GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska, Grazyna; O'Dwyer, Gillian; Teleki, Zsofia; Stockmeier, Craig A; Miguel-Hidalgo, Jose Javier

doi:10.1038/sj.npp.1301234

Cited by 430Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Open access

Rajkowska, Grazyna, O'Dwyer, Gillian, Teleki, Zsofia, Stockmeier, Craig A, Miguel-Hidalgo, Jose Javier·2007·Neuropsychopharmacology

DOI 10.1038/sj.npp.1301234PMC PMC2771699

Open this paper in CoChat — free account Open PDF

Abstract

Post-mortem morphometric studies report reductions in the average density and size of cortical neurons in the dorsolateral prefrontal cortex (dlPFC) and orbitofrontal cortex (ORB) in major depressive disorder (MDD). The contribution of specific neuronal phenotypes to this general pathology in depression is still unclear. Post-mortem sections from the dlPFC and ORB regions of 14 subjects with MDD and 11 controls were immunostained to visualize calbindin-immunoreactive (CB-IR) and parvalbumin-immunoreactive (PV-IR) presumptive GABAergic neurons. A three-dimensional cell counting probe was used to assess the cell packing density and size of CB-IR neurons in layers II+IIIa and PV-IR neurons in layers III-VI. The density of CB-IR neurons was significantly reduced by 50% in depression in the dlPFC and there was a trend toward reduction in the ORB. The size of CB-IR somata was significantly decreased (18%) in depression in the dlPFC with a trend toward reduction in the ORB. In contrast, there was no difference in the density of PV-IR neurons between the depressed and control groups in the dlPFC. The size of PV-IR neuronal soma was unchanged in depressed compared to control subjects in either dlPFC or ORB. In depression, subpopulations of GABAergic neurons may be affected differently in dlPFC and ORB. A significant reduction in the density and size of GABAergic interneurons immunoreactive for calcium binding proteins was found predominantly in the dlPFC region. These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1301234

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The density of nonpyramidal neurons was decreased in the ACC and hippocampus in BD, and in the dorsal anterolateral PFC (BA9) of MDD.
“the density of nonpyramidal neurons was decreased in the ACC and hippocampus in BD (Benes et al. 2001; Todtenkopf et al. 2005), and in the dorsal anterolateral PFC (BA9) of MDD (Rajkowska et al. 2007).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Rajkowska et al. 2007
The Area 9 results report a 50% lower density of calbindin-immunoreactive interneurons in MDD, supporting the BA9 portion of the claim. But the same results find no density difference for parvalbumin-immunoreactive neurons, so the finding does not establish a decrease in nonpyramidal neurons generally. The ACC and hippocampus findings in BD are attributed to other citations in the sentence. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The reduction in GABA in the dorsal anterolateral PFC is compatible with the report of reduced GABA-ergic neurons in this region (BA9) in MDD.
“the reduction in GABA in the dorsal anterolateral PFC is compatible with the report of reduced GABA-ergic neurons in this region (BA9) in MDD (Rajkowska et al. 2007).”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Rajkowska et al. 2007
GABA deficits may contribute to depression symptoms.
“Immunohistochemical analysis of interneurons and transcripts of interneuron-associated proteins are decreased within the PFC and anterior cingulate cortex in human MDD brain tissue and in chronically stressed rats, suggesting that deficits in GABA levels may contribute to the symptoms of depression [205][206][207][208].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [205]
Interneuron markers and interneuron-associated transcripts are decreased in the prefrontal cortex and anterior cingulate cortex in human MDD brain tissue and chronically stressed rats.
“Immunohistochemical analysis of interneurons and transcripts of interneuron-associated proteins are decreased within the PFC and anterior cingulate cortex in human MDD brain tissue and in chronically stressed rats, suggesting that deficits in GABA levels may contribute to the symptoms of depression [205][206][207][208].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [205]
GABAergic interneurons, especially the PV+ subtype, have been implicated in neuropsychiatric disease.
