Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus
Open accessAbstract
Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synaptic and hormonal mechanisms, the SCN can drive and synchronize circadian rhythms in extra-SCN brain regions and peripheral tissues. Thus, genetic or environmental perturbations of SCN rhythms could disrupt brain regions more closely related to mood regulation and cause mood disturbances. Here, we review clinical and preclinical studies that provide evidence both for and against a causal role for the SCN in mood disorders.
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Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion.
“Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [81]
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Mood phenotypes in rodent models with circadian disturbances
Imamura, K., & Takumi, T. (2022) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2022.100083 · Cited by 11 · see citing works
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- Authors
- Vadnie, C. A., & McClung, C. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Vadnie, Chelsea A.
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-28
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC5694588
- OpenAlex
- W2767056255
- Cited by
- 199
- References
- 383
- Citations by year
- 2026: 13 · 2025: 20 · 2024: 25 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 29 · 2019: 13 · 2018: 15 · 2017: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (DA039865, DA023988, DA037636, MH106460, MH082876)
- Pfizer (DA039865, DA023988, DA037636, MH106460, MH082876)
- McKnight Foundation for Neuroscience (DA039865, DA023988, DA037636, MH106460, MH082876)
- International Mental Health Research Organization (DA039865, DA023988, DA037636, MH106460, MH082876)
- The Brain and Behavior Foundation (NARSAD) (DA039865, DA023988, DA037636, MH106460, MH082876)
- National Institute on Drug Abuse (DA039865, DA023988, DA037636, MH106460, MH082876)
- National Institute of Mental Health (DA039865, DA023988, DA037636, MH106460, MH082876)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm disruption, mood disorders, suprachiasmatic nucleus, circadian rhythm, mood regulation, circadian clock, hypothalamus
- MeSH terms
- Animals, Circadian Rhythm, Humans, Neural Pathways, Suprachiasmatic Nucleus, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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