Cited by 452Down syndrome and intellectual disability researchDementia and Cognitive Impairment ResearchGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study

Pinter, Joseph D., Eliez, Stephan, Schmitt, J. Eric, Capone, George T., Reiss, Allan L.·2001·American Journal of Psychiatry

DOI 10.1176/appi.ajp.158.10.1659

Open this paper in CoChat — free account

Abstract

Objective Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. Method Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. Results Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. Conclusions The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal…

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.158.10.1659

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Co-planar stereotaxic atlas of the human brain : 3-dimensional proportional system : an approach to cerebral imaging
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
The cerebellar cognitive affective syndrome
Schmahmann, J. (1998) · Brain · doi:10.1093/brain/121.4.561 · Cited by 3,230
Spatial working memory in humans as revealed by PET
Jonides, J. J., Smith, E. E., Koeppe, R. A., Awh, E., Minoshima, S., & Mintun, M. A. (1993) · Nature · doi:10.1038/363623a0 · Cited by 1,198
THE ANATOMY OF PHONOLOGICAL AND SEMANTIC PROCESSING IN NORMAL SUBJECTS
Démonet, J., Chollet, F., Ramsay, S. C., Cardebat, D., Nespoulous, J., WISE, R., Rascol, A., & Frackowiak, R. S. J. (1992) · Brain · doi:10.1093/brain/115.6.1753 · Cited by 1,157
The cerebellum contributes to linguistic production
Silveri, M. C., Leggio, M. G., & Molinari, M. (1994) · Neurology · doi:10.1212/wnl.44.11.2047 · Cited by 350
Evidence from two genetic syndromes for a dissociation between verbal and visual-spatial short-term memory
Wang, P. P., & Bellugi, U. (1994) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639408402641 · Cited by 329
Automatic Atlas-Based Volume Estimation of Human Brain Regions from MR Images
Andreasen, N. C., Rajarethinam, R., Cizadlo, T., Arndt, S. V., Swayze, V. W., Flashman, L. A., OʼLeary, D. S., Ehrhardt, J. C., & Yuh, W. T. C. (1996) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199601000-00018 · Cited by 312
Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative golgi study
Takashima, S., Becker, L. E., Armstrong, D. L., & Chan, F. (1981) · Brain Research · doi:10.1016/0006-8993(81)90314-0 · Cited by 307
Selective neuroanatornic abnormalities in Down's syndrome and their cognitive correlates
Raz, N., Torres, I. J., Briggs, S. D., Spencer, W. D., Thornton, A. E., Loken, W. J., Gunning, F. M., McQuain, J., Driesen, N. R., & Acker, J. D. (1995) · Neurology · doi:10.1212/wnl.45.2.356 · Cited by 297
down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.
Wisniewski, K. E. (2005) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320370755 · Cited by 297

