The Phenomenology of Major Depression and the Representativeness and Nature of DSM Criteria.
Open accessAbstract
How should DSM criteria relate to the disorders they are designed to assess? To address this question empirically, the author examines how well DSM-5 symptomatic criteria for major depression capture the descriptions of clinical depression in the post-Kraepelin Western psychiatric tradition as described in textbooks published between 1900 and 1960. Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia. For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks. Five symptoms and signs (changes in volition/motivation, slowing of speech, anxiety, other physical symptoms, and depersonalization/derealization) are not present in the DSM criteria. Compared with the DSM criteria, these authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms. These results suggest that important features of major depression are not captured by DSM criteria. This is unproblematic as long as DSM criteria are understood to index rather than constitute psychiatric disorders. However, since DSM-III, our field has moved toward a reification of DSM that implicitly assumes that psychiatric disorders are actually just the DSM criteria. That is, we have taken an index of something for the thing itself. For example, good diagnostic criteria should be succinct and require minimal inference, but some critical clinical phenomena are subtle, difficult to assess, and experienced in widely varying ways. This conceptual error has contributed to the impoverishment of psychopathology and has affected our research, clinical work, and teaching in some undesirable ways.
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1 of 10 cited sources checked · 1 supported · 0 flagged
- Findingown data
Eighteen symptoms and signs of depression were described in the textbooks, 10 of which are covered by the DSM criteria for major depression or melancholia.
“Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia.”
Quote in the paperSubstantial claim - Findingown data
For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks.
“For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks.”
Quote in the paperSubstantial claim - Findingreasoning
The descriptive literature placed greater relative emphasis on cognitive and attitudinal changes associated with depression than do the DSM criteria, where these features constitute only one criterion characterized solely by worthlessness and guilt.
“Second, the descriptive literature placed greater relative emphasis on the cognitive and attitudinal changes associated with depression than do the DSM criteria, where these features constitute only one criterion, characterized solely by worthlessness and guilt.”
Quote in the paperSubstantial claim - Findingown data
None of the textbook authors noted increased appetite and weight gain, which are also described in DSM criterion A3.
“However, none of the authors noted increased appetite and weight gain, which are also described in this DSM criterion.”
Quote in the paperSubstantial claim - Findingown data
Fatigue, exhaustion, and feelings of being tired out, well captured by DSM criterion A6, were described by only eight textbook authors.
“Fatigue, exhaustion, and feelings of being tired out, symptoms well captured by DSM criterion A6, were described by only eight authors.”
Quote in the paperNot a substantial claim
- Findingcitation
Consistent with recent work, the textbook authors gave greater prominence to changes in psychomotor functioning, especially psychomotor retardation, than is current practice.
“Sixth, consistent with recent work (30), these authors gave greater prominence to changes in psychomotor functioning, especially psychomotor retardation, than is our current practice.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [30] source
- Findingown data
Depression-related changes in volition and motivation were described by 15 textbook authors, typically distinguished from physical fatigue and decision difficulty, most commonly as lack of initiative, loss of will, or inability to work.
“Depression-related changes in volition and motivation were described by 15 authors and were typically distinguished both from the more physical feelings of fatigue and the difficulty in decision making.Most commonly, this was described as lack of initiative, loss of will, or inability to work.”
Quote in the paperSubstantial claim - Findingown data
Only one textbook author described neurovegetative changes in sleep, appetite, or weight as a central symptom of depression.
“Of note, only one author described neurovegetative changes in sleep, appetite, or weight as a central symptom of depression.”
Quote in the paperNot a substantial claim - Findingcitation
Second to mood changes, the most frequently noted key symptom of major depression was changes in cognitive functioning, typically difficulties in thinking and concentrating.
“Third, second to mood changes, the most frequently noted key symptom of major depression was changes in cognitive Am J Psychiatry 173:8, August 2016 ajp.psychiatryonline.org773 functioning, typically characterized by difficulties in thinking and concentrating.”
Quote in the paperSubstantial claim - Findingown data
All 19 textbook authors described mood disturbances in the course of major depression.
“Mood disturbances in the course of major depression were described by all 19 textbook authors (Table 1).”
Quote in the paperNot a substantial claim - Findingown data
Two symptoms and signs (mood changes and changes in cognitive content) were partly covered by DSM criteria.
“Two symptoms and signs (mood changes and changes in cognitive content) were partly covered by DSM criteria.”
Quote in the paperSubstantial claim - Findingown data
Changes in volition and motivation are not included in the DSM-5 A criteria for major depression.
“This symptomatic domain is not included in the DSM-5 A criteria for major depression.”
Quote in the paperSubstantial claim - Findingown data
Five symptoms and signs were not reflected in the DSM criteria for major depression.
“Five symptoms and signs were not reflected in the DSM criteria for major depression.”
Quote in the paperSubstantial claim - Findingreasoning
The textbook authors described a range of somatic symptoms and signs in depressed patients that receive little attention in DSM.
“Fourth, these authors describe a range of somatic symptoms and signs in depressed patients that receive little attention in DSM.”
Quote in the paperSubstantial claim - Findingown data
All textbook authors described specific cognitive content as characteristic of depressed patients.
“All authors described specific cognitive content as characteristic of depressed patients.”
Quote in the paperNot a substantial claim - Findingown data
Five symptoms and signs (changes in volition/motivation, slowing of speech, anxiety, other physical symptoms, and depersonalization/derealization) are not present in the DSM criteria.
“Five symptoms and signs (changes in volition/motivation, slowing of speech, anxiety, other physical symptoms, and depersonalization/ derealization) are not present in the DSM criteria.”
Quote in the paperSubstantial claim - Findingown data
Nearly two-thirds of the textbook authors described a domain of symptomatology in depression rarely noted in the post-DSM-III world: derealization and depersonalization.
“Seventh, nearly two-thirds of the textbook authors described a domain of symptomatology in depression rarely noted in the post-DSM-III world: derealization and depersonalization.”
Quote in the paperSubstantial claim - Findingown data
Twelve textbook authors commented on loss of interest using language broadly similar to DSM-5 criterion A2, often using terms indicating apathy or indifference.
“Twelve of the authors commented on loss of interest using language broadly similar to DSM-5 criterion A2, often using terms indicating apathy or indifference.”
Quote in the paperNot a substantial claim - Findingown data
Only five of the 19 textbook authors described psychomotor agitation as a common symptom of depression or melancholia.
“However, only five of the 19 textbook authors described psychomotor agitation as a common symptom of depression or melancholia.”
Quote in the paperSubstantial claim - Findingown data
DSM-5 criteria do not cover anxiety among the 18 symptoms and signs assessed by textbook authors.
“Anxiety | Not covered”
Quote in the paperSubstantial claim - Findingnone given
None of the textbook authors distinguished between depressions occurring in bipolar illness and those occurring in unipolar illness.
“Second, none of these authors distinguished between depressions occurring in bipolar illness and those occurring in unipolar illness.”
