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An fMRI Study of Self-Regulatory Control and Conflict Resolution in Adolescents With Bulimia Nervosa
Open accessAbstract
OBJECTIVE: The authors examined functional activity in the frontostriatal systems that mediate self-regulatory capacities and conflict resolution in adolescents with bulimia nervosa. METHOD: Functional magnetic resonance imaging was used to compare blood-oxygen-level-dependent response in 18 female adolescents with bulimia nervosa and 18 healthy female age-matched subjects during performance on a Simon spatial incompatibility task. Bayesian analyses were used to compare the two groups on patterns of brain activation during correct responses to conflict stimuli and to explore the effects of antecedent stimulus context on group differences in self-regulation and conflict resolution. RESULTS: Adolescents with and without bulimia nervosa performed similarly on the task. During correct responses in conflict trials, frontostriatal circuits-including the right inferolateral and dorsolateral prefrontal cortices and putamen-failed to activate to the same degree in adolescents with bulimia nervosa as in healthy comparison subjects. Instead, deactivation was seen in the left inferior frontal gyrus as well as a neural system encompassing the posterior cingulate cortex and superior frontal gyrus. Group differences in cortical and striatal regions were driven by the differential responses to stimuli preceded by conflict and nonconflict stimuli, respectively. CONCLUSIONS: When engaging the self-regulatory control processes necessary to resolve conflict, adolescents with bulimia nervosa displayed abnormal patterns of activation in frontostriatal and default-mode systems. Their abnormal processing of the antecedent stimulus context conditioned their brain response to conflict differently from that of healthy comparison subjects, specifically in frontal regions. It is suspected that functional disturbances in frontal portions of frontostriatal systems may release feeding behaviors from regulatory control, thereby perpetuating the conflicting desires to consume fattening foods and avoid weight gain that characterize bulimia nervosa.
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Metadata
- Authors
- Marsh, R., Horga, G., Wang, Z., Wang, P., Klahr, K. W., Berner, L. A., Walsh, B. T., & Peterson, B. S.
- Affiliations
- New York State Psychiatric Institute (US)
- From the Division of Child and Adolescent Psychiatry, Department of Psychiatry, New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York; and the Eating Disorders Research Unit, Department of Psychiatry, New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York.
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2011-11
- Volume
- 168
- Issue
- 11
- Pages
- 1210-1220
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3328859
- OpenAlex
- W2158454070
- Cited by
- 142
- References
- 19
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 10 · 2013: 14 · 2012: 6
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k02mh074677-05)
- National Institute of Mental Health (K01MH077652, R01MH090062, K02-MH-074677)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- bulimia nervosa, adolescents, conflict resolution, frontostriatal circuits, prefrontal cortex, putamen, default mode network, posterior cingulate cortex, inferior frontal gyrus, stimulus context, eating disorders
- MeSH terms
- Adolescent, Brain, Brain Mapping, Female, Humans, Internal-External Control, Magnetic Resonance Imaging, Nerve Net, Psychomotor Performance, Social Control, Informal, Negotiating, Bulimia Nervosa, Neuroimaging
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