Genetics of the serotonergic system in suicidal behavior
Abstract
Genetic factors contribute to the risk of psychopathology in many psychiatric conditions, but the specific genes are yet to be identified. Neurotransmitter alterations are implicated in the etiology of psychopathology based, in part, on studies of neurotransmitter receptors and their biosynthetic or degradative enzymes in postmortem tissue. Identification of the altered receptors and enzymes serves to identify candidate genes of potential etiological significance. Polymorphisms in these genes can contribute to alterations in protein function in vivo that are part of the neurochemical underpinnings of psychopathologies such as major depressive disorder, psychoses, alcoholism, personality disorders, aggressive-impulsive traits, or suicidal behavior. Altered serotonergic function is implicated in the etiology and pathogenesis of several major psychiatric conditions. In particular, there is much evidence for an association of lower serotonergic function and suicidal behavior. Thus genes related to the serotonergic system are candidate genes worthy of study as part of the genetic diathesis for suicidal behavior. This review examines the following polymorphisms in the serotonin biosynthetic enzyme tryptophan hydroxylase (TPH; A779C substitution), the serotonin transporter (5-HTT, 5-HTTLPR allele), the 5-HT(1B) receptor (G861C, C129T substitution) and the 5-HT(2A) receptor (T102C) for their relationship to suicidal behavior. For the TPH gene, we found the less common U or A allele variant of the A779C polymorphism was associated with suicide attempt. Other studies have found the U allele to be associated with aggression and lower serotonergic function in vivo. A 44 base pair insertion/deletion in the 5' flanking promoter region of the 5-HTT gene may result in less 5-HTT expression and 5-HTT binding. We examined 220 cases postmortem and found no association between the promoter genotype and 5-HTT binding. We also found no association with major depressive disorder (MDD), suicide or pathological aggression, despite finding significantly fewer 5-HTT sites in the prefrontal cortex of depressed and/or suicide cases. In genomic DNA samples from 178 unrelated subjects, we detected two polymorphisms for the 5-HT(1B) receptor at nucleotides 861 and 129. However, no association between either polymorphism and depression, suicide, aggression, or alcoholism was observed. There are two common polymorphisms for the 5-HT(2A) receptor gene in humans. The results of studies of 5-HT(2A) receptor gene polymorphisms do not indicate significant major associations with suicidal behavior. In contrast, the 5-HT(2A) receptor itself is reported to be increased in suicide. Functional polymorphisms involving the promoter region that affect gene expression may explain this finding. Studies of candidate genes related to serotonergic function in brain are increasingly used to establish genetic alterations contributing to psychiatric illness. The most meaningful studies combine the study of candidate genes with direct measures of related proteins as well as psychopathology.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Abnormalities in dopaminergic, glutamatergic, GABAergic, and endocannabinoid systems have been implicated in suicide.
“Abnormalities in dopaminergic, glutamatergic, GABAergic, and endocannabinoid systems have also been implicated in suicide.”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [33]
Alterations in CB1 receptor expression in the dorsolateral prefrontal cortex of suicide victims, particularly among those with comorbid substance use, implicate the endocannabinoid system in emotional regulation and stress response.
“Alterations in CB1 receptor expression in the dorsolateral prefrontal cortex (PFC) of suicide victims, particularly among those with comorbid substance use, further implicate the endocannabinoid system in emotional regulation and stress response (32–34).”
From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [33]
Cites
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
Assessment of suicidal intention: The Scale for Suicide Ideation.
Beck, A. T., Kovacs, M., & Weissman, A. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.47.2.343 · Cited by 3,419 · see citing works
Davenport, Y. B., Adland, M. L., Gold, P. W., & Goodwin, F. K. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92810-1 · Cited by 2,925 · see citing works
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · see citing works
Self-citation(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.5.559 · Cited by 1,723 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform
Walther, D. J., Peter, J., Bashammakh, S., Hörtnagl, H., Voits, M., Fink, H., & Bäder, M. (2003) · Science · doi:10.1126/science.1078197 · Cited by 1,576 · see citing works
Papageorgis, D. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90087-j · Cited by 1,542 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079 · see citing works
Merritt, H. H., FREMONT-SMITH, F., & Ayer, J. B. (1938) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193804000-00024 · Cited by 876 · see citing works
Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839 · see citing works
Collier, D. A., Stöber, G., Li, T., Heils, A., Catalano, M., Bella, D. D., Arranz, M. J., Murray, R. M., Vallada, H., Bengel, D., et al. (1996) · PubMed · Cited by 665 · see citing works
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613 · see citing works
