Cited by 160NF-κB Signaling PathwaysSkin Protection and AgingPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

A role for NF-κB–dependent gene transactivation in sunburn

Open access

Abeyama, Kazuhiro, Eng, William, Jester, James V., Vink, Arie A., Edelbaum, Dale, Cockerell, Clay J., Bergstresser, Paul R., Takashima, Akira·2000·Journal of Clinical Investigation

DOI 10.1172/jci9745PMC PMC378515

Open this paper in CoChat — free account Open PDF

Abstract

Exposure of skin to ultraviolet (UV) radiation is known to induce NF-kappaB activation, but the functional role for this pathway in UV-induced cutaneous inflammation remains uncertain. In this study, we examined whether experimentally induced sunburn reactions in mice could be prevented by blocking UV-induced, NF-kappaB-dependent gene transactivation with oligodeoxynucleotides (ODNs) containing the NF-kappaB cis element (NF-kappaB decoy ODNs). UV-induced secretion of IL-1, IL-6, TNF-alpha, and VEGF by skin-derived cell lines was inhibited by the decoy ODNs, but not by the scrambled control ODNs. Systemic or local injection of NF-kappaB decoy ODNs also inhibited cutaneous swelling responses to UV irradiation. Moreover, local UV-induced inflammatory changes (swelling, leukocyte infiltration, epidermal hyperplasia, and accumulation of proinflammatory cytokines) were all inhibited specifically by topically applied decoy ODNs. Importantly, these ODNs had no effect on alternative types of cutaneous inflammation caused by irritant or allergic chemicals. These results indicate that sunburn reactions culminate from inflammatory events that are triggered by UV-activated transcription of NF-kappaB target genes, rather than from nonspecific changes associated with tissue damage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci9745

