The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation
Open accessAbstract
T helper 2 (Th2) cells play a critical role in the pathogenesis of asthma, but the precise immunological mechanisms that inhibit Th2 cell function in vivo are not well understood. Using gene therapy, we demonstrated that ovalbumin-specific (OVA-specific) Th cells engineered to express latent TGF-beta abolished airway hyperreactivity and airway inflammation induced by OVA-specific Th2 effector cells in SCID and BALB/c mice. These effects correlated with increased concentrations of active TGF-beta in the bronchoalveolar lavage (BAL) fluid, demonstrating that latent TGF-beta was activated in the inflammatory environment. In contrast, OVA-specific Th1 cells failed to inhibit airway hyperreactivity and inflammation in this system. The inhibitory effect of TGF-beta-secreting Th cells was antigen-specific and was reversed by neutralization of TGF-beta. Our results demonstrate that T cells secreting TGF-beta in the respiratory mucosa can indeed regulate Th2-induced airway hyperreactivity and inflammation and suggest that TGF-beta-producing T cells play an important regulatory role in asthma.
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Cites
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
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Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856
The development and function of regulatory T cells
Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0026-2 · Cited by 344
Park, S. K., Cho, M. K., Park, H.-K., Lee, K. H., Lee, S. J., Choi, S. H., Ock, M. S., Jeong, H. J., Lee, M. H., & Yu, H. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803533 · Cited by 82
Metadata
- Authors
- Hansen, G., McIntire, J. J., Yeung, V. P., Berry, G., Thorbecke, G. J., Chen, L., DeKruyff, R. H., & Umetsu, D. T.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-01-01
- Volume
- 105
- Issue
- 1
- Pages
- 61-70
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2160373918
- Cited by
- 269
- References
- 1
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hansen, G., McIntire, J. J., Yeung, V. P., Berry, G., Thorbecke, G. J., Chen, L., DeKruyff, R. H., & Umetsu, D. T. (2000). CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation. Journal of Clinical Investigation. https://doi.org/10.1172/jci7589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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