The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.
Reduced Sleep Spindle Activity in Schizophrenia Patients
Abstract
Objective: High-density EEG during sleep represents a powerful new tool to reveal potential abnormalities in rhythm-generating mechanisms while avoiding confounding factors associated with waking activities. As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ between schizophrenia subjects, healthy individuals, and a psychiatric control group with a history of depression. Method: Healthy comparison subjects (N=17), medicated schizophrenia patients (N=18), and subjects with a history of depression (N=15) were recruited. Subjects were recorded during the first sleep episode of the night with a 256-electrode high-density EEG. Recordings were analyzed for changes in EEG power spectra, power topography, and sleep-specific cortical oscillations. Results: The authors found that the schizophrenia group had a significant reduction in centroparietal EEG power, from 13.75 to 15.00 Hz, in relation to both the comparison and depression groups. No significant difference in EEG power between the comparison and depression groups was identified. The authors also found a decrease in sleep spindle number, amplitude, duration, and integrated spindle activity in schizophrenia patients. Furthermore, integrated spindle activity had an effect size corresponding to 93.0% or 90.2% separation of the schizophrenia from the comparison or depression group. Conclusions: Sleep spindles are generated by the thalamic reticular nucleus in conjunction with specific thalamic nuclei and are modulated by corticothalamic and thalamocortical connections. The deficit in sleep spindles in schizophrenia subjects may reflect dysfunction in thalamic-reticular and thalamocortical mechanisms and could represent a biological marker of illness.
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“For example, over 90% of schizophrenic subjects show a dramatic reduction in sleep spindles, suggesting dysfunction in the reticular nucleus of the thalamus (Ferrarelli et al., 2007).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Ferrarelli et al., 2007
Citations
Cites
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Self-citationFunction of the thalamic reticular complex: the searchlight hypothesis
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Cited by
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Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings
Andrillon, T., Nir, Y., Staba, R. J., Ferrarelli, F., Cirelli, C., Tononi, G., & Fried, I. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2604-11.2011 · Cited by 504
“While it should be noted that our sampling was mostly limited to medial brain areas, scalp topography suggests that human spindle activity is maximal at midline regions (Ferrarelli et al., 2007), thereby making our data particularly well suited to examine sleep spindles.”
BackgroundMethodSelf-citationSleep spindle activity is associated with the integration of new memories and existing knowledge
Tamminen, J., Payne, J. D., Stickgold, R., Wamsley, E. J., & Gaskell, M. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3028-10.2010 · Cited by 478
“Automated detection (Ferrarelli et al., 2007) derived the number of discrete spindle events: for each channel, amplitude fluctuations in the filtered time series exceeding a predetermined threshold counted as spindles.”
BackgroundAcoustic Enhancement of Sleep Slow Oscillations and Concomitant Memory Improvement in Older Adults
Papalambros, N. A., Santostasi, G., Malkani, R. G., Braun, R., Weintraub, S., Paller, K. A., & Zee, P. C. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00109 · Cited by 259
“Spindle detection was done as described by Ferrarelli et al. (2007) using the Hilbert transform to calculate spindle amplitude envelopes in channel Fpz.”
BackgroundMethodGenzel, L., Kroes, M. C. W., Dresler, M., & Battaglia, F. P. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.002 · Cited by 285
Benca, R. M., & Peterson, M. J. (2008) · Sleep Medicine · doi:10.1016/s1389-9457(08)70010-8 · Cited by 259
“The first application of hd-EEG sleep recording in psychiatry was in patients with schizophrenia, who showed reduced spindle activity in centroparietal regions compared to normal controls and patients with depression [55].”
BackgroundSelf-citation
Metadata
- Authors
- Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A., Watson, A., Bria, P., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Don Carlo Gnocchi Foundation (IT)
- Venue
- American Journal of Psychiatry
- Published
- 2007-03
- Volume
- 164
- Issue
- 3
- Pages
- 483-492
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2077633827
- Cited by
- 541
- References
- 49
- Citations by year
- 2026: 28 · 2025: 32 · 2024: 32 · 2023: 21 · 2022: 39 · 2021: 29 · 2020: 42 · 2019: 31 · 2018: 32 · 2017: 39 · 2016: 39 · 2015: 39 · 2014: 28 · 2013: 32 · 2012: 21
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- schizophrenia, sleep spindles, high-density EEG, sleep rhythm, thalamic reticular nucleus, thalamocortical connections, corticothalamic connections, depression, biomarkers, EEG power spectra
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebral Cortex, Depressive Disorder, Diagnosis, Differential, Electroencephalography, Female, Humans, Male, Middle Aged, Neural Pathways, Parietal Lobe, Reticular Formation, Schizophrenia, Sleep, Sleep Stages, Thalamus, Biomarkers
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