Flagged first, then by citations

Show all 41 references

Sorted by citations

Items 101–200 of 442

Pain perception in people with Down syndrome: a synthesis of clinical and experimental research
McGuire, B. E., & Defrin, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00194 · Cited by 46
Neuroanatomic correlates of autism and stereotypy in children with Down syndrome
Carter, J. C., Capone, G. T., & Kaufmann, W. E. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282faa8d8 · Cited by 46
Self-citation
Elevated Expression of the G-Protein-Activated Inwardly Rectifying Potassium Channel 2 (GIRK2) in Cerebellar Unipolar Brush Cells of a Down Syndrome Mouse Model
Harashima, C., Jacobowitz, D. M., Stoffel, M., Chakrabarti, L., Haydar, T. F., Siarey, R. J., & Galdzicki, Z. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9066-4 · Cited by 45
Clinical use of structural magnetic resonance imaging in the diagnosis of dementia in adults with Down's syndrome
Strydom, A., Hassiotis, A., & Walker, Z. (2002) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700006984 · Cited by 44
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease
Lauterborn, J. C., Cox, C. D., Chan, S. W., Vanderklish, P. W., Lynch, G., & Gall, C. M. (2020) · Brain Pathology · doi:10.1111/bpa.12779 · Cited by 43
Receptive vocabulary and semantic knowledge in children with SLI and children with Down syndrome
Laws, G., Briscoe, J., Ang, S.-Y., Brown, H., Hermena, E. W., & Kapikian, A. (2014) · Child Neuropsychology · doi:10.1080/09297049.2014.917619 · Cited by 42
Estimates of the prevalence of speech and motor speech disorders in adolescents with Down syndrome
Wilson, E. M., Abbeduto, L., Camarata, S., & Shriberg, L. D. (2019) · Clinical Linguistics & Phonetics · doi:10.1080/02699206.2019.1595735 · Cited by 42
A transchromosomic rat model with human chromosome 21 shows robust down syndrome features.
Kazuki, Y., Gao, F. J., Yamakawa, M., Hirabayashi, M., Kazuki, K., Kajitani, N., Miyagawa-Tomita, S., Abe, S., Sanbo, M., Hara, H., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.12.015 · Cited by 41
Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres
Moldrich, R. X., Dauphinot, L., Laffaire, J., Vitalis, T., Hérault, Y., Beart, P. M., Rossier, J., Vivien, D., Gehrig, C., Antonarakis, S. E., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22131 · Cited by 43
Motor speech skills in children with Down syndrome: A descriptive study
Rupela, V., Velleman, S. L., & Andrianopoulos, M. V. (2016) · International Journal of Speech-Language Pathology · doi:10.3109/17549507.2015.1112836 · Cited by 41
Excitatory/Inhibitory Synaptic Ratios in Polymicrogyria and Down Syndrome Help Explain Epileptogenesis in Malformations
Sarnat, H. B., & Flores‐Sarnat, L. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.11.001 · Cited by 41
Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region
Brault, V., Duchon, A., Romestaing, C., Sahún, I., Pothion, S., Karout, M., Borel, C., Dembélé, D., Bizot, J., Messaddeq, N., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005062 · Cited by 45
Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy
Edgin, J. O., Clark, C. A. C., Massand, E., & Karmiloff‐Smith, A. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00232 · Cited by 44
Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65Dn
Pollonini, G., Gao, V., Rabe, A., Palminiello, S., Albertini, G., & Alberini, C. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.025 · Cited by 41
Cognitive control of movement in down syndrome
Brunamonti, E., Pani, P., Papazachariadis, O., Onorati, P., Albertini, G., & Ferraina, S. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.03.008 · Cited by 40
Dancing with Down syndrome: a phenomenological case study
Reinders, N. J., Bryden, P. J., & Fletcher, P. C. (2015) · Research in Dance Education · doi:10.1080/14647893.2015.1036018 · Cited by 40
Molecular and Cellular Mechanisms Elucidating Neurocognitive Basis of Functional Impairments Associated With Intellectual Disability in Down Syndrome
Rachidi, M., & Lopes, C. (2010) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-115.2.83 · Cited by 40
Assessing Specific Cognitive Deficits Associated with Dementia in Older Adults with Down Syndrome: Use and Validity of the Arizona Cognitive Test Battery (ACTB)
Sinai, A., Hassiotis, A., Rantell, K. R., & Strydom, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153917 · Cited by 41
Effects of Traditional Indian Dance on Motor Skills and Balance in Children with Down syndrome
Raghupathy, M. K., Divya, M., & Karthikbabu, S. (2021) · Journal of Motor Behavior · doi:10.1080/00222895.2021.1941736 · Cited by 39
