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Cited by 541Schizophrenia research and treatmentSleep and Wakefulness ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.

Reduced Sleep Spindle Activity in Schizophrenia Patients

Ferrarelli, Fabio, Huber, Reto, Peterson, Michael J., Massimini, Marcello, Murphy, Michael, Riedner, Brady A., Watson, Adam, Bria, Pietro, Tononi, Giulio·2007·American Journal of Psychiatry
DOI 10.1176/appi.ajp.164.3.483
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Abstract

Objective: High-density EEG during sleep represents a powerful new tool to reveal potential abnormalities in rhythm-generating mechanisms while avoiding confounding factors associated with waking activities. As a first step in this direction, the authors employed high-density EEG to explore whether sleep rhythms differ between schizophrenia subjects, healthy individuals, and a psychiatric control group with a history of depression. Method: Healthy comparison subjects (N=17), medicated schizophrenia patients (N=18), and subjects with a history of depression (N=15) were recruited. Subjects were recorded during the first sleep episode of the night with a 256-electrode high-density EEG. Recordings were analyzed for changes in EEG power spectra, power topography, and sleep-specific cortical oscillations. Results: The authors found that the schizophrenia group had a significant reduction in centroparietal EEG power, from 13.75 to 15.00 Hz, in relation to both the comparison and depression groups. No significant difference in EEG power between the comparison and depression groups was identified. The authors also found a decrease in sleep spindle number, amplitude, duration, and integrated spindle activity in schizophrenia patients. Furthermore, integrated spindle activity had an effect size corresponding to 93.0% or 90.2% separation of the schizophrenia from the comparison or depression group. Conclusions: Sleep spindles are generated by the thalamic reticular nucleus in conjunction with specific thalamic nuclei and are modulated by corticothalamic and thalamocortical connections. The deficit in sleep spindles in schizophrenia subjects may reflect dysfunction in thalamic-reticular and thalamocortical mechanisms and could represent a biological marker of illness.

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Crossref · 10.1176/ajp.2007.164.3.483

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Metadata

Authors
Ferrarelli, F., Huber, R., Peterson, M. J., Massimini, M., Murphy, M., Riedner, B. A., Watson, A., Bria, P., & Tononi, G.
Affiliations
  • University of Wisconsin–Madison (US)
  • Don Carlo Gnocchi Foundation (IT)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2007-03
Volume
164
Issue
3
Pages
483-492
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.164.3.483
OpenAlex
W2077633827
Cited by
541
References
49
Citations by year
2026: 28 · 2025: 32 · 2024: 32 · 2023: 21 · 2022: 39 · 2021: 29 · 2020: 42 · 2019: 31 · 2018: 32 · 2017: 39 · 2016: 39 · 2015: 39 · 2014: 28 · 2013: 32 · 2012: 21
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
schizophrenia, sleep spindles, high-density EEG, sleep rhythm, thalamic reticular nucleus, thalamocortical connections, corticothalamic connections, depression, biomarkers, EEG power spectra
MeSH terms
Adolescent, Adult, Brain Mapping, Cerebral Cortex, Depressive Disorder, Diagnosis, Differential, Electroencephalography, Female, Humans, Male, Middle Aged, Neural Pathways, Parietal Lobe, Reticular Formation, Schizophrenia, Sleep, Sleep Stages, Thalamus, Biomarkers

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