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Cited by 790

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Structural Brain Magnetic Resonance Imaging of Limbic and Thalamic Volumes in Pediatric Bipolar Disorder

Frazier, Jean A., Chiu, Sufen, Breeze, Janis L., Makris, Nikos, Lange, Nicholas, Kennedy, David N., Herbert, Martha R., Bent, Eileen K., Koneru, Vamsi K., Dieterich, Megan E., Hodge, Steven M., Rauch, Scott L., Grant, P. Ellen, Cohen, Bruce M., Seidman, Larry J., Caviness, Verne S., Biederman, Joseph·2005·American Journal of Psychiatry
DOI 10.1176/appi.ajp.162.7.1256
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Abstract

BACKGROUND: Youths with bipolar disorder are ideal for studying illness pathophysiology given their early presentation, lack of extended treatment, and high genetic loading. Adult bipolar disorder MRI studies have focused increasingly on limbic structures and the thalamus because of their role in mood and cognition. On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities. METHOD: Forty-three youths 6-16 years of age with DSM-IV bipolar disorder (23 male, 20 female) and 20 healthy comparison subjects (12 male, eight female) similar in age and sex underwent structured and clinical interviews, neurological examination, and cognitive testing. Differences in limbic and thalamic brain volumes, on the logarithmic scale, were tested using a two-way (diagnosis and sex) univariate analysis of variance, with total cerebral volume and age controlled. RESULTS: The subjects with bipolar disorder had smaller hippocampal volumes. Further analysis revealed that this effect was driven predominantly by the female bipolar disorder subjects. In addition, both male and female youths with bipolar disorder had significantly smaller cerebral volumes. No significant hemispheric effects were seen. CONCLUSIONS: These findings support the hypothesis that the limbic system, in particular the hippocampus, may be involved in the pathophysiology of pediatric bipolar disorder. While this report may represent the largest MRI study of pediatric bipolar disorder to date, more work is needed to confirm these findings and to determine if they are unique to pediatric bipolar disorder.

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Research works printed but not linked: 46

