The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Abnormalities of Thalamic Volume and Shape in Schizophrenia
Abstract
OBJECTIVE: Postmortem and neuroimaging studies of schizophrenia have reported deficits in the volume of the thalamus and its component nuclei. However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia. METHOD: T(1)-weighted magnetic resonance scans were collected in 52 schizophrenia and 65 comparison subjects matched for age, gender, race, and parental socioeconomic status. High-dimensional (large-deformation) brain mapping was used to assess thalamic morphology. RESULTS: Significant differences in thalamic volume, deformities of thalamic shape at the anterior and posterior extremes of the structure, and a significant exaggeration of thalamic asymmetry (i.e., left smaller than right) were found in the schizophrenia subjects. After covarying for total cerebral volume, the difference in thalamic volume became insignificant. When information about thalamic shape was combined with previously collected information about hippocampal shape, the discrimination between schizophrenia patients and comparison subjects was improved. CONCLUSIONS: Thalamic volume was smaller than normal in schizophrenia patients, but only proportionate to reductions in reduced total cerebral volume. The presence of changes in thalamic shape and asymmetry suggest greater pathologic involvement of individual nuclei at its anterior and posterior extremes of the thalamic complex.
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Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Ponto, L. L., Watkins, G. L., & Hichwa, R. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9985 · Cited by 625
Diverse thalamic projections to the prefrontal cortex in the rhesus monkey
Barbas, H., Henion, T. H. H., & Dermon, C. R. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130106 · Cited by 292
Cited by
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Arbabshirani, M. R., Plis, S., Sui, J., & Calhoun, V. D. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.079 · Cited by 912
Machine Learning Approaches for Clinical Psychology and Psychiatry
Dwyer, D. B., Falkai, P., & Koutsouleris, N. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045037 · Cited by 966
Abnormal asymmetries in subcortical brain volume in schizophrenia
COCORO, Okada, N., Fukunaga, M., Yamashita, F., Koshiyama, D., Yamamori, H., Ohi, K., Yasuda, Y., Fujimoto, M., Watanabe, Y., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.209 · Cited by 369
Self-citationSchizophrenia: a tale of two critical periods for prefrontal cortical development
Selemon, L. D., & Zecevic, N. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.115 · Cited by 336
Self-citationFrancks, C., Maegawa, S., Laurén, J., Abrahams, B. S., Velayos-Baeza, A., Medland, S. E., Colella, S., Groszer, M., McAuley, E. Z., Caffrey, T. M., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002053 · Cited by 356
Metadata
- Authors
- Csernansky, J. G., Schindler, M. K., Splinter, N. R., Wang, L., Gado, M., Selemon, L. D., Rastogi-Cruz, D., Posener, J. A., Thompson, P. A., & Miller, M. I.
- Venue
- American Journal of Psychiatry
- Published
- 2004-05-01
- Volume
- 161
- Issue
- 5
- Pages
- 896-902
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2113532276
- Cited by
- 166
- References
- 2
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Csernansky, J. G., Schindler, M. K., Splinter, N. R., Wang, L., Gado, M., Selemon, L. D., Rastogi-Cruz, D., Posener, J. A., Thompson, P. A., & Miller, M. I. (2004). Abnormalities of Thalamic Volume and Shape in Schizophrenia. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.161.5.896
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