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Neonatal thymectomy reveals differentiation and plasticity within human naive T cells
Open accessAbstract
The generation of naive T cells is dependent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral proliferation. Naive T cells have long been regarded as relatively quiescent cells; however, it was recently shown that IL-8 production is a signatory effector function of naive T cells, at least in newborns. How this functional signature relates to naive T cell dynamics and aging is unknown. Using a cohort of children and adolescents who underwent neonatal thymectomy, we demonstrate that the naive CD4+ T cell compartment in healthy humans is functionally heterogeneous and that this functional diversity is lost after neonatal thymectomy. Thymic tissue regeneration later in life resulted in functional restoration of the naive T cell compartment, implicating the thymus as having functional regenerative capacity. Together, these data shed further light on functional differentiation within the naive T cell compartment and the importance of the thymus in human naive T cell homeostasis and premature aging. In addition, these results affect and alter our current understanding on the identification of truly naive T cells and recent thymic emigrants.
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“In a cohort of children and adolescents after neonatal thymectomy, CD31− naive T cells had lost the ability to produce IL-8, an effector function attributed to naive cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as van den Broek et al., 2016
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Metadata
- Authors
- van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., Jansen, N. J. G., & van Wijk, F.
- Affiliations
- University Medical Center Utrecht (NL)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2016-02-22
- Volume
- 126
- Issue
- 3
- Pages
- 1126-1136
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC4767338
- OpenAlex
- W2275156413
- Cited by
- 104
- References
- 50
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 4 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 5 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Center for Translational Molecular Medicine
- Dutch Arthritis Association
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- neonatal thymectomy, naive T cells, CD4+ T cells, thymus regeneration, thymus, T cell homeostasis, interleukin-8, T cell differentiation, T cell plasticity, premature aging, recent thymic emigrants, thymic output, children and adolescents
- MeSH terms
- Cell Differentiation, Cells, Cultured, Child, Child, Preschool, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Male, T-Lymphocytes, Thymectomy, Thymus Gland, Case-Control Studies, Interleukin-8, Platelet Endothelial Cell Adhesion Molecule-1
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