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
NF-κB: Ten Years After
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596
Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors
Rosette, C., & Karin, M. (1996) · Science · doi:10.1126/science.274.5290.1194 · Cited by 1,034
DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1
Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721
Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.
Köck, A., Schwarz, T., Kirnbauer, R., Urbanski, A., Perry, P., Ansel, J. C., & Luger, T. A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1609 · Cited by 712
Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway
Lee, F. S., Hagler, J., Chen, Z. J., & Maniatis, T. (1997) · Cell · doi:10.1016/s0092-8674(00)81842-5 · Cited by 710
CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
Hartmann, G., Weiner, G. J., & KRIEG, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9305 · Cited by 623
ATF‐2 is preferentially activated by stress‐activated protein kinases to mediate c‐jun induction in response to genotoxic agents.
van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. A., & Angel, P. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07168.x · Cited by 598
In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction
Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Sawa, Y., Kaneda, Y., Higaki, J., et al. (1997) · Nature Medicine · doi:10.1038/nm0897-894 · Cited by 584
Increased Microvascular Density and Enhanced Leukocyte Rolling and Adhesion in the Skin of VEGF Transgenic Mice
Detmar, M. J., Brown, L. F., Schön, M. P., Elicker, B. M., Velasco, P., Richard, L., Fukumura, D., Monsky, W. L., Claffey, K. P., & Jain, R. K. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00262.x · Cited by 550
Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA
Jakob, T., Walker, P., Krieg, A. Μ., Udey, M. C., & Vogel, J. C. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.3042 · Cited by 535
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.
Knebel, A., Rahmsdorf, H. J., Ullrich, A., & Herrlich, P. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00916.x · Cited by 514
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.Preprint
Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 466
Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L
Aragane, Y., Kulms, D., Metze, D., Wilkes, G., Pöppelmann, B., Luger, T. A., & Schwarz, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.1.171 · Cited by 463
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB
Schmidt, K. N., Amstad, P., Cerutti, P., & Baeuerle, P. A. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90076-4 · Cited by 453
Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication
Sullenger, B. A., Gallardo, H. F., Ungers, G. E., & Gilboa, E. (1990) · Cell · doi:10.1016/0092-8674(90)90455-n · Cited by 443
Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell
Yablonski, D., Kuhné, M. R., Kadlecek, T. A., & Weiss, A. (1998) · Science · doi:10.1126/science.281.5375.413 · Cited by 413
UV-induced reactive oxygen species in photocarcinogenesis and photoaging.
Scharffetter‐Kochanek, K., Wlaschek, M., Brenneisen, P., Schauen, M., Blaudschun, R., & Wenk, J. (1997) · PubMed · Cited by 406
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation
Elmets, C. A., Bergstresser, P. R., Tigelaar, R. E., Wood, P. J., & Streilein, J. W. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.781 · Cited by 392
Self-citation
Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides
Bielinska, A. U., Shivdasani, R. A., Zhang, L., & Nabel, G. J. (1990) · Science · doi:10.1126/science.2237444 · Cited by 372
Mechanisms of Ultraviolet Light‐Induced Pigmentation
Gilchrest, B. A., Park, H., Eller, M. S., & Yaar, M. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb02988.x · Cited by 367
IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice
Klement, J. F., Rice, N. R., Car, B. D., Abbondanzo, S. J., Powers, G. D., Bhatt, H., Chen, C.-H., Rosen, C. A., & Stewart, C. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2341 · Cited by 340
A survey of transformation markers in differentiating epidermal cell lines in culture.
Yuspa, S. H., Hawley‐Nelson, P., Koehler, B., & Stanley, J. R. (1980) · PubMed · Cited by 324
DNA damage enhances melanogenesis.
Eller, M. S., Ostrom, K., & Gilchrest, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1087 · Cited by 285
Activation of human B cells by phosphorothioate oligodeoxynucleotides.
Liang, H., Nishioka, Y., Reich, C. F., Pisetsky, D. S., & Lipsky, P. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118894 · Cited by 284
Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy
Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether‐Beck, S., Ruzicka, T., Kapp, A., Klotz, L., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.10.1763 · Cited by 280
Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase
Nemoto, S., DiDonato, J. A., & Lin, A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7336 · Cited by 224
Ultraviolet Light Induces Increased Circulating Interleukin-6 in Humans
Urbanski, A., Schwarz, T., Neuner, P., Krutmann, J., Kirnbauer, R., Luger, T. A., & Köck, A. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12874666 · Cited by 221
Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene
Grether‐Beck, S., Olaizola‐Horn, S., Schmitt, H., Grewe, M., Jahnke, A., Johnson, J. P., Briviba, K., Sies, H., & Krutmann, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14586 · Cited by 212
CREB is activated by UVC through a p38/HOG‐1‐dependent protein kinase
Iordanov, M. S., Bender, K., Ade, T., Schmid, W., Sachsenmaier, C., Engel, K., Gaestel, M., Rahmsdorf, H. J., & Herrlich, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1009 · Cited by 208
Genomic Organization of Human and Mouse Genes for Vascular Endothelial Growth Factor C
Chilov, D., Kukk, E., Taira, S., Jeltsch, M., Kaukonen, J., Palotie, A. V., Joukov, V., & Alitalo, K. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25176 · Cited by 207
Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for a p53-mediated mammalian SOS response
Eller, M. S., Maeda, T., Magnoni, C., Atwal, D., & Gilchrest, B. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12627 · Cited by 204
UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic Extracts
Simon, M. M., Aragane, Y., Schwarz, A., Luger, T. A., & Schwarz, T. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12372194 · Cited by 167
The Effect of In Vitro and In Vivo UV Irradiation on the Production of ETAF Activity by Human and Murine Keratinocytes
