Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder
Open accessAbstract
Background Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from lifelong recurring episodes of increasing severity, reduced therapeutic response, and shorter remission periods, suggesting the presence of a persistent and potentially progressive pathology.Methods Subgenual anterior cingulate cortex postmortem samples from four MDD cohorts (single episode, n = 20; single episode in remission, n = 15; recurrent episode, n = 20; and recurrent episode in remission, n = 15), and one control cohort (n = 20) were analyzed by mass spectrometry-based proteomics (n = 3630 proteins) combined with statistical analyses. The data was investigated for trait and state progressive neuropathologies in MDD using both unbiased approaches and tests of a priori hypotheses.Results The data provided weak evidence for proteomic differences as a function of state (depressed/remitted) or number of previous episodes. Instead it suggested the presence of persistent MDD effects, regardless of episodes or remitted state, namely on proteomic measures related to presynaptic neurotransmission, synaptic function, cytoskeletal rearrangements, energy metabolism, phospholipid biosynthesis/metabolism, and calcium ion homeostasis. Selected proteins (dihydropyrimidinase-related protein 1, synaptosomal-associated protein 29, glutamate decarboxylase 1, metabotropic glutamate receptor 1, and excitatory amino acid transporter 3) were validated by Western blot analysis. The findings were independent of technical, demographic (sex or age), or other clinical parameters (death by suicide and drug treatment).Conclusions Collectively, the results provide evidence for persistent MDD effects across current episodes or remission, in the absence of detectable progressive neuropathology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
It shows imbalance in cortical-subcortical limbic regions with decreased GABAergic signaling and increased glutamatergic signaling.
“It shows the imbalance in cortical-subcortical limbic regions with decreased GABAergic signaling and increased glutamatergic signaling. 210 , 211”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [211]
The Introduction (page not specified) describes reduced inhibitory GABA levels and an altered excitation–inhibition balance in MDD. The Discussion (page not specified) reports downregulated GABA- and glutamate-related proteins, but does not establish increased glutamatergic signaling or demonstrate that imbalance across cortical–subcortical limbic regions. (LLM, conf=0.87)
Experimental — accuracy not yet measuredScifo and colleagues did not observe differences in protein expression within the MDD groups, suggesting that synapse-related changes may persist in stress-related disorders.
“they did not observe differences in protein expression within the MDD groups, suggesting that synapse-related changes may persist in stress-related disorders”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [84]
Scifo and colleagues found robust changes in proteins that regulate synaptic plasticity and transmission in individuals with MDD (current or remitted at time of death) relative to controls.
“Scifo and colleagues examined cellular pathology in individuals with MDD (current or remitted at time of death) relative to controls, and found robust changes in proteins that regulate synaptic plasticity and transmission”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [84]
D2HGDH encodes for the enzyme D-2-hydroxyglutarate dehydrogenase, and is suggested to be downregulated in depressed patients during remission.
“D2HGDH encodes for the enzyme D-2-hydroxyglutarate dehydrogenase, and is suggested to be downregulated in depressed patients during remission54.”
