The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Neonatal thymectomy reveals differentiation and plasticity within human naive T cells
Open accessAbstract
The generation of naive T cells is dependent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral proliferation. Naive T cells have long been regarded as relatively quiescent cells; however, it was recently shown that IL-8 production is a signatory effector function of naive T cells, at least in newborns. How this functional signature relates to naive T cell dynamics and aging is unknown. Using a cohort of children and adolescents who underwent neonatal thymectomy, we demonstrate that the naive CD4+ T cell compartment in healthy humans is functionally heterogeneous and that this functional diversity is lost after neonatal thymectomy. Thymic tissue regeneration later in life resulted in functional restoration of the naive T cell compartment, implicating the thymus as having functional regenerative capacity. Together, these data shed further light on functional differentiation within the naive T cell compartment and the importance of the thymus in human naive T cell homeostasis and premature aging. In addition, these results affect and alter our current understanding on the identification of truly naive T cells and recent thymic emigrants.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a cohort of children and adolescents after neonatal thymectomy, CD31− naive T cells had lost the ability to produce IL-8, an effector function attributed to naive cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as van den Broek et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974 · cited 3×
“Interestingly, a relative increase in the recently described (25) self-renewing stem cell memory T cells (Tscm) was noted after neonatal thymectomy (Figure 1D), although their absolute numbers were still lower compared with HCs (Supplemental Figure 1A).”
BackgroundResultInfluentialChanges in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Calcium signaling mechanisms in T lymphocytes.
Lewis, R. S. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.497 · Cited by 860
Selecting and maintaining a diverse T-cell repertoire
Goldrath, A. W., & Bevan, M. J. (1999) · Nature · doi:10.1038/46218 · Cited by 777
Ernst, B., Dong-Sup, L., Chang, J. M., Sprent, J., & Surh, C. D. (1999) · Immunity · doi:10.1016/s1074-7613(00)80092-8 · Cited by 717
Selecting and maintaining a diverse T-cell repertoire
Goldrath, A. W., & Bevan, M. J. (1999) · Nature · doi:10.1038/35005508 · Cited by 714
Harnessing the biology of IL-7 for therapeutic application
Mackall, C. L., Fry, T. J., & Gress, R. E. (2011) · Nature reviews. Immunology · doi:10.1038/nri2970 · Cited by 602
Cited by
Sorted by citations
Human T cell development, localization, and function throughout life
Kumar, B. V., Connors, T. J., & Farber, D. L. (2018) · Immunity · doi:10.1016/j.immuni.2018.01.007 · Cited by 1,257
Aging and the immune system: An overview
Akha, A. A. S. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.08.005 · Cited by 400
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362
The Role of the Thymus in the Immune Response
Thapa, P., & Färber, D. L. (2019) · Thoracic surgery clinics/Thorac. surg. clin. · doi:10.1016/j.thorsurg.2018.12.001 · Cited by 339
The full spectrum of human naive T cells
van den Broek, T., Borghans, J. A. M., & van Wijk, F. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0001-y · Cited by 273
Self-citationNeonatal T Cells: A Reinterpretation
Rudd, B. D. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-091319-083608 · Cited by 161
Sánchez‐Martínez, D., Baroni, M. L., Gutiérrez‐Agüera, F., Roca-Ho, H., Blanch-Lombarte, O., González-García, S., Torrebadell, M., Juncà, J., Ramírez, M. R., Velasco-Hernández, T., et al. (2019) · Blood · doi:10.1182/blood-2018-10-882944 · Cited by 138
An Immunological Perspective on Neonatal Sepsis
Kan, B., Razzaghian, H. R., & Lavoie, P. M. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.02.001 · Cited by 116
Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators
Ayasoufi, K., Pfaller, C. K., Evgin, L., Khadka, R. H., Tritz, Z. P., Goddery, E. N., Fain, C. E., Yokanovich, L. T., Himes, B. T., Jin, F., et al. (2020) · Brain · doi:10.1093/brain/awaa343 · Cited by 93
Building a T cell compartment: how immune cell development shapes function
Davenport, M. P., Smith, N. L., & Rudd, B. D. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0332-3 · Cited by 86
When the Damage Is Done: Injury and Repair in Thymus Function
Kinsella, S. M., & Dudakov, J. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01745 · Cited by 75
Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
Pękalski, M. Ł., García, A. R., Ferreira, R. C., Rainbow, D. B., Smyth, D. J., Mashar, M., Brady, J., Yarkoni, N. S., Dopico, X. C., Mahmood, S., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93739 · Cited by 74
Xu, J., Li, Q., Deng, L., Xiong, J., Cheng, Z., & Ye, C. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1522644 · Cited by 83
The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
Moreau, J.-F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J.-L., Garagnani, P., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.11.005 · Cited by 67
Immunity and inflammation: the neglected key players in congenital heart disease?