Ansel, J. C., Luger, T. A., & Green, I. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12522862 · Cited by 164
Ultraviolet B and H2O2 Are Potent Inducers of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes
Brauchle, M. A., Funk, J. O., Kind, P., & Werner, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21793 · Cited by 158
Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells
Matsue, H., Matsue, K., Walters, M., Okumura, K., Yagita∥, H., & Takashima, A. (1999) · Nature Medicine · doi:10.1038/11375 · Cited by 157
Self-citation
Successive generation of antigen-presenting, dendritic cell lines from murine epidermis.
Xu, S., Ariizumi, K., Càceres‐Dittmar, G., Edelbaum, D., Hashimoto, K., Bergstresser, P. R., & Takashima, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2697 · Cited by 153
Self-citation
Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice
Vink, A., Strickland, F., Bucana, C., Cox, P., Roza, L., Yarosh, D. B., & Kripke, M. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.183.4.1491 · Cited by 153
Self-citation
The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers.
Vink, A., Moodycliffe, A., Shreedhar, V., Ullrich, S. E., Roza, L., Yarosh, D. B., & Kripke, M. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.10.5255 · Cited by 152
Self-citation
Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions.
Brown, L. F., Olbricht, S. M., Berse, B., Jackman, R. W., Matsueda, G. R., Tognazzi, K., Manseau, E. J., Dvorak, H. F., & Water, L. V. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2801 · Cited by 150
Molecular Regulation of UVB-Induced Cutaneous Angiogenesis
Bielenberg, D. R., Bucana, C. D., Sànchez, R., Donawho, C. K., Kripke, M. L., & Fidler, I. J. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00378.x · Cited by 141
DNA damage enhances melanogenesis
Eller (1996) · Medical Entomology and Zoology · Cited by 139
DETECTION OF CYCLOBUTANE THYMINE DIMERS IN DNA OF HUMAN CELLS WITH MONOCLONAL ANTIBODIES RAISED AGAINST A THYMINE DIMER‐ CONTAINING TETRANUCLEOTIDE
Roza, L., Kj, V. D. W., MacFarlane, S. J., Lohman, P. H. M., & Baan, R. A. (1988) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1988.tb02873.x · Cited by 136
Sunscreens and T4N5 Liposomes Differ in Their Ability to Protect Against Ultraviolet-Induced Sunburn Cell Formation, Alterations of Dendritic Epidermal Cells, and Local Suppression of Contact Hypersensitivity
Wolf, P., Cox, P., Yarosh, D. B., & Kripke, M. L. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12612828 · Cited by 127
Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1
Branda, R. F., Moore, A. L., Mathews, L., McCormack, J. J., & Zon, G. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90014-n · Cited by 119
Involvement of Cytokines, DNA Damage, and Reactive Oxygen Intermediates in Ultraviolet Radiation-Induced Modulation of Intercellular Adhesion Molecule-1 Expression
Krutmann, J., & Grewe, M. (1995) · Journal of Investigative Dermatology · doi:10.1038/jid.1995.14 · Cited by 118
Intratumoral injection of oligonucleotides to the NFκB binding site inhibits cachexia in a mouse tumor model
Kawamura, I., Morishita, R., Tomita, N., Lacey, E., Aketa, M., Tsujimoto, S., Manda, T., Tomoi, M., Kida, I., Higaki, J., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300819 · Cited by 117
Immune Recognition of Foreign DNA
Klinman, D. M., Verthelyi, D. I., Takeshita, F., & Ishii, K. J. (1999) · Immunity · doi:10.1016/s1074-7613(00)80087-4 · Cited by 116
Impact of UVB Radiation on the Epidermal Cytokine Network
Takashima, A., & Bergstresser, P. R. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03054.x · Cited by 116
Self-citation
Oligodeoxynucleotides Containing Palindrome Sequences with Internal 5′-CpG-3′ Act Directly on Human NK and Activated T Cells to Induce IFN-γ Production In Vitro
Iho, S., Yamamoto, T., Takahashi, T., & Yamamoto, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3642 · Cited by 114
Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-gamma production in vitro.
Iho, S., Yamamoto, T., Takahashi, T., & Yamamoto, S. (1999) · PubMed · Cited by 110
Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination
Carson, D. A., & Raz, E. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.10.1621 · Cited by 105
Quantitative analysis of the immunopotency of genetically transfected dendritic cells
Timares, L., Takashima, A., & Johnston, S. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13147 · Cited by 93
Self-citation
Effects of physicochemical agents on murine epidermal Langerhans cells and Thy-1-positive dendritic epidermal cells.
Aberer, W., Romani, N., Elbe, A., & Stingl, G. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.4.1210 · Cited by 85
c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.
Shapiro, V. S., Mollenauer, M. N., Greene, W. C., & Weiss, A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1663 · Cited by 77
Decoy Administration of NF- κ B into the Subarachnoid Space for Cerebral Angiopathy
Ono, S., Date, I., Onoda, K., Shiota, T., Ohmoto, T., Ninomiya, Y., Asari, S., & Morishita, R. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.7-1003 · Cited by 72
T cell-mediated terminal maturation of dendritic cells: loss of adhesive and phagocytotic capacities
Kitajima, T., Càceres‐Dittmar, G., Tapia, F. J., Jester, J. V., Bergstresser, P. R., & Takashima, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.6.2340 · Cited by 71
Self-citation
PHOTOBIOLOGY SCHOOL
Kripke, M. L. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb08703.x · Cited by 71
DNA double strand breaks in epidermal cells cause immune suppression in vivo and cytokine production in vitro.
O'Connor, A., Nishigori, C., Yarosh, D. B., Alas, L., Kibitel, J., Burley, L., Cox, P., Bucana, C., Ullrich, S. E., & Kripke, M. (1996) · Journal of Immunology · doi:10.4049/jimmunol.157.1.271 · Cited by 51
Ultraviolet B radiation sensitizes a murine epidermal dendritic cell line (XS52) to undergo apoptosis upon antigen presentation to T cells.
Kitajima, T., Ariizumi, K., Bergstresser, P., & Takashima, A. (1996) · Journal of Immunology · doi:10.4049/jimmunol.157.8.3312 · Cited by 40
Self-citation
In vivo activation of mouse dendritic epidermal T cells in sites of contact dermatitis
Kamiński, M., Bergstresser, P. R., & Takashima, A. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230748 · Cited by 29
Self-citation
Ibuprofen in the Treatment of UV-B-Induced Inflammation
Stern, R. S. (1985) · Archives of Dermatology · doi:10.1001/archderm.1985.01660040092018 · Cited by 12
Darwin deal marks growth of link-ups for gene companies
Lehrman, S. (1994) · Nature · doi:10.1038/371546b0 · Cited by 6