Importance of Initiating a “Tummy Time” Intervention Early in Infants With Down Syndrome
Wentz, E. E. (2016) · Pediatric Physical Therapy · doi:10.1097/pep.0000000000000335 · Cited by 40
Anomalous White Matter Structure and the Effect of Age in Down Syndrome Patients
Fenoll, R., Pujol, J., Esteba‐Castillo, S., de Sola, S., Ribas‐Vidal, N., García‐Alba, J., Sánchez‐Benavides, G., Martínez‐Vilavella, G., Deus, J., Dierssen, M., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161112 · Cited by 43
Manual MRI parcellation of the frontal lobe
Ranta, M. E., Crocetti, D., Clauss, J. A., Kraut, M. A., Mostofsky, S. H., & Kaufmann, W. E. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.01.006 · Cited by 39
Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome
Witton, J., Padmashri, R., Zinyuk, L. E., Popov, V. I., Kraev, I., Line, S. J., Jensen, T. P., Tedoldi, A., Cummings, D. M., Tybulewicz, V. L. J., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4072 · Cited by 43
Metabolic Rate and Accelerometer Output during Walking in People with Down Syndrome
Agiovlasitis, S., Motl, R. W., Fahs, C. A., Ranadive, S. M., Yan, H., Echols, G. H., Rossow, L. M., & Fernhall, B. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31820936c4 · Cited by 38
α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials
Sieghart, W., Chiou, L., Ernst, M. C., Fabjan, J., Savić, M. M., & Lee, M. T. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000293 · Cited by 40
Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
Contestabile, A., Fila, T., Cappellini, A., Bartesaghi, R., & Ciani, E. (2009) · Cell Proliferation · doi:10.1111/j.1365-2184.2009.00587.x · Cited by 39
A genetic interaction between the APP and Dab1 genes influences brain development
Pramatarova, A., Chen, K., & Howell, B. W. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.09.008 · Cited by 39
Complexity of force output during static exercise in individuals with Down syndrome
Heffernan, K. S., Sosnoff, J. J., Ofori, E., Jae, S. Y., Baynard, T., Collier, S. R., Goulopoulou, S., Figueroa, A., Woods, J. A., Pitetti, K. H., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90555.2008 · Cited by 38
Perturbation of dendritic protrusions in intellectual disability
Levenga, J., & Willemsen, R. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00008-x · Cited by 38
Preschoolers with Down syndrome do not yet show the learning and memory impairments seen in adults with Down syndrome
Roberts, L., & Richmond, J. L. (2014) · Developmental Science · doi:10.1111/desc.12225 · Cited by 40
Astrocytes in Down Syndrome Across the Lifespan
Ponroy Bally, B., & Murai, K. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702685 · Cited by 35
Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome
Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Wegiel, J., Ma, S. Y., Zhong, N., Wierzba‐Bobrowicz, T., de Leon, M., Lai, F., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01300-9 · Cited by 35
Relationship between functional connectivity and sensory impairment: Red flag or red herring?
Dinomais, M., Groeschel, S., Staudt, M., Krägeloh‐Mann, I., & Wilke, M. (2011) · Human Brain Mapping · doi:10.1002/hbm.21227 · Cited by 36
Motor Coordination and Global Development in Subjects with Down Syndrome: The Influence of Physical Activity
Alesi, M., Giustino, V., Gentile, A., López, M. G., & Battaglia, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175031 · Cited by 38
Patterns of differences in wayfinding performance and correlations among abilities between persons with and without Down syndrome and typically developing children
Davis, M., Merrill, E. C., Conners, F. A., & Roskos, B. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01446 · Cited by 33
Modeling Down syndrome in animals from the early stage to the 4.0 models and next
Moreno, M. D. M. M., Brault, V., Birling, M., Pavlovic, G., & Hérault, Y. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2019.08.001 · Cited by 35
Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans
Hasina, Z., Wang, N., & Wang, C. C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.877711 · Cited by 36
Aging and intellectual disability: Insights from mouse models of down syndrome
Ruparelia, A., Pearn, M. L., & Mobley, W. C. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1127 · Cited by 37
From Genes to Brain: Understanding Brain Development in Neurogenetic Disorders Using Neuroimaging Techniques
Schaer, M., & D, S. E. M. (2007) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.02.002 · Cited by 33
Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome
Yun, H. J., Perez, J. D. R., Sosa, P., Valdés, J. A., Madan, N., Kitano, R., Akiyama, S., Skotko, B. G., Feldman, H. A., Bianchi, D. W., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhaa255 · Cited by 33
Motor Skills and Executive Functions in Pediatric Patients with Down Syndrome: A Challenge for Tailoring Physical Activity Interventions
Vandoni, M., Giuriato, M., Pirazzi, A., Zanelli, S., Gaboardi, F., Pellino, V. C., Gazzarri, A. A., Baldassarre, P., Zuccotti, G., & Calcaterra, V. (2023) · Pediatric Reports · doi:10.3390/pediatric15040062 · Cited by 36
Lessons Learned From Neuroimaging Studies of Copy Number Variants: A Systematic Review
Modenato, C., Martin‐Brevet, S., Moreau, C. A., Rodríguez‐Herreros, B., Kumar, K., Draganski, B., Sønderby, I. E., & Jacquemont, S. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.028 · Cited by 34
Verbal short-term memory deficits in Down syndrome: phonological, semantic, or both?
Lee, N., Pennington, B. F., & Keenan, J. M. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9029-4 · Cited by 36
Functional Magnetic Resonance Imaging of Cognitive Processing in Young Adults With Down Syndrome
Jacola, L. M., Byars, A. W., Chalfonte-Evans, M., Schmithorst, V. J., Hickey, F. J., Patterson, B. J., Hotze, S. L., Vannest, J. J., Chiu, C.-Y. P., Holland, S. K., et al. (2011) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-116.5.344 · Cited by 32
Lateralisation of auditory processing in Down syndrome: A study of T-complex peaks Ta and Tb
Groen, M. A., Alku, P., & Bishop, D. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.04.003 · Cited by 31
A stereological study of the mediodorsal thalamic nucleus in Down syndrome.
Karlsen, A. S., Korbo, S., Uylings, H., & Pakkenberg, B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.046 · Cited by 26
Human and mouse model cognitive phenotypes in Down syndrome
Edgin, J. O., Mason, G. M., Spanò, G., Fernández, A., & Nadel, L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00007-8 · Cited by 36
Structural magnetic resonance imaging demonstrates volumetric brain abnormalities in down syndrome: Newborns to young adults
McCann, B., Levman, J., Baumer, N., Lam, M. Y., Shiohama, T., Cogger, L., MacDonald, A., Ijner, P., & Takahashi, E. (2021) · NeuroImage: Clinical · doi:10.1016/j.nicl.2021.102815 · Cited by 30
Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
Créau, N. (2012) · Neural Plasticity · doi:10.1155/2012/171639 · Cited by 30
Abnormal fMRI Activation Pattern During Story Listening in Individuals With Down Syndrome
Losin, E. A. R., Rivera, S. M., O’Hare, E. D., Sowell, E. R., & Pinter, J. D. (2009) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-114.5.369 · Cited by 30
Self-citation
Aging With Down Syndrome: The Dual Diagnosis: Alzheimer’s Disease and Down Syndrome
Cipriani, G., Danti, S., Carlesi, C., & Fiorino, M. D. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518761093 · Cited by 32
Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation
Lao, P. J., Handen, B. L., Betthauser, T. J., Cody, K. A., Cohen, A. D., Tudorascu, D., Stone, C. K., Price, J. C., Johnson, S. C., Klunk, W. E., et al. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9888-y · Cited by 30
Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry
Lee, N., Nayak, A., Irfanoglu, M. O., Sadeghi, N., Stoodley, C. J., Adeyemi, E. I., CLASEN, L. S., & Pierpaoli, C. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61799-1 · Cited by 29
Consequences of trisomy 21 for brain development in Down syndrome
Russo, M. L., Sousa, A. M. M., & Bhattacharyya, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00866-2 · Cited by 28
“These cognitive and brain structure deficits emerge as early as 6 months of age and progress to have substantial impacts on daily life, as well as academic and occupational outcomes 5–7 .”
Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review
Hamadelseed, O., Chan, M. K. S., Wong, M. B., & Skutella, T. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1225228 · Cited by 28
Structural magnetic resonance imaging demonstrates abnormal cortical thickness in Down syndrome: Newborns to young adults
Levman, J. E. D., MacDonald, A., Baumer, N., MacDonald, P., Stewart, N., Lim, A., Cogger, L., Shiohama, T., & Takahashi, E. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101874 · Cited by 29
Developmentally Altered Inhibition in Ts65Dn, a mouse model of Down syndrome
Mitra, A., Blank, M., & Madison, D. (2012) · Brain Research · doi:10.1016/j.brainres.2011.12.034 · Cited by 28
Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model
Bala, U., Leong, M. P.-Y., Lim, C. L., Shahar, H. K., Othman, F., Lai, M. I., Law, Z. K., Ramli, K., Htwe, O., Ling, K., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197711 · Cited by 29
