inhibition in estrogen receptor‐positive breast cancer
Yang, W., Hosford, S. R., Traphagen, N. A., Shee, K., Demidenko, E., Liu, S., & Miller, T. W. (2017) · The FASEB Journal · doi:10.1096/fj.201700477r · Cited by 33
Autophagy regulates the survival of cells with chromosomal instability
Liu, D., Shaukat, Z., Xu, T., Denton, D., Saint, R. B., & Gregory, S. L. (2016) · Oncotarget · doi:10.18632/oncotarget.11736 · Cited by 32
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma
Demirsoy, Ş., Martín-Acebes, M. A., Maes, H., & Agostinis, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00240 · Cited by 35
Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment
Dumas, J., Brisson, L., Chevalier, S., Mahéo, K., Fromont, G., Moussata, D., Besson, P., & Roger, S. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.03.004 · Cited by 33
Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib
Yuan, J., Zhang, N., Yin, L., Zhu, H., Zhang, L., Zhou, L., & Yang, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-18165-5 · Cited by 32
Autophagy Promotes Tumor-like Stem Cell Niche Occupancy
Zhao, S., Fortier, T. M., & Baehrecke, E. H. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.075 · Cited by 32
Oncogene SRSF3 suppresses autophagy via inhibiting BECN1 expression
Zhou, L., Guo, J., & Jia, R. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.048 · Cited by 32
DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
Sutton, M. N., Huang, G. Y., Liang, X., Sharma, R., Reger, A. S., Mao, W., Pang, L., Rask, P. J., Lee, K., Gray, J. P., et al. (2019) · Cancers · doi:10.3390/cancers11040557 · Cited by 31
Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
Gao, X., Jiang, P., Zhang, Q. Y., Liu, Q., Jiang, S., Liu, L., Guo, M., Cheng, Q., Zheng, J., & Yao, H. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1348-z · Cited by 32
miR‑21 inhibits autophagy and promotes malignant development in the bladder cancer T24�cell line
Zhang, H., Huang, Z., Zhong, S., Fei, K., & Cao, Y. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.4984 · Cited by 32
A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status
Garufi, A., Baldari, S., Pettinari, R., Montani, M. S. G., D’Orazi, V., Pistritto, G., Crispini, A., Giorno, E., Toietta, G., Marchetti, F., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01628-5 · Cited by 34
miR‑143‑3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis
Yang, H., Hu, T., Hu, P., Qi, C., & Lin, Q. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11995 · Cited by 32
Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy
Xing, Y., Wei, X., Wang, M., Liu, Y., Sui, Z., Wang, X., Zhang, Y., Fei, Y.-H., Jiang, Y., Chen, L., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.043 · Cited by 33
Small Molecules Targeting Programmed Cell Death in Breast Cancer Cells
Maniam, S., & Maniam, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189722 · Cited by 33
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling
Koehler, B. C., Jassowicz, A., Scherr, A., Lorenz, S., Radhakrishnan, P., Kautz, N., Elßner, C., Weiß, J., Jaeger, D., Schneider, M., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1929-y · Cited by 32
Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition
Young, A. N., Herrera, D., Huntsman, A. C., Korkmaz, M. A., Lantvit, D. D., Mazumder, S., Kolli, S., Coss, C. C., King, S. L., Wang, H., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1195 · Cited by 32
Knockout of ATG5 leads to malignant cell transformation and resistance to Src family kinase inhibitor PP2
Hwang, S., Han, B., & Lee, M. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25912 · Cited by 31
Cancer chemoprevention via activation of proteostatic modules
Sklirou, A. D., Papanagnou, E., Fokialakis, N., & Trougakos, I. P. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.10.034 · Cited by 32
Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1
Ketteler, J., Panic, A., Reis, H., Wittka, A., Maier, P., Herskind, C., Yagüe, E., Jendrossek, V., & Klein, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8030348 · Cited by 31
CDCA4 suppresses epithelial–mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy
Xu, C., Cao, H., Sui, Y., Zhang, H., Chen, S., Wu, J., Ma, R., & Feng, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01754-w · Cited by 31
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4 ‐mediated mitophagy induced by hexavalent chromium
Dlamini, M. B., Gao, Z., Hasenbilige, Jiang, L., Geng, C., Li, Q., Shi, X., Liu, Y., & Cao, J. (2021) · Environmental Toxicology · doi:10.1002/tox.23115 · Cited by 32
Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy
Chen, S., Zhao, L., Chen, Z., Huang, C., Kong, R., Wang, Y., Zhang, D., Li, S., Ti, H., & Cheng, H. B. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.12.059 · Cited by 32
Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue
Martinet, W., Roth, L., & Meyer, G. R. Y. D. (2017) · Cells · doi:10.3390/cells6030017 · Cited by 32
Inhibition of autophagy promotes apoptosis and enhances anticancer efficacy of adriamycin via augmented ROS generation in prostate cancer cells
Wang, J., Tan, X., Yang, Q., Zeng, X., Zhou, Y., Luo, W., Lin, X., Li, S., Cai, J., Wang, T., et al. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.05.020 · Cited by 30
Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures
Schroll, M. M., Liu, X., Herzog, S. K., Skube, S. B., & Hummon, A. B. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.08.002 · Cited by 31
Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells
Zhang, L., Lei, Y., Zhang, Y., Li, Y., Bu, Y., Song, F., & Zhang, C. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.12.003 · Cited by 30
Multichannel DNA Sensor Array Fingerprints Cell States and Identifies Pharmacological Effectors of Catabolic Processes
Saha, N. D., Sasmal, R., Meethal, S. K., Vats, S., Gopinathan, P. V., Jash, O., Manjithaya, R. R., Gagey‐Eilstein, N., & Agasti, S. S. (2019) · ACS Sensors · doi:10.1021/acssensors.9b01009 · Cited by 31
Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease
Díaz, P., Sandoval, A., Bravo, R., Quest, A. F. G., & Lavandero, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.613336 · Cited by 31
Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications
Ristic, B. Z., Harhaji-Trajkovic, L. M., Bošnjak, M., Dakić, I., Mijatović, S., & Trajković, V. (2021) · Cancers · doi:10.3390/cancers13164145 · Cited by 31
PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage
Brunelli, F., Torosantucci, L., Gelmetti, V., Franzone, D., Grünewald, A., Krüger, R., Arena, G., & Valente, E. M. (2022) · Cells · doi:10.3390/cells11040678 · Cited by 30
Stromal cell‐derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin‐8‐induced autophagy
Wang, X., Xu, F., Kou, H., Zheng, Y., Yang, J., Xu, Z., Yao, F., Sun, W., Zhu, S., Jiang, Q. L., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12342 · Cited by 32
Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation
Xue, F., Hu, L., Ge, R., Yang, L., Liu, K., Li, Y., Sun, Y., & Wang, K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.022 · Cited by 32
Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
Viry, E., Noman, M. Z., Arakelian, T., Lequeux, A., Chouaı̈b, S., Berchem, G., Moussay, E., Paggetti, J., & Janji, B. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00246 · Cited by 31
Histone methyl-transferases and demethylases in the autophagy regulatory network: the emerging role of KDM1A/LSD1 demethylase
Ambrosio, S., Ballabio, A., & Majello, B. (2018) · Autophagy · doi:10.1080/15548627.2018.1520546 · Cited by 30
Chaperone-Mediated Autophagy in the Liver: Good or Bad?