Research works printed but not linked: 2

Scharffetter-Kochanek, 1997, Biol Chem, 378, 1247
Yuspa, 1980, Cancer Res, 40, 4694

Sorted by citations

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe
Aggarwal, B. B., Vijayalekshmi, R. V., & Sung, B. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0149 · Cited by 812
Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – a review
Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706
Photoaging: mechanisms and repair
Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610
Ultraviolet light induced injury: Immunological and inflammatory effects
Clydesdale, G. J., Dandie, G. W., & Muller, H. K. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.01047.x · Cited by 590
Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
Huang, S., Pettaway, C. A., Uehara, H., Bucana, C. D., & Fidler, I. J. (2001) · Oncogene · doi:10.1038/sj.onc.1204535 · Cited by 556

See all 160

Authors: Abeyama, K., Eng, W., Jester, J. V., Vink, A. A., Edelbaum, D., Cockerell, C. J., Bergstresser, P. R., & Takashima, A.
Affiliations: The University of Texas Southwestern Medical Center (US)
Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Takashima, Akira
ORCID: Jester, James V.
Cockerell, Clay J.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2000-06-15
Volume: 105
Issue: 12
Pages: 1751-1759
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci9745
PMC: PMC378515
OpenAlex: W2136200385
Cited by: 160
References: 66
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 1 · 2019: 7 · 2018: 7 · 2017: 1 · 2016: 11 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
FWCI: 4.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR 35068, R01-AR40042, R01-AR43777, R01AR040042, R01AR043777, R01AR035068)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: NF-κB, sunburn, ultraviolet radiation, skin inflammation, decoy oligonucleotides, gene transactivation, inflammatory cytokines, interleukin-1, interleukin-6, TNF-α, vascular endothelial growth factor, epidermal hyperplasia, leukocyte infiltration, topical gene therapy
MeSH terms: Animals, Base Sequence, Cell Line, Edema, Female, Gene Expression Regulation, Hyperplasia, Langerhans Cells, Mice, Inbred A, Mice, Inbred BALB C, Oligodeoxyribonucleotides, Skin, Sunburn, Ultraviolet Rays, Transcriptional Activation, Keratinocytes, NF-kappa B, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A role for NF-κB–dependent gene transactivation in sunburn

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks