Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study

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Automatic Atlas-Based Volume Estimation of Human Brain Regions from MR Images

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Selective neuroanatornic abnormalities in Down's syndrome and their cognitive correlates

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down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis.

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The Cerebellar Development in Chinese Children—A Study by Voxel-Based Volume Measurement of Reconstructed 3D MRI Scan

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Cell models for Down syndrome-Alzheimer’s disease research

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4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

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Cerebellar Calcium-Binding Protein and Neurotrophin Receptor Defects in Down Syndrome and Alzheimer's Disease

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Prediction of Energy Expenditure From Wrist Accelerometry in People With and Without Down Syndrome

Agiovlasitis, S., Motl, R. W., Foley, J. T., & Fernhall, B. (2012) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.29.2.179 · Cited by 17

Energetic optimization during over-ground walking in people with and without Down syndrome

Agiovlasitis, S., Motl, R. W., Ranadive, S. M., Fahs, C. A., Yan, H., Echols, G. H., Rossow, L. M., & Fernhall, B. (2011) · Gait & Posture · doi:10.1016/j.gaitpost.2011.02.007 · Cited by 17

Timing of Muscle Response to a Sudden Leg Perturbation: Comparison between Adolescents and Adults with Down Syndrome

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Neuroanatomical alterations and synaptic plasticity impairment in the perirhinal cortex of the Ts65Dn mouse model of Down syndrome

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A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders

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Basal ganglia involvement in ARX patients: The reason for ARX patients very specific grasping?

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Effect of Transcranial Direct Current Stimulation Combined With Xbox-Kinect Game Experience on Upper Limb Movement in Down Syndrome: A Case Report

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Temporal and brain region‐specific elevations of soluble Amyloid‐β40‐42 in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease

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Parent reports of wayfinding by their children with Down syndrome

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Widespread cerebellar transcriptome changes in Ts65Dn Down syndrome mouse model after lifelong running

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Neurocognitive and psycho-emotional profile of children with disabilities

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Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down’s syndrome

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Using fMRI to Assess Brain Activity in People With Down Syndrome: A Systematic Review

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Williams Syndrome and Memory: A Neuroanatomic and Cognitive Approach

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Disrupted small-world brain network in children with Down Syndrome

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Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome

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Triple play of DYRK1A kinase in cortical progenitor cells of Trisomy 21

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A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex

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Psychosocial Risk Factors for Alzheimer’s Disease in Patients with Down Syndrome and Their Association with Brain Changes: A Narrative Review

Hamadelseed, O., Elkhidir, I., & Skutella, T. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00361-9 · Cited by 16

Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome

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Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies

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Attainment of gross motor milestones in children with Down syndrome in Kosovo - developmental perspective

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Path Learning in Individuals With Down Syndrome: The Floor Matrix Task and the Role of Individual Visuo-Spatial Measures

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Neuro-Ophthalmological Manifestations in Children with Down Syndrome: Current Perspectives

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From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

Watson, L. A., & Meharena, H. S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1198129 · Cited by 13

Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome

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Translating molecular advances in Down syndrome and Fragile X syndrome into therapies

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Monozygotic Twins With Trisomy 21 and Partial Agenesis of the Corpus Callosum

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Implicit and explicit olfactory memory in people with and without Down syndrome

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Percepção da fala em bebês no primeiro ano de vida

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Chromatic and achromatic transient VEPs in adults with Down syndrome

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Auditory Brainstem Evoked Responses in Newborns With Down Syndrome

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Down Syndrome

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Computerized physical and cognitive training improves the functional architecture of the brain in adults with Down syndrome: A network science EEG study

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Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain

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Linguistic lateralization in adolescents with Down syndrome revealed by a dichotic monitoring test

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Gait adaptation during obstacle crossing reveals impairments in the visual control of locomotion in Williams syndrome

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What can Neuropsychology Teach Us About Intellectual Disability?