Quote in the paperNot a substantial claim- Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
- Findingown data
DSM-5 criteria do not cover speech among the 18 symptoms and signs assessed by textbook authors.
“Speech | Not covered”
Quote in the paperSubstantial claim - Findingnone given
Psychiatry still lacks gold-standard validators like coronary angiography.
“However, we still lack gold-standard validators like coronary angiography.”
Quote in the paperNot a substantial claim - Findingown data
DSM-5 criteria do not cover other physical symptoms among the 18 symptoms and signs assessed by textbook authors.
“Other physical symptoms | Not covered”
Quote in the paperSubstantial claim - Findingown data
DSM-5 criteria do not cover volition/motivation among the 18 symptoms and signs assessed by textbook authors.
“Volition/motivation | Not covered”
Quote in the paperSubstantial claim - Findingown data
DSM-5 criteria do not cover depersonalization/derealization among the 18 symptoms and signs assessed by textbook authors.
“Depersonalization/derealization | Not covered”
Quote in the paperSubstantial claim - Premisecitation
Since DSM-III, the field has moved toward a reification of DSM that implicitly assumes psychiatric disorders are actually just the DSM criteria.
“However, its wide use has produced an unanticipated side effect-the reification of the DSM criteria (2).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [2] source
- Premisecitation
Hypersomnia was introduced into the Feighner criteria, although it was not in the two earlier sets of diagnostic criteria for depression that influenced the Feighner criteria.
“One of these symptoms (hypersomnia) was introduced into the Feighner criteria (although it was not in the two earlier sets of diagnostic criteria for depression that influenced the Feighner criteria [33,34]).”
Quote in the paperSubstantial claim0 of 2 sources checked - Interpretationown data
Important features of major depression are not captured by DSM criteria.
“These results suggest that important features of major depression are not captured by DSM criteria.”
Quote in the paperSubstantial claim - Interpretationreasoning
Many in the field have made a serious category mistake in how they have understood and used DSM criteria; they have confused an index of a thing with the thing itself.
“I wish to argue that many in our field have made a serious category mistake in the ways in which we have understood and used the DSM criteria.Put succinctly, we have confused an index of a thing with the thing itself.”
Quote in the paperNot a substantial claim - Interpretationreasoning
If we conflate criteria with disorders, we are in the awkward position of suggesting that anxiety is not important in major depression because it is not in our criteria.
“If we conflate our criteria with our disorders, we are then in the awkward position of suggesting that anxiety is not important in major depression because it is not in our criteria.”
Quote in the paperSubstantial claim - Premisereasoning
In their use as diagnostic criteria, the incompleteness of DSM criteria is unproblematic because, across all of medicine, diagnostic criteria are designed to index rather than exhaustively describe a clinical syndrome.
“In their use as diagnostic criteria, this is unproblematic because, across all of medicine, diagnostic criteria are designed to index rather than exhaustively describe a clinical syndrome.”
Quote in the paperSubstantial claim - Premisenone given
Many symptomatic criteria for major depression, such as changes in appetite, weight, psychomotor performance, and sleep, can be quickly and reliably assessed.
“Many of the symptomatic criteria for major depression-such as changes in appetite, weight, psychomotor performance, and sleep-can be quickly and reliably assessed.”
Quote in the paperSubstantial claim - Premisecitation
For most diagnostic criteria, rapidity and reliability of assessment is critical.
“First, for most diagnostic criteria, rapidity and reliability of assessment is critical.”
Quote in the paperSubstantial claim - Interpretationnone given
DSM criteria for major depression are a good index of the clinical syndrome of depression.
“To be explicit, our DSM criteria for major depression are a good index of the clinical syndrome of depression.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The depressive syndrome is not entirely constituted by the DSM criteria.
“But, as my historical survey suggests, this depressive syndrome is not entirely constituted by the DSM criteria.”
Quote in the paperSubstantial claim- Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
- Interpretationreasoning
The DSM symptomatic criteria for major depression do a reasonable but incomplete job of assessing the prominent clinical symptoms and signs of depressive illness as described in the Western post-Kraepelinian psychiatric tradition.
“The DSM symptomatic criteria for major depression do a reasonable but incomplete job of assessing the prominent clinical symptoms and signs of depressive illness as described in the Western post-Kraepelinian psychiatric tradition.”
Quote in the paperSubstantial claim- Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
- Premisecitation
The developers of DSM-III explicitly preferred criteria that required low levels of inference because such criteria are typically more reliable.
“The developers of DSM-III explicitly preferred criteria that required low levels of inference, because these are typically more reliable (40).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [40] Decker HS, 2013
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationreasoning
We have been misusing the DSM diagnostic criteria because we have confused them with the diagnostic entities they are designed to assess.
“I suggest that, to many intents and purposes, we have been misusing the DSM diagnostic criteria because we have confused them with the diagnostic entities they are designed to assess.”
Quote in the paperNot a substantial claim - Premisenone given
Some important features of psychiatric disorders may be subtle and time-consuming to evaluate.
“But some important features of psychiatric disorders may not be like that.They may be subtle, and time-consuming to evaluate.”
Quote in the paperSubstantial claim - Interpretationcitation
Once we have a name-MI, Apgar, IQ, or DSM major depression-we are at risk of confusing our index with the thing itself, that is, what it was developed to measure.
“Once we have a name-MI, Apgar, IQ, or DSM major depression-we are at risk of confusing our index with the thing itself, that is, what it was developed to measure.”
Quote in the paperNot a substantial claim
- Classified as probably not a substantial claim. 24
- May combine two claims. 26
Probably not a substantial claim: may not pass S3 (load-bearing).
FindingcitationThere has been a diminution in psychopathological expertise and interest since the advent of DSM-III.
“Second, it does not explain the diminution in psychopathological expertise and interest since the advent of DSM-III (4).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites [4] source
May combine two claims.
Findingown dataCompared with the DSM criteria, the textbook authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms.
“Compared with the DSM criteria, these authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataDepression-associated depersonalization and derealization were noted in 12 textbooks, and no DSM-5 criteria for major depression describe this kind of depressive symptomatology.
“Depression-associated depersonalization and derealization were noted in 12 of the textbooks.A number of descriptions were provided, including everything feeling changed or unreal, seeing the world through a mist, and perplexity.No DSM-5 criteria for major depression describe this kind of depressive symptomatology.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataLewis commented on all but two of the symptoms and signs developed from the textbook review, indicating a high degree of consilience between the two sources.
“First, Lewis comments on all but two of the symptoms and signs that I developed from the textbook review, so there is a high degree of consilience between these two sources of information (Table 3).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [7] source
May combine two claims.
Findingown dataPsychomotor changes were reported by all but one textbook author; 12 described only psychomotor retardation and six also commented on agitation; these signs are well presented in DSM-5 criterion A5.
“Psychomotor changes were reported by all but one author, 12 of whom described only aspects of psychomotor retardation and six of whom also commented on agitation.These signs are well presented in DSM-5 criterion A5.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataSpeech that was slow, hesitant, indistinct, and/or monosyllabic was described by all but two textbook authors and is not included in DSM-5.