  1. Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, Mennin D: Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995; 34:867–876 · DOI · Paper page
  2. Geller B, Luby J: Child and adolescent bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1997; 36:1168–1176 · DOI · Paper page
  3. Geller B, Craney JL, Bolhofner K, DelBello MP, Williams M, Zimerman B: One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2001; 158:303–305 · DOI
  4. Lewinsohn PM, Klein DN, Seeley JR: Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry 1995; 34:454–463 · DOI · Paper page
  5. Johnson L, Andersson-Lundman G, Åberg-Wistedt A, Mathé AA: Age of onset in affective disorder: its correlation with hereditary and psychosocial factors. J Affect Disord 2000; 59:139–148 · DOI
  6. Goldstein JM, Seidman LJ, O’Brien LM, Horton NJ, Kennedy DN, Makris N, Caviness VS Jr, Faraone SV, Tsuang MT: Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Arch Gen Psychiatry 2002; 59:154–164 · DOI · Paper page
  7. Reiter EO, Fuldauer VG, Root AW: Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalities. J Pediatr 1977; 90:766–770 · DOI
  8. Soares JC, Mann JJ: The anatomy of mood disorders: review of structural neuroimaging studies. Biol Psychiatry 1997; 41:86–106 · DOI · Paper page
  9. Phillips ML, Drevets WC, Rauch SL, Lane RD: The neurobiology of emotion perception, II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54:515–528 · DOI · Paper page
  10. Packard MG, Cahill L: Affective modulation of multiple memory systems. Curr Opin Neurobiol 2001; 11:752–756 · DOI
  11. Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, Larson ER: Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 1999; 56:254–260 · DOI · Paper page
  12. Pearlson GD, Barta PE, Powers RE, Menon RR, Richards SS, Aylward EH, Federman EB, Chase GA, Petty RG, Tien AY: Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry 1997; 41:1–14 · DOI · Paper page
  13. Dupont RM, Jernigan TL, Heindel W, Butters N, Shafer K, Wilson T, Hesselink J, Gillin JC: Magnetic resonance imaging and mood disorders: localization of white matter and other subcortical abnormalities. Arch Gen Psychiatry 1995; 52:747–755 · DOI
  14. Swayze VW II, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC: Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biol Psychiatry 1992; 31:221–240 · DOI · Paper page
  15. Noga JT, Vladar K, Torrey EF: A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder. Psychiatry Res 2001; 106:25–34 · DOI
  16. Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS: Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Arch Gen Psychiatry 2003; 60:1201–1208 · DOI · Paper page
  17. Botteron KN, Vannier MW, Geller B, Todd RD, Lee BC: Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year-olds with mania. J Am Acad Child Adolesc Psychiatry 1995; 34:742–749 · DOI
  18. Friedman L, Findling RL, Kenny JT, Swales TP, Stuve TA, Jesberger JA, Lewin JS, Schulz SC: An MRI study of adolescent patients with either schizophrenia or bipolar disorder as compared to healthy control subjects. Biol Psychiatry 1999; 46:78–88 · DOI
  19. Dasari M, Friedman L, Jesberger J, Stuve TA, Findling RL, Swales TP, Schulz SC: A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls. Psychiatry Res 1999; 91:155–162 · DOI
  20. DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM: Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 2004; 6:43–52 · DOI · Paper page
  21. Woods SW: Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 2003; 64:663–667 · DOI · Paper page
  22. Caviness VS Jr, Meyer J, Makris N, Kennedy DN: MRI-based topographic parcellation of human neocortex: an anatomically specified method with estimate reliability. J Cogn Neurosci 1996; 8:566–587 · DOI · Paper page
  23. Kennedy DN, Filipek PA, Caviness VS Jr: Autonomic segmentation and volumetric calculations in nuclear magnetic resonance imaging. IEEE Trans Med Imaging 1989; 8:1–7 · DOI · Paper page
  24. Worth AJ, Makris N, Caviness VS Jr, Kennedy DN: Neuroanatomical segmentation in MRI: technological objectives. Intern J Pattern Recognit Artif Intell 1997; 11:1161–1187 · DOI
  25. Filipek PA, Richelme C, Kennedy DN, Caviness VS Jr: The young adult human brain: an MRI-based morphometric study. Cereb Cortex 1994; 4:344–360 · DOI · Paper page
  26. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Matsuda G, Hoge EA, Kennedy D, Makris N, Caviness VS Jr, Tsuang MT: Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging study. Am J Med Genet 1997; 74:507–514 · DOI
  27. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kreman WS, Toomey R, Tourville J, Kennedy D, Makris N, Caviness VS, Tsuang MT: Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis. Biol Psychiatry 1999; 46:941–954 · DOI