Self-citationDeckert, J., Catalano, M., Syagailo, Y. V., Bosi, M., Okladnova, O., Di Bella, D., Nothen, M. M., Maffei, P., Franke, P., Fritze, J., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.621 · Cited by 582 · see citing works
Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims
Mann, J. J. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800100048007 · Cited by 549 · see citing works
Self-citationMalison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496 · see citing works
NEUROBIOLOGY OF MOOD DISORDERS
(2017) · International Supply Chain Technology Journal · doi:10.20545/isctj.v03.n12.03 · Cited by 477 · see citing works
Mann, J. J. (1998) · Nature Medicine · doi:10.1038/nm0198-025 · Cited by 476 · see citing works
Self-citationSuicidal behaviour: an epidemiological and genetic study
STATHAM, D. J., HEATH, A. C., MADDEN, P. A. F., BUCHOLZ, K. K., BIERUT, L., DINWIDDIE, S. H., SLUTSKE, W. S., DUNNE, M. P., & MARTIN, N. G. (1998) · Psychological Medicine · doi:10.1017/s0033291798006916 · Cited by 471 · see citing works
Arango, V., Underwood, M. D., Gubbi, A., & Mann, J. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00523-s · Cited by 458 · see citing works
Self-citationNeurobiology of Mood Disorders
Sullivan, J. L. (1985) · Psychosomatics · doi:10.1016/s0033-3182(85)72842-3 · Cited by 450 · see citing works
Arango, V. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230054009 · Cited by 420 · see citing works
Self-citationThe neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system
Mann, J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00228-1 · Cited by 394 · see citing works
Self-citationLanger, S. Z., Moret, C., Raisman‐Vozari, R., Dubocovich, M. L., & Briley, M. (1980) · Science · doi:10.1126/science.7444441 · Cited by 376 · see citing works
Nielsen, D. A. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010034005 · Cited by 375 · see citing works
Brunner, H. G., Nelen, M. R., van Zandvoort, P., Abeling, N. G. G. M., Gennip, A. H., Wolters, E. C., Kuiper, M. A., Ropers, H., & van Oost, B. A. (1993) · PubMed · Cited by 369 · see citing works
Arango, V (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00310-4 · Cited by 368 · see citing works
Self-citationElevated alcohol consumption in null mutant mice lacking 5–HT1B serotonin receptors
Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N., & Schafer, G. L. (1996) · Nature Genetics · doi:10.1038/ng0996-98 · Cited by 360 · see citing works
Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain
Hoyer, D., & Middlemiss, D. N. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90159-4 · Cited by 352 · see citing works
Hrdina, P. D., Demeter, E., Vu, T. B., Sótonyi, P., & Palkovits, M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91015-k · Cited by 327 · see citing works
Suicide attempts in children and adolescents
Garfinkel, B. D., Froese, A., & Hood, J. E. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.10.1257 · Cited by 326 · see citing works
Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
Rocha, B. A. G., Scearce-Levie, K. A., Lucas, J. J., Hiroi, N., Castanon, N., Crabbe, J. C., Nestler, E. J., & Hen, R. (1998) · Nature · doi:10.1038/30259 · Cited by 322 · see citing works
Linkage of Antisocial Alcoholism to the Serotonin 5-HT1B Receptor Gene in 2 Populations
Lappalainen, J., Long, J. C., Eggert, M., Ozaki, N., Robin, R. W., Brown, G. L., Naukkarinen, H., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.989 · Cited by 311 · see citing works
Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature
Martin, G. R., & Humphrey, P. P. A. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90058-2 · Cited by 305 · see citing works
Kunugi, H., Hattori, M., Kato, T., Tatsumi, M., Sakai, T., Sasaki, T., Hirose, T., & Nanko, S. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000334 · Cited by 305 · see citing works
Weinshank, R. L., Zgombick, J. M., Macchi, M., Branchek, T. A., & Hartig, P. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3630 · Cited by 294 · see citing works
A Tryptophan Hydroxylase Gene Marker for Suicidality and Alcoholism
Nielsen, D. A., Virkkunen, M. E., Lappalainen, J., Eggert, M., Brown, G. L., Long, J. C., Goldman, D. A., & Linnoila, M. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.593 · Cited by 293 · see citing works
Cerebrospinal Fluid Monoamine Metabolites and Suicidal Behavior in Depressed Patients
Roy, A. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810070035005 · Cited by 284 · see citing works
Mann, J. J. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820060022003 · Cited by 281 · see citing works
Self-citationTurecki, G., Brière, R., Dewar, K. M., Antonetti, T., LESAGE, A. D., Séguin, M., Chawky, N., Vanier, C., Alda, M., Joober, R., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1456 · Cited by 276 · see citing works
CSF 5‐HIAA Predicts Suicide Risk After Attempted Suicide
Nordström, P., Samuelsson, M., Åsberg, M., Träskman‐Bendz, L., Åberg‐Wistedt, A., Nordin, C., & Bertilsson, L. (1994) · Suicide and Life-Threatening Behavior · doi:10.1111/j.1943-278x.1994.tb00657.x · Cited by 257 · see citing works
Terwilliger, J. D., & Göring, H. H. H. (2009) · Human Biology · doi:10.3378/027.081.0615 · Cited by 255 · see citing works
Spurlock, G., Heils, A., Holmans, P., Williams, J. H., D’Souza, U. M., Cardno, A. G., Murphy, K. C., Jones, L. A., Buckland, P. R., McGuffin, P., et al. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000342 · Cited by 254 · see citing works
Du, L., Bakish, D., Lapierre, Y. D., Ravindran, A. V., & Hrdina, P. D. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 229 · see citing works
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.