Dash, S., Aydın, Y., & Moroz, K. (2019) · Cells · doi:10.3390/cells8111308 · Cited by 32
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer
Wang, H., Liang, Y., Zhang, T., Yu, X., Song, X., Chen, Y., Mao, Q., Xia, W., Chen, B., Xu, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01222-0 · Cited by 28
The role of SIRT1 in autophagy and drug resistance: unveiling new targets and potential biomarkers in cancer therapy
Tang, Y., Ju, W., Liu, Y., & Deng, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1469830 · Cited by 30
Structure of the WD40‐domain of human ATG16L1
Bajagic, M., Archna, A., Büsing, P., & Scrima, A. (2017) · Protein Science · doi:10.1002/pro.3222 · Cited by 31
Targeting autophagy potentiates antitumor activity of Met-TKIs against Met-amplified gastric cancer
Lin, X., Peng, Z., Wang, X., Zou, J., Chen, D., Chen, Z., Li, Z., Dong, B., Gao, J., & Shen, L. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1314-x · Cited by 29
Roles of E6 and E7 Human Papillomavirus Proteins in Molecular Pathogenesis of Cervical Cancer
Taghizadeh, E., Jahangiri, S., Rostami, D., Taheri, F., Renani, P. G., Taghizadeh, H., & Hayat, S. M. G. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190618101441 · Cited by 31
TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
Chen, Y., Mo, L.-Q., Wang, X., Chen, B., Hua, Y., Gong, L., Yang, F., Li, Y., Chen, F., Zhu, G.-T., et al. (2020) · Aging · doi:10.18632/aging.102704 · Cited by 29
Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy
Wang, Z., Wang, X., Zhang, N., Zhang, H., Dai, Z., Zhang, M., Feng, S., & Cheng, Q. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00795 · Cited by 28
Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells
Lee, H. Y., & Oh, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.019 · Cited by 29
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Liu, J., Li, S., Fei, X., Nan, X., Shen, Y., Xiu, H., Cormier, S. A., Lu, C., Guo, C., Wang, S., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1965421 · Cited by 32
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway
Wang, H., Li, J., Kan, W., Xu, G., Luo, G.-H., Song, N., Wu, W., Feng, B., Fu, J.-F., Tu, Y., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01112-8 · Cited by 29
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Kumar, V., Bauer, C., & Stewart, J. H. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151338 · Cited by 33
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
Palumbo, C., Luca, A. D., Rosato, N., Forgione, M., Rotili, D., & Caccuri, A. M. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0796-x · Cited by 29
SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival
Maxfield, K., Macion, J., Vankayalapati, H., & Whitehurst, A. W. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00380-16 · Cited by 29
Autophagy-mediated upregulation of cytoplasmic claudin 1 stimulates the degradation of SQSTM1/p62 under starvation
Kim, J., Choi, S., Kim, J. O., & Kim, K. K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.017 · Cited by 29
Insights into inflammasome and its research advances in cancer
Cao, X., & Xu, J. (2019) · Tumori Journal · doi:10.1177/0300891619868007 · Cited by 29
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation
Wang, Z., Yan, M., Ye, L., Zhou, Q., Duan, Y., Jiang, H., Wang, L., Ouyang, Y., Zhang, H., Shen, Y., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00051-2 · Cited by 36
Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy
Qin, P., Li, Q., Zu, Q., Dong, R., & Qi, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1379698 · Cited by 32
Recent advances of lipid droplet-targeted AIE-active materials for imaging, diagnosis and therapy
Yuan, S., & Zhao, E. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116802 · Cited by 29
Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance
Zhu, Y., Yan, W., Tong, L., Yang, J., Ge, S., Fan, J., Jia, R., & Wen, X. (2025) · MedComm · doi:10.1002/mco2.70358 · Cited by 32
Modulators of Redox Metabolism in Head and Neck Cancer
Chen, X., Mims, J., Huang, X., Singh, N., Motea, E. A., Planchon, S. M., Beg, M. S., Tsang, A. W., Porosnicu, M., Kemp, M. L., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7423 · Cited by 29
Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma
Egawa, Y., Saigo, C., Kito, Y., Moriki, T., & Takeuchi, T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198940 · Cited by 28
Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism
Goruppi, S., Jo, S., László, C., Clocchiatti, A., Neel, V., & Dotto, G. P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.043 · Cited by 29
The emerging role of STING-dependent signaling on cell death
Sun, F., Liu, Z., Yang, Z., Liu, S., & Guan, W. (2019) · Immunologic Research · doi:10.1007/s12026-019-09073-z · Cited by 28
