CoChat
Sign Up
Cited by 109Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Psychomotor Slowing as a Predictor of Fluoxetine Nonresponse in Depressed Outpatients

Taylor, Bonnie P., Bruder, Gerard E., Stewart, Jonathan W., McGrath, Patrick J., Halperin, Jeffrey, Ehrlichman, Howard, Quitkin, Frederic M.·2006·American Journal of Psychiatry
DOI 10.1176/appi.ajp.163.1.73
Open this paper in CoChat — free account

Abstract

OBJECTIVE: This study examined the utility of baseline psychomotor speed, measured with neuropsychological tests, to predict fluoxetine response in moderately depressed outpatients. The authors hypothesized that since psychomotor slowing in depressed patients has been linked to reduced dopaminergic neurotransmission, patients with slowing would be unresponsive to fluoxetine, a selective serotonin reuptake inhibitor. METHOD: After baseline neuropsychological testing, patients were treated openly with fluoxetine for 12 weeks. Thirty-seven patients completed the trial. RESULTS: Compared to the 25 patients who responded, the 12 patients who did not respond to fluoxetine exhibited significantly poorer performance in verbal fluency on the Controlled Oral Word Association Test FAS and in color naming on the Stroop Color and Word Test. In addition, the nonresponders tended to perform worse than the responders on the Stroop Color and Word Test reading subtest and the WAIS-III digit symbol subtest. Differential treatment response was specific to psychomotor speed because responders and nonresponders did not perform differently on tasks of executive functioning, attention, visuospatial functioning, or verbal intelligence. CONCLUSIONS: Psychomotor slowing may identify a subgroup of depressed patients who have a dopaminergic deficit that is unresponsive to fluoxetine monotherapy and who should therefore receive an alternative treatment.

Overview

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.163.1.73

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 32 references

1 of the 32 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Bruder GE, Stewart JW, Tenke CE, McGrath PJ, Leite P, Bhattacharya N, Quitkin FM: Electroencephalographic and perceptual asymmetry differences between responders and nonresponders to an SSRI antidepressant. Biol Psychiatry 2001; 49:416–425

Cited by

Sorted by citations

Items 101–109 of 109

Related

See all

Metadata

Authors
Taylor, B. P., Bruder, G. E., Stewart, J. W., McGrath, P. J., Halperin, J., Ehrlichman, H., & Quitkin, F. M.
Affiliations
Columbia University Irving Medical Center (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2006-01-01
Volume
163
Issue
1
Pages
73-78
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.163.1.73
OpenAlex
W2133715864
Cited by
109
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 3
FWCI
3.76
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
psychomotor retardation, fluoxetine, antidepressant non-response, depression, outpatients, treatment response prediction, dopaminergic deficit, selective serotonin reuptake inhibitors, neuropsychological assessment, verbal fluency, Stroop task, Controlled Oral Word Association Test, Digit Symbol Substitution Test, executive function
MeSH terms
Adolescent, Adult, Aged, Ambulatory Care, Major Depressive Disorder, Dopamine, Female, Fluoxetine, Humans, Male, Middle Aged, Synaptic Transmission, Neuropsychological Tests, Probability, Psychiatric Status Rating Scales, Psychomotor Performance, Risk Factors, Severity of Illness Index, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review