Gait profiles as indicators of domain-specific impairments in executive control across neurodevelopmental disorders
Hocking, D. R., Menant, J. C., Kirk, H., Lord, S. R., & Porter, M. A. (2013) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2013.10.005 · Cited by 28
Numerosity Discrimination in Children With Down Syndrome
Camos, V. (2009) · Developmental Neuropsychology · doi:10.1080/87565640902964557 · Cited by 28
Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis?
Reiche, L., Küry, P., & Göttle, P. (2019) · Cells · doi:10.3390/cells8121591 · Cited by 28
Structural Magnetic Resonance Imaging-Based Brain Morphology Study in Infants and Toddlers With Down Syndrome: The Effect of Comorbidities
Shiohama, T., Levman, J., Baumer, N., & Takahashi, E. (2019) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2019.03.015 · Cited by 27
Clinical trials in children with Down syndrome: Issues from a cognitive research perspective
Heller, J. H., Spiridigliozzi, G. A., Crissman, B. G., Sullivan‐Saarela, J. A., Li, J. S., & Kishnani, P. S. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30103 · Cited by 27
Automated MRI parcellation of the frontal lobe
Ranta, M. E., Chen, M., Crocetti, D., Prince, J. L., Subramaniam, K., Fischl, B. R., Kaufmann, W. E., & Mostofsky, S. H. (2013) · Human Brain Mapping · doi:10.1002/hbm.22309 · Cited by 28
Down Syndrome
Capone, G. T. (2004) · Infants & Young Children · doi:10.1097/00001163-200401000-00007 · Cited by 29
Self-citation
Lateral ventricles in fetuses with aneuploidies at 11–13 weeks' gestation
Loureiro, T., Ushakov, F. B., Maíz, N., Montenegro, N. A. M. D. M., & Nicolaides, K. H. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.11197 · Cited by 26
The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome
Li, S., Qu, Z., Haas, M., Ngo, L., Heo, Y. J., Kang, H. J., Britto, J. M., Cullen, H. D., Vanyai, H. K., Tan, S., et al. (2016) · Scientific Reports · doi:10.1038/srep29514 · Cited by 28
Functional magnetic resonance imaging of story listening in adolescents and young adults with D own syndrome: evidence for atypical neurodevelopment
Jacola, L. M., Byars, A. W., Hickey, F. J., Vannest, J. J., Holland, S. K., & Schapiro, M. B. (2013) · Journal of Intellectual Disability Research · doi:10.1111/jir.12089 · Cited by 26
Neuroimaging and Human Genetics
Winterer, G., Hariri, A. R., Goldman, D. A., & Weinberger, D. R. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67010-9 · Cited by 26
A kinematic analysis of visually-guided movement in Williams syndrome.
Hocking, D., Rinehart, N., McGinley, J., Moss, S., & Bradshaw, J. (2011) · Journal of Neurological Sciences · doi:10.1016/j.jns.2010.11.001 · Cited by 33
Down syndrome is accompanied by significantly reduced cortical grey–white matter tissue contrast
Bletsch, A., Mann, C., Andrews, D. S., Daly, E., Tan, G. M. Y., Murphy, D., & Ecker, C. (2018) · Human Brain Mapping · doi:10.1002/hbm.24230 · Cited by 25
Neuroimaging studies in the evaluation of developmental delay/mental retardation
Battaglia, A. (2002) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.10017 · Cited by 25
Comprehensive volumetric phenotyping of the neonatal brain in Down syndrome
Fukami-Gartner, A., Baburamani, A. A., Dimitrova, R., Patkee, P. A., Ojinaga-Alfageme, O., Bonthrone, A. F., Cromb, D., Uus, A. U., Counsell, S. J., Hajnal, J. V., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad171 · Cited by 24
Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome
Li, Z., Klein, J. A., Rampam, S., Kurzion, R., Campbell, N. B., Patel, Y., Haydar, T. F., & Zeldich, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.932384 · Cited by 24
Age‐Related Cortical Thickness Reduction in Non‐Demented Down's Syndrome Subjects
Romano, A., Cornia, R., Moraschi, M., Bozzao, A., Chiacchiararelli, L., Coppola, V., Iani, C., Stella, G., Albertini, G., & Pierallini, A. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12259 · Cited by 25
Parental Age Effects on Cortical Morphology in Offspring
Shaw, P., Gilliam, M., Malek, M., Rodriguez, N. L., Greenstein, D. K., CLASEN, L. S., Evans, A. C., Rapoport, J. L., & Giedd, J. N. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr194 · Cited by 26
Third Ventricle Enlargement Among Newborn Infants With Trisomy 21
Schimmel, M. S., Hammerman, C., Bromiker, R., & Berger, I. (2006) · PEDIATRICS · doi:10.1542/peds.2005-1788 · Cited by 24
Step-rate thresholds for moderate and vigorous-intensity activity in persons with Down syndrome
Agiovlasitis, S., Beets, M. W., Motl, R. W., & Fernhall, B. (2012) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2012.03.001 · Cited by 24