“GABAergic interneurons, especially the PV+ subtype, play an important role in the regulation of neuronal oscillations in the brain (24–27) and have also been implicated in neuropsychiatric disease (66; 67).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [67]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
Self-citation
GABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416 · see citing works
Calcium-binding proteins in the nervous system
Baimbridge, K. G., Celio, M. R., & ROGERS, J. H. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90081-i · Cited by 1,336 · see citing works
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240 · see citing works
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works
Salient features of synaptic organisation in the cerebral cortex1Published on the World Wide Web on 3 March 1998.1
Somogyi, P., Tamás, G., Luján, R., & Buhl, E. H. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00061-1 · Cited by 860 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
The human raphe nuclei and the serotonergic system
Hornung, J.-P. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.002 · Cited by 742 · see citing works
Molecular and Physiological Diversity of Cortical Nonpyramidal Cells
Cauli, B., Audinat, E., Lambolez, B., Angulo, M. C., Ropert, N., Tsuzuki, K., Hestrin, S., & Rossier, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03894.1997 · Cited by 738 · see citing works
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732 · see citing works
Self-citation
Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.237 · Cited by 697 · see citing works
Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors
Pazos, Á., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90326-5 · Cited by 684 · see citing works
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works
Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Grasby, P. M., & Cowen, P. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.2.174 · Cited by 642 · see citing works
Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works
Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627 · see citing works
GABAergic dysfunction in mood disorders
Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567 · see citing works
Cytoarchitectonic Definition of Prefrontal Areas in the Normal Human Cortex: II. Variability in Locations of Areas 9 and 46 and Relationship to the Talairach Coordinate System
Rajkowska, G., & Goldman, P. S. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.4.323 · Cited by 562 · see citing works
Self-citation
Correlation of physiological subgroupings of nonpyramidal cells with parvalbumin- and calbindinD28k-immunoreactive neurons in layer V of rat frontal cortex
Kawaguchi, Y., & Kubota, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.387 · Cited by 558 · see citing works
Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex
DeFelipe, J. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)10013-8 · Cited by 550 · see citing works
Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT
Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R., & Krystal, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.577 · Cited by 512 · see citing works
Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology
Condé, F., Lund, J. S., Jacobowitz, D. M., Baimbridge, K. G., & Lewis, D. A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410109 · Cited by 500 · see citing works
Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors
Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 495 · see citing works
A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
Benes, F. M., Kwok, E. W., Vincent, S. L., & Todtenkopf, M. S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00138-3 · Cited by 470 · see citing works
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
BEASLEY, C., & REYNOLDS, G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00122-3 · Cited by 426 · see citing works
A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia
Woo, T.-U. W., Whitehead, R. E., Melchitzky, D. S., & Lewis, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5341 · Cited by 410 · see citing works
Destruction and Creation of Spatial Tuning by Disinhibition: GABAABlockade of Prefrontal Cortical Neurons Engaged by Working Memory
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407 · see citing works
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAAReceptor Subunits in Frontal Cortical Brain Region
Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400 · see citing works
Cytoarchitectonic Definition of Prefrontal Areas in the Normal Human Cortex: I. Remapping of Areas 9 and 46 using Quantitative Criteria
Rajkowska, G., & Goldman, P. S. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.4.307 · Cited by 392 · see citing works
Self-citation
GABA and mood disorders: a brief review and hypothesis
Petty, F. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00025-i · Cited by 378 · see citing works
Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Beasley, C. L., Zhang, Z. J., Patten, I., & Reynolds, G. P. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01360-4 · Cited by 374 · see citing works
Anatomic and Behavioral Aspects of Frontal‐Subcortical Circuitsa
CUMMINGS, J. L. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb38127.x · Cited by 362 · see citing works
Serotonergic control of the hippocampus via local inhibitory interneurons.
Freund, T. F., Gulyás, A. I., Acsády, L., Görcs, T. J., & Tóth, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8501 · Cited by 360 · see citing works
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Pazos, A., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90327-7 · Cited by 355 · see citing works
Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.
DeFelipe, J., Hendry, S. H. C., & Jones, E. G. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.6.2093 · Cited by 338 · see citing works
Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex.
Constantinidis, C., & Goldman-Rakic, P. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00188.2002 · Cited by 337 · see citing works
Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain.
Varnäs, K., Halldin, C., & Hall, H. (2004) · Human Brain Mapping · doi:10.1002/hbm.20035 · Cited by 332 · see citing works
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
Tomita, H., Vawter, M. P., Walsh, D. M., Evans, S. J., Choudary, P. V., Li, J., Overman, K. M., Atz, M. E., Myers, R. M., Jones, E. G., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.013 · Cited by 331 · see citing works
Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303 · see citing works
Discussion
Cummings, J. L. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(98)00034-8 · Cited by 302 · see citing works
Alterations in Chandelier Neuron Axon Terminals in the Prefrontal Cortex of Schizophrenic Subjects
Pierri, J. N., Chaudry, A. S., Woo, T.-U. W., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1709 · Cited by 294 · see citing works
Changes in Extra- and Intracellular pH in the Brain during and following Ischemia in Hyperglycemic and in Moderately Hypoglycemic Rats
Smith, M., von Hanwehr, R., & Siesjö, B. K. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.104 · Cited by 286 · see citing works
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain
Burnet, P. W. J., Eastwood, S. L., Lacey, K., & Harrison, P. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00104-x · Cited by 283 · see citing works
Validity of DSM‐III‐R diagnosis by psychological autopsy: a comparison with clinician ante‐mortem diagnosis
Kelly, T. M., & Mann, J. J. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09869.x · Cited by 272 · see citing works
Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635
Bhagwagar, Z., Rabiner, E. A., Sargent, P. A., Grasby, P. M., & Cowen, P. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001401 · Cited by 255 · see citing works
Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor
Bhagwagar, Z., Wylezinska, M., Taylor, M. J., Jezzard, P., Matthews, P. M., & Cowen, P. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.368 · Cited by 227 · see citing works
Axon terminals immunolabeled for dopamine or tyrosine hydroxylase synapse on GABA‐immunoreactive dendrites in rat and monkey cortex
Sesack, S. R., Snyder, C. L., & Lewis, D. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903630208 · Cited by 226 · see citing works
Heterogeneity of chandelier neurons in monkey neocortex: Corticotropin‐releasing factor‐and parvalbumin‐immunoreactive populations
Lewis, D. A., & Lund, J. S. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930406 · Cited by 220 · see citing works
The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
Cotter, D., Landau, S., Beasley, C. L., Stevenson, R. N., Chana, G., MacMillan, L., & Everall, I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01243-4 · Cited by 211 · see citing works
Local circuit neurons of developing and mature macaque prefrontal cortex: Golgi and immunocytochemical characteristics
Lund, J. S., & Lewis, D. A. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903280209 · Cited by 208 · see citing works
Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.
Balestrino, M., & Somjen, G. G. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp016961 · Cited by 203 · see citing works
Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons
Woo, T., Miller, J. L., & Lewis, D. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1013 · Cited by 191 · see citing works
Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons
DAVISS, S. R., & Lewis, D. A. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02720-3 · Cited by 187 · see citing works
Cerebral pO2, pCO2 and pH: Changes During Convulsive Activity and their Significance for Spontaneous Arrest of Seizures
Caspers, H., & Speckmann, E. ‐. (1972) · Epilepsia · doi:10.1111/j.1528-1157.1972.tb04403.x · Cited by 182 · see citing works
The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain
Aznar, S., Qian, Z.-X., Shah, R., Kornum, B. R., & Knudsen, G. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03727-7 · Cited by 181 · see citing works
Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex
Jakab, R. L., & Goldman, P. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000214)417:3 · Cited by 180 · see citing works
