The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sex Differences in the Striatal Dopamine D2 Receptor Binding Characteristics in Vivo
Open accessAbstract
OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 receptor density (Bmax), affinity (Kd), and binding potential (Bmax/Kd) were measured with positron emission tomography and [11C]raclopride in 54 healthy subjects (33 men and 21 women). RESULTS: Women had generally lower D2 receptor affinity than men, and this difference was statistically significant in the left striatum. Bmax and Bmax/Kd tended to decline with age twice as fast in men as in women, but the difference did not reach statistical significance. CONCLUSIONS: These results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo. The lower D2 receptor affinity suggests an increased endogenous striatal dopamine concentration in women. This may have implications for the differential vulnerability of men and women to psychiatric disorders like schizophrenia and alcohol and substance dependence.
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Citations
Cites
Imaging endogenous dopamine competition with [11C]raclopride in the human brain
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Angrist, B., Pappas, N., MacGregor, R., et al. (1994) · Synapse · doi:10.1002/syn.890160402 · Cited by 379
Sex difference in the bed nucleus of the stria terminalis of the human brain
Allen, L. S., & Gorski, R. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903020402 · Cited by 281
Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Hietala, J., West, C., Syvälahti, E., Någren, K., Lehikoinen, P., Sonninen, P., & Ruotsalainen, U. (1994) · Psychopharmacology · doi:10.1007/bf02245330 · Cited by 269
Self-citation
Cited by
Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove, K. P., Mazure, C. M., & Staley, J. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.001 · Cited by 996
Garcia-Segura, L. M., Azcoitia, I., & DonCarlos, L. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00025-3 · Cited by 938
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvälahti, E. K. G., & Hietala, J. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000350 · Cited by 673
Self-citationSex differences in Parkinson’s disease
Gillies, G. E., Pienaar, I. S., Vohra, S., & Qamhawi, Z. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.02.002 · Cited by 489
Metadata
- Authors
- Pohjalainen, T., Rinne, J. O., Någren, K., SyvÄlahti, E., & Hietala, J.
- Venue
- American Journal of Psychiatry
- Published
- 1998-06-01
- Volume
- 155
- Issue
- 6
- Pages
- 768-773
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1962893342
- Cited by
- 247
- References
- 3
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pohjalainen, T., Rinne, J. O., Någren, K., SyvÄlahti, E., & Hietala, J. (1998). Sex Differences in the Striatal Dopamine D2 Receptor Binding Characteristics in Vivo. American Journal of Psychiatry. https://doi.org/10.1176/ajp.155.6.768
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