The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Stressful Life Events and Previous Episodes in the Etiology of Major Depression in Women: An Evaluation of the “Kindling” Hypothesis
Abstract
OBJECTIVE: Although previous evidence has suggested that the etiologic role of stressful life events in major depression is reduced in recurrent versus first-onset cases, this question deserves reexamination because of potential methodological limitations of the previous studies. METHOD: Members of female-female twin pairs from a population-based registry (N=2,395), who were interviewed four times over a period of 9 years, formed a study group that contained 97,515 person-months and 1,380 onsets of major depression. Discrete-time survival, proportional hazards model, and piece-wise regression analyses were used to examine the interaction between life event exposure and number of previous depressive episodes in the prediction of episodes of major depression. RESULTS: For those with zero to nine previous depressive episodes, the depressogenic effect of stressful life events declined substantially with increasing episode number. However, the association between stressful life events and major depression was not substantially influenced by additional episodes. This pattern of results was robust to the addition of indices of event severity, measures of genetic risk, and restriction to independent stressful life events. The same pattern was also seen upon examining within-person changes in number of episodes. CONCLUSIONS: The association between previous number of depressive episodes and the pathogenic impact of stressful life events on major depression is likely causal and biphasic. Through approximately nine episodes, the association between stressful life event exposure and risk of major depression progressively declines but is largely unchanged with further episodes. These results are consistent with the kindling hypothesis but suggest a threshold at which the mind/brain is no longer additionally sensitized to the depressive state.
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“A more liberal estimate, which includes any type of preonset major life event, raises the risk estimate several fold to an odds ratio of 9.38 for a first lifetime episode of MDD”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Kendler, Thornton, & Gardner, 2000
In the citing paper
“Many of the factors reported on here appear to have robust properties as predictors of relapse or recurrence risk independent of medication discontinuation: number of previous episodes (Berlanga et al. 1999; Kendler et al. 2000; Burcusa & Iacono, 2007; Hardeveld et al. 2010), residual symptoms (Hardeveld et al. 2010; Nierenberg et al. 2010) and other factors all robustly increase the risk of rela”
From Predicting relapse after antidepressant withdrawal – a systematic review (2017) · cites this paper as Kendler et al. 2000
In the citing paper
“Moreover, in psychiatry depression is conceptualized as heterogeneous, multifactorial in causation, and it is believed to arise from the cumulative effects [56–58] of genetics [59–62], adverse events in childhood [63–66], and ongoing life stressors [67–70].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [57]
In the citing paper
“The course of MDD shows a worsening pattern, with each episode occurring sooner, increasing in severity and becoming more resistant to effective treatments.10”
In the citing paper
“These results are consistent with the substantial literature on the “kindling hypothesis” for MD in which, over episodes, MD becomes more autonomous and less associated with prior stressors”
From The development of an environmental risk score using Swedish National Registers and its impact on subsequent episodes of major depression (2025) · cites this paper as Kendler, Thornton, & Gardner, 2000
In the citing paper
“research suggests that in many individuals, depressive episodes show a worsening pattern over the course of repeated episodes, characterised by increased severity, frequency, autonomy (i.e. episodes are less clearly precipitated by psychosocial stress) and lack of responsiveness to initially effective treatments (Kendler 2000; Post 1992).”
From Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents (2012) · cites this paper as Kendler 2000
In the citing paper
“There is compelling evidence that intervention in this early stage may prevent the development of cognitive factors associated with recurrent episodes (Kendler 2000; Lewinsohn 1999; Ma 2004).”
From Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents (2012) · cites this paper as Kendler 2000
In the citing paper
“Moreover, there is commonly a dose-response relationship between the number of types of adversity associated and the magnitude of the risk for depression.4-11”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [9]
In the citing paper
“A higher number of previous episodes (Berwian, Walter, Seifritz, & Huys, 2017; Kendler, Thornton, & Gardner, 2000), more residual symptoms (Berwian et al., 2017; Nierenberg et al., 2010), and failure to reach remission after acute antidepressant treatment (APA, 2010; Rush et al., 2006) are associated with a greater risk of relapse”
From Relapse prevention with levomilnacipran ER in adults with major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled study (2019) · cites this paper as Kendler, Thornton, & Gardner, 2000
Citations
Cites
A Coefficient of Agreement for Nominal Scales
Cohen, J. (1960) · Educational and Psychological Measurement · doi:10.1177/001316446002000104 · Cited by 42,398
Applied Linear Statistical Models
Kutner, M., Nachtsheim, C. J., Neter, J., & Li, W. (1997) · Technometrics · doi:10.1080/00401706.1997.10485141 · Cited by 7,186
Social Origins of Depression: A Study of Psychiatric Disorder in Women.
