Cited by 109Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on Behavior

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Psychomotor Slowing as a Predictor of Fluoxetine Nonresponse in Depressed Outpatients

Taylor, Bonnie P., Bruder, Gerard E., Stewart, Jonathan W., McGrath, Patrick J., Halperin, Jeffrey, Ehrlichman, Howard, Quitkin, Frederic M.·2006·American Journal of Psychiatry

DOI 10.1176/appi.ajp.163.1.73

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Abstract

OBJECTIVE: This study examined the utility of baseline psychomotor speed, measured with neuropsychological tests, to predict fluoxetine response in moderately depressed outpatients. The authors hypothesized that since psychomotor slowing in depressed patients has been linked to reduced dopaminergic neurotransmission, patients with slowing would be unresponsive to fluoxetine, a selective serotonin reuptake inhibitor. METHOD: After baseline neuropsychological testing, patients were treated openly with fluoxetine for 12 weeks. Thirty-seven patients completed the trial. RESULTS: Compared to the 25 patients who responded, the 12 patients who did not respond to fluoxetine exhibited significantly poorer performance in verbal fluency on the Controlled Oral Word Association Test FAS and in color naming on the Stroop Color and Word Test. In addition, the nonresponders tended to perform worse than the responders on the Stroop Color and Word Test reading subtest and the WAIS-III digit symbol subtest. Differential treatment response was specific to psychomotor speed because responders and nonresponders did not perform differently on tasks of executive functioning, attention, visuospatial functioning, or verbal intelligence. CONCLUSIONS: Psychomotor slowing may identify a subgroup of depressed patients who have a dopaminergic deficit that is unresponsive to fluoxetine monotherapy and who should therefore receive an alternative treatment.

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Peer Reviewed Title: Cognitive performance of pregnant and postpartum women with and without major depression
Nowakowski, S. (2010)

Authors: Taylor, B. P., Bruder, G. E., Stewart, J. W., McGrath, P. J., Halperin, J., Ehrlichman, H., & Quitkin, F. M.
Affiliations: Columbia University Irving Medical Center (US)
ORCID: Taylor, Bonnie P.
McGrath, Patrick J.
Halperin, Jeffrey
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2006-01-01
Volume: 163
Issue: 1
Pages: 73-78
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.163.1.73
OpenAlex: W2133715864
Cited by: 109
References: 32
Citations by year: 2026: 2 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 11 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 3
FWCI: 3.76
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: psychomotor retardation, fluoxetine, antidepressant non-response, depression, outpatients, treatment response prediction, dopaminergic deficit, selective serotonin reuptake inhibitors, neuropsychological assessment, verbal fluency, Stroop task, Controlled Oral Word Association Test, Digit Symbol Substitution Test, executive function
MeSH terms: Adolescent, Adult, Aged, Ambulatory Care, Major Depressive Disorder, Dopamine, Female, Fluoxetine, Humans, Male, Middle Aged, Synaptic Transmission, Neuropsychological Tests, Probability, Psychiatric Status Rating Scales, Psychomotor Performance, Risk Factors, Severity of Illness Index, Treatment Outcome, Selective Serotonin Reuptake Inhibitors

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Psychomotor Slowing as a Predictor of Fluoxetine Nonresponse in Depressed Outpatients

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