From Methylome-wide change associated with response to electroconvulsive therapy in depressed patients (2021) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
Mi, H., Huang, X., Muruganujan, A., Tang, H., Mills, C., Kang, D. S., & Thomas, P. D. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1138 · Cited by 1,985 · see citing works
Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.929 · Cited by 1,868 · see citing works
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Structural dynamics of dendritic spines in memory and cognition
Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1243 · Cited by 721 · see citing works
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710 · see citing works
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627 · see citing works
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works
Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT
Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R., & Krystal, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.577 · Cited by 512 · see citing works
Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 495 · see citing works
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.582 · Cited by 480 · see citing works
Aston, C., Jiang, L., & Sokolov, B. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001565 · Cited by 427 · see citing works
Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works
Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378 · see citing works
Self-citationDefining the transcriptome and proteome in three functionally different human cell lines
Lundberg, E., Fagerberg, L., Klevebring, D., Matic, I., Geiger, T., Cox, J., Älgenäs, C., Lundeberg, J., Mann, M., & Uhlen, M. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.106 · Cited by 373 · see citing works
Normalization and missing value imputation for label-free LC-MS analysis
Karpievitch, Y. V., Dabney, A. R., & Smith, R. D. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s16-s5 · Cited by 345 · see citing works
Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304 · see citing works
Calcium homeostasis and modulation of synaptic plasticity in the aged brain
Foster, T. C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00283.x · Cited by 303 · see citing works
Tripp, A., Oh, H., Guilloux, J.-P., Martinowich, K., Lewis, D. A., & Sibille, E. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020248 · Cited by 273 · see citing works
Self-citationEvidence of Cortical Inhibitory Deficits in Major Depressive Disorder
Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261 · see citing works
Gorwood, P. A. P. M., Corruble, E., Falissard, B., & Goodwin, G. M. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07040574 · Cited by 254 · see citing works
Sex differences in glutamate receptor gene expression in major depression and suicide
Gray, A. L., Hyde, T. M., Deep-Soboslay, A., Kleinman, J. E., & Sodhi, M. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.91 · Cited by 250 · see citing works
The challenge of the proteome dynamic range and its implications for in‐depth proteomics
Zubarev, R. A. (2013) · PROTEOMICS · doi:10.1002/pmic.201200451 · Cited by 230 · see citing works
GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001616 · Cited by 217 · see citing works
Self-citationA Molecular Signature of Depression in the Amygdala
Sibille, E. L., Wang, Y., Joeyen-Waldorf, J., Gaiteri, C., Surget, A., Oh, S., Belzung, C., Tseng, G. C., & Lewis, D. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121760 · Cited by 208 · see citing works
Self-citationReduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression
Karolewicz, B., Maciag, D., O'Dwyer, G., Stockmeier, C. A., Feyissa, A. M., & Rajkowska, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990587 · Cited by 203 · see citing works
Martins‐de‐Souza, D., Guest, P. C., Harris, L. W., Vanattou‐Saïfoudine, N., Webster, M. J., Rahmoune, H., & Bahn, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.13 · Cited by 202 · see citing works
Lewis, D. A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00393-1 · Cited by 197 · see citing works
Self-citationReduced somatostatin in subgenual anterior cingulate cortex in major depression
Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190 · see citing works
