The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT
Abstract
OBJECTIVE: Reduced gamma-aminobutyric acid (GABA) concentrations have been reported in the plasma, CSF, and cortex of depressed subjects. Of interest is that ECT, one of the most effective treatments for severe refractory depression, produces considerable anticonvulsant effects that may be related to increased GABAergic transmission. The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT. METHOD: Occipital cortex GABA concentrations in eight depressed patients were measured by using proton magnetic resonance spectroscopy before and after a course of ECT. RESULTS: A significant increase in occipital cortex GABA concentrations was seen following ECT treatment of depression. CONCLUSIONS: Occipital cortex GABA concentrations increase two-fold following ECT. This suggests possible GABAergic involvement in ECT's mechanism of anticonvulsant and antidepressant actions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The hopkins verbal learning test: Development of a new memory test with six equivalent forms
Brandt, J. (1991) · Clinical Neuropsychologist · doi:10.1080/13854049108403297 · Cited by 1,317
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627
Self-citationLocalized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
Rothman, D. L., Petroff, O. A., Behar, K. L., & Mattson, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5662 · Cited by 509
Self-citationSanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 494
Self-citationStimulus Intensity, Seizure Threshold, and Seizure Duration
Sackeim, H. A., Devanand, D. P., & Prudic, J. (1991) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30271-5 · Cited by 336
Studies of dosage, seizure threshold, and seizure duration in ECT
Sackeim, H. A., Decina, P., Portnoy, S., Neeley, P., & Malitz, S. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90144-2 · Cited by 240
Sackeïm, H. A., Decina, P., Prohovnik, I., Malitz, S., & Resor, S. R. (1983) · PubMed · Cited by 211
Low brain GABA level is associated with poor seizure control
Petroff, O. A. C., Rothman, D. L., Behar, K. L., & Mattson, R. H. (1996) · Annals of Neurology · doi:10.1002/ana.410400613 · Cited by 160
Self-citationTopiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy
Petroff, O. A. C., Hyder, F., Mattson, R. H., & Rothman, D. L. (1999) · Neurology · doi:10.1212/wnl.52.3.473 · Cited by 119
Self-citationReliability and Validity of the Symptoms of Major Depressive Illness
Mazure, C. M. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800050053006 · Cited by 103
Cited by
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846
Electroconvulsive Therapy for Depression
Lisanby, S. H. (2007) · New England Journal of Medicine · doi:10.1056/nejmct075234 · Cited by 503
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329
Metadata
- Authors
- Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R. M., & Krystal, J. H.
- Venue
- American Journal of Psychiatry
- Published
- 2003-03-01
- Volume
- 160
- Issue
- 3
- Pages
- 577-579
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2167578061
- Cited by
- 513
- References
- 13
- FWCI
- 10.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT. https://app.cochat.ai/papers/10.1176/appi.ajp.160.3.577
- The paper
- Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R. M., & Krystal, J. H. (2003). Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.160.3.577
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
