Depression and the risk for cardiovascular diseases: Systematic review and meta analysis

Van der Kooy, Koen; van Hout, Hein; Marwijk, Harm; Marten, Haan; Stehouwer, Coen; Beekman, Aartjan

doi:10.1002/gps.1723

Cited by 951Cardiac Health and Mental HealthCardiovascular Health and Risk FactorsMental Health Treatment and Access

Depression and the risk for cardiovascular diseases: Systematic review and meta analysis

Van der Kooy, Koen, van Hout, Hein, Marwijk, Harm, Marten, Haan, Stehouwer, Coen, Beekman, Aartjan·2007·International Journal of Geriatric Psychiatry

DOI 10.1002/gps.1723

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Abstract

BACKGROUND: Depression and cardiovascular diseases are both common among elderly. Depression is suspected to be an independent risk factor for the onset of coronary heart disease, yet it is not clear to what extent and if depression also is associated with the onset of other diseases of the circulatory system. AIMS: To estimate the risk of depression as an independent risk factor for various cardiovascular diseases (CVD) and explore the effects of heterogeneity and methodological quality. METHOD: Meta-analyses and meta-regression analyses of longitudinal cohort and case-control studies reporting depression at baseline and CVD outcomes at follow-up. DATA SOURCES: MEDLINE (1966-2005) and PSYCHINFO (1966-2005). RESULTS: Of the 28 studies that met the inclusion criteria, 11 were assesed as high quality studies. Although depressed mood increased the risk for a wide range of CVDs, heterogeneity was substantial in most cases. Only the overall combined risk of depression for the onset of myocardial infarctions (n=8, OR=1.60, 95%CI 1.34-1.92) was homogenous. Clinically diagnosed major depressive disorder was identified as the most important risk factor for developing CVD. CONCLUSIONS: Depression seems to be an independent risk factor for the onset of a wide range of CVDs, although this evidence is related to a high level of heterogeneity.

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Baseline MDD increases the risk of future cardiovascular events.
“Indeed, several meta-analyses of prospective cohort studies have reported that baseline MDD increases the risk of future cardiovascular events38-41.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [40]
MDD patients are at risk for cardiovascular disease.
“Adding the repeated measurement of blood pressure (and heart rate, for which ambulatory devices are also available) to ESM/EMA studies of MDD patients may ultimately help explain why they are at risk for cardiovascular disease (van der Kooy et al., 2007).”
From Mood Disorders in Everyday Life: A Systematic Review of Experience Sampling and Ecological Momentary Assessment Studies (2012) · cites this paper as van der Kooy et al., 2007

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Authors: Van der Kooy, K., van Hout, H., Marwijk, H., Marten, H., Stehouwer, C., & Beekman, A.
Affiliations: Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Maastricht University Medical Centre (NL)
ORCID: Marwijk, Harm
Stehouwer, Coen
Beekman, Aartjan
Venue: International Journal of Geriatric Psychiatry
Publisher: Wiley
Published: 2007-01-19
Volume: 22
Issue: 7
Pages: 613-626
ISSN: 0885-6230 (ISSN-L)
1099-1166
DOI: 10.1002/gps.1723
OpenAlex: W2084079665
Cited by: 951
References: 46
Citations by year: 2026: 19 · 2025: 26 · 2024: 58 · 2023: 36 · 2022: 56 · 2021: 54 · 2020: 63 · 2019: 54 · 2018: 62 · 2017: 51 · 2016: 73 · 2015: 61 · 2014: 64 · 2013: 63 · 2012: 60
FWCI: 5.48
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Geriatric Psychiatry (publishedVersion)
PubMed (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: depression, cardiovascular disease, major depressive disorder, myocardial infarction, coronary artery disease, cardiovascular risk factors, older adults
MeSH terms: Aged, Cardiovascular Diseases, Cross-Sectional Studies, Major Depressive Disorder, Depressive Disorder, Humans, Myocardial Infarction, Risk Factors, Statistics as Topic, Causality

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Depression and the risk for cardiovascular diseases: Systematic review and meta analysis

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