Cited by 199Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and related disorders

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

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Vadnie, Chelsea A., McClung, Colleen A.·2017·Neural Plasticity

Abstract

Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders.

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  • Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion.

    “Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [81]

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Research works printed but not linked: 2

  1. [3]Rosenwasser A. M. Wirz-Justice A. Redfern P. H. Lemmer B. Circadian rhythms and depression: clinical and experimental models Physiology and Pharmacology of Biological Rhythms 1997 Berlin, Heidelberg Springer Berlin Heidelberg 457 486
  2. [25]Pittendrigh C. S. Aschoff J. Circadian systems: entrainment Biological Rhythms 1981 Boston, MA Springer US

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Authors
Vadnie, C. A., & McClung, C. A.
Affiliations
University of Pittsburgh (US)
Corresponding author
Vadnie, Chelsea A.
Venue
Neural Plasticity
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-28
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
OpenAlex
W2767056255
Cited by
199
References
383
Citations by year
2026: 13 · 2025: 20 · 2024: 25 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 29 · 2019: 13 · 2018: 15 · 2017: 1
FWCI
1.92
Type
journal article
Language
en
Open access
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (DA039865, DA023988, DA037636, MH106460, MH082876)
  • Pfizer (DA039865, DA023988, DA037636, MH106460, MH082876)
  • McKnight Foundation for Neuroscience (DA039865, DA023988, DA037636, MH106460, MH082876)
  • International Mental Health Research Organization (DA039865, DA023988, DA037636, MH106460, MH082876)
  • The Brain and Behavior Foundation (NARSAD) (DA039865, DA023988, DA037636, MH106460, MH082876)
  • National Institute on Drug Abuse (DA039865, DA023988, DA037636, MH106460, MH082876)
  • National Institute of Mental Health (DA039865, DA023988, DA037636, MH106460, MH082876)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
circadian rhythm disruption, mood disorders, suprachiasmatic nucleus, circadian rhythm, mood regulation, circadian clock, hypothalamus
MeSH terms
Animals, Circadian Rhythm, Humans, Neural Pathways, Suprachiasmatic Nucleus, Mood Disorders

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