Self-citationGupta, D. S., McCullumsmith, R. E., Beneyto, M., Haroutunian, V., Davis, K. L., & Meador‐Woodruff, J. H. (2005) · Synapse · doi:10.1002/syn.20164 · Cited by 146 · see citing works
Label-Free Quantitative LC–MS Proteomics of Alzheimer’s Disease and Normally Aged Human Brains
Andreev, V. P., Petyuk, V., Brewer, H. M., Karpievitch, Y. V., Xie, F., Clarke, J., Camp, D., Smith, R. D., Lieberman, A. P., Albin, R. L., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr3001546 · Cited by 140 · see citing works
Evidence for alterations of the glial syncytial function in major depressive disorder
Medina, A., Watson, S. J., Bunney, W. E., Myers, R., Schatzberg, A. F., Barchas, J. D., Akil, H., & Thompson, R. C. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.010 · Cited by 108 · see citing works
Wiśniewski, J. R., Duś‐Szachniewicz, K., Ostasiewicz, P., Ziolkowski, P. P., Rakus, D., & Mann, M. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00523 · Cited by 91 · see citing works
Gottschalk, M. G., Wesseling, H., Guest, P. C., & Bahn, S. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu019 · Cited by 71 · see citing works
Bader, V., Tomppo, L., Trossbach, S. V., Bradshaw, N. J., Prikulis, I., Leliveld, S. R., Lin, C.-Y., Ishizuka, K., Sawa, A., Ramos, A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds273 · Cited by 70 · see citing works
Glantz, L. A., Austin, M. C., & Lewis, D. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00923-9 · Cited by 68 · see citing works
Self-citationScifo, E., Szwajda, A., Soliymani, R., Pezzini, F., Bianchi, M., Dapkunas, A., Dȩbski, J., Uusi-Rauva, K., Dadlez, M., Gingras, A., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.03.038 · Cited by 65 · see citing works
Self-citationDing, Y., Chang, L.-C., Wang, X., Guilloux, J.-P., Parrish, J., Oh, H., French, B. J., Lewis, D. A., Tseng, G. C., & Sibille, E. (2015) · Complex Psychiatry · doi:10.1159/000369974 · Cited by 61 · see citing works
Self-citationDuration of untreated illness and antidepressant fluvoxamine response in major depressive disorder
Okuda, A., Suzuki, T., Kishi, T., Yamanouchi, Y., Umeda, K., Haitoh, H., Hashimoto, S., Ozaki, N., & Iwata, N. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02091.x · Cited by 54 · see citing works
Wesseling, H., Gottschalk, M. G., & Bahn, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu015 · Cited by 54 · see citing works
Kuge, H., Akahori, K., Yagyu, K.-I., & Honke, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571075 · Cited by 50 · see citing works
Biological substrates underpinning diagnosis of major depression
Sibille, E. L., & French, B. J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000436 · Cited by 50 · see citing works
Self-citationErratum: Sex differences in glutamate receptor gene expression in major depression and suicide
Gray, A., Hyde, T. M., Deep‐Soboslay, A., Kleinman, J. E., & Sodhi, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.114 · Cited by 31 · see citing works
Wang, C., Qu, B., Wang, Z., Ju, J., Wang, Y., Wang, Z., Cao, P., & Wang, D.-K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.11.027 · Cited by 30 · see citing works
Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia
Afshari, P., Myles‐Worsley, M., Cohen, O. S., Tiobech, J., Faraone, S. V., Byerley, W., & Middleton, F. A. (2015) · Complex Psychiatry · doi:10.1159/000433599 · Cited by 23 · see citing works
Tominaga, K. (2011) · International Journal of General Medicine · doi:10.2147/ijgm.s21029 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [45]Wesseling H Gottschalk MG Bahn S Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders The international journal of neuropsychopharmacology/official scientific journal of the Collegium Internationale Neuropsychopharmacologicum 2015 18 1 PMC4368865 25539505
Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works
“210,211 Meanwhile, GABAergic signaling is decreased in regions comprising the default mode network (DMN), while it is increased in the lateral prefrontal cortex (LPFC).”
BackgroundPham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Hu, Y.-T., Tan, Z.-L., Hirjak, D., & Northoff, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02193-x · Cited by 127 · see citing works
Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders
Morella, I., Brambilla, R., & Morè, L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104892 · Cited by 96 · see citing works