Schnitzer, P. K., Brown, G. W., & Harris, T. (1980) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2065631 · Cited by 3,053
Survival analysis using the SAS system : a practical guide
Allison, P. D. (1995) · Medical Entomology and Zoology · Cited by 2,402
THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111
Discrete-Time Methods for the Analysis of Event Histories
Allison, P. D. (1982) · Sociological Methodology · doi:10.2307/270718 · Cited by 2,080
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Manic-Depressive Insanity and Paranoia.
(1921) · JAMA · doi:10.1001/jama.1921.02630330070026 · Cited by 1,612
Large sample standard errors of kappa and weighted kappa.
Fleiss, J. L., Cohen, J., & Everitt, B. S. (1969) · Psychological Bulletin · doi:10.1037/h0028106 · Cited by 1,536
Stressful life events, genetic liability, and onset of an episode of major depression in women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.833 · Cited by 1,063
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Items 201–300 of 719
Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women
Comings, D. E., Wu, S., Rostamkhani, M., McGue, M. K., Iacono, W. G., & MacMurray, J. P. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10406 · Cited by 75
Post, R. M. (2016) · Bipolar Disorders · doi:10.1111/bdi.12401 · Cited by 78
The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features
Iverson, G. L., Keene, C. D., Perry, G., & Castellani, R. J. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170654 · Cited by 72
Bay, E., Sikorskii, A. E., & Arnault, D. S. (2009) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3181b6be81 · Cited by 71
Devanand, D. P., Kim, M. K., Paykina, N., & Sackeïm, H. A. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200205000-00005 · Cited by 70
Hussey, I., & Barnes‐Holmes, Y. (2012) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2012.03.002 · Cited by 84
Categories, Dimensions, and the Mental Health of Children and Adolescents
Rutter, M. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1301.002 · Cited by 68
Rodgers, M., Asaria, M., Walker, S., McMillan, D., Lucock, M. P., Harden, M., Palmer, S., & Eastwood, A. J. (2012) · Health Technology Assessment · doi:10.3310/hta16280 · Cited by 66
Jindal, R. D., Thase, M. E., Fasiczka, A. L., Friedman, E. S., Buysse, D. J., Frank, E., & Kupfer, D. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01226-4 · Cited by 68
Comorbidity of Mood and Anxiety Disorders: The Rule, Not the Exception?
Nemeroff, C. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.1.3 · Cited by 68
The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning
Bogdan, R., Perlis, R. H., Fagerness, J. A., & Pizzagalli, D. A. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00600.x · Cited by 70
Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
Post, R. M. (2002) · Epilepsy Research · doi:10.1016/s0920-1211(02)00081-5 · Cited by 65
Suicide and chronic traumatic encephalopathy
Iverson, G. L. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15070172 · Cited by 66
Prevention of depression: The state of the science at the beginning of the 21st Century
Barrera, A. Z., Torres, L. D., & Muñoz, R. F. (2007) · International Review of Psychiatry · doi:10.1080/09540260701797894 · Cited by 65
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 72
Fibromyalgia and Depression: A Literature Review of Their Shared Aspects
Yepez, D., Grandes, X. A., Manjunatha, R. T., Habib, S., & Sangaraju, S. L. (2022) · Cureus · doi:10.7759/cureus.24909 · Cited by 72
Minelli, A., Zanardini, R., Bonvicini, C., Sartori, R., Pedrini, L., Gennarelli, M., & Bocchio‐Chiavetto, L. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0189-3 · Cited by 66
Neurobiology of antidepressant withdrawal: implications for the longitudinal outcome of depression
Harvey, B. H., McEwen, B. S., & Stein, D. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00528-6 · Cited by 63
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Joca, S. R. L., Sartim, A. G., Roncalho, A. L., Diniz, C. F. A., & Wegener, G. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-02987-4 · Cited by 63
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Bagley, S. L., Weaver, T. L., & Buchanan, T. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.004 · Cited by 68
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Kasala, E. R., Bodduluru, L. N., Maneti, Y., & Thipparaboina, R. (2013) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2013.10.001 · Cited by 67