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Prediction of energy expenditure during walking in adults with down syndrome

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Gait and Balance

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Physical activity, memory function, and hippocampal volume in adults with Down syndrome

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Prediction of oxygen uptake during over-ground walking in people with and without Down syndrome

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Working memory in adolescent males with Down syndrome and males with autism and intellectual disability: Implications for the classroom

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Down Syndrome

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Time-dependent diffusion MRI probes cerebellar microstructural alterations in a mouse model of Down syndrome

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Youth with Down syndrome display widespread increased functional connectivity during rest

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Magnetoencephalographic analysis of cortical activity in adults with and without Down syndrome

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Impairment of cerebello-thalamo-frontal pathway in Rab-GDI mutated patients with pure mental deficiency

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Profils mnésiques distincts chez des enfants atteints du syndrome de Down ou du syndrome de Williams

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Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model

Hawley, L. E., Stringer, M., Deal, A. J., Folz, A., Goodlett, C. R., & Roper, R. J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106359 · Cited by 10

The Association between Difficulties with Speech Fluency and Language Skills in a National Age Cohort of Children with Down Syndrome

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Binaural Masking Release in Children With Down Syndrome

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Outer Brain Oscillations in Down Syndrome

Ruiz-Mejías, M. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00017 · Cited by 10

Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms Towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome

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Down syndrome’s brain dynamics: analysis of fractality in resting state

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Single cell ATAC-seq identifies broad changes in neuronal abundance and chromatin accessibility in Down SyndromePreprint

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Purkinje cell ablation and Purkinje cell‐specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses

Nishiyama, H., Nishiyama, N., & Zemelman, B. V. (2024) · The Journal of Physiology · doi:10.1113/jp285887 · Cited by 9

Molecular cartography of the human down syndrome and trisomic mouse brain

Feng, M. Y., Cao, W., Tahmasian, N., Kukreja, B., Li, G. L., Rusu, B., Youn, J., & Kalish, B. T. (2025) · Nature Communications · doi:10.1038/s41467-025-63752-0 · Cited by 9

Assessing the Efficacy of Very Early Motor Rehabilitation in Children with Down Syndrome

Okada, S., Uejo, T., Hirano, R., Nishi, H., Matsuno, I., Muramatsu, T., Fujiwara, M., Miyake, A., Okada, Y., Fukunaga, S., et al. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.05.038 · Cited by 9

Brain activity and upper limb movement analysis in children with Down syndrome undergoing transcranial direct current stimulation combined with virtual reality training: study protocol for a randomized controlled trial

Lopes, J. B. P., Miziara, I. M., Kahani, D., Parreira, R. B., Duarte, N. D. A. C., Lazzari, R. D., Santos, L. V., Monteiro, C. B. D. M., Cardoso, D. C. D. S., Mendes, J. D. O. H., et al. (2022) · Trials · doi:10.1186/s13063-022-06014-4 · Cited by 9

Perspectives on pain in Down syndrome

Shaikh, A., Li, Y., & Lu, J. (2023) · Medicinal Research Reviews · doi:10.1002/med.21954 · Cited by 10

Neural Mechanisms Underlying Action Observation in Adults With Down Syndrome

Virji‐Babul, N., Moiseev, A., Cheung, T., Weeks, D. J., Cheyne, D. O., & Ribary, U. (2010) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7588-115.2.113 · Cited by 9

Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome

Chiotto, A. M. A., Migliorero, M., Pallavicini, G., Bianchi, F. T., Gai, M., Di Cunto, F., & Berto, G. E. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01081 · Cited by 9

Age-Group Differences in Body Mass Index, Weight, and Height in Adults With Down Syndrome and Adults With Intellectual Disability From the United States

Agiovlasitis, S., Jin, J., & Yun, J. (2021) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2020-0004 · Cited by 7

Reading as an intervention for vocabulary, short-term memory and speech development of school-aged children with down syndrome

Laws, G. (2010) · Advances in child development and behavior · doi:10.1016/b978-0-12-374748-8.00004-4 · Cited by 9

Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of down syndrome.

