Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Abstract
Striatal D2 dopamine receptor characteristics of nine male patients with alcohol dependence abstinent for 1-68 weeks and eight healthy male volunteers were studied in vivo with positron emission tomography. The selective D2 receptor ligand [11C]raclopride and equilibrium model was used for D2 receptor density (Bmax) and affinity (Kd) measurements. A trend for a decreased striatal D2 receptor density and for reduced D2 receptor affinity was observed in patients with alcohol dependence. These parameters were not statistically significantly different between alcoholics and controls, but the ratio between D2 receptor density and affinity (Bmax/Kd or the striatum/cerebellum ratio from the high specific activity scan) was highly significantly lower in alcoholics than that of controls. In conclusion, the low D2 dopamine receptor Bmax/Kd ratio (striatum/cerebellum ratio) indicates that specific aspects of striatal [11C]raclopride binding in vivo are deviant in alcoholics compared to controls. The result is compatible with a reduced avidity of striatal dopamine D2 receptors in alcoholics, which is in line with the idea that D2 dopaminergic mechanisms are involved in the biology of alcohol dependence in man.
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Decreases in D2 receptor binding have been found in heroin addiction, alcohol dependence, and methamphetamine abuse.
“Decreases in D2 receptor binding have also been found in heroin addiction [168], alcohol dependence [169,170], methamphetamine abuse [171,172]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [169]
Alcohol dependence is associated with decreased D2 receptor availability in the striatum, replicated in additional studies, although some groups report no difference.
“In alcohol dependence, Hietala et al (Hietala et al., 1994) showed a decrease in D2 receptor availability in the striatum and this has now been replicated in additional studies (Heinz et al., 2005; Heinz et al., 2004; Martinez et al., 2005; Volkow et al., 1996; Volkow et al., 2002b; Volkow et al., 2007b), although some groups report a lack of a difference”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Hietala et al., 1994
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- Authors
- Hietala, J., West, C., Syvälahti, E., Någren, K., Lehikoinen, P., Sonninen, P., & Ruotsalainen, U.
- Affiliations
- University of Turku (FI)
- Turku University Hospital (FI)
- Venue
- Psychopharmacology
- Published
- 1994-11
- Volume
- 116
- Issue
- 3
- Pages
- 285-290
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1993691356
- Cited by
- 269
- References
- 49
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 12 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 13
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- alcoholism, dopamine D2 receptor, striatum, [11C]raclopride, receptor density, receptor binding affinity, receptor avidity
- MeSH terms
- Adult, Alcoholism, Humans, Male, Salicylamides, Tomography, Emission-Computed, Tomography, X-Ray Computed, Neostriatum, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride
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