“Speech that was slow, hesitant, indistinct, and/ or monosyllabic was described by all but two authors.This symptom is not included in DSM-5.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataVarious aspects of anxiety, including panic attacks and obsessive fears, were noted by 14 textbook authors, but anxiety is not included in the DSM criteria for major depression.
“Various aspects of anxiety, including panic attacks and obsessive fears, were noted by 14 authors, but anxiety is not included in the DSM criteria for major depression.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataLowered mood, impairment in cognitive function, and psychomotor changes are all well reflected in the DSM criteria for major depression.
“All three of these are well reflected in the DSM criteria for major depression.”
Quote in the paperSubstantial claimMay combine two claims.
FindingcitationCompared with DSM-5 criteria, Muncie's 1939 criteria included symptoms of depersonalization and derealization and gave greater emphasis to physiological symptoms and changes in facial expression and posture.
“Compared with the DSM-5 criteria, Muncie's criteria included symptoms of depersonalization and derealization and gave greater emphasis to physiological symptoms and changes in facial expression and posture.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [22] Muncie W, 1939 source
May combine two claims.
Findingown dataThe next most common central symptom, volitional changes, was noted by only 20% of these authors and is not described in DSM-5 criteria.
“The next most common central symptom, volitional changes, was noted by only 20% of these authors and is not described in DSM-5 criteria.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOther physical symptoms and signs were noted by 17 textbook authors, most commonly gastrointestinal complaints, diminished libido, amenorrhea, headaches, and changes in facial expression and posture; these are not captured by any part of the DSM-5 A criterion for major depression.
“Other physical symptoms and signs, noted by 17 authors, was the most difficult symptom category to summarize.Most commonly described were gastrointestinal complaints, but diminished libido, amenorrhea, and headaches were also often noted.Also frequently described were changes in facial expression and posture.These phenomena are not captured by any part of the A criterion in DSM-5 major depression.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataTen of the 18 symptoms and signs were well described by the DSM A criteria for major depression and one by a criterion for melancholia.
“As seen in Table 4, ten of the 18 symptoms and signs were well described by the DSM A criteria for major depression and one by a criterion for melancholia.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataPoor appetite and weight loss were described by 10 and nine textbook authors respectively, consistent with DSM criterion A3.
“Poor appetite and weight loss were described by, respectively, 10 and nine textbook authors, consistent with DSM criterion A3.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone givenNearly all textbook authors commented on changes in the speech of depressed patients, most typically describing it as slow, low in volume, with long pauses; this sign is not in DSM-5.
“Eighth, nearly all authors commented on changes in the speech of depressed patients, most typically describing it as slow, low in volume, with long pauses.This sign is not in DSM-5.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe textbook authors gave less importance to the neurovegetative features of depression-changes in sleep, appetite, and weight-than the DSM criteria do, and no author noted them as key depressive symptoms.
“Fifth, the textbook authors gave less importance to the neurovegetative features of depression-changes in sleep, appetite, and weight-than the DSM criteria do.No author noted them as key depressive symptoms.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based).
Findingnone givenThe nature of psychiatric practice changed during the 20th century, with outpatient care constituting a larger proportion of our work, especially after 1960.
“First, the nature of psychiatric practice changed during the 20th century, with outpatient care constituting a larger proportion of our work, especially after 1960.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
FindingreasoningBy the time DSM-III was published in 1980, the majority of depressed patients were being seen in ambulatory settings and were often more mildly ill.
“By the time DSM-III was published in 1980, the majority of depressed patients were being seen in ambulatory settings and were often more mildly ill.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
Findingnone givenMany classical textbook authors believed that derealization was an important clinical feature of major depression.
“But many of our classical textbook authors believed that derealization was an important clinical feature of major depression.”
- Also stated in: § Illustrations of the Problems Associated With Our Category Mistake · plain
“Yet, senior clinicians of earlier generations thought it was a critical feature of the depressive syndrome that reflected their patients' lived experiences.”
Quote in the paperNot a substantial claim- Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
- Also stated in: § Illustrations of the Problems Associated With Our Category Mistake · plain
Probably not a substantial claim: may not pass S4 (based). May combine two claims.
Findingnone givenFor the key major depression criteria A1 and A7, DSM-5 lists three and two descriptors, respectively.
“For the key major depression criteria A1 and A7, DSM-5 lists three and two descriptors, respectively.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S4 (based).
Findingnone givenMost textbook writers considered anxiety to be a prominent and clinically important part of the presentation of major depression.
“Most of our textbook writers considered anxiety to be a prominent and clinically important part of the presentation of major depression.”
Quote in the paperNot a substantial claim- Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
Classified as probably not a substantial claim.
Findingnone givenMany classical textbook writers were seeing severely depressed patients in hospitals.
“Many of the classical textbook writers were seeing severely depressed patients in hospitals.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based).
Findingnone givenMany mental health clinicians have conflated clinical evaluation and assessment of DSM criteria in clinical work, research, and teaching.
“First, it fails to recognize the degree to which many mental health clinicians have conflated clinical evaluation and assessment of DSM criteria in our clinical work, research, and teaching.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningMeeting the DSM criteria for major depression is not the same thing as having major depression, and the DSM criteria do not constitute clinically significant depression.
“But meeting the DSM criteria for major depression is not the same thing as having major depression.The DSM criteria do not constitute clinically significant depression.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationIncreased eating and weight gain were introduced into the Research Diagnostic Criteria for major depression and carried over into all subsequent editions of DSM.
“Increased eating and weight gain were introduced into the Research Diagnostic Criteria (35) for major depression and carried over into all subsequent editions of DSM.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [35] Spitzer RL, 1975
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S2 (checkable), S4 (based). May combine two claims.
InterpretationreasoningThis conceptual error has contributed to the impoverishment of psychopathology and has affected research, clinical work, and teaching in undesirable ways.
“This conceptual error has contributed to the impoverishment of psychopathology and has affected our research, clinical work, and teaching in some undesirable ways.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S4 (based).
InterpretationreasoningThe critique does not address the underlying conceptual problems of diagnostic literalism and reification that arise directly from our category mistake of confusing our fallible diagnostic criteria with the categories they are designed to assess.
“Third and most importantly, the critique does not address the underlying conceptual problems of diagnostic literalism and reification that arise directly from our category mistake of confusing our fallible diagnostic criteria with the categories they are designed to assess.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
PremisereasoningDevelopers of diagnostic criteria are appropriately concerned about specificity.
“Second, developers of diagnostic criteria are also appropriately concerned about specificity.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningMany of us have become diagnostic literalists with respect to DSM, stymied by an excessive respect for our own creation.
“Many of us have become diagnostic literalists with respect to DSM, stymied by an excessive respect for own creation.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
PremisereasoningDiagnostic criteria need only to identify true cases with sufficient sensitivity and specificity, and not to reflect complete catalogs of important symptoms and signs.