Analysis of Adult Cerebral Cortex and Hippocampus Transcriptomes Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of D own Syndrome
Guedj, F., Pennings, J. L. A., Wick, H. C., & Bianchi, D. W. (2014) · Brain Pathology · doi:10.1111/bpa.12151 · Cited by 23
Infantile Nystagmus and Abnormalities of Conjugate Eye Movements in Down Syndrome
Weiss, A. H., Kelly, J. P., & Phillips, J. O. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-18532 · Cited by 23
The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders
Stachowicz, K. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-019 · Cited by 23
Increased Dosage of DYRK1A and Brain Volumetric Alterations in a YAC Model of Partial Trisomy 21
Sebrié, C., Chabert, C., Ledru, A., Guedj, F., Po, C., Smith, D., Rubin, E. M., Rivals, I., Belœil, J., Gillet, B., et al. (2008) · The Anatomical Record · doi:10.1002/ar.20640 · Cited by 23
Structural Connectivity in Down Syndrome and Alzheimer’s Disease
Saini, F., Dell’Acqua, F., & Strydom, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.908413 · Cited by 22
Cornelia de Lange syndrome: Correlation of brain MRI findings with behavioral assessment
Lal, T. R., Kliewer, M. A., Lopes, T. C., Rebsamen, S. L., O’Connor, J. T., Grados, M. A., Kimball, A. S., Clemens, J. L., & Kline, A. D. (2016) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31503 · Cited by 22
Evidence for Slowing as a Function of Index of Difficulty in Young Adults With Down Syndrome
Lam, M. Y., Hodges, N. J., Virji‐Babul, N., & Latash, M. L. (2009) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-114.6.411 · Cited by 23
Therapies and rehabilitation in Down syndrome
Rondal, J.-A., & Quartino, A. R. (2007) · Wiley eBooks · Cited by 22
An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model
Mensah, A. A., Mulligan, C., Linehan, J., Ruf, S., O’Doherty, A., Grygalewicz, B., SHIPLEY, J. M., Groet, J., Tybulewicz, V. L. J., Fisher, E., et al. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-131 · Cited by 23
A small pons as a characteristic finding in Down syndrome: A quantitative MRI study
Fujii, Y., Aida, N., Niwa, T., Enokizono, M., Nozawa, K., & Inoue, T. (2016) · Brain and Development · doi:10.1016/j.braindev.2016.10.016 · Cited by 21
Gray Matter Atrophy in the Cerebellum—Evidence of Increased Vulnerability of the Crus and Vermis with Advancing Age
Yu, T., Korgaonkar, M. S., & Grieve, S. M. (2016) · The Cerebellum · doi:10.1007/s12311-016-0813-x · Cited by 20
Modeling Down syndrome in cells: From stem cells to organoids
Gough, G., O’Brien, N. L., Alić, I., Goh, P. A., Yeap, Y. J., Groet, J., Nižetić, D., & Murray, A. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.003 · Cited by 21
Autism in Genetic Intellectual Disability
Kaufmann, W. E., Capone, G. T., Clarke, M., & Budimirovic, D. B. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-489-0_4 · Cited by 20
Self-citation
Rethinking intellectual disability from neuro- to astro-pathology.
Fernández-Blanco, Á., & Dierssen, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239039 · Cited by 19
The medial temporal memory system in Down syndrome: Translating animal models of hippocampal compromise
Clark, C. A. C., Fernandez, F., Sakhon, S., Spanò, G., & Edgin, J. O. (2017) · Hippocampus · doi:10.1002/hipo.22724 · Cited by 19
Down Syndrome, Ageing and Epigenetics
Gensous, N., Franceschi, C., Salvioli, S., Garagnani, P., & Bacalini, M. G. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_7 · Cited by 19
Cerebellar mutism syndrome and its relation to cerebellar cognitive and affective function: Review of the literature
Kabataş, S., Yildiz, O., Yılmaz, C., Altınörs, N., & Ağaoğlu, B. (2010) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.61272 · Cited by 19
Effects of external and internal cues on gait function in Williams syndrome
Hocking, D. R., McGinley, J. L., Moss, S. A., Bradshaw, J. L., & Rinehart, N. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.12.026 · Cited by 19
Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome
Powell, N. M., Marc Modat, A., Cardoso, M. J., Ma, D., Holmes, H. E., Yu, Y., O’Callaghan, J. M., Cleary, J. O., Sinclair, B., Wiseman, F. K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162974 · Cited by 20
Psychopathology in Down Syndrome
Ersoy, S. A., Güler, H. A., & Çetin, F. H. (2018) · InTech eBooks · doi:10.5772/intechopen.71061 · Cited by 19
Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome
Blazek, J. D., Billingsley, C. N., Newbauer, A., & Roper, R. J. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22295 · Cited by 18
Motor development and Down syndrome
Alesi, M., & Battaglia, G. (2019) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2019.06.007 · Cited by 23