Wienecke, L. M., Cohen, S., Bauersachs, J. K., Mebazaa, A., & Chousterman, B. G. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10187-6 · Cited by 64
Boháčová, P., Terekhova, M., Tsurinov, P., Mullins, R. D. Z., Husarcikova, K., Shchukina, I., Antonova, A. U., Echalar, B., Kössl, J., Saidu, A., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.019 · Cited by 66
Gudmundsdottir, J. A., Söderling, J. K., Berggren, H., Óskarsdóttir, S., Neovius, M., Stephansson, O., & Ekwall, O. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.01.037 · Cited by 53
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease
Granadier, D., Iovino, L., Kinsella, S. M., & Dudakov, J. A. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00840-5 · Cited by 46
An update on thymectomy in myasthenia gravis
Evoli, A., & Meacci, E. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1600404 · Cited by 46
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Kared, H., Tan, S. W., Lau, M. C., Chevrier, M., Tan, C. T. Y., How, W., Wong, G. C. L., Strickland, M., Malleret, B., Amoah, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14442-6 · Cited by 49
Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review
Cavalcanti, N. V., Palmeira, P., Jatene, M. B., Dorna, M. D. B., & Carneiro-Sampaio, M. M. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.774780 · Cited by 44
Early thymectomy leads to premature immunologic ageing: An 18-year follow-up
Gudmundsdottir, J. A., Óskarsdóttir, S., Skogberg, G., Lindgren, S., Lundberg, V., Berglund, M., Lundell, A., Berggren, H., Fasth, A. L., Telemo, E., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.014 · Cited by 44
IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity
Silva, S. L., Albuquerque, A. S., Matoso, P., Muylder, B. C.-D., Cheynier, R., Ligeiro, D., Abecasis, M., Anjos, R. T., Barata, J. T., Victorino, R. M. M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00020 · Cited by 42
Neonatal thymectomy in children—accelerating the immunologic clock?
Deyà‐Martínez, À., Flinn, A. M., & Gennery, A. R. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.028 · Cited by 41
Recent Advancements in Regenerative Approaches for Thymus Rejuvenation
Sharma, H., & Moroni, L. (2021) · Advanced Science · doi:10.1002/advs.202100543 · Cited by 41
Terekhova, M., Boháčová, P., & Artyomov, M. N. (2025) · Immunity · doi:10.1016/j.immuni.2025.10.009 · Cited by 41
Endogenous thymic regeneration: restoring T cell production following injury
Granadier, D., Acenas, D. D., II, & Dudakov, J. A. (2025) · Nature reviews. Immunology · doi:10.1038/s41577-024-01119-0 · Cited by 40
Cardinale, A., Luca, C. D. D., Locatelli, F., & Velardi, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.752042 · Cited by 38
Primary and secondary defects of the thymus
Dinges, S. S., Amini, K., Notarangelo, L. D., & Delmonte, O. M. (2024) · Immunological Reviews · doi:10.1111/imr.13306 · Cited by 37
Shaping immunity for life: Layered development of CD8 + T cells
Tabilas, C., Smith, N. L., & Rudd, B. D. (2023) · Immunological Reviews · doi:10.1111/imr.13185 · Cited by 30
Das, A., Rouault‐Pierre, K., Kamdar, S., Gomez-Touriño, I. M., Wood, K., Donaldson, I., Mein, C. A., Bonnet, D. A., Hayday, A., & Gibbons, D. L. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700551 · Cited by 30
Human Naive T Cells Express Functional CXCL8 and Promote Tumorigenesis
Crespo, J., Wu, K., Li, W., Kryczek, I., Maj, T., Vatan, L., Wei, S., Opipari, A. W., & Zou, W. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700755 · Cited by 24
Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia: Innocent or Guilty?