Hamblin, M. W., & Metcalf, M. A. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12918-0 · Cited by 229 · see citing works
Association Between the Tryptophan Hydroxylase Gene and Manic-depressive Illness
Bellivier, F., Leboyer, M., Courtet, P., Burési, C., Beaufils, B., Samolyk, D., Allilaire, J., Feingold, J., Mallet, J. J., & Malafosse, A. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.33 · Cited by 202 · see citing works
Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior
Gorwood, P. A. P. M., Batel, P., Adès, J., Hamon, M., & Boni, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00840-4 · Cited by 198 · see citing works
5-HT1 receptor knock out — behavioral consequences
Ramboz, S., Saudou, F., Amara, D. A., Belzung, C., Ségu, L., Misslin, R., Buhot, M.-C., & Hen, R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00119-2 · Cited by 197 · see citing works
Rosenthal, N. E., Mazzanti, C. M., Barnett, R. L., Hardin, T. A., Turner, E. H., Lam, G. K. W., Ozaki, N., & Goldman, D. A. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000360 · Cited by 185 · see citing works
Evidence for the 5-HT Hypothesis of Suicide A Review of Post-mortem Studies
Mann, J. J., Arango, V., Marzuk, P. M., Theccanat, S. M., & Reis, D. J. (1989) · The British Journal of Psychiatry · doi:10.1192/s000712500029171x · Cited by 183 · see citing works
Self-citationMann, J. J., Malone, K. M., Nielsen, D. A., Goldman, D. A., Erdos, J., & Gelernter, J. E. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.10.1451 · Cited by 177 · see citing works
Self-citationCourtet, P., Baud, P., Abbar, M., Boulenger, J.-P., Castelnau, D., Mouthon, D., Malafosse, A., & Burési, C. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000856 · Cited by 169 · see citing works
Warren, J. T., Michael, L., & Fink, J. K. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.9.778-a · Cited by 167 · see citing works
Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims
Du, L., Faludi, G., Palkovits, M., Demeter, E., Bakish, D., Lapierre, Y. D., Sótonyi, P., & Hrdina, P. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00376-x · Cited by 166 · see citing works
Attempted suicide among living co-twins of twin suicide victims
Roy, A., Segal, N. L., & Sarchiapone, M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.1075 · Cited by 165 · see citing works
Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims
Underwood, M. D., Khaibulina, A. A., Ellis, S. P., Moran, A., Rice, P. M., Mann, J. J., & Arango, V. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00043-8 · Cited by 165 · see citing works
Self-citationNielsen, D. A., Jenkins, G. L., Stefanisko, K. M., Jefferson, K. K., & Goldman, D. A. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00304-x · Cited by 160 · see citing works
Bellivier, F., Szöke, A., Henry, C., Lacoste, J., Bottos, C., Nosten‐Bertrand, M., Hardy, P., Rouillon, F., Launay, J., Laplanche, J., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00891-x · Cited by 158 · see citing works
Complications associated with genetic background effects in research using knockout mice
Phillips, T. J., Hen, R., & Crabbe, J. C. (1999) · Psychopharmacology · doi:10.1007/s002130051128 · Cited by 154 · see citing works
Huang, Y. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00030-5 · Cited by 149 · see citing works
Self-citationAssociation studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)
Rees, M. I., Norton, N., Jones, I. R., McCandless, F., Scourfield, J., Holmans, P., Moorhead, S., Feldman, E., Sadler, S., Cole, T. J., et al. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000256 · Cited by 146 · see citing works
Suicidal Children Grow Up: Suicidal Behavior and Psychiatric Disorders among Relatives
Pfeffer, C. R., Normandin, L., & Kakuma, T. (1994) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199410000-00004 · Cited by 140 · see citing works
Warren, J. T., Peacock, M. L., Rodriguez, L. C., & Fink, J. K. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.3.338 · Cited by 139 · see citing works
Brain 5-HT1A, 5-HT1D, and 5-HT2 Receptors in suicide victims
Arranz, B., Eriksson, A., Mellerup, E. T., Plenge, P., & Marcusson, J. O. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90044-2 · Cited by 120 · see citing works
Åsberg, M., Nordström, P., & Träskman‐Bendz, L. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27903.x · Cited by 120 · see citing works
Roy, A., Rylander, G., & Sarchiapone, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52358.x · Cited by 110 · see citing works
Russ, M. J., Lachman, H. M., Kashdan, T. B., Saito, T., & Bajmakovic-Kacila, S. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00128-1 · Cited by 109 · see citing works
A new polymorphic probe on chromosome 22q (XD6) (D22S313)
Cardoso, H., Mori, M. A., Crispino, B., Mimbacas, A., & Uriarte, R. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.3.338-a · Cited by 109 · see citing works
Postmortem Findings in Suicide Victims. Implications for <i>in Vivo</i> Imaging Studies<sup>a</sup>
ARANGO, V., UNDERWOOD, M. D., & MANN, J. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52365.x · Cited by 106 · see citing works
Self-citationSuicide, impulsive aggression, and HTR1B genotype
New, A. S., Gelernter, J. E., Goodman, M. S., Mitropoulou, V., Koenigsberg, H. W., Silverman, J. M., & Siever, L. J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01108-8 · Cited by 98 · see citing works
Search for association between suicide attempt and serotonergic polymorphisms
Geijer, T., Frisch, A., Persson, M.-L., Wasserman, D., Rockah, R., Michaelovsky, E., Apter, A. S., Jönsson, E. G., Nöthen, M. M., & Weizman, A. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010010-00004 · Cited by 96 · see citing works
A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.