“That is, criteria need only to identify true cases with sufficient sensitivity and specificity, and not to reflect complete catalogs of important symptoms and signs.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningIt is problematic when we focus our teaching, our clinical work, and our research solely around DSM criteria.
“But it is problematic when we focus our teaching, our clinical work, and our research solely around DSM criteria.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningThe presence of such validators helps illustrate the difference between indexing and constituting a disorder.
“The presence of such validators helps illustrate the difference between indexing and constituting a disorder.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningBy losing sight of the indexical function of diagnostic criteria and confounding the criteria with the disorders themselves, we open the door to reification.
“By losing sight of the indexical function of our diagnostic criteria and confounding the criteria with the disorders themselves, we open the door to reification.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Premisenone givenThe goals of those who develop diagnostic criteria are not the same as those of the textbook writers, with the former being much more concerned with brevity, reliability (and hence low inferential content), and specificity.
“Third, as noted above, the goals of those who develop diagnostic criteria are not the same as those of the textbook writers, with the former being much more concerned with brevity, reliability (and hence low inferential content), and specificity.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationreasoningDerealization did not make it into DSM because it is a subtle concept, time-consuming to evaluate, and perhaps of limited reliability.
“We can understand why this did not make it into DSM: It is a subtle concept, time-consuming to evaluate, and perhaps of limited reliability.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationIt is possible, although unlikely given modest symptomatic differences seen for depression in major depression as compared with bipolar illness, that some of the differences between the symptoms described and those listed in the DSM-5 criteria result from admixture of patients with bipolar illness.
“It is possible, although unlikely given modest symptomatic differences seen for depression in major depression as compared with bipolar illness (37), that some of the differences between the symptoms described and those listed in the DSM-5 criteria result from admixture of patients with bipolar illness.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [37] source
Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.
InterpretationreasoningDSM criteria are imperfect approximations created by a very human process that, although scientifically informed, could not be claimed by any knowledgeable individual to be infallible.
“DSM criteria are imperfect approximations created by a very human process that, although scientifically informed, could not be claimed by any knowledgeable individual to be infallible.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
InterpretationreasoningThe DSM-5 descriptor lists for criteria A1 and A7 are too short to capture adequately the range of human experience of the mood state of depression and the range of self-derogatory/pessimistic depressive cognitions.
“As illustrated by our textbook writers, these lists are too short to capture adequately the range of human experience of the mood state of depression and the range of self-derogatory/pessimistic depressive cognitions.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningGiven our pride in diagnosis and lack of definitive validators, our field has undergone a conceptual creep in which our criteria have mistakenly become our disorder.
“Given our pride in our diagnosis and our lack of definitive validators, it is understandable that our field has had undergone a”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
PremisereasoningA symptom could be clinically important, but if it is shared by many other syndromes, it would likely not make a good diagnostic criterion.
“A symptom could be quite clinically important, but if it is shared by many other syndromes, it would likely not make a good diagnostic criterion.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Premisenone givenTo be practical, diagnostic criteria need to be succinct.
“Third, to be practical, diagnostic criteria need to be succinct.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable). May combine two claims.
Interpretationnone givenDSM criteria have been enshrined in diagnostic algorithms and structured interviews, and are so often required by journal and grant reviewers that they approach the tokens of an orthodox faith.
“These criteria have been enshrined in our diagnostic algorithms and structured interviews, and are so often required by journal and grant reviewers that they approach the tokens of an orthodox faith.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
Textbooks are the best place to obtain expert opinion about the important symptoms and signs of depression.
“I focus initially on textbooks as the best place to obtain expert opinion about the important symptoms and signs of depression.”
The paper relies on this without support.
The 19 selected textbooks are representative of the post-Kraepelinian Western psychiatric tradition circa 1900-1960.
“In total, 19 textbooks, published from 1899 to 1956 from five countries (nine from the United States, seven from the United Kingdom, and one each from Germany, France, and Switzerland), met inclusion criteria.”
The paper relies on this without support.
The textbook descriptions and Lewis's cases accurately reflect the phenomenology of depressive illness or major depression.
“I next review the phenomenology of depression described by Aubrey Lewis in what is the most detailed survey of the phenomenology of depression written in the 20th century (7).”
The paper relies on this without support.
Lewis's monograph is the most detailed survey of the phenomenology of depression written in the 20th century.
“I next review the phenomenology of depression described by Aubrey Lewis in what is the most detailed survey of the phenomenology of depression written in the 20th century (7).”
The paper relies on this without support.
The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
“The DSM symptomatic criteria for major depression do a reasonable but incomplete job of assessing the prominent clinical symptoms and signs of depressive illness as described in the Western post-Kraepelinian psychiatric tradition.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Abstract understates the number of symptoms covered by DSM criteria
MinorThe abstract says 10 symptoms or signs are covered by criteria for major depression or melancholia. The quantitative analysis counts 10 well covered by major-depression criteria plus one covered by a melancholia criterion, for a total of 11.
“Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia.”
“ten of the 18 symptoms and signs were well described by the DSM A criteria for major depression and one by a criterion for melancholia.”
Dana textbook has two publication years
MinorTable 1 dates Dana's textbook to 1907, while its bibliography entry gives 1904.
“| Dana, 1907 (11) | Mental |”
“11. Dana CL: Text-Book of Nervous Diseases and Psychiatry: For the Use of Students and Practitioners of Medicine, 6th rev and enlarged ed. New York, William Wood, 1904”
Conflicting counts of central neurovegetative symptoms
MinorOne section says one author considered a sleep, appetite, or weight change central to depression; a later section says no author considered those changes key symptoms.
“Of note, only one author described neurovegetative changes in sleep, appetite, or weight as a central symptom of depression.”
“No author noted them as key depressive symptoms.”
Cites
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Major Depression and Its Recurrences: Life Course Matters
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“Cardinal presentations of depression (16), most notably anhedonia, are thought to reflect alterations of the experience of reward (17, 18).”
BackgroundEpidemiology of anxiety disorders: from surveys to nosology and back.
Stein, D. J., Scott, K. M., de Jonge, P., & Kessler, R. C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/dstein · Cited by 283 · see citing works
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“However, DSM descriptions are narrower than descriptions of MDD found in textbook literature (Kendler, 2016), and common rating scales for depression feature over 50 distinct symptoms (Fried, 2017).”
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“Finally, the lack of deep symptomatic pro fi les is the most egregious omission in genetic studies of MDD. Central to MDD are episodic severe shifts of mood, together with neurovegetative and cognitive changes [43, 132, 133].”
BackgroundStudying Mental Health Problems as Systems, Not Syndromes
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“And if Wernicke (an influential competitor of one of the founding fathers of modern psychiatry, Kraepelin) had not died prematurely in a bicycle accident, psychiatric nosology as a whole might look somewhat different today (Kendler, 2016a).”
BackgroundEditorial: What is depression?
