The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Limbic Circuitry in Patients With Autism Spectrum Disorders Studied With Positron Emission Tomography and Magnetic Resonance Imaging
Abstract
OBJECTIVE: Cytoarchitectonic changes in the anterior cingulate cortex, hippocampus, subiculum, entorhinal cortex, amygdala, mammillary bodies, and septum were reported in a postmortem study of autism. Previously, the authors found smaller cingulate volume and decreased metabolism of the cingulate in seven autistic patients. In this study, they measured the volume and glucose metabolism of the amygdala, hippocampus, and cingulate gyrus in an expanded group of 17 patients with autism spectrum disorders (autism [N=10] or Asperger's disorder [N=7]) and 17 age- and sex-matched healthy volunteers. METHOD: Subjects performed a serial verbal learning test during (18)F-deoxyglucose uptake. The amygdala, hippocampus, and cingulate gyrus were outlined on magnetic resonance imaging scans, volumes of the structures were applied to matching coregistered positron emission tomography scans, and three-dimensional significance probability mapping was performed. RESULTS: Significant metabolic reductions in both the anterior and posterior cingulate gyri were visualized in the patients with autism spectrum disorders. Both Asperger's and autism patients had relative glucose hypometabolism in the anterior and posterior cingulate as confirmed by analysis of variance; regional differences were also found with three-dimensional significance probability mapping. No group differences were found in either the metabolism or the volume of the amygdala or the hippocampus. However, patients with autism spectrum disorders showed reduced volume of the right anterior cingulate gyrus, specifically in Brodmann's area 24'. CONCLUSIONS: Compared with age- and sex-matched healthy volunteers, patients with autism spectrum disorders showed significantly decreased metabolism in both the anterior and posterior cingulate gyri.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Concerning ASD, several neuroimaging studies have found support for a hypofunctional ACC in autism (Gomot et al., 2006; Haznedar et al., 2000; Ohnishi et al., 2000)”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Haznedar et al., 2000
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Pardo, J. V., Pardo, P. J., Janer, K. W., & Raichle, M. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.256 · Cited by 1,495
Social intelligence in the normal and autistic brain: An fMRI study
Baron‐Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00621.x · Cited by 1,320
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083
Social Intelligence in the Normal and Autistic Brain: An fMRI Study
Baron‐Cohen, S., RING, H. A., Wheelwright, S. J., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0028 · Cited by 1,044
Autism diagnostic interview: A standardized investigator-based instrument
Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. (1989) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02212936 · Cited by 1,036
Functional localization of the system for visuospatial attention using positron emission tomography
Nobre, A. (1997) · Brain · doi:10.1093/brain/120.3.515 · Cited by 900
Paus, T., Petrides, M., Evans, A. C., & Meyer, E. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.2.453 · Cited by 834
Cited by
Sorted by citations
The role of the posterior cingulate cortex in cognition and disease
Leech, R., & Sharp, D. J. (2014) · Brain · doi:10.1093/brain/awt162 · Cited by 2,247
Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.12.005 · Cited by 1,492
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898
Metadata
- Authors
- Haznedar, M. M., Buchsbaum, M. S., Wei, T.-C., Hof, P. R., Cartwright, C., Bienstock, C. A., & Hollander, E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-12-01
- Volume
- 157
- Issue
- 12
- Pages
- 1994-2001
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2119674528
- Cited by
- 420
- References
- 28
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 18 · 2023: 5 · 2022: 16 · 2021: 15 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 24 · 2014: 18 · 2013: 21 · 2012: 19
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, Asperger syndrome, anterior cingulate cortex, posterior cingulate cortex, glucose hypometabolism, amygdala, hippocampus, limbic system, brain volume, regional cerebral glucose metabolism
- MeSH terms
- Adult, Amygdala, Autistic Disorder, Female, Glucose, Gyrus Cinguli, Hippocampus, Humans, Limbic System, Magnetic Resonance Imaging, Male, Task Performance and Analysis, Tomography, Emission-Computed, Verbal Learning, Fluorodeoxyglucose F18, Asperger Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