Demchyshyn, L. L., Sunahara, R. K., Miller, K., Teitler, M., Hoffman, B. J., Kennedy, J. L., Seeman, P. M., Tol, H. H. M. V., & Niznik, H. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5522 · Cited by 95 · see citing works
Advances in the molecular characterization of tryptophan hydroxylase
Mockus, S. M., & Vrana, K. E. (1998) · Journal of Molecular Neuroscience · doi:10.1007/bf02761772 · Cited by 95 · see citing works
Identification of four variants in the tryptophan hydroxylase promoter and association to behavior
Rotondò, A., Schuebel, K. E., Bergen, A. W., Aragon, R., Virkkunen, M. E., Linnoila, M., Goldman, D. A., & Nielsen, D. A. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000578 · Cited by 94 · see citing works
Cravchik, A., & Goldman, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1105 · Cited by 94 · see citing works
Kunugi, H., Ishida, S., Kato, T., Sakai, T., Tatsumi, M., Hirose, T., & Nanko, S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.774 · Cited by 93 · see citing works
Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders
Ohara, K., Nagai, M., Tsukamoto, T., Tani, K., Suzuki, Y., & Ohara, K. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00112-7 · Cited by 91 · see citing works
Suicide attempts and the tryptophan hydroxylase gene
Abbar, M., Courtet, P., Bellivier, F., Leboyer, M., Boulenger, J.-P., Castelhau, D., Ferreira, M., Lambercy, C., Mouthon, D., Paoloni‐Giacobino, A., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000846 · Cited by 89 · see citing works
Lappalainen, J., Dean, M. C., Charbonneau, L., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600214 · Cited by 88 · see citing works
The serotonin transporter in the midbrain of suicide victims with major depression
Bligh-Glover, W. Z., Kolli, T. N., Shapiro-Kulnane, L., Dilley, G. E., Friedman, L., Balraj, E. K., Rajkowska, G., & Stockmeier, C. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00313-3 · Cited by 87 · see citing works
Furlong, R., Ho, L. W., Rubinsztein, J. S., et al. (1998) · PubMed · Cited by 87 · see citing works
Zalsman, G., Frisch, A., Bromberg, M., Gelernter, J. E., Michaelovsky, E., Campino, A., Erlich, Z., Tyano, S., Apter, A. S., & Weizman, A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1261 · Cited by 87 · see citing works
Prediction of Suicidal Behavior from Biologic Tests
Träskman‐Bendz, L., Alling, C., Oreland, L., REGN??LL, G., Vinge, E., & HMAN, R. (1992) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199204001-00005 · Cited by 86 · see citing works
TPH and suicidal behavior: a study in suicide completers
Turecki, G., Zhu, Z.-W., Tzenova, J., LESAGE, A. D., Séguin, M., Tousignant, M., Chawky, N., Vanier, C., Lipp, O., Alda, M., et al. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000816 · Cited by 84 · see citing works
Levy, F. O., Gudermann, T. W., Perez‐Reyes, E., Birnbaumer, M. E., Kaumann, A. J., & Birnbaumer, L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42552-5 · Cited by 76 · see citing works
Nielsen, D. A., Dean, M. C., & Goldman, D. A. (1992) · Europe PMC (PubMed Central) · Cited by 76 · see citing works
Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors
Tsai, S., Hong, C., & Wang, Y.-C. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00010 · Cited by 74 · see citing works
Tryptophan hydroxylase polymorphisms in suicide victims
Bennett, P. J., McMahon, W. M., Watabe, J., Achilles, J. S., Bacon, M., Coon, H. H., Grey, T. C., Keller, T., Tate, D. F., Tcaciuc, I., et al. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010010-00003 · Cited by 71 · see citing works
Souery, D., Gestel, S. V., Massat, I., Blairy, S., Adolfsson, R., Blackwood, D., Del‐Favero, J., Dikeos, D. G., Jakovljević, M., Kaneva, R. P., et al. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01043-x · Cited by 70 · see citing works
Altered Serotonin Function in Suicide
Pandey, G. N. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52360.x · Cited by 68 · see citing works
Genetic and biologic risk factors for suicide in depressive disorders
Roy, A. (1993) · Psychiatric Quarterly · doi:10.1007/bf01064927 · Cited by 66 · see citing works
Identification of Genetic Variation in the Human Serotonin 1Dβ Receptor Gene
Nöthen, M. M., Erdmann, J., Shimron‐Abarbanell, D., & Propping, P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2792 · Cited by 64 · see citing works
Paik, I., Toh, K.-Y., Kim, J.-J., Lee, C., & Lee, C.-U. (2000) · Human Heredity · doi:10.1159/000022942 · Cited by 52 · see citing works
Zalsman, G., Frisch, A., King, R. A., Pauls, D. L., Grice, D. E., Gelernter, J. E., Alsobrook, J. P., Michaelovsky, E., Apter, A., Tyano, S., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1406 · Cited by 52 · see citing works
Chong, S. A., Lee, W., Tan, C. H., Hou-NgeeTay, A., Chan, A. O. M., & Tan, E. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00229-8 · Cited by 50 · see citing works
Ono, H., Shirakawa, O., Kitamura, N., Hashimoto, T., Nishiguchi, N., Nishimura, A., Nushida, H., Ueno, Y., & Maeda, K. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001150 · Cited by 50 · see citing works
Lack of an association between 5‐HT1A receptor gene structural polymorphisms and suicide victims
Nishiguchi, N., Shirakawa, O., Ono, H., Nishimura, A., Nushida, H., Ueno, Y., & Maeda, K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10414 · Cited by 50 · see citing works
Nishiguchi, N., Shirakawa, O., Ono, H., Nishimura, A., Nushida, H., Ueno, Y., & Maeda, K. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1347 · Cited by 49 · see citing works
Association between tryptophan hydroxylase gene polymorphism (A218C) and schizophrenic disorders
Hong, C., Tsai, S., & Wang, Y.-C. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00039-6 · Cited by 44 · see citing works