Localization of Calcium-binding Proteins in Physiologically and Morphologically Characterized Interneurons of Monkey Dorsolateral Prefrontal Cortex
Zaitsev, A. V., González‐Burgos, G., Povysheva, N. V., Kröner, S., Lewis, D. A., & Krimer, L. S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh218 · Cited by 180 · see citing works
Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses
Takahashi, M., Kovalchuk, Y., & Attwell, D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05693.1995 · Cited by 169 · see citing works
Stress-induced activation of nitric oxide-producing neurons in the rat brain
Krukoff, T. L., & Khalili, P. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 167 · see citing works
Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders
Sanacora, G., Rothman, D. L., Mason, G. F., & Krystal, J. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.018 · Cited by 157 · see citing works
The Effects of Extracellular Acidosis on Neurons and Glia in vitro
Goldman, S. A., Pulsinelli, W. A., Clarke, W. Y., Kraig, R. P., & Plum, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.70 · Cited by 155 · see citing works
Preliminary Evidence of Low Cortical GABA Levels in Localized1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients
Behar, K. L., Rothman, D. L., Petersen, K. F., Hooten, M. W., Delaney, R. C., Petroff, O. A. C., Shulman, G. I., Navarro, V., Petrakis, I. L., Charney, D. S., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.952 · Cited by 147 · see citing works
Prominent Reduction in Pyramidal Neurons Density in the Orbitofrontal Cortex of Elderly Depressed Patients
Rajkowska, G., Miguel-Hidalgo, J. J., Dubey, P., Stockmeier, C. A., & Krishnan, K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.013 · Cited by 146 · see citing works
Self-citation
Modulation of non-vesicular glutamate release by pH
Billups, B., & Attwell, D. (1996) · Nature · doi:10.1038/379171a0 · Cited by 145 · see citing works
Reduced levels of GABA-benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy
Lingford-Hughes, A. R., Acton, P. D., Gacinovic, S., et al. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.173.2.116 · Cited by 141 · see citing works
GABAergic neuronal subtypes in the human frontal cortex — development and deficits in schizophrenia
Reynolds, G. P., & Beasley, C. L. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00113-2 · Cited by 138 · see citing works
Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies
Sanacora, G., Mason, G. F., & Krystal, J. H. (2000) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v14.i1.20 · Cited by 133 · see citing works
Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophrenia
Cotter, D., Hudson, L., & Landau, S. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00230.x · Cited by 133 · see citing works
Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism
Sen, S., Villafuerte, S. M., Nesse, R. M., Stoltenberg, S. F., Hopcian, J. T., Gleiberman, L., Weder, A. B., & Burmeister, M. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.006 · Cited by 125 · see citing works
Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex
Cruz, D. A., Eggan, S. M., & Lewis, D. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10833 · Cited by 118 · see citing works
Depression: What We can Learn from Postmortem Studies
Rajkowska, G. (2003) · The Neuroscientist · doi:10.1177/1073858403252773 · Cited by 114 · see citing works
Self-citation
Delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in Japanese macaque monkeys
Sawaguchi, T., Matsumura, M., & Kubota, K. (1989) · Experimental Brain Research · doi:10.1007/bf00249897 · Cited by 109 · see citing works
Glutamate decarboxylase65-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain
Benes, F. M., Todtenkopf, M. S., Logiotatos, P., & Williams, M. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00105-8 · Cited by 109 · see citing works
Hydrogen ions have multiple effects on the excitability of cultured mammalian neurons
Gruol, D. L., Barker, J. L., Huang, L.-Y. M., et al. (1980) · Brain Research · doi:10.1016/0006-8993(80)90138-9 · Cited by 101 · see citing works
The Selective innervation by serotoninergic axons of calbindin‐containing interneurons in the neocortex and hippocampus of the marmoset
Hornung, J., & Celio, M. R. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903200404 · Cited by 94 · see citing works
Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi
Pappas, C. A., Ullrich, N. J., & Sontheimer, H. W. (1994) · Neuroreport · doi:10.1097/00001756-199412300-00049 · Cited by 88 · see citing works
Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study
Ke, Y., Streeter, C. C., Nassar, L. E., Sarid‐Segal, O., Hennen, J. A., Yurgelun-Todd, D. A., Awad, L. A., Rendall, M. J., Gruber, S. A., Nason, A., et al. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2003.12.001 · Cited by 85 · see citing works
Low nNOS protein in the locus coeruleus in major depression
Karolewicz, B., Szebeni, K., Stockmeier, C. A., Konick, L. C., Overholser, J. C., Jurjus, G., Roth, B. L., & Ordway, G. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02792.x · Cited by 84 · see citing works
Self-citation
The serotonergic innervation of the cerebral cortex in man and its changes in focal cortical dysplasia
Trottier, S., Evrard, B., Vignal, J., Scarabin, J., & Chauvel, P. (1996) · Epilepsy Research · doi:10.1016/0920-1211(96)00033-2 · Cited by 78 · see citing works
L-Glutamate Decarboxylase
Sze, P. Y. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-5199-1_4 · Cited by 77 · see citing works
The effect of pH on Ca2+ extrusion mechanisms in dialyzed squid axons
DiPolo, R., & Beaugé, L. (1982) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(82)90599-5 · Cited by 72 · see citing works
3-D Cytoarchitectonic parcellation of human orbitofrontal cortex
Uylings, H. B. M., Sanz‐Arigita, E., de Vos, K., Pool, C. W., Evers, P., & Rajkowska, G. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.04.012 · Cited by 67 · see citing works
Self-citation
Altered distribution of parvalbumin-immunoreactive local circuit neurons in the anterior cingulate cortex of schizophrenic patients
Kalus, P., Senitz, D., & Beckmann, H. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00020-6 · Cited by 67 · see citing works
Regional distribution of neurotrophin receptors in the developing auditory brainstem
Hafidi, A., Moore, T., & Sanes, D. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960408)367:3 · Cited by 51 · see citing works
Modulation by extracellular pH of the activity of GABAA receptors on rat cerebellum granule cells
Robello, M., Baldelli, P., & Cupello, A. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90406-5 · Cited by 42 · see citing works
Calbindin immunoreactivity in the hippocampal formation and neocortex of schizophrenics
Iritani, S., Kuroki, N., Keda, K., & Kazamatsuri, H. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00005-6 · Cited by 34 · see citing works
BDNF Val66Met Polymorphism and GAD67 mRNA Expression in the Prefrontal Cortex of Subjects With Schizophrenia
Hashimoto, T., & Lewis, D. A. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.534 · Cited by 33 · see citing works
Persistent metabolic sequelae of severe head injury in humansin vivo
Cadoux-Hudson, T. A. D., Wade, D. T., Taylor, D. J. F., et al. (1990) · Acta Neurochirurgica · doi:10.1007/bf01842884 · Cited by 24 · see citing works
Immunohistochemistry of neural markers for the study of the laminar architecture in celloidin sections from the human cerebral cortex
Miguel-Hidalgo, J. J., & Rajkowska, G. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00114-4 · Cited by 23 · see citing works
Self-citation
The gamma amino butyric acid (GABA) receptor alpha‐3 subunit gene polymorphism in unipolar depressive disorder: A genetic association study
Henkel, V., Baghai, T. C., Eser, D., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20137 · Cited by 23 · see citing works
Unchanged packing density but altered size of neurofilament immunoreactive neurons in the prefrontal cortex in schizophrenia and major depression
Miguel-Hidalgo, J. J., Dubey, P., Shao, Q., Stockmeier, C. A., & Rajkowska, G. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.02.015 · Cited by 23 · see citing works
Self-citation
Structural and Immunocytochemical Differentiation of Neurons in Prenatal and Postnatal Human Prefrontal Cortex
Uylings, H. B. M., Delalle, I., Petanjek, Z., & Koenderink, M. J. T. (2002) · Neuroembryology and Aging · doi:10.1159/000066268 · Cited by 17 · see citing works

Flagged first, then by citations

Sorted by citations

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · see citing works
“For example, the common ‘‘short’’ allele of the functional 5-HTT LPR polymorphism increases the vulnerability for developing MDD within the context of stressful life events (Caspi et al. 2003).”