  28. Seidman LJ, Faraone SV, Goldstein JM, Kreman WS, Horton NH, Makris N, Toomey R, Kennedy D, Caviness VS, Tsuang MT: Left hippocampal volume as a vulnerability indicator for schizophrenia. Arch Gen Psychiatry 2002; 59:839–849 · DOI · Paper page
  29. Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL: Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res 1997; 75:31–48 · DOI
  30. Lange N, Giedd JN, Castellanos FX, Vaituzis AC, Rapoport JL: Variability of human brain structure size: ages 4–20 years. Psychiatry Res 1997; 74:1–12 · DOI · Paper page
  31. Benes FM, Kwok EW, Vincent SL, Todtenkopf MS: A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 1998; 44:88–97 · DOI · Paper page
  32. Fatemi SH, Earle JA, Stary JM, Lee S, Sedgewick J: Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophrenia. Neuroreport 2001; 12:3257–3262 · DOI
  33. Fatemi SH, Earle JA, McMenomy T: Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry 2000; 5:654–663 · DOI · Paper page
  34. Eastwood SL, Harrison PJ: Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs. Mol Psychiatry 2000; 5:425–432 · DOI · Paper page
  35. Dowlatshahi D, MacQueen G, Wang JF, Chen B, Young LT: Increased hippocampal supragranular Timm staining in subjects with bipolar disorder. Neuroreport 2000; 11:3775–3778 · DOI
  36. Law AJ, Deakin JF: Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. Neuroreport 2001; 12:2971–2974 · DOI
  37. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy D, Caviness VS, Faraone S, Tsuang MT: Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 2001; 11:490–497 · DOI · Paper page
  38. DelBello MP, Zimerman ME, Getz GE, Strakowski S: Structural MRI analysis of adolescents with bipolar disorder. Biol Psychiatry 2001; 49:20S-21S
  39. Kennedy DN, Lange N, Makris N, Bates J, Meyer J, Caviness VS Jr: Gyri of the human neocortex: an MRI-based analysis of volume and variance. Cereb Cortex 1998; 8:372–384 · DOI · Paper page
  40. Pantelis C, Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips LJ, Yung AR, Bullmore ET, Brewer W, Soulsby B, Desmond P, McGuire PK: Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003; 361:281–288 · DOI · Paper page
  41. Sigurdsson E, Fombonne E, Sayal K, Checkley S: Neurodevelopmental antecedents of early-onset bipolar affective disorder. Br Med J 1999; 174:121–127 · DOI
  42. Hellgren L, Gillberg IC, Bagenholm A, Gillberg C: Children with deficits in attention, motor control and perception (DAMP) almost grown up: psychiatric and personality disorders at age 16 years. J Child Psychol Psychiatry 1993; 35:1255–1271 · DOI · Paper page
  43. Frazier JA, Biederman J, Tohen M, Feldman PD, Jacobs TG, Toma V, Rater MA, Tarazi RA, Kim GS, Garfield SB, Sohma M, Gonzalez-Heydrich J, Risser RC, Nowling ZM: A prospective open-label treatment trial of olanzapine monotherapy in children and adolescents with bipolar disorder. J Child Adolesc Psychopharmacol 2001; 11:239–250 · DOI
  44. Tsuang M: Schizophrenia: genes and environment. Biol Psychiatry 2000; 47:210–220 · DOI · Paper page
  45. Todd RD, Reich W, Petti TA, Joshi P, DePaulo JR Jr, Nurnberger J Jr, Reich T: Psychiatric diagnoses in the child and adolescent members of extended families identified through adult bipolar affective disorder probands. J Am Acad Child Adolesc Psychiatry 1996; 35:664–671 · DOI
  46. Goldstein JM, Kennedy DN, Caviness VS Jr: Brain development, XI: sexual dimorphism (image, neuro). Am J Psychiatry 1999; 156:352 · DOI

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Metadata

Authors
Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., Lange, N., Kennedy, D. N., Herbert, M. R., Bent, E. K., Koneru, V. K., Dieterich, M. E., Hodge, S. M., Rauch, S. L., Grant, P. E., Cohen, B. M., Seidman, L. J., Caviness, V. S., & Biederman, J.
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2005-07-01
Volume
162
Issue
7
Pages
1256-1265
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.162.7.1256
OpenAlex
W2133054185
Cited by
790
References
8
FWCI
11.36
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Structural Brain Magnetic Resonance Imaging of Limbic and Thalamic Volumes in Pediatric Bipolar Disorder. https://app.cochat.ai/papers/10.1176/appi.ajp.162.7.1256
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Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., Lange, N., Kennedy, D. N., Herbert, M. R., Bent, E. K., Koneru, V. K., Dieterich, M. E., Hodge, S. M., Rauch, S. L., Grant, P. E., Cohen, B. M., Seidman, L. J., Caviness, V. S., & Biederman, J. (2005). Structural Brain Magnetic Resonance Imaging of Limbic and Thalamic Volumes in Pediatric Bipolar Disorder. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.162.7.1256

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