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Placental Passage of Antidepressant Medications
Abstract
OBJECTIVE: This study determined the placental transfer of antidepressants and their metabolites. METHOD: A total of 38 pregnant women taking citalopram, fluoxetine, paroxetine, or sertraline participated. Maternal and umbilical cord blood samples were obtained to determine antidepressant and metabolite concentrations. RESULTS: Antidepressant and metabolite concentrations were detectable in 86.8% of umbilical cord samples. The mean ratios of umbilical cord to maternal serum concentrations ranged from 0.29 to 0.89. The lowest ratios were for sertraline and paroxetine; the highest were for citalopram and fluoxetine. Maternal doses of sertraline and fluoxetine correlated with umbilical cord concentrations of these medications. CONCLUSIONS: Umbilical cord concentrations of antidepressants and their metabolites were almost invariably lower than corresponding maternal concentrations. Maternal doses predicted umbilical concentrations of fluoxetine and sertraline. Mean umbilical cord to maternal serum ratios were significantly lower for sertraline than fluoxetine, suggesting that sertraline may produce less fetal medication exposure than fluoxetine near delivery.
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Citations
Cited by
Gender differences in depression and response to psychotropic medication
Gorman, J. M. (2006) · Gender Medicine · doi:10.1016/s1550-8579(06)80199-3 · Cited by 195
Lattimore, K. A., Donn, S. M., Kaciroti, N., Kemper, A. R., Neal, C. R., & Vazquez, D. M. (2005) · Journal of Perinatology · doi:10.1038/sj.jp.7211352 · Cited by 189
Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay
Harrington, R. A., Lee, L.-C., Crum, R. M., Zimmerman, A. W., & Hertz-Picciotto, I. (2014) · Pediatrics · doi:10.1542/peds.2013-3406 · Cited by 174
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167
Gao, S.-Y., Wu, Q.-J., Sun, C., Zhang, T.-N., Shen, Z.-Q., Liu, C.-X., Gong, T.-T., Xu, X., Ji, C., Huang, D.-H., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1193-5 · Cited by 152
Metadata
- Authors
- Hendrick, V., Stowe, Z. N., Altshuler, L. L., Hwang, S., Lee, E., & Haynes, D.
- Venue
- American Journal of Psychiatry
- Published
- 2003-05-01
- Volume
- 160
- Issue
- 5
- Pages
- 993-996
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2101143167
- Cited by
- 380
- References
- 0
- FWCI
- 16.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hendrick, V., Stowe, Z. N., Altshuler, L. L., Hwang, S., Lee, E., & Haynes, D. (2003). Placental Passage of Antidepressant Medications. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.160.5.993
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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