Serotonin 2A receptor gene polymorphism is not associated with completed suicide
Ono, H., Shirakawa, O., Nishiguchi, N., Nishimura, A., Nushida, H., Ueno, Y., & Maeda, K. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00015-2 · Cited by 44 · see citing works
Rujescu, D., Giegling, I., Sato, T., & Moeller, H. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200109000-00011 · Cited by 43 · see citing works
Sidenberg, D. G., Bassett, A. S., Demchyshyn, L. L., Niznik, H. B., Macciardi, F. M., Kamble, A. B., Honer, W. G., & Kennedy, J. L. (1993) · Human Heredity · doi:10.1159/000154150 · Cited by 41 · see citing works
Soucy, J., Lafaille, F., Lemoine, P., Mrini, A., & Descarries, L. (1994) · PubMed · Cited by 38 · see citing works
Tryptophan hydroxylase gene 218A/C polymorphism is not associated with depressed suicide
Du, L., Faludi, G., Palkovits, M., Bakish, D., & Hrdina, P. D. (2000) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145700001954 · Cited by 36 · see citing works
Relevance of serotonergic postmortem studies to suicidal behavior
Arango, V., & Mann, J. J. (1992) · International Review of Psychiatry · doi:10.3109/09540269209066310 · Cited by 34 · see citing works
Self-citationTryptophan Hydroxylase Gene and Manic-Depressive Illness
Kirov, G., Owen, M. J., Jones, I. R., McCandless, F., & Craddock, N. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.98 · Cited by 32 · see citing works
Lowther, S., Katona, C., Crompton, M. R., & Horton, R. W. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000259 · Cited by 30 · see citing works
Behavioral phenotypes: Conceptual and methodological issues
Flint, J. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980508)81:3 · Cited by 28 · see citing works
The Gene Encoding the 5-HT1A Receptor Is Intact in Mood Disorders
Xie, D.-W. (1995) · Neuropsychopharmacology · doi:10.1016/0893-133x(94)00085-e · Cited by 22 · see citing works
Calzolari, E., Aiello, V., Palazzi, P., Sensi, A., Calzolari, S., Orrico, D., Calliari, L., Holler, H., Marzi, C., Belli, S., et al. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960409)67:2 · Cited by 21 · see citing works
Faludi, G., Du, L., Palkovits, M., Antal, B., Sótonyi, P., & Pd, H. (2000) · PubMed · Cited by 18 · see citing works
Chapter 8 Receptors for 5-hydroxytryptamine
Bobker, D. H., & Williams, J. T. (1993) · New comprehensive biochemistry · doi:10.1016/s0167-7306(08)60361-0 · Cited by 10 · see citing works
[Association analysis of attempted suicide and 5-HT2A receptor gene].
Cao, L., Li, T., Xu, K., & Liu, X. (2001) · PubMed · Cited by 7 · see citing works
Whitaker‐Azmitia, P. M., & Peroutka, S. J. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16868.x · Cited by 7 · see citing works
The Gene Encoding the 5-HT1A Receptor Is Intact in Mood Disorders
Xie, D.-W., Deng, Z.-L., Ishigaki, T., et al. (1995) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380260 · Cited by 5 · see citing works
Jonnal (2000) · doi:10.1002/1096-8628(20001204)96:6
Flagged first, then by citations
5 of the 122 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Psychology and Neurobiology of Suicidal Behavior
Joiner, T. E., Brown, J. S., & Wingate, L. R. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070320 · Cited by 481 · see citing works
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., Sotnikova, T. D., Burch, L. H., Williams, R. B., Schwartz, D. A., Krishnan, K. R. R., & Caron, M. G. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.014 · Cited by 473 · see citing works
Zalsman, G., Huang, Y.-Y., Oquendo, M. A., Burke, A. K., Hu, X.-Z., Brent, D. A., Ellis, S. P., Goldman, D., & Mann, J. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1588 · Cited by 371 · see citing works
Self-citationSusman, E. J. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.08.002 · Cited by 340 · see citing works
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works
Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan
Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.004 · Cited by 326 · see citing works
5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
Albert, P. R., & Lemonde, S. (2004) · The Neuroscientist · doi:10.1177/1073858404267382 · Cited by 275 · see citing works
Parsey, R. V., Hastings, R. S., Oquendo, M. A., Hu, X., Goldman, D., Huang, Y.-Y., Simpson, N., Arcement, J., Huang, Y., Ogden, R. T., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.48 · Cited by 262 · see citing works
Self-citationSerotonin: A never-ending story
Olivier, B. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.031 · Cited by 253 · see citing works
Genetic Gating of Human Fear Learning and Extinction
Lonsdorf, T. B., Weike, A. I., Nikamo, P., Schalling, M., Hamm, A. O., & Öhman, A. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02280.x · Cited by 242 · see citing works
From genes to aggressive behavior: the role of serotonergic system
Popova, N. K. (2006) · BioEssays · doi:10.1002/bies.20412 · Cited by 236 · see citing works
The role of child sexual abuse in the etiology of suicide and non-suicidal self-injury
Maniglio, R. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01612.x · Cited by 225 · see citing works
Suicide risk assessment in clinical practice: pragmatic guidelines for imperfect assessments
Fowler, J. C. (2012) · Psychotherapy · doi:10.1037/a0026148 · Cited by 222 · see citing works
Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior
Li, D. M. L., & He, L. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001890 · Cited by 214 · see citing works
Agerbo, E. (2005) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2004.024950 · Cited by 180 · see citing works
Jorge, R. E., & Arciniegas, D. B. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2013.11.005 · Cited by 168 · see citing works