BackgroundResultInfluential
Major depressive disorder
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Synaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · see citing works
Neurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026 · see citing works
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works
Major depressive disorder: new clinical, neurobiological, and treatment perspectives
Kupfer, D. J., Frank, E., & Phillips, M. L. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60602-8 · Cited by 894 · see citing works
Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714 · see citing works
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603 · see citing works
Self-citation
Pathophysiology of depression: do we have any solid evidence of interest to clinicians?
HASLER, G. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00298.x · Cited by 604 · see citing works
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458 · see citing works
Orbitofrontal cortex function and structure in depression
DREVETS, W. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.029 · Cited by 417 · see citing works
Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression
Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421 · see citing works
Self-citation
Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions
Fogaça, M. V., & Duman, R. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00087 · Cited by 396 · see citing works
Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-Are we there yet?
Jesulola, E., Micalos, P., & Baguley, I. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.025 · Cited by 379 · see citing works
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Hare, B. D., & Duman, R. S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0685-9 · Cited by 366 · see citing works
Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329 · see citing works
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression
Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00199 · Cited by 321 · see citing works
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
Browne, C. A., & Lucki, I. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00161 · Cited by 285 · see citing works
Discovering imaging endophenotypes for major depression
Hasler, G., & Northoff, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.23 · Cited by 274 · see citing works
Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder
Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261 · see citing works
Trial of SAGE-217 in Patients with Major Depressive Disorder
Gunduz-Bruce, H., Silber, C., Kaul, I., Rothschild, A. J., Riesenberg, R., Sankoh, A. J., Li, H., Lasser, R., Zorumski, C. F., Rubinow, D. R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1815981 · Cited by 232 · see citing works
Striatum-Based Circuitry of Adolescent Depression and Anhedonia
Gabbay, V., Ely, B. A., Li, Q., Bangaru, S. D., Panzer, A. M., Alonso, C. M., Castellanos, F. X., & Milham, M. P. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.04.003 · Cited by 222 · see citing works
Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition
Page, C. E., & Coutellier, L. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.024 · Cited by 213 · see citing works
The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorder
Northoff, G., Wiebking, C., Feinberg, T., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.007 · Cited by 222 · see citing works
GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001616 · Cited by 217 · see citing works
Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression
Karolewicz, B., Maciag, D., O'Dwyer, G., Stockmeier, C. A., Feyissa, A. M., & Rajkowska, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990587 · Cited by 203 · see citing works
Self-citation
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
Fuchs, T., Jefferson, S. J., Hooper, A., Yee, P.-H., Maguire, J., & Luscher, B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.188 · Cited by 204 · see citing works
Cell atrophy and loss in depression: reversal by antidepressant treatment
Banasr, M., Dwyer, J. M., & Duman, R. S. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.09.002 · Cited by 201 · see citing works
Anterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia
Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201 · see citing works
Reduced somatostatin in subgenual anterior cingulate cortex in major depression
Tripp, A., Kota, R. S., Lewis, D. A., & Sibille, E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.014 · Cited by 190 · see citing works
Fast-acting antidepressant activity of ketamine: Highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186 · see citing works
Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress
Ma, K., Xu, A., Cui, S., Sun, M.-R., Xue, Y.-C., & Wang, J.-H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.181 · Cited by 168 · see citing works
Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression
Elsayed, M., Banasr, M., Duric, V., Fournier, N. M., Licznerski, P., & Duman, R. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.003 · Cited by 169 · see citing works
Neuropathology of mood disorders: Do we see the stigmata of inflammation?
Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165 · see citing works
Neuropathology of suicide: Recent findings and future directions
Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works
Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice
Soumier, A., & Sibille, E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.76 · Cited by 136 · see citing works
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski, P., & Duman, R. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.057 · Cited by 157 · see citing works
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149 · see citing works
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149 · see citing works
Characterization of GABAergic Marker Expression in the Chronic Unpredictable Stress Model of Depression
Banasr, M., Lepack, A., Fee, C., Duric, V., Maldonado-Aviles, J., DiLeone, R., Sibille, E., Duman, R. S., & Sanacora, G. (2017) · Chronic Stress · doi:10.1177/2470547017720459 · Cited by 135 · see citing works
A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137 · see citing works
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses
Fogaça, M. V., Wu, M., Li, C., Li, X.-Y., Picciotto, M. R., & Duman, R. S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00916-y · Cited by 129 · see citing works
Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice
Gilabert-Juan, J., Castillo-Gomez, E., Guirado, R., Moltó, M. D., & Nacher, J. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0479-1 · Cited by 125 · see citing works
Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations
Hu, Y.-T., Tan, Z.-L., Hirjak, D., & Northoff, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02193-x · Cited by 127 · see citing works
Principles of inflammasome priming and inhibition: implications for psychiatric disorders
Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115 · see citing works
Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience
Lüscher, B., & Möhler, H. (2019) · F1000Research · doi:10.12688/f1000research.18758.1 · Cited by 105 · see citing works
Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity
Murthy, S., Kane, G. A., Katchur, N. J., Lara Mejia, P. S., Obiofuma, G., Buschman, T. J., McEwen, B. S., & Gould, E. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.021 · Cited by 118 · see citing works
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment
Ren, Z., Pribiag, H., Jefferson, S. J., Shorey, M., Fuchs, T., Stellwagen, D., & Luscher, B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.02.009 · Cited by 114 · see citing works
The molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works
Alleviation of depression by glucagon-like peptide 1 through the regulation of Neuroinflammation, neurotransmitters, neurogenesis, and synaptic function
Kim, Y.-K., Kim, O. Y., & Song, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01270 · Cited by 109 · see citing works
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works
Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder
Kantrowitz, J. T., Dong, Z., Milak, M. S., Rashid, R., Kegeles, L. S., Javitt, D. C., Lieberman, J. A., & John Mann, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01541-1 · Cited by 100 · see citing works
Neuropathological abnormalities of astrocytes, GABAergic neurons, and pyramidal neurons in the dorsolateral prefrontal cortices of patients with major depressive disorder
Oh, D. H., Son, H., Hwang, S., & Kim, S. H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.09.001 · Cited by 103 · see citing works
Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide
Zhao, J., Verwer, R. W. H., Gao, S.-F., Qi, X.-R., Lucassen, P. J., Kessels, H. W., & Swaab, D. F. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.04.020 · Cited by 102 · see citing works
Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
Goeldner, C., Ballard, T. M., Knoflach, F., Wichmann, J., Gatti, S., & Umbricht, D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.001 · Cited by 96 · see citing works
Mice lacking NMDA receptors in parvalbumin neurons display normal depression-related behavior and response to antidepressant action of NMDAR antagonists
Pozzi, L., Dorocic, I. P., Wang, X., Carlén, M., & Meletis, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083879 · Cited by 74 · see citing works
Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients
Zhao, J., Bao, A.-M., Qi, X.-R., Kamphuis, W., Luchetti, S., Lou, J.-S., & Swaab, D. F. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.013 · Cited by 70 · see citing works
Rapid Acting Antidepressants in Chronic Stress Models: Molecular and Cellular Mechanisms
Hare, B. D., Ghosal, S., & Duman, R. S. (2017) · Chronic Stress · doi:10.1177/2470547017697317 · Cited by 67 · see citing works
Sex-dependent anti-stress effect of an α5 subunit containing GABAA receptor positive allosteric modulator
