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Cited by 388

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone

PRANGE, ARTHUR J., WILSON, IAN C., RABON, ARCHIE M., LIPTON, MORRIS A.·1969·American Journal of Psychiatry
DOI 10.1176/ajp.126.4.457
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Abstract

Twenty euthyroid patients with retarded depression were studied to determine the possible role of alterations in thyroid function in the etiology and treatment of depression. A battery of tests was administered regularly to measure change. Patients responded better to usual doses of imipramine when 25 µg. of L-triiodothyronine (T3) was administered daily. T3 was physiologically active, altering protein-bound iodine values and accelerating ankle reflex time. A possible explanation, based on relevant data from animal experiments, is that imipramine may elevate effective biogenic concentration, while T3 increases receptor sensitivity.

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Crossref · 10.1176/ajp.126.4.457

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Metadata

Authors
PRANGE, A. J., WILSON, I. C., RABON, A. M., & LIPTON, M. A.
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1969-10
Volume
126
Issue
4
Pages
457-469
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.126.4.457
OpenAlex
W2061650011
Cited by
388
References
3
FWCI
20.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone. https://app.cochat.ai/papers/10.1176/ajp.126.4.457
The paper
PRANGE, A. J., WILSON, I. C., RABON, A. M., & LIPTON, M. A. (1969). Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone. American Journal of Psychiatry. https://doi.org/10.1176/ajp.126.4.457

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.