Stringaris, A. K. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12844 · Cited by 155 · see citing works
Risio, L. D., Borgi, M., Pettorruso, M., Miuli, A., Ottomana, A. M., Sociali, A., Martinotti, G., Nicolò, G., Macrı̀, S., Giannantonio, M. D., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01055-2 · Cited by 139 · see citing works
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“…through DSM-5, that various important features of major depression highlighted previously were not captured by the DSM criteria (e.g. cognitive, somatic, and psychomotor changes), while formerly devalued others were given greater emphasis (e.g. sleep, appetite, and weight problems) (Kendler, 2016).”
BackgroundVerduijn, J., Verhoeven, J. E., Milaneschi, Y., Schoevers, R. A., van Hemert, A. M., Beekman, A. T. F., & Penninx, B. W. J. H. (2017) · BMC Medicine · doi:10.1186/s12916-017-0972-8 · Cited by 122 · see citing works
“However, in a recent review paper [32], Kendler showed that the large majority of descriptions of major depression up until the 1960s included anxiety as a symptom of depression.”
BackgroundMeasurement-based Care in Psychiatry-Past, Present, and Future.
Aboraya, A., Nasrallah, H. A., Elswick, D. E., Ahmed, E., Estephan, N., Aboraya, D., Berzingi, S., Chumbers, J., Berzingi, S., Justice, J., et al. (2018) · Europe PMC (PubMed Central) · Cited by 121 · see citing works
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Phenomenology of Schizophrenia and the Representativeness of Modern Diagnostic Criteria
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Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
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“Introduction Depression is a recurrent and devastating mental disease that is highly prevalent worldwide [1].”
BackgroundAnhedonia in Depressive Disorder: A Narrative Review
Fruyt, J. D., Sabbe, B., & Demyttenaere, K. (2020) · Psychopathology · doi:10.1159/000508773 · Cited by 97 · see citing works
Epistemic Injustice and Psychiatric Classification
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“…diagnostic criteria fail to sufficiently represent the clinical reality and phenomenology of mental disorders (e.g., Parnas and Sass 2003; Andreasen 2006; Kendler 2016), which leads to a lack of clinical utility and has negative impacts on the treatment of patients (e.g., Sadler 2005; Tekin 2015).”
BackgroundMixed symptoms in major depressive and bipolar disorders: A systematic review
Vázquez, G. H., Lolich, M., Cabrera, C., Jokic, R., Kolar, D., Tondo, L., & Baldessarini, R. J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.006 · Cited by 88 · see citing works
“…2011; Fountoulakis et al., 2012; Judd et al., 2012; Muralidharan et al., 2013; Gotlib and LeMoult, 2014; Shim et al., 2014; Uher et al., 2014; Perugi et al., 2015; Popovic et al., 2015; Kendler, 2016; Kennedy et al., 2016; Petri et al., 2017; Barbuti et al., 2017b; Rosenblat and McIntyre, 2017).”
BackgroundPhilosophy of psychiatry: theoretical advances and clinical implications
Stein, D. J., Nielsen, K., Hartford, A., Gagné‐Julien, A., Glackin, S. N., Friston, K. J., Maj, M., Zachar, P., & Aftab, A. (2024) · World Psychiatry · doi:10.1002/wps.21194 · Cited by 84 · see citing works
“Clinicians ought to be aware that important features of mental disorders may well have been described in the psychiatric literature, and yet may not be listed in the DSM 118 .”
BackgroundImplications of the Hierarchical Structure of Psychopathology for Psychiatric Neuroimaging
Zald, D. H., & Lahey, B. B. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.02.003 · Cited by 76 · see citing works
“Factor analysis studies indicate that these first-order dimensions generally (but not universally) parallel different DSM-IV/DSM-5 diagnoses (8–13), although there is some circularity in such studies given that the symptoms queried are frequently limited to those that are included in the DSM. Examination of first-orde…”
Mental Disorders Around the World
Scott, K. M., de Jonge, P., Stein, D. J., & Kessler, R. C. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316336168 · Cited by 75 · see citing works
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900
Kendler, K. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.148 · Cited by 75 · see citing works
Self-citationGeraci, J., Wilansky, P., Luca, V. D., Roy, A., Kennedy, J. L., & Strauss, J. (2017) · Evidence-Based Mental Health · doi:10.1136/eb-2017-102688 · Cited by 72 · see citing works
“28 Psychiatric symptoms have successfully been extracted from EMR data on patients with serious mental illness, 29 and this may be an alternative approach; to improve on a symptom-based phenotyping method, a network/complex dynamic system model may also be informative.”
MethodUeafuea, K., Boonnag, C., Sudhawiyangkul, T., Leelaarporn, P., Gulistan, A., Chen, W., Mukhopadhyay, S. C., Wilaiprasitporn, T., & Piyayotai, S. (2020) · IEEE Sensors Journal · doi:10.1109/jsen.2020.3046259 · Cited by 72 · see citing works
“1) Increased Depression Levels During COVID-19: Individuals with depression may display several clinical features such as negative cognitive contexts as well as psychomotor signs and symptoms, leading to difficulties with decision making, and eventually other psychological disorders such as major depression [66].”
BackgroundPharmacological Challenge Studies with Acute Psychosocial Stress
van Hedger, K., Bershad, A., & de Wit, H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.08.020 · Cited by 67 · see citing works
“There is growing recognition that symptoms of depression and anxiety have significant overlap, and researchers have questioned whether they indeed reflect separate underlying disorders (Kendler, 2016; MacNamara et al., 2017).”
Murri, M. B., Caruso, R., Ounalli, H., Zerbinati, L., Berretti, E., Costa, S., Recla, E., Folesani, F., Kissane, D. W., Nanni, M. G., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.074 · Cited by 68 · see citing works
The Origin of Our Modern Concept of Depression—The History of Melancholia From 1780-1880: A Review
Kendler, K. S. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4709 · Cited by 65 · see citing works
Self-citationDSM disorders and their criteria: how should they inter-relate?
Kendler, K. S. (2017) · Psychological Medicine · doi:10.1017/s0033291717000678 · Cited by 65 · see citing works
Self-citationThe centrality of DSM and non-DSM depressive symptoms in Han Chinese women with major depression
Kendler, K. S., Aggen, S. H., Jonathan Flint, C., Borsboom, D., & Fried, E. I. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.032 · Cited by 61 · see citing works
“A recent review provided a broader historical context within which to view the DSM criteria for MD (Kendler, 2016).”
InfluentialSelf-citationAli, A., Siddiqui, A. A., Arshad, M. S., Iqbal, F., & Arif, T. B. (2021) · Annales Médico-psychologiques revue psychiatrique · doi:10.1016/j.amp.2021.02.004 · Cited by 60 · see citing works
“In this study, self-reported lack of otivation, tiredness, and frequency of getting involved with amily conflicts – all of which come under DSM-V criteria of mental ealth problems [14] – were significantly positively related to edia usage after controlling all covariates.”
BackgroundPre-pubertal bipolar disorder: origins and current status of the controversy
Duffy, A. C., Carlson, G. A., Dubicka, B., & Hillegers, M. H. J. (2020) · International Journal of Bipolar Disorders · doi:10.1186/s40345-020-00185-2 · Cited by 60 · see citing works
“That is, we have taken the index of something for the thing itself” (Kendler 2016).”
BackgroundGao, W., Yan, X., & Yuan, J. (2022) · Psychoradiology · doi:10.1093/psyrad/kkac014 · Cited by 63 · see citing works
“…found that depression is associated with broad impairments in cognitive functioning, and cognitive deficits have been listed in the Diagnostic and Statistical Manual of Mental Disorders that can reflect depressive symptoms (Kendler, 2016; Martínez-Arán et al. , 2004; Withall et al. , 2009).”
BackgroundMaron‐Katz, A., Zhang, Y., Narayan, M., Wu, W., Toll, R. T., Naparstek, S., Angeles, C. D. L., Longwell, P., Shpigel, E., Newman, J., et al. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010060 · Cited by 56 · see citing works
Adolescent depression beyond DSM definition: a network analysis
Manfro, P. H., Pereira, R. B., Rosa, M., Cogo‐Moreira, H., Fisher, H. L., Kohrt, B. A., Mondelli, V., & Kieling, C. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01908-1 · Cited by 59 · see citing works
“Highly central nodes in our results such as pessimism and hopelessness are important clinical features of depression [11, 12, 48], but neither is adequately captured by the DSM A7 criteria of excessive guilt and worthlessness [12].”
BackgroundMethodInfluentialChristensen, M. C., Fagiolini, A., Florea, I., Loft, H., Cuomo, A., & Goodwin, G. M. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.07.099 · Cited by 52 · see citing works
Benatar, M. G., Wuu, J., Huey, E. D., McMillan, C. T., Petersen, R. C., Postuma, R. B., McHutchison, C. A., Dratch, L., Arias, J. J., Crawley, A., et al. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00961-z · Cited by 57 · see citing works
“…MBI on the Rascovsky criteria maximizes compatibility but runs the risk of failing to include cognitive, behavioural and neuropsychiatric symptoms that are not included in the Rascovsky criteria, especially since prodromal symptoms might differ from clinically manifest symptoms of an illness 35 .”
Morales-García, W. C., Vallejos, M. A., Sairitupa-Sanchez, L. Z., Morales-García, S. B., Rivera‐Lozada, O., & Morales-García, M. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1268336 · Cited by 60 · see citing works
“Depression is a common mental disorder characterized by symptoms like persistent sadness and loss of interest (35).”
Backgroundvon Mücke-Heim, I.-A., Urbina-Treviño, L., Bordes, J., Ries, C., Schmidt, M. V., & Deussing, J. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01762-w · Cited by 51 · see citing works
Vigor, Effort-Related Aspects of Motivation and Anhedonia
Treadway, M. T., & Salamone, J. D. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_355 · Cited by 48 · see citing works
Decline of depressive symptoms in Europe: differential trends across the lifespan
Beller, J., Regidor, E., Lostao, L., Miething, A., Kröger, C. B., Safieddine, B., Tetzlaff, F., Sperlich, S., & Geyer, S. (2020) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-020-01979-6 · Cited by 51 · see citing works
Digital phenotyping in depression diagnostics: Integrating psychiatric and engineering perspectives
Kamath, J., León-Barriera, R., Jain, N., Keisari, E. J., & Wang, B. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i3.393 · Cited by 54 · see citing works
Memantine in neurological disorders – schizophrenia and depression
Czarnecka, K., Chuchmacz, J., Wójtowicz, P., & Szymański, P. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01982-z · Cited by 46 · see citing works
Bech, P., Austin, S. F., & Lau, M. E. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1451918 · Cited by 45 · see citing works
“Clinical decisions on the DSM-IV diagnosis of major depression is inherently a task for the treating clinicians, not for the patients.”
BackgroundInfluentialBore, M. C., Liu, X., Gan, X., Wang, L., Xu, T., Ferraro, S., Li, L., Zhou, B., Zhang, J., Vatansever, D., et al. (2023) · Psychological Medicine · doi:10.1017/s0033291723003410 · Cited by 47 · see citing works
Criticisms of Kraepelin’s Psychiatric Nosology: 1896–1927
Kendler, K. S., & Engstrom, E. J. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.17070730 · Cited by 43 · see citing works
Self-citationBalbuena, L., Bowen, R., Baetz, M., & Marwaha, S. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00174 · Cited by 42 · see citing works
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BackgroundInfluentialThe clinical features of mania and their representation in modern diagnostic criteria
Kendler, K. S. (2016) · Psychological Medicine · doi:10.1017/s0033291716003238 · Cited by 41 · see citing works
“Second, operationalized criteria for mania have changed very modestly since the Feighner criteria, in notable contrast to schizophrenia (Kendler, 2016b).”
BackgroundMethodResultInfluentialSelf-citationKendler, K. S., Gardner, C. O., Neale, M. C., Aggen, S. H., Heath, A. C., Colodro‐Conde, L., Couvy‐Duchesne, B., Byrne, E. M., Martin, N. G., & Gillespie, N. A. (2018) · Psychological Medicine · doi:10.1017/s003329171800377x · Cited by 39 · see citing works
“These temporally dynamic features, essential to the clinical concept of MD since the late 19th century (Kraepelin, 1990; Kendler, 2016, 2017), are not assessed in typical self-report depressive symptom inventories (Fried, 2016) or in personality measures like Neuroticism.”
BackgroundSelf-citationPsychiatric comorbidity: a concept in need of a theory
Nordgaard, J., Nielsen, K. M., Rasmussen, A. R., & Henriksen, M. G. (2023) · Psychological Medicine · doi:10.1017/s0033291723001605 · Cited by 40 · see citing works
The benefits of antidepressants: news or fake news?
Parker, G. B. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.98 · Cited by 35 · see citing works
More phenomenology in psychiatry? Applied ontology as a method towards integration
Larsen, R. R., Maschião, L. F., Piedade, V. L., Messas, G. P., & Hastings, J. (2022) · The Lancet Psychiatry · doi:10.1016/s2215-0366(22)00156-0 · Cited by 35 · see citing works
Public epistemic trustworthiness and the integration of patients in psychiatric classification
Bueter, A. (2018) · Synthese · doi:10.1007/s11229-018-01913-z · Cited by 34 · see citing works
“ogy of mental disorders (e.g., Andreasen 2006; Kendler 2016; Parnas and Sass 2003), which leads to a lack of clinical utility (e.”
BackgroundKendler, K. S. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw161 · Cited by 29 · see citing works
Self-citationMørch, R. H., Dieset, I., Færden, A., Hope, S., Aas, M., Nerhus, M., Gardsjord, E. S., Haram, M., Falk, R. S., Joa, I., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12783 · Cited by 28 · see citing works
“Even though we do not find significant associations between the inflammatory markers and changes in psychotic and/or affective symptoms in the present sample, inflammation may also be related to other features of severe mental disorders such as cognitive function (31) or neurovegetative symptoms like changes in sleep…”
BackgroundBreeksema, J. J., Niemeijer, A. R., Kuin, B., Veraart, J. K. E., Vermetten, E. H. G. J. M., Kamphuis, J., van den Brink, W., & Schoevers, R. A. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06388-6 · Cited by 30 · see citing works
“Interestingly, detachment, or disconnection, has been called a core element of depression (Karp, 1997; Osler, 2022), and there are other similarities in how depressive and ketamine states are described, such as diminished affect; emptiness or void; and decreased selfimportance (Kendler, 2016).”
BackgroundHankin, B. L., & Griffith, J. M. (2023) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-023-00437-4 · Cited by 33 · see citing works
The interpersonal structure of depression
Ratcliffe, M. (2018) · Psychoanalytic Psychotherapy · doi:10.1080/02668734.2018.1455729 · Cited by 26 · see citing works
“For instance, it has been argued that it fails to distinguish a range of importantly different predicaments (Ratcliffe, 2015), has undergone an unprincipled widening of scope (Horwitz & Wakefield, 2007), and tends to be mistakenly ‘reified’ (Kendler, 2016).”
BackgroundDirection of Dependence Between Specific Symptoms of Depression: A Non-Gaussian Approach
Velázquez, R. G., Jokela, M. M., & Rosenström, T. H. (2019) · Clinical Psychological Science · doi:10.1177/2167702619875410 · Cited by 24 · see citing works
“Depression presents with many different symptoms (Fried, 2017; Kendler, 2016), but its diagnosis is reduced to nine diagnostic criteria in Major Depressive Disorder (MDD), as defined by the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM–5; American Psychiatric Association, 2013).”
Backgroundvan Zelst, D. C. R., Veltman, E. M., Rhebergen, D., Naarding, P., Kok, A. A. L., Ottenheim, N. R., & Giltay, E. J. (2022) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5787 · Cited by 23 · see citing works
Psychopathological dimensions and the clinician's subjective experience
Picardi, A., Pallagrosi, M., Fonzi, L., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.079 · Cited by 23 · see citing works
Imaging genetics paradigms in depression research: Systematic review and meta-analysis
Pereira, L. P., Köhler, C. A., Stubbs, B., Miskowiak, K. W., Morris, G., de Freitas, B. P., Thompson, T., Fernandes, B. S., Brunoni, A. R., Maes, M. H. J., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.012 · Cited by 24 · see citing works
“However, the search for genetic risk variants for depression has been challenging, partially due to the phenotypic heterogeneity of this syndrome that may imply distinct genetic architectures (Kendler, 2016; Mullins and Lewis, 2017).”
Lin, J., Ling, F., Huang, P., Chen, M., Song, M., Lu, K., & Wang, W. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.874137 · Cited by 23 · see citing works
Advance in Diagnosis of Depressive Disorder
Fang, Y., & Wu, Z. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_9 · Cited by 21 · see citing works
Moods in Clinical Depression Are More Unstable than Severe Normal Sadness
Bowen, R., Peters, E. M., Marwaha, S., Baetz, M., & Balbuena, L. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00056 · Cited by 20 · see citing works
“Moods in broadly defined depression would likely appear even more complex and distressing if anxiety, irritability, and psychotic symptoms were included (63).”
BackgroundTrait anhedonia is a transdiagnostic correlate of internalizing problems during adolescence
Conway, C., Li, Y. I., & Starr, L. R. (2019) · Journal of Research in Personality · doi:10.1016/j.jrp.2019.05.004 · Cited by 22 · see citing works
Cai, N., Verhulst, B., Andreassen, O. A., Buitelaar, J. K., Edenberg, H. J., Hettema, J. M., Gandal, M. J., Grotzinger, A. D., Jonas, K. G., Lee, P., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02878-x · Cited by 18 · see citing works
“DSM criteria do not, nor are they designed to, exhaustively capture the diagnostic complexity of any speci fi c disorder [63, 64].”
Self-citationA closer look at the nosological status of the highs (hypomanic symptoms) in the postpartum period
Sharma, V., Singh, P., Baczynski, C., & Khan, M. (2020) · Archives of Women s Mental Health · doi:10.1007/s00737-020-01023-1 · Cited by 20 · see citing works
“To rephrase Kendler (2016), we should not confuse the index of a thing (the Highs scale) with the thing (the highs) itself.”
BackgroundDelirium disorder: Unity in diversity
Oldham, M. A. (2021) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2021.11.007 · Cited by 19 · see citing works
Fried, E. I., & Haslbeck, J. M. B. (2018) · doi:10.31234/osf.io/84ske · Cited by 17 · see citing works
Bech, P., & Timmerby, N. (2018) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2018.1465592 · Cited by 18 · see citing works
“This has recently been strengthened by Kendler [10].”
ResultBitan, D. T., Grossman‐Giron, A., Alon, G., Mendlovic, S., Bloch, Y., & Segev, A. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1897-2 · Cited by 18 · see citing works
McPherson, S., Rost, F., Town, J. M., & Abbass, A. A. (2018) · Psychoanalytic Psychotherapy · doi:10.1080/02668734.2018.1458331 · Cited by 18 · see citing works
“Experiences of depression will have been affected by this and there is no scientific basis for the assumption that experience of depression is a static biological phenomenon (see, for example Kendler, 2016).”
BackgroundViduani, A. C., Arenas, D. L., Benetti, S. P. D. C., Wahid, S. S., Kohrt, B. A., & Kieling, C. (2024) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2023.11.013 · Cited by 18 · see citing works
Alves, L. P. D. C., & da Rocha, N. S. (2018) · Bipolar Disorders · doi:10.1111/bdi.12636 · Cited by 17 · see citing works
Studying mental health problems as systems, not syndromesPreprint
Fried, E. I. (2021) · doi:10.31234/osf.io/k4mhv · Cited by 17 · see citing works
Tiego, J., Martin, E. A., DeYoung, C. G., et al. (2022) · doi:10.31219/osf.io/geh6q · Cited by 17 · see citing works
Stewart, J. G., Singleton, P., Benau, E. M., Dan, F.-T., Allchurch, H., Kaplan, C., Aguirre, B., & Auerbach, R. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000439 · Cited by 12 · see citing works
“For example, in one study, reduced reward-related delta predicted the onset of MDD over and above the timedomain RewP and increased the sensitivity and positive predictive value of the models (Nelson et al., 2018).”
Backgroundvan Loo, H. M., Aggen, S. H., & Kendler, K. S. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.064 · Cited by 17 · see citing works
“This is in line with older descriptions of MD in the pre-DSM literature, in which less importance was attributed to sleep, appetite, and weight than in the DSM (Kendler, 2016).”
ResultSelf-citationde Oliveira-Júnior, B. A., Marques, D. B., Rossignoli, M. T., Prizon, T., Leite, J. P., & Ruggiero, R. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-59984-7 · Cited by 16 · see citing works
“For instance, according to the DSM-5 criteria, major depression diagnosis requires the presence of 5 out of 9 criteria, potentially resulting in two individuals sharing just 1 symptom yet receiving the same diagnosis 3 .”
Rajewska‐Rager, A., Dmitrzak‐Węglarz, M., Lepczyńska, N., Kapelski, P., Pawlak, J., Szczepankiewicz, A., Wilczynski, M., & Skibińska, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12051744 · Cited by 15 · see citing works
A critical evaluation of dynamical systems models of bipolar disorder
Nunes, A., Singh, S., Allman, J., Becker, S., Ortiz, A., Trappenberg, T. P., & Alda, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02194-4 · Cited by 14 · see citing works
“, the AR[1] model) [30, 39] (Cohen’s κ= 0.”
Prototypes of People With Depression
Ziano, I., & Koç, Y. (2023) · Psychological Science · doi:10.1177/09567976231204035 · Cited by 14 · see citing works
“This is because diagnoses and diagnostic instruments are varied and unreliable (Fried et al., 2022) and should not be blindly relied on, lest we fall into “diagnostic realism” (i.e., mistaking diagnoses for syndromes) (Kendler, 2016; Kendler et al., 2011).”
BackgroundBorges-Aguiar, A. C., Schauffer, L. Z., de Kloet, E. R., & Schenberg, L. C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.020 · Cited by 13 · see citing works
“Because the lack of pleasure and appetite are conspicuous symptoms of depression [61], the preference for sucrose is taken as an index of euthymia.”
The challenge of psychiatric diagnosis: Looking beyond the symptoms to the company that they keep
Duffy, A. C., Malhi, G. S., & Carlson, G. A. (2018) · Bipolar Disorders · doi:10.1111/bdi.12686 · Cited by 13 · see citing works
Extending the usefulness of the verbal memory test: The promise of machine learning
Chandler, C., Holmlund, T. B., Foltz, P. W., Cohen, A. S., & Elvevåg, B. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.113743 · Cited by 13 · see citing works
“Currently, measurements of symptoms and signs of psychiatric disorders are often conflated with the underlying disorders themselves, but these limits must be carefully avoided in diagnostic assessment (Kendler, 2016).”
BackgroundMichal, M., Wiltink, J., Tibubos, A. N., Wild, P. S., Münzel, T. F., Lackner, K. J., Pfeiffer, N., König, J., Gieswinkel, A., Beutel, M. E., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05658-7 · Cited by 12 · see citing works
“However, these symptoms were frequently described as part of major depression in older textbooks of psychiatry or psychological medicine published from ∼ 1900 to 1960 [14].”
BackgroundGlucose Metabolic Abnormality: A Crosstalk between Depression and Alzheimer’s Disease
Yang, S., Li, Y., Tang, Q., Zhang, Y., & Shao, T. (2024) · Current Neuropharmacology · doi:10.2174/011570159x343281240912190309 · Cited by 12 · see citing works
“Generally, depression is defined by constant feelings of sadness and a lack of interest in activities that are usually enjoyed, and symptoms include energy loss, change in appetite, anxiety, or feelings of worthlessness [38].”
Rosenström, T. H., Fawcett, T. W., Higginson, A. D., Metsä‐Simola, N., Hagen, E. H., Houston, A. I., & Martikainen, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179495 · Cited by 12 · see citing works
“For example, Rosenstro¨m & Jokela [58] showed that the current DSM definition includes a sub-population that have no disability and therefore may represent false positive diagnoses (the symptoms they found unnecessary have not been present in many older definitions of MD [60]).”
A Multi-Dimensional Pluralist Response to the DSM-Controversies
Bueter, A. (2019) · Perspectives on Science · doi:10.1162/posc_a_00309 · Cited by 12 · see citing works
“For instance, several authors have argued that the operationalist criteria of the DSM do not do justice to the complex phenomenology of mental disorders (e.g., Andreasen 2006; Kendler 2016; Parnas and Sass 2003).”
BackgroundDuffy, A. C., & Grof, P. (2024) · International Journal of Bipolar Disorders · doi:10.1186/s40345-024-00333-y · Cited by 11 · see citing works
“…defaulting to a checklist approach to confirm a psychiatric diagnosis is not new and goes to the heart of the principles of evidence-based medicine (Duffy et al. 2018; Kendler 2016; ) - that is using all of the available informative evidence in the formulation of a diagnosis and treatment plan.”
BackgroundYang, J., Li, J., Zhao, S., Zhang, Y., Li, B., & Liu, X. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106964 · Cited by 12 · see citing works
Mulc, D., Vukojević, J., Kalafatic, E., Cifrek, M., Vidović, D., & Jović, A. (2025) · Sensors · doi:10.3390/s25020409 · Cited by 13 · see citing works
Assessment of Depression in Adults and Youth
Klein, D. N. (2023) · Assessment · doi:10.1177/10731911231167446 · Cited by 13 · see citing works
“…of explicit diagnostic criteria in the early 1970s (Feighner et al., 1972) and continuing to the present day, the construct of depression was narrowed by eliminating symptoms that overlapped with anxiety and somatoform disorders to maximize its distinctiveness from other diagnoses (Kendler, 2016).”
BackgroundInfluentialIncreasing the Role of Phenomenology in Psychiatric Diagnosis–The Clinical Staging Approach
Drożdżowicz, A. (2020) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1093/jmp/jhaa022 · Cited by 11 · see citing works
“…and does not provide adequate tools for psychiatric practice and research (e.g., Parnas, Sass, and Zahavi, 2013; Kendler, 2016).5 To show that the above criticism is based on more than theoretical reflection, Kenneth Kendler (2016) provides a useful case study that illustrates the criticism.”
BackgroundMethodInfluentialSampson, E., Kavakbasi, E., Mills, N. T., Hori, H., Schubert, K. O., Fourrier, C., & Baune, B. T. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad066 · Cited by 10 · see citing works
“…reduced ability to feel pleasure or enjoyment for usual interests and hobbies and, in more pronounced form, inability to enjoy or feel anything positive or negative or complete emotional unresponsiveness has been recognized as a core symptomatic feature in depressed individuals (Kendler, 2016).”
Background
- Authors
- Kendler, K. S.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Kendler, Kenneth S.
- ORCID
- Kendler, Kenneth S.
- Venue
- American Journal of Psychiatry
- Published
- 2016-08-01
- Volume
- 173
- Issue
- 8
- Pages
- 771-780
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2346168897
- Cited by
- 255
- References
- 42
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 32 · 2023: 20 · 2022: 27 · 2021: 19 · 2020: 24 · 2019: 15 · 2018: 27 · 2017: 27 · 2016: 5 · 2013: 1
- FWCI
- 153.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
- Keywords
- major depressive disorder, DSM-5 diagnostic criteria, melancholia, history of psychiatry, psychomotor symptoms, neurovegetative symptoms, depersonalization/derealization
- MeSH terms
- Attitude of Health Personnel, Curriculum, Major Depressive Disorder, Diagnosis, Differential, Education, Medical, Humans, Psychopathology, Research, Textbooks as Topic, United States, Diagnostic and Statistical Manual of Mental Disorders
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