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Cited by 295Mental Health Treatment and AccessTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Long-term Outcome of Episodes of Major Depression: Clinical and Public Health Significance

Keller, Martin B.·1984·JAMA
DOI 10.1001/jama.252.6.788
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Abstract

Twenty-one percent (20/97) of patients with an episode of major depressive disorder and no history of chronic minor depression who sought treatment at five university medical centers had not recovered after two years of prospective follow-up. The rate of recovery was highest in the three months after entry into the study, with a notable decrease in rate after one year. Most patients who did not recover had severe depressive symptoms throughout the two years of follow-up. Long duration of episode before entry into the study, inpatient hospitalization status at entry, intact marriage, low family income, admitting research center, and a history of nonaffective psychiatric disorders (including alcoholism) predicted a chronic course. The implications of these findings for clinicians, researchers, and public health planners are discussed.

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Crossref · 10.1001/jama.1984.03350060032024

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  • Relapse rates after a first episode of depression in those with no depression history are 20% to 30%, compared with 70% to 80% for those who have experienced two or more episodes.

    “Relapse rates after a first episode of depression in those with no depression history are 20% to 30% compared with 70% to 80% for those who have experienced two or more episodes (Keller 1984).”

    From Interventions for preventing relapse and recurrence of a depressive disorder in children and adolescents (2012) · cites this paper as Keller 1984

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Authors
Keller, M. B.
Corresponding author
Keller, Martin B.
ORCID
Keller, Martin B.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
1984-08-10
Volume
252
Issue
6
Pages
788
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.252.6.788
OpenAlex
W4253268125
Cited by
295
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 6
FWCI
12.36
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH025478, U01MH025478)
Topics
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, long-term outcomes, recovery from depression, chronic depression, episode duration, hospitalization, marital status, household income, alcoholism, public health implications
MeSH terms
Adult, Depressive Disorder, Humans, Middle Aged, Outcome and Process Assessment, Health Care, Probability

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