Cited by 517Stress Responses and CortisolPosttraumatic Stress Disorder ResearchAdrenal Hormones and Disorders

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Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder

Rachel Yehuda, Steven Mark Southwick, John Harrison Krystal, J. Douglas Bremner, Dennis S. Charney, John W Mason·1993·American Journal of Psychiatry

DOI 10.1176/ajp.150.1.83

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Abstract

OBJECTIVE: The authors investigated the possibility of enhanced negative feedback sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in posttraumatic stress disorder (PTSD) by using a low dose of dexamethasone. METHOD: Baseline blood samples were obtained at 8:00 a.m., and 0.5 mg of dexamethasone was administered to 21 male patients with PTSD and 12 normal age-comparable men at 11:00 p.m. Cortisol and dexamethasone levels were measured 9 and 17 hours after dexamethasone administration. RESULTS: After correction for differences in dexamethasone levels, the PTSD patients showed greater suppression of cortisol in response to dexamethasone than did the normal subjects. This was true even in patients meeting concurrent diagnostic criteria for major depression. CONCLUSIONS: The data support earlier studies showing that HPA abnormalities in PTSD are different from those seen in depression and suggest that the low-dose dexamethasone suppression test may be a potentially useful tool for differentiating the two syndromes and further exploring differences in their pathophysiology.

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Authors: Yehuda, R., Southwick, S. M., Krystal, J. H., Bremner, J. D., Charney, D. S., & Mason, J. W.
Affiliations: Yale University (US)
ORCID: Rachel Yehuda
Steven Mark Southwick
John Harrison Krystal
J. Douglas Bremner
Dennis S. Charney
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1993-01-01
Volume: 150
Issue: 1
Pages: 83-86
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.150.1.83
OpenAlex: W49144085
Cited by: 517
References: 18
Citations by year: 2026: 1 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 16 · 2015: 21 · 2014: 5 · 2013: 15 · 2012: 20
FWCI: 6.47
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r03mh049536-02)
National Institute of Mental Health (MH-49536)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: post-traumatic stress disorder, dexamethasone suppression test, cortisol, hypothalamic-pituitary-adrenal axis, negative feedback sensitivity, major depressive disorder, differential diagnosis, glucocorticoid receptor sensitivity
MeSH terms: Adult, Depressive Disorder, Dexamethasone, Diagnosis, Differential, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic

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Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder

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