Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation
Open accessAbstract
Acute, low dose ultraviolet B radiation of murine body wall skin followed by local application of DNFB produces a state of antigen-specific unresponsiveness. This state is maintained at least in part by an Lyt-1+ T cell that effects unresponsiveness by impairing the induction phase of contact hypersensitivity. The absence of suppressor cells capable of acting at the effector stage of immunity suggests that tolerogenic signals derived from the skin establish suppressor networks that are incomplete and perhaps different from networks that are induced by systemic administration of tolerogens. It is proposed that ultraviolet radiation produces its effects by impairing the antigen-presenting potential of resident Langerhans cells in whose absence hapten-derivatized keratinocytes (or their products) are able to deliver a tolerogenic signal.
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Defective Langerhans cells and Treg cells may mediate UV-induced suppression of contact hypersensitivity.
“The defective LCs and Treg cells may mediate UV-induced suppression of contact hypersensitivity (CHS) [66].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [66]
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- Authors
- Elmets, C. A., Bergstresser, P. R., Tigelaar, R. E., Wood, P. J., & Streilein, J. W.
- ORCID
- Elmets, C A
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1983-09-01
- Volume
- 158
- Issue
- 3
- Pages
- 781-794
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2187099
- OpenAlex
- W2158046602
- Cited by
- 392
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- UV-B radiation, 2,4-dinitrofluorobenzene, antigen-specific unresponsiveness, contact hypersensitivity, Lyt-1+ T cells, regulatory T cells, Langerhans cells, antigen presentation, mouse skin, keratinocytes
- MeSH terms
- Animals, Epitopes, Dermatitis, Contact, Dinitrofluorobenzene, Female, Haptens, Immune Tolerance, Immunization, Passive, Lymph Nodes, Lymphocyte Activation, Mice, Inbred C3H, Phenotype, Skin, Spleen, Ultraviolet Rays, T-Lymphocytes, Regulatory, Mice
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