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167 · see citing works
Mechanistic Insights into the Link between Gut Dysbiosis and Major Depression: An Extensive Review
Sonali, S., Ray, B., Hediyal, T. A., Rathipriya, A. G., Sunanda, T., Mahalakshmi, A. M., Rungratanawanich, W., Essa, M. M., Qoronfleh, M. W., Chidambaram, S. B., et al. (2022) · Cells · doi:10.3390/cells11081362 · Cited by 159 · see citing works
Serotonin synthesis, release and reuptake in terminals: a mathematical model
Best, J. A., Nijhout, H. F., & Reed, M. C. (2010) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-7-34 · Cited by 154 · see citing works
Direct Effect of Sunshine on Suicide
Vyssoki, B., Kapusta, N. D., Praschak-Rieder, N., Dorffner, G., & Willeit, M. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1198 · Cited by 153 · see citing works
Victims of bullying in childhood and suicide attempts in adulthood
Meltzer, H., Vostanis, P., Ford, T., Bebbington, P., & Dennis, M. S. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.11.006 · Cited by 150 · see citing works
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
Albert, P. R., François, B. L., & Millar, A. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-21 · Cited by 149 · see citing works
5-HT1B receptors and aggression: A review
Olivier, B., & van Oorschot, R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.066 · Cited by 146 · see citing works
Shelton, R. C., Sanders‐Bush, E., Manier, D. H., & Lewis, D. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.036 · Cited by 144 · see citing works
Anisman, H., Du, L., Palkovits, M., Faludi, G., Kovács, G. G., Szontagh-Kisházi, P., Merali, Z., & Poulter, M. O. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0815 · Cited by 143 · see citing works
Neurotrophic factors (BDNF and GDNF) and the serotonergic system of the brain
Popova, N. K., Ilchibaeva, T. V., & Naumenko, V. S. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917030099 · Cited by 143 · see citing works
Pathophysiologic Aspects of Major Depression Following Traumatic Brain Injury
Jorge, R. E., & STARKSTEIN, S. E. (2005) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200511000-00001 · Cited by 142 · see citing works
Trauma, Genes, and the Neurobiology of Personality Disorders
Goodman, M. S., New, A. S., & Siever, L. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.008 · Cited by 134 · see citing works
Glutamate mediated signaling in the pathophysiology of autism spectrum disorders
Choudhury, P. R., Lahiri, S., & Rajamma, U. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.06.023 · Cited by 121 · see citing works
Ontogeny and regulation of the serotonin transporter: Providing insights into human disorders
Daws, L. C., & Gould, G. G. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.013 · Cited by 116 · see citing works
Suicidal behavior: Relationship between phenotype and serotonergic genotype
Courtet, P., Jollant, F., Castelnau, D., Burési, C., & Malafosse, A. (2005) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30043 · Cited by 107 · see citing works
Li, D., & He, L. (2006) · Human Genetics · doi:10.1007/s00439-005-0113-x · Cited by 101 · see citing works
The role of dopamine and serotonin in suicidal behaviour and aggression
Ryding, E., LINDSTROM, M., & Träskman‐Bendz, L. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00915-1 · Cited by 96 · see citing works
Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide
Dracheva, S. M., Patel, N., Woo, D. A., Marcus, S., Siever, L. J., & Haroutunian, V. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002081 · Cited by 95 · see citing works
Li, D., Duan, Y., & He, L. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.101 · Cited by 93 · see citing works
Maternal Suicidality and Risk of Suicidality in Offspring: Findings From a Community Study
Lieb, R., Bronisch, T., Höfler, M., Schreier, A., & Wïttchen, H. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1665 · Cited by 93 · see citing works
Depression and antidepressants: molecular and cellular aspects
Lanni, C., Govoni, S. M., Lucchelli, A., & Boselli, C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0055-x · Cited by 92 · see citing works
Crowell, S. E., Beauchaine, T. P., Hsiao, R. C.-J., Vasilev, C. A., Yaptangco, M., Linehan, M. M., & McCauley, E. (2011) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-011-9578-3 · Cited by 90 · see citing works
Cantarelli, M. D. G., Nardin, P., Buffon, A., Eidt, M. C., Godoy, L. A., Fernandes, B. S., & Gonçalves, C. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.033 · Cited by 87 · see citing works
Neurobiology of Suicidal Behavior. An Integration of Biological and Clinical Findings
Carballo, J. J., Akamnonu, C. P., & Oquendo, M. A. (2008) · Archives of Suicide Research · doi:10.1080/13811110701857004 · Cited by 85 · see citing works
Clayden, R. C., Zaruk, A., Meyre, D., Thabane, L., & Samaan, Z. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.96 · Cited by 84 · see citing works
Zubenko, G. S., Maher, B. S., Hughes, H. B., Zubenko, W. N., Stiffler, J. S., & Marazita, M. L. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30092 · Cited by 83 · see citing works
Popova, N. K., Tsybko, A. S., & Naumenko, V. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158814 · Cited by 81 · see citing works
Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2
Zhang, X., Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5417-4 · Cited by 81 · see citing works
Effects of sunshine on suicide rates
Vyssoki, B., Praschak-Rieder, N., Sonneck, G., Blüml, V., Willeit, M., Kasper, S. F., & Kapusta, N. D. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.06.003 · Cited by 80 · see citing works
Molecular Genetic Findings in Suicidal Behavior: What is Beyond the Serotonergic System?
Rujescu, D., Thalmeier, A., Möller, H., Bronisch, T., & Giegling, I. (2006) · Archives of Suicide Research · doi:10.1080/13811110600897317 · Cited by 79 · see citing works
Osipova, D. V., Kulikov, A. V., & Popova, N. K. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21928 · Cited by 77 · see citing works
Gibb, B. E., McGeary, J. E., Beevers, C. G., & Miller, I. W. (2006) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.2006.36.6.687 · Cited by 77 · see citing works
Zouk, H., McGirr, A., Lebel, V., Benkelfat, C., Rouleau, G. A., & Turecki, G. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30521 · Cited by 77 · see citing works
Price, R. K., Risk, N. K., Haden, A. H., Lewis, C. E., & Spitznagel, E. L. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.08.005 · Cited by 75 · see citing works
Zalsman, G., Patya, M., Frisch, A., Ofek, H., Schapir, L., Blum, I., Harell, D., Apter, A. S., Weizman, A., & Tyano, S. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.518628 · Cited by 74 · see citing works
KRAKOWSKI, M. I., Czobor, P., & Citrome, L. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.02.006 · Cited by 73 · see citing works
Genetic evaluation of the serotonergic system in chronic fatigue syndrome
Smith, A. K., Dimulescu, I. M., Falkenberg, V. R., Narasimhan, S., Heim, C. C., Vernon, S. D., & Rajeevan, M. S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.11.001 · Cited by 71 · see citing works
Kumar, J. S. D., Majo, V. J., Hsiung, S., Milak, M. S., Liu, K., Tamir, H., Prabhakaran, J., Simpson, N. R., Heertum, R. L. V., Mann, J. J., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050725j · Cited by 67 · see citing works
Self-citationBah, J., Lindström, M., Westberg, L., Mannerås, L., Ryding, E., Henningsson, S., Melke, J., Rosén, I., Träskman‐Bendz, L., & Eriksson, E. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.07.004 · Cited by 67 · see citing works
Hahn, M. K., Blackford, J. U., Haman, K., Mazei‐Robison, M. S., English, B. A., Prasad, H. C., Steele, A., Hazelwood, L. A., Fentress, H. M., Myers, R. L., et al. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00384.x · Cited by 65 · see citing works
Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
Hesse, S., Barthel, H., SCHWARZ, J., Sabri, O., & Müller, U. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.004 · Cited by 63 · see citing works
Kumar, J. S. D., Prabhakaran, J., Majo, V. J., Milak, M. S., Hsiung, S., Tamir, H., Simpson, N. R., Heertum, R. L. V., Mann, J. J., & Parsey, R. V. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0324-y · Cited by 63 · see citing works
Self-citationFrom gene to aggressive behavior: The role of brain serotonin
Popova, N. K. (2008) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-008-9004-7 · Cited by 61 · see citing works
Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms
Goenjian, A. K., Bailey, J. N., Walling, D. P., Steinberg, A. M., Schmidt, D., Dandekar, U., & Noble, E. P. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.015 · Cited by 60 · see citing works
Proudnikov, D., LaForge, K. S., Hofflich, H., Levenstien, M. A., Gordon, D., Barral, S., Ott, J., & Kreek, M. J. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000182782.87932.d6 · Cited by 60 · see citing works
The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.
Wasserman, D., Geijer, T., Sokolowski, M., Rozanov, V. A., & Wasserman, J. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-14 · Cited by 60 · see citing works
Consistency of immigrant and country‐of‐birth suicide rates: a meta‐analysis
Voracek, M., & Loibl, L. M. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01238.x · Cited by 58 · see citing works
Weissmann, D., van der Laan, S., Underwood, M. D., Salvetat, N., Cavarec, L., Leviel, V., Molina, F., Mann, J. J., Arango, V., & Pujol, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.121 · Cited by 58 · see citing works
Self-citationPET tracers for 5-HT1A receptors and uses thereof
Kumar, J. S. D., & Mann, J. J. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.07.008 · Cited by 57 · see citing works
Self-citationAnisman, H., Poulter, M. O., Gandhi, R., Merali, Z., & Hayley, S. P. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.02.008 · Cited by 57 · see citing works
Risk Neurogenes for Long-Term Spaceflight: Dopamine and Serotonin Brain System
Popova, N. K., Kulikov, A. V., Kondaurova, E. M., Tsybko, A. S., Kulikova, E. A., Krasnov, I. B., Shenkman, E. A., Bazhenova, E. Y., Sinyakova, N. A., & Naumenko, V. S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8821-7 · Cited by 56 · see citing works
Tryptophan Hydroxylase-1 Gene Variants Associate with a Group of Suicidal Borderline Women
Zaboli, G., Gizatullin, R. Z., Nilsonne, Å., Wilczek, A., Jönsson, E. G., Ahnemark, E., Åsberg, M., & Leopardi, R. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301046 · Cited by 55 · see citing works
Serotonin in Trigeminal Ganglia of Female Rodents: Relevance to Menstrual Migraine
Berman, N. E. J., Puri, V., Chandrala, S., Puri, S., MacGregor, R. R., Liverman, C. S., & Klein, R. M. (2006) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2006.00528.x · Cited by 53 · see citing works
Schechter, D. S., Moser, D. A., Perizzolo, V. C., Aue, T., Stenz, L., Paoloni‐Giacobino, A., Adouan, W., Manini, A., Suardi, F., Vital, M., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.009 · Cited by 52 · see citing works
Volf, N. V., Kulikov, V. A., Bortsov, C. U., & Popova, N. K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.070 · Cited by 51 · see citing works
The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality
Gonda, X., Fountoulakis, K. Ν., Harro, J., Pompili, M., Akiskal, H. S., Bagdy, G., & Rihmer, Z. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110376693 · Cited by 51 · see citing works
Stress inhibits tryptophan hydroxylase expression in a rat model of depression
Chen, Y., Xu, H., Zhu, M., Liu, K., Lin, B., Luo, R., Chen, C., & Li, M. (2017) · Oncotarget · doi:10.18632/oncotarget.18780 · Cited by 51 · see citing works
Walitza, S., Wewetzer, C., Gerlach, M., Klampfl, K., Geller, F., Barth, N., Hahn, F., Herpertz‐Dahlmann, B., G�ssler, M., Fleischhaker, C., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0134-y · Cited by 50 · see citing works
Suicidality and epilepsy: A neuropsychobiological perspective
Hečimović, H., Salpekar, J. A., Kanner, A. M., & Barry, J. J. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.04.059 · Cited by 49 · see citing works
Wasserman, D., Geijer, T., Rozanov, V. A., & Wasserman, J. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30128 · Cited by 49 · see citing works
Serotonin transporter gene polymorphism and psychiatric disorders: Is there a link?
