The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Decreased Presynaptic Dopamine Function in the Left Caudate of Depressed Patients With Affective Flattening and Psychomotor Retardation
Abstract
OBJECTIVE: The study assessed striatal presynaptic dopamine function in patients with different subtypes of depression. METHOD: Magnetic resonance imaging and positron emission tomography with [(18)F]fluorodopa ([(18)F]DOPA) were used to compare six depressed patients with marked affective flattening and psychomotor retardation, six depressed patients with marked impulsivity and anxiety, and 10 healthy comparison subjects. Depressed patient groups were matched for severity of depression. RESULTS: [(18)F]DOPA uptake K(i) values in the left caudate were significantly lower in patients with psychomotor retardation than in patients with high impulsivity and in comparison subjects. CONCLUSIONS: These results suggest that left caudate dopamine function differs between depressed patients with psychomotor retardation and those with impulsivity and provide direct evidence of a link between dopamine hypofunction and psychomotor retardation in depression.
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“Moreover, depressed patients with psychomotor slowing (as assessed by a clinician) exhibit decreased cerebrospinal fluid levels of homovanillic acid, the primary metabolite of dopamine (van Praag and Korf, 1971), and decreased presynaptic dopamine function in the left caudate (Martinot et al., 2001).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Martinot et al., 2001
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A new depression scale designed to be sensitive to change
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Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
Hietala, J. A., Syvälahti, E. K. G., Vilkman, H., Vuorio, K. A., Räkköläinen, V., Bergman, J. R., Haaparanta‐Solin, M., Solin, O. H., Kuoppamäki, M., Eronen, E., et al. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00113-3 · Cited by 247
Differential Mood Changes Following Basal Ganglia vs Thalamic Lesions
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Presynaptic dopaminergic function in the striatum of schizophrenic patients
Dao-Castellana, M. H., Martinot, M. P., Hantraye, P., Attar-Levy, D., Rémy, P., Crouzel, C., Artiges, É., Féline, A., Syrota, A., & Martinot, J. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00102-8 · Cited by 160
Self-citationRetarded depression and the dopamine metabolism
van Praag, H. M., & Korf, J. (1971) · Psychopharmacology · doi:10.1007/bf00402643 · Cited by 138
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Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,334
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244
Metadata
- Authors
- Martinot, M.-L. P., Bragulat, V., Artiges, E., Dollé, F., Hinnen, F., Jouvent, R., & Martinot, J.-L.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- Venue
- American Journal of Psychiatry
- Published
- 2001-02-01
- Volume
- 158
- Issue
- 2
- Pages
- 314-316
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2104260598
- Cited by
- 194
- References
- 13
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 10
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- depression, caudate nucleus, psychomotor retardation, affective flattening, impulsivity, anxiety, striatum, depression subtypes
- MeSH terms
- Adult, Caudate Nucleus, Depressive Disorder, Dihydroxyphenylalanine, Dopamine, Female, Humans, Functional Laterality, Male, Middle Aged, Psychiatric Status Rating Scales, Radionuclide Imaging, Severity of Illness Index, Presynaptic Terminals
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