Inhibition LC3B can increase chemosensitivity of ovarian cancer cells
Tang, J., Zhu, J., Ye, Y., Liu, Y., He, Y., Zhang, L., Tang, D., Qiao, C., Feng, X., Li, J., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0921-z · Cited by 28
Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway
Xie, X., Hu, L., Liu, L., Wang, J., Liu, Y., Ma, L., Sun, G., Li, C., Aisa, H. A., & Meng, S. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101388 · Cited by 28
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress
Seo, G., Yu, C., Han, H., Li, X., Kattan, R. E., An, J., Kizhedathu, A., Yang, B., Luo, A., Buckle, A. L., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.07.019 · Cited by 28
Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
Chen, G., Gong, R., Yang, D., Zhang, G., Lü, A., Yan, S., Lin, S., & Bian, Z. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.203 · Cited by 28
The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells
Sun, H., Huang, M., Yao, N., Hu, J., Li, Y., Chen, L., Hu, N., Ye, W., Tai, W., Zhang, D., et al. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.10.012 · Cited by 28
Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis
Yin, Q., Feng, W., Shen, X., & Ju, S. (2018) · Bioscience Reports · doi:10.1042/bsr20180516 · Cited by 28
Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment
Wang, Y., Sun, L., Qiu, W., Qi, W., Qi, Y., Liu, Z., Liu, S., & Lv, J. (2020) · Aging · doi:10.18632/aging.103013 · Cited by 28
Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma
Li, H., Feng, Y., Lin, C.-L., & Hsu, T. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.101836 · Cited by 29
Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in Indonesia
Departemen Farmakologi dan Farmasi Klinik, F. F., Fitriatuzzakiyyah, N., Sinuraya, R. K., Departemen Farmakologi dan Farmasi Klinik, F. F., Puspitasari, I. M., & Departemen Farmakologi dan Farmasi Klinik, F. F. (2017) · Indonesian Journal of Clinical Pharmacy · doi:10.15416/ijcp.2017.6.4.311 · Cited by 41
Role of Autophagy in Breast Cancer Development and Progression: Opposite Sides of the Same Coin
Romero, M. A., Bayraktar, O., Bağca, B. G., Avcı, Ç. B., Sabitaliyevich, U. Y., Zhenisovna, T. G., Aras, A., & Farooqı, A. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-20301-6_5 · Cited by 27
Anti-tumor immunity influences cancer cell reliance upon ATG7
Arensman, M. D., Yang, X. S., Zhong, W., Bisulco, S., Upeslacis, E., Rosfjord, E. C., Deng, S., Abraham, R. T., & Eng, C. H. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1800162 · Cited by 27
Macrophage autophagy protects against hepatocellular carcinogenesis in mice
Deust, A., Chobert, M.-N., Démontant, V., Gricourt, G., Denaës, T., Thiolat, A., Ruiz, I., Rodriguez, C., Pawlotsky, J., & Teixeira-Clerc, F. (2021) · Scientific Reports · doi:10.1038/s41598-021-98203-5 · Cited by 27
MicroRNA-320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor-1α
Liang, Y., Chen, X., & Liang, Z. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4779 · Cited by 27
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer
Wang, T., Qin, Y., Zeng, Y., Jing, D., Fan, G., Liu, M., Zhuo, Q., Ji, S., Chen, X., Yu, X., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01078-7 · Cited by 27
MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma
Meng, L., Gao, J., Mo, W., Wang, B., Shen, H., Cao, W., Ding, M., Diao, W., Chen, W., Zhang, Q. H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102956 · Cited by 25
Mechanisms underlying the interplay between autophagy and the inflammasome in age-related diseases: Implications for exercise immunology
Ramos, E. L. P., Neto, I. V. D. S., Pinto, A. P., Cintra, D. E., Ropelle, E. R., Pauli, J., de Freitas, E. C., Mineo, T. W. P., & da Silva, A. S. R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102821 · Cited by 30
Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis
Hu, Y., Zhang, J., Luo, Q., Xu, J., Yan, Y., Mu, L.-M., Bai, J., & Lü, W.-L. (2018) · Nanomaterials · doi:10.3390/nano8100804 · Cited by 26
Lectin from Dioclea violacea induces autophagy in U87 glioma cells
Nascimento, A. P. M., Wolin, I. A. V., Welter, P. G., Heinrich, I. A., Zanotto‐Filho, A., Osterne, V. J. S., Lóssio, C. F., Silva, M. T. L., Nascimento, K. S., Cavada, B. S., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.203 · Cited by 26
Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells
Khan, N., Yılmaz, S., Aksoy, S. Ç., Uzel, A., Tosun, Ç., Ballar, P., & Bedіr, E. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.04.035 · Cited by 28
Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy
Jin, H., Ma, J., Xu, J., Li, H., Chang, Y., Zang, N., Tian, Z., Wang, X., Zhao, N., Liu, L., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1733262 · Cited by 26
Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer
Nollet, E. A., Cardó‐Vila, M., Ganguly, S. S., Tran, J. D., Schulz, V. V., Cress, A. E., Corey, E., & Miranti, C. K. (2020) · Oncogene · doi:10.1038/s41388-020-1370-9 · Cited by 27
New Insights into Therapy-Induced Progression of Cancer
Shnaider, P. V., Ivanova, O. M., Malyants, I. K., Anufrieva, K. S., Semenov, I. A., Pavlyukov, M. S., Lagarkova, M. A., Govorun, V. M., & Shender, V. О. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217872 · Cited by 28
LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway
Chen, H., Wei, L., Luo, M., Wang, X., Zhu, C., Huang, H., Liu, X., Lu, H., & Zhong, Y. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09632-x · Cited by 26
Development and characterization of inhalable transferrin functionalized amodiaquine nanoparticles – Efficacy in Non-Small Cell Lung Cancer (NSCLC) treatment
Parvathaneni, V., Shukla, S. K., Kulkarni, N. S., & Gupta, V. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121038 · Cited by 26
N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression
Sun, Y., Guan, Z., Sheng, Q., Duan, W., Zhao, H., Zhou, J., Deng, Q., & Pei, X. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.001 · Cited by 29
Update on Autophagy Inhibitors in Cancer: Opening up to a Therapeutic Combination with Immune Checkpoint Inhibitors
Bestion, E., Raymond, É., Mezouar, S., & Halfon, P. (2023) · Cells · doi:10.3390/cells12131702 · Cited by 27
The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk
Rizk, N. I., Midan, H. M., Helal, G. K., Abulsoud, A. I., Elshaer, S. S., El-Husseiny, A. A., Fathi, D., Abdelmaksoud, N. M., Mageed, S. S. A., Elballal, M. S., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154771 · Cited by 26
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation
Altuntas, S., Rossin, F., Marsella, C., D’Eletto, M., Diaz-Hidalgo, L., Farrace, M. G., Campanella, M., Antonioli, M., Fimia, G. M., & Piacentini, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6759 · Cited by 26
Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells
Zhu, W., Qu, H., Xu, K., Jia, B., Li, H., Yi-min, D., Liu, G., Wei, H., & Zhao, H. (2017) · Animal Cells and Systems · doi:10.1080/19768354.2017.1330763 · Cited by 26
Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy
Bustos, S. O., Pereira, G. J. S., Saito, R. D. F., Gil, C. D., Zanatta, D. B., Smaili, S. S., & Chammas, R. J. (2018) · Oncotarget · doi:10.18632/oncotarget.24516 · Cited by 26
A near infrared fluorescent probe based on ICT for monitoring mitophagy in living cells
Tang, W., Dai, Y., Gu, B., Liu, M., Yi, Z., Li, Z., Zhang, Z., He, H., & Zeng, R. (2019) · The Analyst · doi:10.1039/c9an02053e · Cited by 26
Inhibition of Ral GTPases Using a Stapled Peptide Approach
Thomas, J. C., Cooper, J. M., Clayton, N. S., Wang, C., White, M. A., Abell, C., Owen, D., & Mott, H. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.720243 · Cited by 25
Autophagy therapeutics: preclinical basis and initial clinical studies
Zhan, L., Li, J., & Wei, B. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3688-3 · Cited by 25
Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation
Wang, J., Bian, S., Wang, S., Song, Y., Zhang, W., Zhao, D., Liu, M., & Bai, X. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00396-w · Cited by 25
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells
Nia, A. B., Caliri, A. W., & Tommasi, S. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103180 · Cited by 27
Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment
Si, L., Yang, Z., Ding, L., & Zhang, D. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03892-0 · Cited by 25
The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up
Shim, M. S., & Liton, P. B. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101064 · Cited by 27

Authors: White, E.
Corresponding author: White, Eileen
ORCID: White, Eileen
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2015-01-02
Volume: 125
Issue: 1
Pages: 42-46
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci73941
PMC: PMC4382247
OpenAlex: W2055811314
Cited by: 1,332
References: 58
Citations by year: 2026: 63 · 2025: 68 · 2024: 111 · 2023: 116 · 2022: 129 · 2021: 158 · 2020: 157 · 2019: 138 · 2018: 142 · 2017: 132 · 2016: 92 · 2015: 24
FWCI: 16.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Rutgers Cancer Institute of New Jersey
National Institutes of Health
National Cancer Institute (R01CA053370, R37CA053370, RC1CA147961, R01CA130893, R01CA163591)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords: autophagy, cancer, carcinogenesis, lysosomes, p53, mitochondrial metabolism, tumor microenvironment, starvation, cancer therapy, autophagy inhibition
MeSH terms: Animals, Autophagy, Humans, Neoplasms, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role for autophagy in cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks