Cited by 224Personality Disorders and PsychopathologyBipolar Disorder and TreatmentSchizophrenia research and treatment

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Double-Blind, Placebo-Controlled Study of Dialectical Behavior Therapy Plus Olanzapine for Borderline Personality Disorder

Soler, Joaquim, Pascual, Juan Carlos, Campins, Josefa, Barrachina, Judith, Puigdemont, Dolors, Alvarez, Enrique, Pérez, Victor·2005·American Journal of Psychiatry

DOI 10.1176/appi.ajp.162.6.1221

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Abstract

OBJECTIVE: The aim of this study was to determine the efficacy and safety of dialectical behavior therapy plus olanzapine compared with dialectical behavior therapy plus placebo in patients with borderline personality disorder. METHOD: Sixty patients with borderline personality disorder were included in a 12-week, double-blind, placebo-controlled study. All patients received dialectical behavior therapy and were randomly assigned to receive either olanzapine or placebo following a 1-month baseline period. RESULTS: Seventy percent of the patients completed the 4-month trial. Combined treatment showed an overall improvement in most symptoms studied in both groups. Olanzapine was associated with a statistically significant improvement over placebo in depression, anxiety, and impulsivity/aggressive behavior. The mean dose of olanzapine was 8.83 mg/day. CONCLUSIONS: A combined psychotherapeutic plus pharmacological approach appears to lower dropout rates and constitutes an effective treatment for borderline personality disorder.

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Barrachina J, Soler J, Campins MJ, Tejero A, Pascual JC, Alvarez E, Zanarini MC, Perez Sola V: Validation of a Spanish version of the Diagnostic Interview for Borderlines—Revised (DIB-R). Actas Esp Psiquiatr 2004; 32:293–298

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Authors: Soler, J., Pascual, J. C., Campins, J., Barrachina, J., Puigdemont, D., Alvarez, E., & Pérez, V.
Affiliations: Hospital de Sant Pau (ES)
ORCID: Soler, Joaquim
Pascual, Juan Carlos
Puigdemont, Dolors
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2005-06-01
Volume: 162
Issue: 6
Pages: 1221-1224
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.162.6.1221
OpenAlex: W2149470409
Cited by: 224
References: 6
Citations by year: 2026: 2 · 2025: 6 · 2024: 10 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 11 · 2018: 2 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 10 · 2012: 18
FWCI: 21.11
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: borderline personality disorder, dialectical behavior therapy, olanzapine, combined psychotherapy and pharmacotherapy, depression, anxiety, impulsivity, aggression, treatment discontinuation
MeSH terms: Olanzapine, Adult, Behavior Therapy, Benzodiazepines, Borderline Personality Disorder, Combined Modality Therapy, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Placebos, Antipsychotic Agents, Treatment Outcome

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Double-Blind, Placebo-Controlled Study of Dialectical Behavior Therapy Plus Olanzapine for Borderline Personality Disorder

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