Connecting Dots between Mitochondrial Dysfunction and Depression
Khan, M., Baussan, Y., & Hébert-Chatelain, É. (2023) · Biomolecules · doi:10.3390/biom13040695 · Cited by 77 · see citing works
Biophysical Modeling of Large-Scale Brain Dynamics and Applications for Computational Psychiatry
Murray, J. D., Demirtaş, M., & Anticevic, A. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.07.004 · Cited by 67 · see citing works
Shweiki, M. R. A., Oeckl, P., Steinacker, P., Barschke, P., Dorner‐Ciossek, C., Hengerer, B., Schönfeldt‐Lecuona, C., & Otto, M. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0825-7 · Cited by 66 · see citing works
Banasr, M., Sanacora, G., & Esterlis, I. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.004 · Cited by 65 · see citing works
Yang, L., Liu, J., Liu, X., Su, C., Zhang, Q., Wang, Z.-H., Cao, L.-F., Guo, X., Huang, Y., Luo, W., et al. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00367-8 · Cited by 58 · see citing works
Mitochondria and early-life adversity
Zitkovsky, E. K., Daniels, T. E., & Tyrka, A. R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.005 · Cited by 51 · see citing works
Rappeneau, V., Wilmes, L., & Touma, C. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103555 · Cited by 46 · see citing works
Molecular characterization of depression trait and state
Shukla, R., Newton, D. F., Sumitomo, A., Zare, H., McCullumsmith, R. E., Lewis, D. A., Tomoda, T., & Sibille, E. L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01347-z · Cited by 41 · see citing works
Self-citationMisquitta, K. A., Miles, A. E., Prévot, T. D., Knoch, J., Fee, C., Newton, D. F., Ellegood, J., Lerch, J. P., Sibille, E. L., Nikolova, Y. S., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108562 · Cited by 34 · see citing works
Self-citationSingh, H., Wray, N. H., Schappi, J. M., & Rasenick, M. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0016-x · Cited by 33 · see citing works
RetractedMethylome-wide change associated with response to electroconvulsive therapy in depressed patients
Sirignano, L., Frank, J., Kranaster, L., Witt, S. H., Streit, F., Zillich, L., Sartorius, A., Rietschel, M., & Foo, J. C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01474-9 · Cited by 32 · see citing works
Chronic Social Stress Leads to Reduced Gustatory Reward Salience and Effort Valuation in Mice
Kúkeľová, D., Bergamini, G., Sigrist, H., Seifritz, E., Hengerer, B., & Pryce, C. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00134 · Cited by 31 · see citing works
Miyata, S., Kumagaya, R., Kakizaki, T., Fujihara, K., Wakamatsu, K., & Yanagawa, Y. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00131 · Cited by 29 · see citing works
Singh, H., Chmura, J., Bhaumik, R., Pandey, G. N., & Rasenick, M. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3033-19.2020 · Cited by 28 · see citing works
Schubert, K. O., Stacey, D., Arentz, G., Clark, S. R., Air, T., Hoffmann, P., & Baune, B. T. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.02.023 · Cited by 25 · see citing works
Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice
Miyata, S., Kakizaki, T., Fujihara, K., Obinata, H., Hirano, T., Nakai, J., Tanaka, M., Itohara, S., Watanabe, M., Tanaka, K. F., et al. (2021) · Molecular Brain · doi:10.1186/s13041-020-00713-2 · Cited by 23 · see citing works
Ziani, P. R., Feiten, J. G., Goularte, J. F., Colombo, R., Antqueviezc, B., Géa, L. P., & Rosa, A. R. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.2.211 · Cited by 24 · see citing works
Kim, B. I., Kim, D., Schulmann, A., Patel, Y., Caban-Rivera, C., Kim, P., Jambhale, A. D., Johnson, K. R., Feng, N., Xu, Q., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0830-22.2023 · Cited by 20 · see citing works
Suicide Is a Confounder in Postmortem Studies on Depression
Zhao, J., Lucassen, P. J., & Swaab, D. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.015 · Cited by 15 · see citing works
Paul, K. C., Kusters, C., Furlong, M., Zhang, K., Yu, Y., Folle, A. D., Rosario, I. D., Keener, A. M., Bronstein, J. M., Sinsheimer, J. S., et al. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100530 · Cited by 14 · see citing works
Asch, R. H., Abdallah, C. G., Carson, R. E., & Esterlis, I. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01913-3 · Cited by 13 · see citing works
