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Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects
Abstract
The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin. They also compared a second, separate group of 14 women and five men suffering from melancholic depression with seven healthy male control subjects and nine depressed women without melancholia. The melancholic patients had a significantly lower concentration of serum melatonin at 11:00 p.m. than either the control subjects or the nonmelancholic depressed patients. These findings support the possibility that the functioning of the pineal gland is altered in these patients.
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Cited by
Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600571822 · Cited by 292
Pierre Olié, J., & Kasper, S. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007766 · Cited by 256
Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199
Parry, B. L., Berga, S. L., Mostofi, N., Klauber, M. R., & Resnick, A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200107 · Cited by 129
Altered Waveform of Plasma Nocturnal Melatonin Secretion in Premenstrual Depression
Parry, B. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810240059010 · Cited by 128
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1985-07-01
- Volume
- 142
- Issue
- 7
- Pages
- 811-816
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2409513133
- Cited by
- 243
- References
- 0
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects. (1985). American Journal of Psychiatry. https://doi.org/10.1176/ajp.142.7.811
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