Folate and B12 serum levels in association with depression in the aged: A systematic review and meta-analysis
Abstract
OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people. METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25). CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.
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Vermeulen, E., Stronks, K., Visser, M., Brouwer, I. A., Snijder, M. B., Mocking, R. J. T., Derks, E. M., Schene, A. H., & Nicolaou, M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.61 · Cited by 15 · see citing works
Dieta y riesgo de enfermedades mentales en adultos peruanos, estudio transversal
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Role of Vitamin B in Healthy Ageing and Disease
Mikkelsen, K., Trapali, M., & Apostolopoulos, V. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_12 · Cited by 14 · see citing works
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Vitamin B12 Supplementation in Psychiatric Practice
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Ketogenic Therapy for Major Depressive Disorder: A Review of Neurobiological Evidence
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Textbook of Medical Psychiatry
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Relation between blood vitamin B12 levels with premature ejaculation: case-control study
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Associations of methylmalonic acid and depressive symptoms with mortality: a population-based study
Cao, B., Xiao, Y., & Liu, D. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03015-6 · Cited by 9 · see citing works
FOLATO E SEU PAPEL NA DEPRESSÃO
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Kramer, C. S., Szmidt, M. K., Sicińska, E., Brzozowska, A., Santoro, A., Franceschi, C., de Groot, C. P. G. M., & Berendsen, A. A. M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00150 · Cited by 9 · see citing works
Decreased Levels of Vitamin D in Bipolar Patients
Marazziti, D., Mangiapane, P., Carbone, M. G., Morana, F., Arone, A., Massa, L., Palermo, S., Violi, M., Bertini, G., Massoni, L., et al. (2023) · Life · doi:10.3390/life13040883 · Cited by 11 · see citing works
The neuropsychiatric effects of nitrous oxide and low vitamin B12
Farmer, J., Romain, K., Ibrahim, M., Kumar, M. T., & Moore, W. Y. (2021) · BJPsych Advances · doi:10.1192/bja.2021.55 · Cited by 7 · see citing works
The Role of Folate-supplementation in Depression: A Narrative Review
Falade, J., Onaolapo, A. Y., & Onaolapo, O. J. (2020) · Current Psychopharmacologye · doi:10.2174/2211556009666201207233954 · Cited by 7 · see citing works
Li, D., Zheng, H., Tong, Y., & Li, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.057 · Cited by 6 · see citing works
Risk and protective factors for severe mental disorders in Asia
Rami, F. Z., Li, L., Le, T. H., Kang, C., Han, M. A., & Chung, Y. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105652 · Cited by 5 · see citing works
Micronutrients in Ageing and Longevity
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Xiong, Y., Zhou, G., Zhou, L., Guo, M., & Lu, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36980 · Cited by 4 · see citing works
Integrative Interventions for Improving Outcomes in Depression: A Narrative Review
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Association of Vitamin B12 and Polymorphism of TCN2 with Early-Onset Post-Stroke Depression
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Toward Better Science-Based Advice on Nutrition
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Testing and Prescribing Vitamin B12 in Swiss General Practice: A Survey among Physicians
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Consultation-Liaison Case Conference: Psychiatric Care of Patients Who Undergo Bariatric Surgery
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Effects of Vitamin B12 Deficiency on Ejaculation Time in Patients with Chronic Gastritis
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Association between neck circumference and depressive mood among Korean adults
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Morovati, M., Morsali, Y., Rezaee, S., Pezeshki, A., Esmaeilzadeh, A., Ranjbar, H., & Islambulchilar, M. (2020) · doi:10.21203/rs.3.rs-18168/v1 · Cited by 1 · see citing works
Nutrition in Neurocognition and Mental Health
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DEFICIÊNCIA DE VITAMINA B12 E DOENÇAS DO SISTEMA NERVOSO
Lopes, A. J. R., Boaventura, I. T., Teixeira, B. G. G. B., Boaventura, J. M. T., Oliveira, F. D. S. R., Parreira, E. D. S., Silva, D. N., Pereira, M. A. D. S., & de Mendonça, E. D. (2022) · Editora Pasteur eBooks · doi:10.29327/547549.1-6
Clinical Laboratories and Their Role in Anti-Aging Strategies
Sitar, M. E. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_13
Chapter 22. Neurocognitive Disorders
Merideth, F. L., Vahia, I. V., & Jeste, D. V. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg22
Chapter 2. The Neurological Examination for Neuropsychiatric Assessment
Benjamin, S., & Lauterbach, M. D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg02
Chapter 25. Somatic Symptom and Related Disorders
Dickerman, A. L., & Muskin, P. R. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg25
Chapter 1. An Internist’s Approach to the Neuropsychiatric Patient
Rencic, J. J., & Salem, D. N. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg01
Chapter 4. Neuroimaging, Electroencephalography, and Lumbar Puncture in Medical Psychiatry
Talmasov, D., & Klein, J. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg04
Chapter 6. Cardiovascular Disease
Shapiro, P. A. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg06
Chapter 7. Endocrine Disorders and Their Psychiatric Manifestations
Gagliardi, J. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg07
Doghramji, K. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg24
McCarron, R. M., Sheth, S. J., Mesa, C. D., & Parish, M. B. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg23
Chapter 3. The Bedside Cognitive Examination in Medical Psychiatry
Glass, S. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg03
Chapter 17. Psychotic Disorders Due to Medical Illnesses
Brown, H. E., Mukerji, S., & Freudenreich, O. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg17
Chapter 10. Gastroenterological Disease in Patients With Psychiatric Disorders
Nadkarni, A., & Silbersweig, D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg10
(2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.index
Chapter 16. Neurodevelopmental Disorders
Hauptman, A. J., & Benjamin, S. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg16
Chapter 18. Catatonia in the Medically Ill Patient
Beach, S. R., & Fricchione, G. L. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg18
Chapter 12. Neurological Conditions and Their Psychiatric Manifestations
Fogel, B. S., Baslet, G. C., Safar, L. T., Raynor, G., & Silbersweig, D. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg12
Chapter 20. Anxiety and Related Disorders: Manifestations in the General Medical Setting
Hebert, C. L., Banayan, D. J., Forcén, F. E., Perticone, K., Guttikonda, S., & Pollack, M. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg20
Chapter 13. Cancer: Psychiatric Care of the Oncology Patient
Fernandez-Robles, C. G., & Glass, S. P. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg13
Chapter 19. Mood Disorders Due to Medical Illnesses
Mauer, S., Querques, J., & D, P. S. M. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615378869.lg19
- Authors
- Petridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Uppsala University (SE)
- Corresponding author
- Petridou, Eleni Th.
- ORCID
- Venue
- Aging & Mental Health
- Publisher
- Informa UK Limited
- Published
- 2015-06-08
- Volume
- 20
- Issue
- 9
- Pages
- 965-973
- ISSN
- 1360-7863 (ISSN-L)
- 1364-6915
- OpenAlex
- W2215638520
- Cited by
- 112
- References
- 57
- Citations by year
- 2025: 2 · 2024: 14 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 41 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aging & Mental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- folic acid, vitamin B12, serum folate, serum vitamin B12, depression, older adults, aging, sex differences, vitamin deficiency
- MeSH terms
- Aged, Aged, 80 and over, Depressive Disorder, Female, Folic Acid, Humans, Male
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