The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Decreased Conflict- and Error-Related Activity in the Anterior Cingulate Cortex in Subjects With Schizophrenia
Abstract
OBJECTIVE: People with schizophrenia have exhibited reduced functional activity in the anterior cingulate cortex during the performance of many types of cognitive tasks and during the commission of errors. According to conflict theory, the anterior cingulate cortex is involved in the monitoring of response conflict, acting as a signal for a need for greater cognitive control. This study examined whether impaired conflict monitoring in people with schizophrenia could underlie reduced anterior cingulate activity during both correct task performance and error-related activity. METHOD: Functional activity in the anterior cingulate of 13 schizophrenia patients and 13 healthy comparison subjects was investigated by using event-related fMRI and a Stroop task that allowed simultaneous examination of activity during both conflict (incongruent trials) and error (commission of error trials). RESULTS: In the presence of comparable reaction time measures for conflict as well as comparable error rates, the schizophrenia subjects showed both decreased conflict- and error-related activity in the same region of the anterior cingulate cortex. Moreover, those with schizophrenia did not exhibit significant post-conflict or post-error behavioral adjustments. CONCLUSIONS: Concurrently reduced conflict- and error-related activity in the anterior cingulate cortex along with reduced trial-to-trial adjustments in performance has not previously been reported in schizophrenia. The current results suggest that impaired conflict monitoring by the anterior cingulate cortex might play an important role in contributing to cognitive control deficits in patients with schizophrenia.
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“schizophrenia and post-traumatic stress disorder are both characterized by prefrontal dysfunction during tasks that require sustained attention [4,5].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [4]
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Metadata
- Authors
- Kerns, J. G., Cohen, J. D., MacDonald, A. W., Johnson, M. K., Stenger, V. A., Aizenstein, H., & Carter, C. S.
- Affiliations
- University of California, Davis (US)
- University of Minnesota (US)
- Venue
- American Journal of Psychiatry
- Published
- 2005-10-01
- Volume
- 162
- Issue
- 10
- Pages
- 1833-1839
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2112138490
- Cited by
- 336
- References
- 34
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 19 · 2020: 7 · 2019: 28 · 2018: 18 · 2017: 12 · 2016: 16 · 2015: 15 · 2014: 17 · 2013: 25 · 2012: 21
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 059883, R01MH059883, K02MH064190, K02 MH64190)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, anterior cingulate cortex, conflict monitoring, cognitive control deficits, Stroop task, response conflict, event-related fMRI
- MeSH terms
- Adult, Cognition Disorders, Conflict, Psychological, Evoked Potentials, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology
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