The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vitamin B12 Deficiency and Depression in Physically Disabled Older Women: Epidemiologic Evidence From the Women’s Health and Aging Study
Abstract
OBJECTIVE: It has been hypothesized that adequate concentrations of vitamin B(12) and folate are essential to maintain the integrity of the neurological systems involved in mood regulation, but epidemiologic evidence for such a link in the general population is unavailable. This study examined whether community-dwelling older women with metabolically significant vitamin B(12) or folate deficiency are particularly prone to depression. METHOD: Serum levels of vitamin B(12), folate, methylmalonic acid, and total homocysteine were assayed in 700 disabled, nondemented women aged 65 years and over living in the community. Depressive symptoms were measured by means of the Geriatric Depression Scale and categorized as no depression, mild depression, and severe depression. RESULTS: Serum homocysteine levels, serum folate levels, and the prevalences of folate deficiency and anemia were not associated with depression status. The depressed subjects, especially those with severe depression, had a significantly higher serum methylmalonic acid level and a nonsignificantly lower serum vitamin B(12) level than the nondepressed subjects. Metabolically significant vitamin B(12) deficiency was present in 14.9% of the 478 nondepressed subjects, 17. 0% of the 100 mildly depressed subjects, and 27.0% of the 122 severely depressed women. After adjustment for sociodemographic characteristics and health status, the subjects with vitamin B(12) deficiency were 2.05 times as likely to be severely depressed as were nondeficient subjects. CONCLUSIONS: In community-dwelling older women, metabolically significant vitamin B(12)deficiency is associated with a twofold risk of severe depression.
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Cites
Development and validation of a geriatric depression screening scale: a preliminary report
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Enhancement of recovery from psychiatric illness by methylfolate
Godfrey, P. S. A., Toone, B. K., Bottiglien, T., Laundy, M., Reynolds, E. H., Carney, M. W. P., Flynn, T. G., & Chanarin, I. (1990) · The Lancet · doi:10.1016/0140-6736(90)91942-4 · Cited by 389
Vitamin B 12 -Folate Interrelationships
Shane, B., & Stokstad, E. L. R. (1985) · Annual Review of Nutrition · doi:10.1146/annurev.nu.05.070185.000555 · Cited by 311
Cited by
Facts and recommendations about total homocysteine determinations: an expert opinion
Refsum, H., Smith, A. D., Ueland, P. M., Nexo, E., Clarke, R., McPartlin, J., Johnston, C., Engbaek, F., Schneede, J., McPartlin, C., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.021634 · Cited by 1,056
Depression and cardiovascular disease: Epidemiological evidence on their linking mechanisms
Penninx, B. W. J. H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.003 · Cited by 576
Self-citationDepressive symptoms and risk of dementia: The Framingham Heart Study
Saczynski, J. S., Beiser, A., Seshadri, S., Auerbach, S., Wolf, P. A., & Au, R. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e62138 · Cited by 488
Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study
Tiemeier, H., van Tuijl, H. R., Hofman, A., Meijer, J., Kiliaan, A. J., & Breteler, M. M. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2099 · Cited by 408
Homocysteine, B vitamin status, and cognitive function in the elderly
Duthie, S. J., Whalley, L. J., Collins, A. R., Leaper, S., Berger, K., & Deary, I. J. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.908 · Cited by 244
Mental health effects of climate change
Padhy, S., Sarkar, S., Panigrahi, M., & Paul, S. (2015) · Indian Journal of Occupational and Environmental Medicine · doi:10.4103/0019-5278.156997 · Cited by 238
The association of folate and depression: A meta-analysis
Bender, A., Hagan, K. E., & Kingston, N. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.019 · Cited by 194
Linking What We Eat to Our Mood: A Review of Diet, Dietary Antioxidants, and Depression
Huang, Q., Liu, H., Suzuki, K., Ma, S., & Liu, C. (2019) · Antioxidants · doi:10.3390/antiox8090376 · Cited by 144
Petridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C. (2016) · Aging & Mental Health · doi:10.1080/13607863.2015.1049115 · Cited by 112
Kendrick, T., Dunn, N., Robinson, S., Oestmann, A., Godfrey, K., Cooper, C., Inskip, H., & the Southampton Women’s Survey Study Group (2008) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2007.069765 · Cited by 29
Metadata
- Authors
- Penninx, B. W. J. H., Guralnik, J. M., Ferrucci, L., Fried, L. P., Allen, R. H., & Stabler, S. P.
- Venue
- American Journal of Psychiatry
- Published
- 2000-05-01
- Volume
- 157
- Issue
- 5
- Pages
- 715-721
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2110647017
- Cited by
- 285
- References
- 4
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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