Aziz, N. M., Klein, J. A., Brady, M. R., Olmos-Serrano, J. L., Gallo, V., & Haydar, T. F. (2019) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-019-9294-9 · Cited by 9

Brachycephaly and frontal lobe hypoplasia in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks

Borenstein, M., Dagklis, T., Csapó, B., Sotiriadis, A., & Nicolaides, K. H. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3858 · Cited by 9

Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

Campbell, N. B., Patel, Y., Moore, T. L., Medalla, M., & Zeldich, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043477 · Cited by 8

Overlap between ophthalmology and psychiatry – A narrative review focused on congenital and inherited conditions

Kiely, C., Douglas, K. A. A., Douglas, V. P., Miller, J. B., & Lizano, P. L. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115629 · Cited by 8

Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials

Sajid, A., Chavez‐Valdez, R., Sharp, A. N., & Shah, D. K. (2025) · Pediatric Research · doi:10.1038/s41390-025-04360-y · Cited by 8

Influence of COVID-19 pandemic lockdown on a sample of Egyptian children with Down syndrome

Meguid, N. A., Nashaat, N. H., Abdallah, H. R., Hemimi, M., Elnahry, A., El-Hariri, H. M., & Elsaeid, A. (2022) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-022-00280-2 · Cited by 8

Correlating MRI‐based brain volumetry and cognitive assessment in people with Down syndrome

Hamadelseed, O., & Skutella, T. (2023) · Brain and Behavior · doi:10.1002/brb3.3186 · Cited by 8

Testing the “Boundaries” of boundary extension: Anticipatory scene representation across development and disorder

Spanò, G., Intraub, H., & Edgin, J. O. (2017) · Hippocampus · doi:10.1002/hipo.22728 · Cited by 8

Comparison of forward and backward gait in males with and without intellectual disabilities

Gimunová, M., Bozděch, M., Skotáková, A., Grün, V., & Válková, H. (2021) · Journal of Intellectual Disability Research · doi:10.1111/jir.12873 · Cited by 8

Magnetic resonance imaging biomarkers for cognitive decline in Down syndrome

DiProspero, N. D., Kim, S., & Yassa, M. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00014-1 · Cited by 11

Classic “PCH” Genes are a Rare Cause of Radiologic Pontocerebellar Hypoplasia

Zakaria, R. B. M., Malta, M., Pelletier, F., Addour-Boudrahem, N., Pinchefsky, E. F., Martin, C. S., & Srour, M. (2023) · The Cerebellum · doi:10.1007/s12311-023-01544-2 · Cited by 7

Measurement of synaptic density in Down syndrome using PET imaging: a pilot study

DiFilippo, A. H., Jonaitis, E. M., Makuch, R., Piro‐Gambetti, B., Fleming, V., Ennis, G. E., Barnhart, T. E., Engle, J. W., Bendlin, B. B., Johnson, S. C., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-54669-7 · Cited by 7

Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome

Alldred, M. J., Pidikiti, H., Ibrahim, K. W., Lee, S. H., Heguy, A., Hoffman, G. E., Roussos, P., Wısnıewskı, T., Węgiel, J., Stutzmann, G. E., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02768-0 · Cited by 8

Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

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The Relationship between Executive Function and Maladaptive Behavior in Adolescents with Down Syndrome

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Severe Brain Malformations in an Infant With Pyruvate Dehydrogenase Deficiency and Down Syndrome

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Memory and Learning in Intellectual Disabilities

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Effect of mouse Sim2 gene on the cell cycle of PC12 cells

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Whole-brain voxel-based morphometry study of children and adolescents with Down syndrome.

(2013) · Europe PMC (PubMed Central) · doi:10.11138/fneur/2013.28.1.019 · Cited by 82

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