Dekker, L., Sanders, E., Lindemans, C. A., de Koning, C. C. H., & Nierkens, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.893545 · Cited by 28
Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells
Helgeland, H., Gabrielsen, I., Akselsen, H., Sundaram, A. Y. M., Flåm, S. T., & Lie, B. A. (2020) · BMC Genomics · doi:10.1186/s12864-020-6755-1 · Cited by 24
Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment
Silva, S. L., & Sousa, A. E. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00119 · Cited by 26
Wilhelmson, A. S., Rodriguez, M. L., Eriksson, E. S., Johansson, I., Fogelstrand, P., Stubelius, A., Lindgren, S., Fagman, J. B., Hansson, G. K., Carlsten, H., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311252 · Cited by 23
Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses
Hirai, T., & Yoshioka, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918611 · Cited by 21
A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy
Lagou, M. K., Anastasiadou, D. P., & Karagiannis, G. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.933547 · Cited by 22
Immunological aspects of age-related diseases
Isobe, K., Nishio, N., & Hasegawa, T. (2017) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v8.i2.129 · Cited by 22
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy
Silva, S. L., Albuquerque, A. S., Amaral, A. J., Li, Q., Mota, C., Cheynier, R., Victorino, R. M. M., Santos, M. C. P., & Sousa, A. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180385 · Cited by 21
The immune system in infants: Relevance to xenotransplantation
Bikhet, M. H., Morsi, M., Hara, H., Rhodes, L. A., Carlo, W. F., Cleveland, D. C., Cooper, D. K. C., & Iwase, H. (2020) · Pediatric Transplantation · doi:10.1111/petr.13795 · Cited by 22
Newman, D. K., Fu, G., McOlash, L., Schauder, D., Newman, P. J., Cui, W., Rao, S., Johnson, B. D., Gershan, J. A., & Riese, M. J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2hi0617-229rrr · Cited by 24
Interleukin-8 as a candidate for thymoma identification and recurrence surveillance
Gao, S., Jiang, J., Jin, C., Gao, J., Xiong, D., Yang, P., Cui, S., Yang, W., Leng, Q., Dong, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18697-x · Cited by 20
Attenuation of apoptotic cell detection triggers thymic regeneration after damage
Kinsella, S. M., Evandy, C., Cooper, K., Iovino, L., DeRoos, P. C., Hopwo, K. S., Granadier, D., Smith, C. W., Rafii, S., & Dudakov, J. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109789 · Cited by 21
Persistent changes in circulating white blood cell populations after splenectomy
Rab, M. A. E., Meerveld-Eggink, A., van Velzen‐Blad, H., van Loon, D., Rijkers, G. T., & de Weerdt, O. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2335-9 · Cited by 20
Recent thymic emigrants as the bridge between thymoma and autoimmune diseases
Ao, Y.-Q., Jiang, J.-H., Gao, J., Wang, H., & Ding, J. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188730 · Cited by 19
Human neonatal thymectomy induces altered B‐cell responses and autoreactivity
van den Broek, T., Madi, A., Delemarre, E. M., Schadenberg, A. W. L., Tesselaar, K., Borghans, J. A. M., Nierkens, S., Redegeld, F. A., Otten, H. G., Rossetti, M. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201746971 · Cited by 18
Self-citationThymus Regeneration and Future Challenges
Shichkin, V. P., & Antica, M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09955-y · Cited by 19
Bernaldo-de-Quirós, E., López‐Abente, J., Camino, M., Gil, N., Panadero, E., López-Esteban, R., Martínez‐Bonet, M., Pion, M., & Correa‐Rocha, R. (2021) · Transplantation Direct · doi:10.1097/txd.0000000000001152 · Cited by 17
Dessalles, R., Pan, Y., Xia, M., Maestrini, D., D'Orsogna, M. R., & Chou, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.735135 · Cited by 17
Burton, C., Sester, M., Robinson, J. L., Eurich, D. T., Preiksaitis, J. K., & Urschel, S. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy309 · Cited by 15
Thymectomy in Juvenile Myasthenia Gravis Is Safe Regarding Long Term Immunological Effects
Popperud, T. H., Gul, K. A., Brunborg, C., Olaussen, R. W., Abrahamsen, T. G., Osnes, L., & Kerty, E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.596859 · Cited by 14
Stosio, M., Ruszkowski, J., Mikosik, A., Haponiuk, I., & Witkowski, J. M. (2017) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2017.72231 · Cited by 12
Baliu‐Piqué, M., Tesselaar, K., & Borghans, J. A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1059481 · Cited by 13
Self-citationShichkin, V., Gorbach, O., Zuieva, O. A., Grabchenko, N., Aksyonova, I. A., & Todurov, B. (2017) · Cryobiology · doi:10.1016/j.cryobiol.2017.06.010 · Cited by 12
Depletion-Resistant CD4 T Cells Enhance Thymopoiesis During Lymphopenia
Ayasoufi, K., Fan, R., & Valujskikh, A. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14309 · Cited by 10
Burning Down the House: Thymic Repair and Regeneration After Acute Damage
Dudakov, J. A., & van den Brink, M. R. M. (2025) · Immunological Reviews · doi:10.1111/imr.70050 · Cited by 9
Peripheral differentiation patterns of human T cells
Heikkilä, N., Hetemäki, I., Sormunen, S., Isoniemi, H., Kekäläinen, E., Saramäki, J., & Arstila, T. P. (2022) · European Journal of Immunology · doi:10.1002/eji.202149465 · Cited by 10
The CXCR4-CXCL12 axis promotes T cell reconstitution via efficient hematopoietic immigration
Zhao, F., Lu, Y., Li, Z., He, J., Cui, N., Luo, L., & Li, L. (2022) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2022.04.005 · Cited by 9
Heterogeneity of thymic output in the elderly and its association with sex and smoking
Sandhar, B. S., Vyas, V. S., Harding, D., Ragazzini, R., Bonfanti, P., Marelli‐Berg, F. M., Bell, C. G., Chain, B., & Longhi, M. P. (2025) · JCI Insight · doi:10.1172/jci.insight.189008 · Cited by 10
Immunity and Genetics at the Revolving Doors of Diagnostics in Primary Immunodeficiencies
Rispoli, F., Valencic, E., Girardelli, M., Pin, A., Tesser, A., Piscianz, E., Boz, V., Faletra, F., Severini, G. M., Taddio, A., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11030532 · Cited by 8
Optimization of quality parameters for human thymic cell samples stored in liquid nitrogen
Shichkin, V. P., Gorbach, O. I., Zuieva, O. A., & Martsenyuk, O. P. (2018) · Trends in Transplantation · doi:10.15761/tit.1000244 · Cited by 7
Bauermann, F. V., Falkenberg, S. M., Rudd, J. M., Peter, C. M., Merchioratto, I., Ritchey, J. W., Gilliam, J. N., Taylor, J. D., Ma, H., & Maggioli, M. F. (2023) · Viruses · doi:10.3390/v15122442 · Cited by 6
Long‐term immunological changes after corrective cardiac surgery
Eltan, S. B., Amirov, R., Babayeva, R., Altunbaş, M. Y., Karakurt, L. T., Can, S., Gungoren, E. Y., Bozkurt, S., Ozturk, N. K., Çatak, M. C., et al. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13418 · Cited by 6