Ji, S., Liu, B., Li, Y., Chen, N., Fu, Y., Shi, J., Zhao, Z., Yao, Z., & Hu, B. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111356 · Cited by 12 · see citing works
Murata, S., Castillo, M. F. R., Murphy, M. L. M., Schwarz, M., Moll, N., Martin, B., Weidinger, E., Leitner, B., Mueller, N., & Halaris, A. E. (2019) · Neurology Psychiatry and Brain Research · doi:10.1016/j.npbr.2019.07.001 · Cited by 10 · see citing works
Schroeter, C. A., Вячеславовна, Г. А., Sicker, M., Umriukhin, A., Burova, A., Shulgin, B., Morozov, S., Costa-Nunes, J. P., & Strekalova, T. V. (2025) · Biomolecules · doi:10.3390/biom15010067 · Cited by 9 · see citing works
Dynamic Behavioral and Molecular Changes Induced by Chronic Restraint Stress Exposure in Mice
Prevot, T. D., Knoch, J., Chatterjee, D., Codeluppi-Arrowsmith, S. A., Misquitta, K. A., Fee, C., Newton, D. F., Oh, H., Sibille, E. L., & Banasr, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010167 · Cited by 6 · see citing works
Self-citationDonix, M., Haußmann, R., Helling, F., Zweiniger, A., Werner, A., Linn, J., Bauer, M., & Buthut, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.10.118 · Cited by 6 · see citing works
Proteomics of neuropsychiatric disorders
Liu, A., Sun, L., & Meng, W. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120093 · Cited by 5 · see citing works
Filipović, D., Novak, B., Xiao, J.-S., Tadić, P., & Turck, C. W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053026 · Cited by 6 · see citing works
Joyce, M. K. P., Datta, D., Arellano, J. I., Duque, A., Morozov, Y. M., Morrison, J. H., & Arnsten, A. F. T. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1553056 · Cited by 3 · see citing works
Zhong, X., Chen, X., Liu, Y., Gui, S., Pu, J., Wang, D., Wei, T., Chen, Y., Chen, X., Chen, W., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28960 · Cited by 3 · see citing works
Dynamic behavioral and molecular changes induced by chronic stress exposure in micePreprint
Prevot, T. D., Chatterjee, D., Knoch, J., Codeluppi-Arrowsmith, S. A., Misquitta, K. A., Fee, C., Newton, D. F., Oh, H., Sibille, E. L., & Banasr, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.07.443011 · Cited by 3 · see citing works
Self-citationRisks for Major Depression: Searching for Stable Traits
Weissman, M. M., Talati, A., Hao, X., & Posner, J. E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.010 · Cited by 2 · see citing works
Tomoda, T., Sumitomo, A., Shukla, R., Hirota-Tsuyada, Y., Miyachi, H., Oh, H., French, L., & Sibille, E. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/334466 · Cited by 2 · see citing works
Self-citationA mink (Neovison vison) model of self injury: effects of CBP-CREB axis on nerve injury and behaviorPreprint
Liu, C., Guo, X., Si, H., & Li, G. (2020) · doi:10.21203/rs.3.rs-39023/v1
Chemo-electrical Signaling, Protein Translocation, and Neuronal Transcription
Wang, X., Khaled, H. G., Mandelberg, N. J., & Tsien, R. W. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_5
Wang, S., Li, M., Zhang, C., Xu, H., He, J., Guo, Y., Gu, H., Zhan, L., Cai, Y., Tu, T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03092
Hu, T., Yan, L., Huang, C., Zhang, H., Guo, Y., Zhang, W. X., & Jiang, C. (2026) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2026-0033
- Authors
- Scifo, E., Pabba, M., Kapadia, F., Ma, T., Lewis, D. A., Tseng, G. C., & Sibille, E.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Pittsburgh (US)
- Corresponding author
- Sibille, Etienne
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 83
- Issue
- 1
- Pages
- 81-89
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5705452
- OpenAlex
- W2766558591
- Cited by
- 41
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 1
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH077159)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, subgenual anterior cingulate cortex, remission, recurrent depression, presynaptic neurotransmission, synaptic function, energy metabolism, phospholipid metabolism, calcium homeostasis, metabotropic glutamate receptor 1, GAD1
- MeSH terms
- Adult, Chromatography, Liquid, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Mass Spectrometry, Blotting, Western, Cohort Studies, Disease Progression, Proteome, Proteomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