Authors: Pinter, J. D., Eliez, S., Schmitt, J. E., Capone, G. T., & Reiss, A. L.
Affiliations: University of California, San Francisco (US)
Seattle Children's Hospital (US)
ORCID: Schmitt, J. Eric
Capone, George T.
Reiss, Allan L.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2001-10-01
Volume: 158
Issue: 10
Pages: 1659-1665
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.158.10.1659
OpenAlex: W2139031198
Cited by: 452
References: 41
Citations by year: 2026: 8 · 2025: 18 · 2024: 19 · 2023: 26 · 2022: 26 · 2021: 25 · 2020: 19 · 2019: 23 · 2018: 15 · 2017: 20 · 2016: 20 · 2015: 19 · 2014: 15 · 2013: 18 · 2012: 25
FWCI: 8.18
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS01692, K12NS001692)
National Center for Research Resources (RR 000 52)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD031715, HD31715)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: Down syndrome, neuroanatomy, brain volume, cerebellar hypoplasia, subcortical gray matter, white matter, brain asymmetry, cognitive impairment, intellectual disability, fetal brain development, high-resolution MRI
MeSH terms: Adolescent, Adult, Age Factors, Brain, Cerebellum, Child, Child, Preschool, Down Syndrome, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Parietal Lobe, Temporal Lobe

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks