The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
A role for NF-κB–dependent gene transactivation in sunburn
Open accessAbstract
Exposure of skin to ultraviolet (UV) radiation is known to induce NF-kappaB activation, but the functional role for this pathway in UV-induced cutaneous inflammation remains uncertain. In this study, we examined whether experimentally induced sunburn reactions in mice could be prevented by blocking UV-induced, NF-kappaB-dependent gene transactivation with oligodeoxynucleotides (ODNs) containing the NF-kappaB cis element (NF-kappaB decoy ODNs). UV-induced secretion of IL-1, IL-6, TNF-alpha, and VEGF by skin-derived cell lines was inhibited by the decoy ODNs, but not by the scrambled control ODNs. Systemic or local injection of NF-kappaB decoy ODNs also inhibited cutaneous swelling responses to UV irradiation. Moreover, local UV-induced inflammatory changes (swelling, leukocyte infiltration, epidermal hyperplasia, and accumulation of proinflammatory cytokines) were all inhibited specifically by topically applied decoy ODNs. Importantly, these ODNs had no effect on alternative types of cutaneous inflammation caused by irritant or allergic chemicals. These results indicate that sunburn reactions culminate from inflammatory events that are triggered by UV-activated transcription of NF-kappaB target genes, rather than from nonspecific changes associated with tissue damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, it is likely that the photoprotective activity of vitamin D compounds includes a reduction in skin inflammation, which plays a crucial role in sunburn formation [104].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596
Rosette, C., & Karin, M. (1996) · Science · doi:10.1126/science.274.5290.1194 · Cited by 1,034
Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721
Köck, A., Schwarz, T., Kirnbauer, R., Urbanski, A., Perry, P., Ansel, J. C., & Luger, T. A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1609 · Cited by 712
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
Lee, F. S., Hagler, J., Chen, Z. J., & Maniatis, T. (1997) · Cell · doi:10.1016/s0092-8674(00)81842-5 · Cited by 710
CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
Hartmann, G., Weiner, G. J., & KRIEG, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9305 · Cited by 623
Research works printed but not linked: 2
- Scharffetter-Kochanek, 1997, Biol Chem, 378, 1247
- Yuspa, 1980, Cancer Res, 40, 4694
Cited by
Sorted by citations
Items 101–160 of 160
Ko, H., Jung, H. H., Seo, K. H., Kang, Y., Kim, H., Park, S. J., Lee, H.-K., & Im, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.042 · Cited by 22
Marine fungal DHICA as a UVB protectant: Assessment under in vitro and in vivo conditions
Shanuja, S. K., Iswarya, S., & Gnanamani, A. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.01.010 · Cited by 21
Böhm, M. R. R., Schallenberg, M., Brockhaus, K., Melkonyan, H., & Thanos, S. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2015.156 · Cited by 20
Sumi, K., Yokozeki, H., Wu, M., Satoh, T., Kaneda, Y., Takeda, K., Akira, S., & Nishioka, K. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302345 · Cited by 20
Molecular events occurring behind ultraviolet-induced skin inflammation
Terui, T., Okuyama, R., & Tagami, H. (2001) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000011061.54491.2e · Cited by 20
Ikeda, M., Hirose, Y., Miyoshi, K., & Kodama, H. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00164-5 · Cited by 19
Strong In Vivo Activation of NF-κB in Mouse Lenses by Classic Stressors
Alexander, G., Carlsen, H., & Blomhoff, R. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0829 · Cited by 19
Pihl, C., Togsverd‐Bo, K., Andersen, F., Hædersdal, M., Bjerring, P., & Lerche, C. M. (2021) · Cancers · doi:10.3390/cancers13153684 · Cited by 19
Epidermal and dermal changes in response to various skin rejuvenation methods
Helbig, D., Simon, J. C., & Paasch, U. (2010) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2010.00573.x · Cited by 19
Antibiotic cyclic AMP signaling by “primed” leukocytes confers anti-inflammatory cytoprotection
Abeyama, K., Kawahara, K., Iino, S., Hamada, T., Arimura, S., Matsushita, K., Nakajima, T., & Maruyama, I. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303104 · Cited by 18
Self-citationEnhancement of ultraviolet-induced apoptosis by NF-kappaB decoy oligonucleotides
Yokoyama, S., Nakano, H., Yamazaki, T., Tamai, K., Hanada, K., & Takahashi, G. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06969.x · Cited by 17
Wang, P., Peng, H. F., Chen, X., Li, L., Zhou, Y., Zhang, X., Zhu, L., Ying, M., Han, R., Wang, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.841267 · Cited by 16
Dendritic Cell-Based Immunoregulatory Strategies
Matsue, H., Kusuhara, M., Matsue, K., & Takashima, A. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000057741 · Cited by 15
Self-citationAmigó, M., Terencio, M. C., Payá, M., Iodice, C., & Rosa, S. D. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.02.007 · Cited by 14
Differential responses to UVB irradiation in human keratinocytes and epidermoid carcinoma cells.
Zhou, M., Zheng, L., Guo, L., Liu, W. L., Lv, C., Jiang, L., Ou, C. S., & Ding, Z. (2012) · PubMed · doi:10.3967/0895-3988.2012.05.013 · Cited by 14
Kanekura, T., Goorha, S., Kirtikara, K., & Ballou, L. R. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00162-8 · Cited by 14
de Silva, M. B., & Tencomnao, T. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.04.046 · Cited by 13
Role of Langerhans cells in the skin. What’s new?
Nakagawa, S., & Bos, J. D. (2001) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.1468-3083.2001.00305.x · Cited by 13
Xu, M. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i4.573 · Cited by 12
Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice
Nakai, K., Yoneda, K., Ishihara, Y., Ohmori, K., Moriue, T., Igarashi, J., Kohno, M., Kosaka, H., & Kubota, Y. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01223.x · Cited by 11
Examination of Combined Treatment of Ginsenoside Rg3 and 5-Fluorouracil in Lung Adenocarcinoma Cells
Shan, K., Deng, Y., Du, Z., Yue, P., & Yang, S. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/2813142 · Cited by 11
A new NF‐κB inhibitor attenuates a TH1 type immune response in a murine model
Kabashima, K., Honda, T., Nunokawa, Y., & Miyachi, Y. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.065 · Cited by 11
Chang, Y. B., Kim, H. D., Kim, S. M., Lim, J. H., Woo, M. J., Suh, H. J., & Jo, K. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117679 · Cited by 11
Grundmann, J., Böckelmann, R., Bonnekoh, B., & Gollnick, H. P. M. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740587uercom2.0.co2 · Cited by 10
Uchi, H., Koga, T., Urabe, K., Moroi, Y., & Furue, M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12250.x · Cited by 10
Uemura, T., Tsujii, M., Akeda, K., Iino, T., Satonaka, H., Hasegawa, M., & Sudo, A. (2012) · The Journal of Gene Medicine · doi:10.1002/jgm.2677 · Cited by 9
Steinhoff, M. S., & Luger, T. A. (2004) · CRC Press eBooks · doi:10.1201/b14248-19 · Cited by 9
Topical Psoralen Photochemotherapy With Lethal Outcome
Voß, A., Leverkus, M., Bröcker, E. ‐., & Goebeler, M. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.3.383 · Cited by 9
Liu, X., Zhang, Z., Li, P., Zhu, L., Wang, Y., & Wang, C. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.11.003 · Cited by 8
Xeroderma Pigmentosum C: A Valuable Tool to Decipher the Signaling Pathways in Skin Cancers
Nasrallah, A., Fayyad, N., Kobaisi, F., Badran, B., Fayyad‐Kazan, H., Fayyad‐Kazan, M., Sève, M., & Rachidi, W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6689403 · Cited by 8
Çiçek, D., Demir, B., Orhan, C., Tuzcu, M., Özercan, İ. H., Şahin, N., Komorowski, J. R., Ojalvo, S. P., Sylla, S., & Şahin, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.657207 · Cited by 6
Ashigai, H., Komano, Y., Guanying, W. A. N. G., Kawachi, Y., Sunaga, K., YAMAMOTO, R., Takata, R., & Yanai, T. (2018) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.64.301 · Cited by 8
Ling, Y. A. N. G., Zhonghua, H. U., Yanxia, J. I. N., HUANG, N., & Su, X. U. (2022) · Italian Journal of Dermatology and Venereology · doi:10.23736/s2784-8671.20.06825-x · Cited by 6
Digital dermoscopy to determine skin melanin index as an objective indicator of skin pigmentation
Majewski, S., Carneiro, C., Ibler, E., Boor, P., Tran, G., Martini, M. C., Loro, S. D., RADEMAKER, A. W., West, D. P., & Nardone, B. (2016) · Journal of Surgical Dermatology · doi:10.18282/jsd.v1.i1.15 · Cited by 6
Nuclear Factor-κB Decoy Oligodeoxynucleotide Attenuates Cartilage Resorption In Vitro
Nemoto, H., Masuda, K., Watson, D. J., & Sakai, D. (2024) · Bioengineering · doi:10.3390/bioengineering11010046 · Cited by 5
Inhibitors of corneal inflammation and angiogenesis : Prospectives and challenges
Mirabelli, P. (2019) · Linköping University medical dissertations · doi:10.3384/diss.diva-156415 · Cited by 5
Steinhoff, M., Griffiths, C. E. M., Church, M. K., & Luger, T. A. (2004) · Wiley eBooks · doi:10.1002/9780470750520.ch9 · Cited by 4
Grape constituents for protection against photodamage to skin
Kwon, Y., Shafi, R., Oak, A. S. W., Athar, M., Slominski, A. T., & Elmets, C. A. (2025) · Photochemistry and Photobiology · doi:10.1111/php.14110 · Cited by 4
Inflammation after Solar Radiation
Foster, K. W., Katiyar, S. K., Yusuf, N., & Elmets, C. A. (2007) · Royal Society of Chemistry eBooks · doi:10.1039/9781847557957-00025 · Cited by 3