Advances in basic and clinical immunology in 2016
Chinen, J., Badran, Y. R., Geha, R. S., Chou, J. S., & Fried, A. J. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.023 · Cited by 6
How to Reliably Define Human CD8+T-Cell Subsets: Markers Playing TricksPreprint
van Aalderen, M. C., van Lier, R. A. W., & Hombrink, P. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037747 · Cited by 8
Kinsella, S. M., Evandy, C., Cooper, K., Cardinale, A., Iovino, L., DeRoos, P. C., Hopwo, K. S., Smith, C. W., Granadier, D. W., Sullivan, L. B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.19.524800 · Cited by 6
The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention
Müller, L., & Pawelec, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00016-0 · Cited by 5
Lv, D., Hu, B., Lin, X., Wang, R., Wu, D., Long, R., He, M., Liao, S., & Deng, D. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.12 · Cited by 6
Immunology of the Fetus and Newborn
Weitkamp, J.-H., Lewis, D. B., & Levy, O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-40139-5.00036-x · Cited by 4
Nguyen, A. A., & Platt, C. D. (2024) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2024.04.009 · Cited by 4
Dudakov, J. A., Hun, M. L., Wong, K., Holländer, G. A., & Chidgey, A. P. (2019) · Springer eBooks · doi:10.1007/978-3-030-12040-5_13 · Cited by 4
Rantanen, R., Honkila, M., Kämä, H., Pokka, T. M.-L., Pihkala, J. I., Rahkonen, O. P., Mattila, I. P., Renko, M., Helminen, M., Heinonen, S., et al. (2024) · Acta Paediatrica · doi:10.1111/apa.17205 · Cited by 3
Hensen, L. C. M., Streng, B. M. M., van Wijk, F., Nierkens, S., van Binnendijk, R. S., Buisman, A., Coppus, A. M. W., GeurtsvanKessel, C. H., de Graaf, G., van der Klis, F. R. M., et al. (2025) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2025.2583416 · Cited by 3
Self-citationLeone, D. M., Park, H., Ünlü, S., Gurvitz, M. Z., Kang, I., & Elder, R. W. (2022) · International Journal of Cardiology Congenital Heart Disease · doi:10.1016/j.ijcchd.2022.100359 · Cited by 4
Sandgaard, K. S., Gkouleli, T., Attenborough, T. C. H., Adams, S. P., Gibbons, D. L., Holm, M., Eisen, S., Baxendale, H., Rossi, A. D., Pahwa, S. G., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.860316 · Cited by 3
Kinsella, S. M., Evandy, C., Cooper, K., Iovino, L., DeRoos, P. C., Hopwo, K. S., Granadier, D. W., Smith, C. W., Rafii, S., & Dudakov, J. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.31.275834 · Cited by 3
Duarte, V. E., Urey, M. A., ADLER, E. D., Merkelz, B., Hobeika, M. J., Suarez, E. E., Quarti, A. G., & Yousefzai, R. (2025) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcvj.1576 · Cited by 2
Kinsella, S. M., Evandy, C., Cooper, K., Kirsche, E., Warren, M., DeRoos, P. C., Cardinale, A., Iovino, L., Granadier, D. W., Smith, C. W., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08345-x · Cited by 3
Kesäläinen, A., Rantanen, R., Honkila, M., Helminen, M., Rahkonen, O. P., Kallio, M., Ruuska, T. S., Kekäläinen, E., & Heinonen, S. (2024) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2024-002651 · Cited by 2
Age-Specific T Cell Homeostasis
Bourgeois, C., & Sauce, D. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_81-1 · Cited by 2
How to define and measure thymopoiesis after transplantation?
