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Cited by 11Bipolar Disorder and TreatmentTreatment of Major DepressionElectroconvulsive Therapy Studies

Transient Mood Elevation Associated with Antidepressant Drug Decrease*

Corral, M., Sivertz, K., Jones, B.D.·1987·The Canadian Journal of Psychiatry
DOI 10.1177/070674378703200906
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Abstract

The development of hypomania, mania and transient mood elevation within 2–3 days of antidepressant discontinuation, and lasting days to several weeks has been reported in unipolar depressed patients. Imipramine and desipramine are the antidepressants most frequently associated with the above phenomena. A reported case of transient mood elevation following abrupt reduction but not discontinuation of desipramine therapy in a woman with unipolar depression is described. The phenomenon was observed and documented on two separate occasions. Mood elevation occurred despite decreased plasma levels of the drug. Relapse followed despite maintenance of dose and similar drug plasma levels. Factors which could account for the transitory improvement of mood are examined. It is suggested that the patient's improvement in mood may have occurred due to a rebound paradoxical therapeutic effect. The features of the presented case history which appear to support this hypothesis are discussed. Also the clinical implications of this phenomenon are reviewed.

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Crossref · 10.1177/070674378703200906

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9 of 9 references verified0 citation errors · 0 not checkable

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Authors
Corral, M., Sivertz, K., & Jones, B. D.
Affiliations
  • University of British Columbia Hospital (CA)
  • University of Ottawa (CA)
Venue
The Canadian Journal of Psychiatry
Publisher
SAGE Publications
Published
1987-12
Volume
32
Issue
9
Pages
764-767
ISSN
  • 0706-7437 (ISSN-L)
  • 1497-0015
DOI
10.1177/070674378703200906
OpenAlex
W2413866025
Cited by
11
References
9
Citations by year
2024: 1 · 2020: 1 · 2015: 1 · 2014: 1
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The Canadian Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
antidepressant discontinuation syndrome, hypomania, mania, major depressive disorder, imipramine, desipramine, depression relapse, plasma drug concentration
MeSH terms
Bipolar Disorder, Depressive Disorder, Desipramine, Emotions, Female, Humans, Middle Aged, Substance Withdrawal Syndrome

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