The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Divalproex Treatment for Youth With Explosive Temper and Mood Lability: A Double-Blind, Placebo-Controlled Crossover Design
Abstract
OBJECTIVE: The authors sought to replicate open-label findings showing that specific criteria for explosive temper and mood lability identify disruptive youth who improve while receiving the anticonvulsant divalproex sodium. METHOD: Twenty outpatient children and adolescents (ages 10-18) with a disruptive behavior disorder (oppositional defiant disorder or conduct disorder) met the specific criteria for explosive temper and mood lability. They received 6 weeks of divalproex treatment and 6 weeks of placebo by random assignment. Independent evaluators blind to group assignment assessed response at the end of each phase. RESULTS: At the end of phase 1, eight of 10 subjects had responded to divalproex; zero of 10 had responded to placebo. Of the 15 subjects who completed both phases, 12 has superior response taking divalproex. CONCLUSIONS: This preliminary study replicates open-label findings showing that divalproex is an efficacious treatment for explosive temper and mood lability in disruptive children and adolescents.
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In the citing paper
“However, a comparison of behavior therapy combined with either divalproex or stimulants found that the use of divalproex was more efficacious in children with severe aggressive behavior, most of whom also had ADHD (118).”
From Emotion Dysregulation in Attention Deficit Hyperactivity Disorder (2014) · cites this paper as [118]
In the citing paper
“Divalproex was found it to be superior to placebo in treating explosive temper, mood lability [661], and CD [662] in adolescents.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [661]
Citations
Cites
SCL-90: an outpatient psychiatric rating scale--preliminary report.
Derogatis, L. R., Lipman, R. S., & Covi, L. (1973) · PubMed · Cited by 3,800
SHAFFER, D., FISHER, P., DULCAN, M. K., DAVIES, M., PIACENTINI, J., SCHWAB-STONE, M. E., LAHEY, B. B., BOURDON, K., JENSEN, P. S., BIRD, H. R., et al. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199607000-00012 · Cited by 1,587
Divalproex Treatment of Disruptive Adolescents
Donovan, S. J., Susser, E., Nunes, E. V., Stewart, J. W., Quitkin, F. M., & Klein, D. F. (1997) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v58n0102 · Cited by 171
Self-citationDivalproex Sodium for Impulsive Aggressive Behavior in Patients With Personality Disorder
Kavoussi, R. J., & Coccaro, E. F. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n1206 · Cited by 151
The Overt Aggression Scale in a study of lithium in aggressive conduct disorder.
Malone, R. P., Luebbert, J. F., Pena-Ariet, M., BIESECKER, K. A., & Delaney, M. A. (1994) · PubMed · Cited by 51
Treatment of Comorbid Affective and Substance Use Disorders Therapeutic Potential of Anticonvulsants
Donovan, S. J., & Nunes, E. V. (1998) · American Journal on Addictions · doi:10.3109/10550499808998353 · Cited by 17
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Psychiatric Aspects of Impulsivity
Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1783 · Cited by 2,747
“Phenytoin, carbamazepine, and divalproex have all been found to decrease impulsive aggression (13, 102, 103).”
Evidence-Based Psychosocial Treatments for Children and Adolescents With Disruptive Behavior
Eyberg, S. M., Nelson, M. M., & Boggs, S. R. (2008) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374410701820117 · Cited by 1,335
“…with ADHD and possibly also CD (Klein et al., 1997; see also Hinshaw, 1991), and the mood stabilizing drugs lithium and divalproex sodium have been found effective in reducing aggression in children and adolescents with CD (Donovan et al., 2000; Malone, Delaney, Luebbert, Carter, & Campbell, 2000).”
BackgroundEmotion Dysregulation in Attention Deficit Hyperactivity Disorder
Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070966 · Cited by 1,232
“However, a comparison of behavioral therapy combined with either divalproex or stimulants found that the use of divalproex was more efficacious in children with severe aggressive behavior, most of whom also had ADHD (129).”
Greenhill, L. L., Pliszka, S., & Dulcan, M. K. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202001-00003 · Cited by 927
Guerrini, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68182-8 · Cited by 848
Metadata
- Authors
- Donovan, S. J., Stewart, J. W., Nunes, E. V., Quitkin, F. M., Parides, M., Daniel, W., Susser, E., & Klein, D. F.
- Affiliations
- New York State Psychiatric Institute (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-05-01
- Volume
- 157
- Issue
- 5
- Pages
- 818-820
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2154371517
- Cited by
- 273
- References
- 6
- Citations by year
- 2025: 7 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 12 · 2016: 18 · 2015: 7 · 2014: 10 · 2013: 2 · 2012: 9
- FWCI
- 20.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA00246)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- divalproex sodium, valproic acid, emotional lability, disruptive behavior disorders, oppositional defiant disorder, conduct disorder, children and adolescents, anticonvulsant therapy, placebo response, replication
- MeSH terms
- Adolescent, Ambulatory Care, Anticonvulsants, Child, Double-Blind Method, Drug Administration Schedule, Female, Humans, Disruptive, Impulse Control, and Conduct Disorders, Male, Placebos, Psychiatric Status Rating Scales, Valproic Acid, Comorbidity, Treatment Outcome, Cross-Over Studies, Attention Deficit and Disruptive Behavior Disorders, Mood Disorders
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