de Koning, C. C. H., Nierkens, S., & Boelens, J. J. (2018) · Bone Marrow Transplantation · doi:10.1038/s41409-018-0199-0 · Cited by 2
Beigel, K., Alsaati, N., Maurer, K., McDonald‐McGinn, D. M., Crowley, T. B., Knight, M., Henrickson, S. E., Bassett, A. S., & Sullivan, K. E. (2025) · Pediatric Allergy and Immunology · doi:10.1111/pai.70237 · Cited by 1
Tan, Z., Kergaravat, C., Gonzalez, L., Johnsson, A., Negrini, E., Pou, C., Bernhardsson, A. K., Barcenilla, H., Ivanchenko, M., Chen, Y., et al. (2026) · Journal of Human Immunity · doi:10.70962/jhi.20260003 · Cited by 1
Hale, L. P., Macintyre, A. N., Bowles, D. E., Kwun, J., Li, J., Theriot, B. S., & Turek, J. W. (2024) · ImmunoHorizons · doi:10.4049/immunohorizons.2300112 · Cited by 1
Nguyen, A. A., & Platt, C. D. (2025) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2025.01.008 · Cited by 1
Age-Specific T Cell Homeostasis
Bourgeois, C., & Sauce, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_81 · Cited by 1
Jarduli, L. R. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2018.tde-27062018-080953 · Cited by 1
Immunology of the Fetus and Newborn
Weitkamp, J.-H., Lewis, D. B., & Levy, O. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-82823-9.00032-5 · Cited by 1
Immune reconstitution and vaccination following hematopoietic cell transplantation
Azuma, E. (2016) · Journal of Hematopoietic Cell Transplantation · doi:10.7889/hct.5.138
Gibbons, D. L. (2017) · Journal of Pediatrics and Pediatric Medicine · doi:10.29245/2578-2940/2018/1.1102
Immunological, vascular and metabolic actions of androgens
Rodriguez, M. L. (2020)
Ayasoufi, K., Pfaller, C. K., Evgin, L., Khadka, R., Tritz, Z. P., Goddery, E. N., Fain, C. E., Yokanovich, L. T., Himes, B. T., Jin, F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.24.006825
Secondary Immunodeficiencies ☆
Chinen, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05294-6
Karagüzel, G., & Bahadır, K. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.114888
Single-cell multiomics reveals the distinct properties of neonatal and adult recent thymic emigrantsPreprint
Tabilas, C., Venturi, V., Kean, C. M., Minervina, A. A., Thomas, P. G., Grimson, A., Grenier, J. K., Davenport, M. P., Smith, N. L., & Rudd, B. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.26.640106
Long-Term Immune Alterations After Thymectomy in Early Childhood: A Case Series
Kymioni, V. M., Panagiotou, P., Tzanoudaki, M., & Spoulou, V. I. (2025) · Cureus · doi:10.7759/cureus.95517
Helgeland, H., Gabrielsen, I., Akselsen, H., Sundaram, A. Y. M., Flåm, S. T., & Lie, B. A. (2020) · Figshare · doi:10.6084/m9.figshare.12284744
Helgeland, H., Gabrielsen, I., Akselsen, H., Sundaram, A. Y. M., Flåm, S. T., & Lie, B. A. (2020) · Figshare · doi:10.6084/m9.figshare.12284735
Regrowing the thymus: New hopes from the axolotl
Notarangelo, L. D., Pala, F., & Bosticardo, M. (2026) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2026.02.004
Metadata
- Authors
- van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., Jansen, N. J. G., & van Wijk, F.
- Affiliations
- University Medical Center Utrecht (NL)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2016-02-22
- Volume
- 126
- Issue
- 3
- Pages
- 1126-1136
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC4767338
- OpenAlex
- W2275156413
- Cited by
- 104
- References
- 50
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 5 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Center for Translational Molecular Medicine
- Dutch Arthritis Association
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- neonatal thymectomy, naive T cells, CD4+ T cells, thymus regeneration, thymus, T cell homeostasis, interleukin-8, T cell differentiation, T cell plasticity, premature aging, recent thymic emigrants, thymic output, children and adolescents
- MeSH terms
- Cell Differentiation, Cells, Cultured, Child, Child, Preschool, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Male, T-Lymphocytes, Thymectomy, Thymus Gland, Case-Control Studies, Interleukin-8, Platelet Endothelial Cell Adhesion Molecule-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
