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Cited by 522

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Review of the Validity and Significance of Cannabis Withdrawal Syndrome

Budney, Alan J., Hughes, John R., Moore, Brent A., Vandrey, Ryan·2004·American Journal of Psychiatry

Abstract

The authors review the literature examining the validity and significance of cannabis withdrawal syndrome. Findings from animal laboratory research are briefly reviewed, and human laboratory and clinical studies are surveyed in more detail. Converging evidence from basic laboratory and clinical studies indicates that a withdrawal syndrome reliably follows discontinuation of chronic heavy use of cannabis or tetrahydrocannabinol. Common symptoms are primarily emotional and behavioral, although appetite change, weight loss, and physical discomfort are also frequently reported. The onset and time course of these symptoms appear similar to those of other substance withdrawal syndromes. The magnitude and severity of these symptoms appear substantial, and these findings suggest that the syndrome has clinical importance. Diagnostic criteria for cannabis withdrawal syndrome are proposed.

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Registry

Crossref · 10.1176/appi.ajp.161.11.1967

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Metadata

Authors
Budney, A. J., Hughes, J. R., Moore, B. A., & Vandrey, R.
Venue
American Journal of Psychiatry
Published
2004-11-01
Volume
161
Issue
11
Pages
1967-1977
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2139228555
Cited by
522
References
44
FWCI
9.97
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Review of the Validity and Significance of Cannabis Withdrawal Syndrome. https://app.cochat.ai/papers/10.1176/appi.ajp.161.11.1967
The paper
Budney, A. J., Hughes, J. R., Moore, B. A., & Vandrey, R. (2004). Review of the Validity and Significance of Cannabis Withdrawal Syndrome. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.161.11.1967

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.