The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Double-Blind, Placebo-Controlled Study of Dialectical Behavior Therapy Plus Olanzapine for Borderline Personality Disorder
Abstract
OBJECTIVE: The aim of this study was to determine the efficacy and safety of dialectical behavior therapy plus olanzapine compared with dialectical behavior therapy plus placebo in patients with borderline personality disorder. METHOD: Sixty patients with borderline personality disorder were included in a 12-week, double-blind, placebo-controlled study. All patients received dialectical behavior therapy and were randomly assigned to receive either olanzapine or placebo following a 1-month baseline period. RESULTS: Seventy percent of the patients completed the 4-month trial. Combined treatment showed an overall improvement in most symptoms studied in both groups. Olanzapine was associated with a statistically significant improvement over placebo in depression, anxiety, and impulsivity/aggressive behavior. The mean dose of olanzapine was 8.83 mg/day. CONCLUSIONS: A combined psychotherapeutic plus pharmacological approach appears to lower dropout rates and constitutes an effective treatment for borderline personality disorder.
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“the pharmacotherapy review (Stoffers 2010) included three trials testing psychotherapy plus drug against psychotherapy plus placebo (Simpson 2004;Soler 2005;Linehan 2008).”
From Psychological therapies for people with borderline personality disorder. (2012) · cites this paper as Soler 2005
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Oldham, J. M. (2005) · Focus · doi:10.1176/foc.3.3.396 · Cited by 429
Dialectical behavior therapy: Current status, recent developments, and future directions
Robins, C. J., & Chapman, A. L. (2004) · Journal of Personality Disorders · doi:10.1521/pedi.18.1.73.32771 · Cited by 275
Olanzapine Treatment of Female Borderline Personality Disorder Patients
Zanarini, M. C., & Frankenburg, F. R. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n1103 · Cited by 251
Olanzapine Versus Placebo in the Treatment of Borderline Personality Disorder
Bogenschutz, M. P., & Nurnberg, H. G. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0118 · Cited by 168
Research works printed but not linked: 1
- Barrachina J, Soler J, Campins MJ, Tejero A, Pascual JC, Alvarez E, Zanarini MC, Perez Sola V: Validation of a Spanish version of the Diagnostic Interview for Borderlines—Revised (DIB-R). Actas Esp Psiquiatr 2004; 32:293–298
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Items 201–224 of 224
Herpertz, S. C. (2011) · Springer eBooks · doi:10.1007/978-3-642-19844-1_85
(2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615372997.as04
(2015) · Elsevier eBooks · doi:10.1016/b978-0-444-53717-1.01178-1
Contents of The American Journal of Psychiatry
(2005) · The British Journal of Psychiatry · doi:10.1192/s0007125000167054
(2009) · Elsevier eBooks · doi:10.1016/b978-0-444-53266-4.50005-7
(2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615372300.as04
Carvajal, A., Arias, L. H. M., & Bulnes, N. J. (2008) · Side effects of drugs annual · doi:10.1016/s0378-6080(08)00006-8 · Cited by 1
Werkzaamheid en werkzame factoren van psychotherapie
Verheul, R. (2017) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0931-3_15
Dialectical Behavioral Therapy
Sotsky, J., & Brodsky, B. S. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_153-1
Combined Psychotherapy and Somatic Treatments
Teo, D. C. L., Silvio, J. R., Condemarín, R., Nair, S. S., Alfonso, C. A., & Tasman, A. (2023) · Springer eBooks · doi:10.1007/978-3-030-42825-9_95-1
Ballon, J. S., Nunes, J. C., & Salaheldin, K. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375523.as27
Chapter 4. Antipsychotic Drugs
(2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894551289.cd04
Pharmacological and nutraceutical treatments for borderline personality disorder
Gérolymos, C., Boyer, L., Masson, M., & Fond, G. B. (2024) · L Encéphale · doi:10.1016/j.encep.2024.04.001
Combined Psychotherapy and Somatic Treatments
Teo, D. C. L., Silvio, J. R., Condemarín, R., Nair, S. S., Alfonso, C. A., & Tasman, A. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_95
Dialectical Behavioral Therapy
Sotsky, J., & Brodsky, B. S. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_153
Chapter 17. Pharmacological Management
Nelson, K. J., & Tsheringla, S. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379699.lg17
Chapter 18. Collaborative Treatment
Winkeller, V., & Schlesinger, A. B. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379699.lg18
Chapter 21. Co-occurring Substance Use Disorders
Gorfinkel, L., Prins, S. J., Elliott, J. C., Meyers, J. L., & Hasin, D. S. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379699.lg21
Dezfouli, R. A., Hashemzadeh, S., & Saleh, M. (2025) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-025-01011-1
Metadata
- Authors
- Soler, J., Pascual, J. C., Campins, J., Barrachina, J., Puigdemont, D., Alvarez, E., & Pérez, V.
- Affiliations
- Hospital de Sant Pau (ES)
- Venue
- American Journal of Psychiatry
- Published
- 2005-06-01
- Volume
- 162
- Issue
- 6
- Pages
- 1221-1224
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2149470409
- Cited by
- 224
- References
- 6
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 2 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 10 · 2012: 18
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- borderline personality disorder, dialectical behavior therapy, olanzapine, combined psychotherapy and pharmacotherapy, depression, anxiety, impulsivity, aggression, treatment discontinuation
- MeSH terms
- Olanzapine, Adult, Behavior Therapy, Benzodiazepines, Borderline Personality Disorder, Combined Modality Therapy, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Placebos, Antipsychotic Agents, Treatment Outcome
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