SUBRAMANI, P., & Das, R. K. (2023) · Biocell · doi:10.32604/biocell.2023.030383 · Cited by 2
The In Vitro Antioxidant and Anti-Inflammatory Activities of Selected Australian Seagrasses
Perry, M. J., Curic, M., Scott, A. L., Ritmejerytė, E., Rahayu, D. U. C., Keller, P. A., Oelgemöller, M., Yeshi, K., & Wangchuk, P. (2024) · Life · doi:10.3390/life14060710 · Cited by 2
UV-Induced Chemokines as Emerging Targets for Skin Cancer Photochemoprevention
Byrne, S. N., & Halliday, G. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_10 · Cited by 2
Targeting STAT6 in Atopic Eczema/Dermatitis
Katayama, I., Murota, H., Igawa, K., Satoh, T., Nishioka, K., & Yokozeki, H. (2009) · Springer eBooks · doi:10.1007/978-4-431-99365-0_10 · Cited by 2
Inflammation, Immunology and Allergy
Steinhoff, M. S. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0008 · Cited by 2
Epigenetics of autoimmune diseases
Farhadi, E., & Mahmoudi, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814259-2.00009-1 · Cited by 1
Solomon, M., & Leite, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-58954-7_3 · Cited by 1
Chapter 3 Mechanism of action—molecular effects
Moor, A. C. E., & Ortel, B. J. (2001) · Comprehensive series in photosciences · doi:10.1016/s1568-461x(01)80107-1 · Cited by 1
Ikeda, M., Hirose, Y., Hamada, R., Nakajima, H., Miyoshi, K., Matsumoto, M., Seike, M., & Kodama, H. (2004) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2004.06.001 · Cited by 1
Steinhoff, M. S., Groves, R. W., LeBoit, P. E., & Luger, T. A. (2010) · Wiley eBooks · doi:10.1002/9781444317633.ch12 · Cited by 1
An immunological perspective on skin disease
Foley, P. A. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.09.011
Biologia molecolare dell’invecchiamento cutaneo intrinseco ed estrinseco
Terranova, F., & Bartoletti, A. (2008) · EMC - Cosmetologia Medica e Medicina degli Inestetismi Cutanei · doi:10.1016/s1776-0313(08)70406-4
Steinhoff, M. S., Nashan, D., & Luger, T. (2003) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-002-0563-4
Signal Transduction Pathways in the Skin
Iversen, L., & Kragballe, K. (2004) · CRC Press eBooks · doi:10.1201/b14248-23
Identification and Characterization of a Novel CK2-MSK2 Iinteraction in the UV Response
Jacks, K. A. (2011) · TSpace (University of Toronto)
Javarsiani, M. H., Javanmard, S. H., & Sajedianfard, J. (2021) · Current Cancer Therapy Reviews · doi:10.2174/1573394717666210922151736
Mnich, C. D., & Dummer, R. (2006) · Steinkopff eBooks · doi:10.1007/978-3-7985-1626-7_10
Liu, Z., Yang, Y., Chi, Y., & Xu, Z. (2026) · Collagen and Leather · doi:10.1186/s42825-026-00249-6
Mishra, N. K., Tripathi, S., Mohanty, S. R., Gusain, K., Parmar, A. S., Yadav, S. K., & Haldar, C. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503784
Emerging roles of RNA as a driver of UV-induced skin inflammation and inflammatory skin diseases
Verghese, M., & He, Y. (2026) · JID Innovations · doi:10.1016/j.xjidi.2026.100546
Metadata
- Authors
- Abeyama, K., Eng, W., Jester, J. V., Vink, A. A., Edelbaum, D., Cockerell, C. J., Bergstresser, P. R., & Takashima, A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Takashima, Akira
- Venue
- Journal of Clinical Investigation
- Published
- 2000-06-15
- Volume
- 105
- Issue
- 12
- Pages
- 1751-1759
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC378515
- OpenAlex
- W2136200385
- Cited by
- 160
- References
- 66
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 1 · 2019: 7 · 2018: 7 · 2017: 1 · 2016: 11 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR 35068, R01-AR40042, R01-AR43777, R01AR040042, R01AR043777, R01AR035068)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- NF-κB, sunburn, ultraviolet radiation, skin inflammation, decoy oligonucleotides, gene transactivation, inflammatory cytokines, interleukin-1, interleukin-6, TNF-α, vascular endothelial growth factor, epidermal hyperplasia, leukocyte infiltration, topical gene therapy
- MeSH terms
- Animals, Base Sequence, Cell Line, Edema, Female, Gene Expression Regulation, Hyperplasia, Langerhans Cells, Mice, Inbred A, Mice, Inbred BALB C, Oligodeoxyribonucleotides, Skin, Sunburn, Ultraviolet Rays, Transcriptional Activation, Keratinocytes, NF-kappa B, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