Margoob, M., & Mushtaq, D. (2011) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.91901 · Cited by 47 · see citing works
Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression
Zhang, Y., Zhang, C., Yuan, G., Yao, J., Cheng, Z., Liu, C.-J., Liu, Q., Wan, G., Shi, G., Cheng, Y., et al. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-49 · Cited by 47 · see citing works
Albert, P., & Fiori, L. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660740 · Cited by 46 · see citing works
Admixture analysis of age at first suicide attempt
Slama, F., Courtet, P., Golmard, J. L., Mathieu, F., Guillaume, S., Yon, L., Jollant, F., Misson, H., Jaussent, I., Leboyer, M., et al. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.01.007 · Cited by 46 · see citing works
Wasserman, D., Geijer, T., Sokolowski, M., Frisch, A., Michaelovsky, E., Weizman, A., Rozanov, V. A., & Wasserman, J. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.08.006 · Cited by 46 · see citing works
Goldberg, T. E., Kotov, R., Lee, A. T., Gregersen, P. K., Lencz, T., Bromet, E. J., & Malhotra, A. K. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.021 · Cited by 45 · see citing works
Genes within the serotonergic system are differentially expressed in human brain
Sugden, K., Tichopád, A., Khan, N., Craig, I., & D’Souza, U. M. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-50 · Cited by 45 · see citing works
Schwitzer, T., Lavoie, J., Giersch, A., Schwan, R., & Laprévote, V. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.09.003 · Cited by 44 · see citing works
Increased risk of suicide attempt in mood disorders and TPH1 genotype
Galfalvy, H., Huang, Y., Oquendo, M. A., Currier, D., & Mann, J. J. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.09.019 · Cited by 44 · see citing works
Self-citationMaurex, L., Zaboli, G., Wiens, S., Åsberg, M., Leopardi, R., & Öhman, A. (2008) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2008.00689.x · Cited by 44 · see citing works
Cui, H., Nishiguchi, N., Ivleva, E. I., Yanagi, M., Fukutake, M., Nushida, H., Ueno, Y., Kitamura, N., Maeda, K., & Shirakawa, O. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301557 · Cited by 43 · see citing works
Simon, N. G., & Lu, S. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195168761.003.0009 · Cited by 43 · see citing works
Genetic Factors and Suicidal Behavior
Dwivedi, Y. (2012) · CRC Press eBooks · doi:10.1201/b12215-17 · Cited by 41 · see citing works
The Monoamine Hypothesis of Depression
Iversen, L. L. (2005) · Wiley eBooks · doi:10.1002/9783527619672.ch5 · Cited by 41 · see citing works
Suicidal disorders: A nosological entity per se?
Leboyer, M., Slama, F., Siever, L. J., & Bellivier, F. (2005) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30040 · Cited by 40 · see citing works
ZHANG, Y., CHANG, Z., Chen, J., Yang, L., LIU, X., Zhang, F., Chen, C., XIA, M., Zhao, X., YING, W., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3748 · Cited by 39 · see citing works
Ohtani, M., Shindo, S., & Yoshioka, N. (2004) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.202.123 · Cited by 39 · see citing works
Dopamine and serotonin systems modify environmental effects on human behavior: A review
Keltikangas‐Järvinen, L., & Salo, J. (2009) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2009.00785.x · Cited by 38 · see citing works
Gintonin attenuates depressive-like behaviors associated with alcohol withdrawal in mice
Kim, H., Park, S.-D., Lee, R., Lee, B.-H., Choi, S.-H., Hwang, S., Rhim, H., Kim, H., & Nah, S.-Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.026 · Cited by 37 · see citing works
Genetic and environmental contributions to self‐reported thoughts of self‐harm and suicide
Althoff, R. R., Hudziak, J. J., Willemsen, G. A. H. M., Hudziak, V., Bartels, M., & Boomsma, D. I. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32010 · Cited by 37 · see citing works
Lima, L. B. Q., Mata, S., & Urbina, M. (2005) · NeuroImmunoModulation · doi:10.1159/000087108 · Cited by 36 · see citing works
Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia
Li, D., & He, L. (2006) · Human Genetics · doi:10.1007/s00439-006-0190-5 · Cited by 36 · see citing works
Behavioural Genetics of the Serotonin Transporter
Haddley, K., Bubb, V. J., Breen, G. D., Esquivel, U. P., & Quinn, J. P. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_186 · Cited by 35 · see citing works
TPH2 polymorphisms and alcohol-related suicide
Zupanc, T., Pregelj, P., Tomori, M. Ž., Komel, R., & Paska, A. V. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.12.030 · Cited by 35 · see citing works
- Authors
- Arango, V., Huang, Y.-Y., Underwood, M. D., & Mann, J. J.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Arango, Victoria
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 37
- Issue
- 5
- Pages
- 375-386
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2147421788
- Cited by
- 239
- References
- 122
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 8 · 2015: 14 · 2014: 12 · 2013: 6 · 2012: 19
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA09004, R01AA009004)
- National Institute of Mental Health (MH 62185, MH-40210, R01MH040210, P50MH062185)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- suicidal behavior, serotonergic system, candidate genes, tryptophan hydroxylase, serotonin transporter, 5-HTTLPR, 5-HT1B receptor, 5-HT2A receptor, genetic polymorphism, suicide attempts, major depressive disorder, aggression, serotonin transporter binding, prefrontal cortex, postmortem brain
- MeSH terms
- Brain, Carrier Proteins, Genotype, Humans, Membrane Glycoproteins, Monoamine Oxidase, Nerve Tissue Proteins, Polymorphism, Genetic, Risk Factors, Serotonin, Suicide, Tryptophan Hydroxylase, Membrane Transport Proteins, Receptor, Serotonin, 5-HT1A, Serotonin Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review