Crowley, S. K., O’Buckley, T. K., Schiller, C. E., Stuebe, A. M., Morrow, A. L., & Girdler, S. S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4217-x · Cited by 66
Kindling of life stress in bipolar disorder: comparison of sensitization and autonomy models
Weiss, R. B., Stange, J. P., Boland, E. M., Black, S. K., LaBelle, D. R., Abramson, L. Y., & Alloy, L. B. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000014 · Cited by 62
Raedt, R. D., & Hooley, J. M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.03.005 · Cited by 71
Dougherty, L. R., Klein, D. N., & Davila, J. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.6.1012 · Cited by 61
Allen, N. B., Hetrick, S. E., Simmons, J. G., & Hickie, I. B. (2007) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2007.tb01329.x · Cited by 61
Mota, N., Cook, J., Smith, N. B., Tsai, J., Harpaz-Rotem, I., Krystal, J., Southwick, S., & Pietrzak, R. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.09.005 · Cited by 18
Zara, G., & Farrington, D. P. (2010) · Criminal Behaviour and Mental Health · doi:10.1002/cbm.763 · Cited by 60
Nasso, S., Vanderhasselt, M., Demeyer, I., & Raedt, R. D. (2018) · Emotion · doi:10.1037/emo0000448 · Cited by 66
New insights on the antidepressant discontinuation syndrome
Harvey, B. H., & Slabbert, F. N. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2429 · Cited by 62
Commentary: Nature–nurture interplay in emotional disorders
Rutter, M. L. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00178 · Cited by 61
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 63
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Figueira, P. G., Malloy‐Diniz, L. F., Campos, S. B., de Miranda, D. M., Romano‐Silva, M. A., Marco, L. A. D., Neves, F. S., & Corrêa, H. (2010) · Archives of Women s Mental Health · doi:10.1007/s00737-010-0146-6 · Cited by 58
Ramírez-Mahaluf, J. P., Roxin, A., Mayberg, H. S., & Compte, A. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv249 · Cited by 60
Wingenfeld, K., Schaffrath, C., Rullkoetter, N., Mensebach, C., Schlosser, N., Beblo, T., Drießen, M., & Meyer, B. (2011) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2011.04.003 · Cited by 64
Klawohn, J., Bruchnak, A., Burani, K., Meyer, A., Lazarov, A., Bar‐Haim, Y., & Hajcak, G. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103762 · Cited by 69
Monroe, S. M., Torres, L. D., Guillaumot, J., Harkness, K. L., Roberts, J. E., Frank, E., & Kupfer, D. J. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.1.112 · Cited by 60
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Andreescu, C., Ajilore, O., Aizenstein, H. J., Albert, K. M., Butters, M. A., Landman, B. A., Karim, H. T., Krafty, R. T., & Taylor, W. D. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.07.016 · Cited by 57
Haastrup, E. K., Bukh, J. D., Bock, C., Vinberg, M., Thørner, L. W., Hansen, T. F., Werge, T. M., Kessing, L. V., & Ullum, H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.025 · Cited by 56
Kessing, L. V., & Andersen, P. K. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0061-0 · Cited by 56
Vrshek‐Schallhorn, S., Stroud, C. B., Mineka, S., Zinbarg, R. E., Adam, E. K., Redei, E. E., Hammen, C. L., & Craske, M. G. (2015) · Journal of Abnormal Psychology · doi:10.1037/abn0000098 · Cited by 60
Cambon, K., Venero, C., Berezin, V., Bock, E., & Sandi, C. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00597-9 · Cited by 56
Silverman, M. E., & Loudon, H. (2010) · Archives of Women s Mental Health · doi:10.1007/s00737-010-0161-7 · Cited by 55
Post, R. M., Altshuler, L. L., Leverich, G. S., Nolen, W. A., Kupka, R., Grunze, H., Frye, M. A., Suppes, T. M., McElroy, S., Keck, P. E., et al. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.08.007 · Cited by 53
History of Major Depressive Disorder and Endothelial Function in Postmenopausal Women
Wagner, J. A., Tennen, H. A., Mansoor, G. A., & Abbott, G. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195868.68122.9e · Cited by 53
Depression and Exercise: A Clinical Review and Management Guideline
Ranjbar, E., Memari, A. H., Hafizi, S., Shayestehfar, M., Mirfazeli, F. S., & Eshghi, M. A. (2015) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.6(2)2015.24055 · Cited by 69
Lethbridge, R., & Allen, N. B. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2008.06.011 · Cited by 54
Castañeda, P., Muñoz, M., García‐Rojo, G., Ulloa, J. L., Bravo, J. A., Márquez, R., García-Pérez, M. A., Arancibia, D., Araneda, K., Rojas, P. S., et al. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23602 · Cited by 56
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Arango-Dávila, C. A., & Rincón-Hoyos, H. G. (2016) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2016.10.007 · Cited by 75
Hernández, M. E., Cabrera, D. M., Pérez-Tapia, M., Bojalil, R., Estrada‐García, I., Estrada-Parra, S. A., & Pavón, L. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/267871 · Cited by 53
Uvnäs‐Moberg, K., Groß, M. M., Calleja‐Agius, J., & Turner, J. D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1272270 · Cited by 61
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George, L. K. (2007) · Springer eBooks · doi:10.1007/978-0-387-36320-2_9 · Cited by 51
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Furtado, C. P., Maller, J. J., & Fitzgerald, P. B. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.11.005 · Cited by 50
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Drake, C. L., & Roth, T. G. (2006) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.06.005 · Cited by 53
Cox, G. R., Fisher, C. A., De Silva, S., Phelan, M., Akinwale, O. P., Simmons, M. B., & Hetrick, S. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007504.pub2 · Cited by 48
Malan‐Müller, S., Valles‐Colomer, M., Palomo, T., & Leza, J. C. (2023) · Gut Microbes · doi:10.1080/19490976.2022.2162306 · Cited by 54
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Nigatu, Y. T., Bültmann, U., & Reijneveld, S. A. (2015) · BMC Public Health · doi:10.1186/s12889-015-1682-9 · Cited by 51
Bravo, G. L., & Maswood, S. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.09.003 · Cited by 48
Bogdan, R., Arpana Agrawal, A., Gaffrey, M. S., Tillman, R., & Luby, J. L. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12142 · Cited by 51
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Genetic and environmental influences on emotion‐modulated startle reflex: A twin study
Anokhin, A. P., Golosheykin, S., & Heath, A. C. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00486.x · Cited by 46
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Kalmbach, D. A., Pillai, V., & Drake, C. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192088 · Cited by 44
Sandre, A., Bagot, R. C., & Weinberg, A. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.04.001 · Cited by 51
Farabaugh, A. H., Mischoulon, D., D, M. F. M., Green, C., Guyker, W. M., & Alpert, J. E. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00377.x · Cited by 45
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Sidik, S. M., Lekhraj, R., & Foo, C. N. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18030868 · Cited by 56
Haleem, D. J. (2011) · Current Neuropharmacology · doi:10.2174/157015911796558019 · Cited by 43
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Zhang, J., Ning, L., & Wang, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.016 · Cited by 42
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You, S., & Conner, K. R. (2009) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181be7841 · Cited by 41
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Dawson, R., & Lavori, P. W. (2004) · Statistics in Medicine · doi:10.1002/sim.1920 · Cited by 41
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Metadata
- Authors
- Kendler, K. S., Thornton, L. M., & Gardner, C. O.
- Affiliations
- Virginia Commonwealth University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-08-01
- Volume
- 157
- Issue
- 8
- Pages
- 1243-1251
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2150355913
- Cited by
- 721
- References
- 47
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 13 · 2023: 21 · 2022: 27 · 2021: 29 · 2020: 28 · 2019: 27 · 2018: 30 · 2017: 27 · 2016: 46 · 2015: 45 · 2014: 40 · 2013: 33 · 2012: 36
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k05mh001277-05)
- National Institute on Alcohol Abuse and Alcoholism (R01AA009095, AA-09095)
- National Institute of Mental Health (MH-01277, R01MH040828, MH 40828)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- major depressive disorder, life events, recurrent depression, women, depressive episodes, etiology of depression, twin pairs, genetic risk, event severity, within-person change
- MeSH terms
- Adult, Depressive Disorder, Diseases in Twins, Female, Humans, Kindling, Neurologic, Life Change Events, Longitudinal Studies, Models, Psychological, Recurrence, Research Design, Risk Factors, Proportional Hazards Models, Odds Ratio, Survival Analysis, Genetic Predisposition to Disease
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