Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant
Abstract
A unipolar depressed patient developed a fast-cycling bipolar disorder on abrupt discontinuation of long-term treatment with a tricyclic antidepressant. The case illustrates the potential for drug withdrawal to induce mood disturbance that is more severe than the original illness.
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Slow tapering, often extending over a year or more, has been suggested to manage new withdrawal symptoms.
“Slow tapering, often extending over a year or more, has been suggested to manage new withdrawal symptoms [78].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [78]
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- Authors
- Jones, B. D. M., Steinberg, S. I., & Chouinard, G.
- ORCID
- Brett D. M. Jones
- Venue
- American Journal of Psychiatry
- Published
- 1984-01-01
- Volume
- 141
- Issue
- 1
- Pages
- 108-109
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2414541900
- Cited by
- 26
- References
- 9
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- bipolar disorder, tricyclic antidepressants, drug withdrawal, antidepressant discontinuation, major depressive disorder, mood disturbance, adverse drug reactions
- MeSH terms
- Bipolar Disorder, Depressive Disorder, Female, Humans, Imipramine, Middle Aged, Substance Withdrawal Syndrome
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