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Treatment-Resistant Depression and Mortality After Acute Coronary Syndrome
Open accessAbstract
Depression is a risk factor for morbidity and mortality in patients with coronary heart disease, especially following acute coronary syndrome. Evidence from recent clinical trials suggests that treatment-resistant depression may be associated with a particularly high risk of mortality or cardiac morbidity in patients following acute coronary syndrome. This article reviews this evidence and considers possible explanations for this relationship. Directions for future research are also considered, with particular emphasis on efforts to elucidate the underlying mechanisms and to develop more efficacious treatments for depression in patients with coronary heart disease.
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“Although there are conflicting data on the cardiovascular benefits of antidepressants in patients with CVD, a synthesis of data from numerous intervention trials found that unsuccessful treatment of depression after hospitalization for ACS is linked to elevated risk of mortality and cardiac events. 183”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [183]
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Cited by
Sorted by citations
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435
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“Depression is frequently comorbid with other mental and physical difficulties, most often with anxiety disorders, but also with cardiac problems and smoking (e.g., Carney & Freedland 2009).”
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Metadata
- Authors
- Carney, R. M., & Freedland, K. E.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- American Journal of Psychiatry
- Published
- 2009-04
- Volume
- 166
- Issue
- 4
- Pages
- 410-417
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3465939
- OpenAlex
- W2129412441
- Cited by
- 163
- References
- 62
- Citations by year
- 2025: 3 · 2024: 11 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 17 · 2012: 14
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL076808, HL-76808)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- treatment-resistant depression, acute coronary syndrome, mortality, coronary artery disease, cardiac morbidity, depression as risk factor
- MeSH terms
- Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Drug Therapy, Combination, Follow-Up Studies, Humans, Myocardial Infarction, Personality Inventory, Psychometrics, Citalopram, Comorbidity, Cognitive Behavioral Therapy, Survival Rate, Randomized Controlled Trials as Topic, Bupropion, Acute Coronary Syndrome, Secondary Prevention
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