Piantadosi, S. C., French, B. J., Poe, M. M., Timić, T., Marković, B. D., Pabba, M., Seney, M. L., Oh, H., Orser, B. A., Savić, M. M., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00446 · Cited by 67 · see citing works
Direct Alteration of a Specific Inhibitory Circuit of the Hippocampus by Antidepressants
Méndez, P., Pazienti, A., Szabó, G., & Bacci, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1720-12.2012 · Cited by 53 · see citing works
Coping with Stress During Aging: The Importance of a Resilient Brain
Sampedro-Piquero, P., Alvarez-Suarez, P., & Begega, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141610 · Cited by 41 · see citing works
Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
Eriksson, T. M., Alvarsson, A., Stan, T. L., Zhang, X., Hascup, K. N., Hascup, E. R., Kehr, J., Gerhardt, G. A., Warner-Schmidt, J., Arango-Lievano, M., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.130 · Cited by 45 · see citing works
Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of the rate‐limiting enzyme of cholesterol synthesis in a chronic mouse model of depression
Wang, J., Qiao, J., Zhang, Y., Wang, H., Zhu, S., Zhang, H., Hartle, K., Guo, H., Guo, W., He, J., et al. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12792 · Cited by 43 · see citing works
Exercise promotes neuroplasticity in both healthy and depressed brains: An fMRI pilot study
Gourgouvelis, J., Yielder, P., & Murphy, B. (2017) · Neural Plasticity · doi:10.1155/2017/8305287 · Cited by 42 · see citing works
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works
Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants
Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B. (2021) · Advances in Neurobiology · doi:10.1007/978-3-030-77375-5_13 · Cited by 19 · see citing works
Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety- and depression-like behaviors in mice
Yang, X.-Y., Ma, Z.-L., Storm, D. R., Cao, H., & Zhang, Y.-Q. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i2.35 · Cited by 12 · see citing works

Abnormal Neuronal Expression of the Calcium-binding Proteins, Parvalbumin and Calbindin D-28k, in Aged Dogs
Sisó, S., Tort, S., Aparici, C. M., et al. (2003) · Journal of Comparative Pathology · doi:10.1053/jcpa.2002.0597 · Cited by 15 · see citing works
An immunohistochemical study of astrocytes in the entorhinal cortex in schizophrenia: Absence of significant gliosis
Damadzic, R., Goldenson, D. A., Saunders, R. C., et al. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)82104-4 · Cited by 2 · see citing works
Postnatal development of parvalbumin and calbindin D-28k immunoreactivities in the canine hippocampus
Yoon, S. P., Chung, Y. Y., Chang, I. Y., Kim, J. J., Moon, J. S., & Kim, H. S. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00059-4 · Cited by 19 · see citing works
Glutamate, GABA, calbindin-D28k and parvalbumin immunoreactivity in the pulvinar-lateralis posterior complex of the cat: relation to the projection to the Clare-Bishop area
Palestini, M., Guégan, M., Saavedra, H., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90920-g · Cited by 28 · see citing works
Calcium binding proteins and neuropeptides as molecular markers of GABAergic interneurons in the cat visual cortex
Demeulemeester, H. G., Arckens, L., Vandesande, F., Orban, G. A., Heizmann, C. W., & Pochet, R. (1991) · Experimental Brain Research · doi:10.1007/bf00230966 · Cited by 144 · see citing works

Authors: Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J.
Affiliations: University of Mississippi Medical Center (US)
ORCID: Stockmeier, Craig A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-10-25
Volume: 32
Issue: 2
Pages: 471-482
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1301234
PMC: PMC2771699
OpenAlex: W2026826561
Cited by: 430
References: 97
Citations by year: 2026: 9 · 2025: 16 · 2024: 22 · 2023: 26 · 2022: 17 · 2021: 36 · 2020: 24 · 2019: 41 · 2018: 19 · 2017: 33 · 2016: 32 · 2015: 19 · 2014: 25 · 2013: 13 · 2012: 27
FWCI: 6.90
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p20rr017701-10)
National Institute of Mental Health (R01MH067996, MH67996, MH 61578, MH60451, MH63187, R01MH063187, R01MH061578, P50MH060451)
National Center for Research Resources (P20-RR-017701, RR 17701)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: major depressive disorder, GABAergic interneurons, dorsolateral prefrontal cortex, orbitofrontal cortex, neuronal density, neuronal soma size, calcium-binding proteins
MeSH terms: Adult, Aged, Calcium-Binding Proteins, Cell Count, Depressive Disorder, Major, Major Depressive Disorder, Female, gamma-Aminobutyric Acid, Humans, Immunohistochemistry, Interneurons, Male, Middle Aged, Parvalbumins, Biomarkers, Down-Regulation, Prefrontal Cortex, Cell Size, Calbindins, S100 Calcium Binding Protein G

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks