The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder
Abstract
OBJECTIVE: The authors investigated the possibility of enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in posttraumatic stress disorder (PTSD) by using a low dose of dexamethasone. METHOD: Baseline blood samples were obtained at 8:00 a.m., and 0.5 mg of dexamethasone was administered to 21 male patients with PTSD and 12 normal age-comparable men at 11:00 p.m. Cortisol and dexamethasone levels were measured 9 and 17 hours after dexamethasone administration. RESULTS: After correction for differences in dexamethasone levels, the PTSD patients showed greater suppression of cortisol in response to dexamethasone than did the normal subjects. This was true even in patients meeting concurrent diagnostic criteria for major depression. CONCLUSIONS: The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology.
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“Enhanced ASR and HPA-negative feedback have been reliably observed in patients with PTSD (Shalev et al, 1992;Yehuda et al, 1993;Orr et al, 1997).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Yehuda et al, 1993
In the citing paper
“Enhanced ASR and HPA-negative feedback have been reliably observed in patients with PTSD (Shalev et al, 1992;Yehuda et al, 1993;Orr et al, 1997).”
From Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress (2012) · cites this paper as Yehuda et al, 1993
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Cites
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Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder
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Self-citationTreatment of Depression: Old Controversies and New Approaches
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Self-citationHypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder
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Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder
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- Spitzer RL, 1985, Williams JBW: Structured Clinical Interview for DSM-III-R
- SPSS, 1988, SPSSIPC+ 3.0
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Items 501–517 of 517
Dexamethasone Suppression Test
Kudielka, B. M. (2017) · Springer eBooks · doi:10.1007/978-1-4614-6439-6_11-2
Animal Models of Anxiety and Stress-Induced Behavior
Purdy, R. H., Finn, D. A., & Koob, G. F. (2003) · Frontiers in neuroscience · doi:10.1201/9780203508169.ch15
Reaktionen auf schwere Belastungen und Anpassungsstörungen
Paulzen, M., & Gründer, G. (2008) · Springer eBooks · doi:10.1007/978-3-540-68748-1_45
Dexamethasone Suppression Test
Kudielka, B. M. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1005-9_11
Post-Traumatic Stress Disorder: Theoretical Approaches and Animal Models
Toropova, K. A., Ivashkina, O. I., & Anokhin, K. V. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01296-2
Psychiatric Disturbances of Attention
Cohen, R. A. (2013) · Springer eBooks · doi:10.1007/978-0-387-72639-7_17
Chapter 23. Women and Violence
Warshaw, C. (2001) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550411.lg23
Chapter 4. Biological Theories
(2002) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615377152.lg04
Bremner, J. D., & Vermetten, E. H. G. J. M. (2007) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615377503.lg12
Self-citationChapter 1. Posttraumatic Stress Disorder
Friedman, M. J., & Karam, E. G. (2008) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780890427750.lg01
Chapter 4. Biological Treatment of PTSD in Children and Adolescents
Seedat, S., & Stein, D. J. (2000) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615377046.lg04
Jurcău, R., Jurcău, I.-M., Borșan, L. R., CMI, C.-N., Colceriu, N.-A., & Kwak, D. H. (2024) · BULETIN ŞTIINŢIFIC SERIA A Fascicula Pedagogie-Psihologie-Metodică · doi:10.37193/bs-ppm.24.09
Post-traumatic Stress Disorder (PTSD): Linking Inflammatory and Neural Factors
Mudgal, J., Govindula, A., & Arora, D. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_86
Pathogenese und Therapie von Angsterkrankungen
López-Ibor, J. J., Linden, M., & Gibert, J. (2000) · Springer eBooks · doi:10.1007/978-3-642-59627-8_3
Pathogenesis and Treatment of Anxiety Disorders
López-Ibor, J. J., Linden, M., & Gibert, J. (2001) · Springer eBooks · doi:10.1007/978-3-642-59519-6_119
Metadata
- Authors
- Yehuda, R., Southwick, S. M., Krystal, J. H., Bremner, J. D., Charney, D. S., & Mason, J. W.
- Affiliations
- Yale University (US)
- Venue
- American Journal of Psychiatry
- Published
- 1993-01-01
- Volume
- 150
- Issue
- 1
- Pages
- 83-86
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W49144085
- Cited by
- 517
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 16 · 2015: 21 · 2014: 5 · 2013: 15 · 2012: 20
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03mh049536-02)
- National Institute of Mental Health (MH-49536)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- post-traumatic stress disorder, dexamethasone suppression test, cortisol, hypothalamic-pituitary-adrenal axis, negative feedback sensitivity, major depressive disorder, differential diagnosis, glucocorticoid receptor sensitivity
- MeSH terms
- Adult, Depressive Disorder, Dexamethasone, Diagnosis, Differential, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic
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