Diverse thalamic projections to the prefrontal cortex in the rhesus monkey
Abstract
We studied the sources of thalamic projections to prefrontal areas of nine rhesus monkeys with the aid of retrograde tracers (horseradish peroxidase or fluorescent dyes). Our goal was to determine the proportion of labeled neurons contributing to this projection system by the mediodorsal (MD) nucleus compared to those distributed in other thalamic nuclei, and to investigate the relationship of thalamic projections to specific architectonic areas of the prefrontal cortex. We selected areas for study within both the basoventral (areas 11, 12, and ventral 46) and the mediodorsal (areas 32, 14, 46, and 8) prefrontal sectors. This choice was based on our previous studies, which indicate differences in cortical projections to these two distinct architectonic sectors (Barbas, '88; Barbas and Pandya, '89). In addition, for each sector we included areas with different architectonic profiles, which is also relevant to the connectional patterns of the prefrontal cortices. The results showed that MD included a clear majority (over 80%) of all thalamic neurons directed to some prefrontal cortices (areas 11, 46, and 8); it contributed just over half to some others (areas 12 and 32), and less than a third to area 14. Clusters of neurons directed to basoventral and mediodorsal prefrontal areas were largely segregated within MD: the former were found ventrally, the latter dorsally. However, the most striking findings establish a relationship between thalamic origin and laminar definition of t…
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In this view, anterior midcingulate cortex delivers exteroceptive and internal sensory information to direct attention and motor responses.
“In this view, aMCC delivers sources of exteroceptive sensory information (from thalamic projections; Barbas et al. 1991) and internal sensory information (from the insula; Mesulam & Mufson 1982) to direct attention and motor responses (via projections to lateral PFC and the supplementary motor area; e.g., Barbas & Pandya”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Barbas et al. 1991
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- Authors
- Barbas, H., Henion, T. H. H., & Dermon, C. R.
- Affiliations
- Boston University (US)
- Corresponding author
- Barbas, H.
- ORCID
- Barbas, H.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 313
- Issue
- 1
- Pages
- 65-94
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2068623304
- Cited by
- 292
- References
- 1
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 13 · 2022: 6 · 2021: 12 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 14 · 2013: 8 · 2012: 12
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS24760)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- thalamocortical connections, prefrontal cortex, mediodorsal nucleus, medial pulvinar, rhesus monkeys, corticothalamic projections
- MeSH terms
- Animals, Cerebral Cortex, Fluorescent Dyes, Frontal Lobe, Horseradish Peroxidase, Limbic System, Macaca mulatta, Neural Pathways, Thalamic Nuclei, Thalamus
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