Cited by 256Mental Health and PsychiatryTreatment of Major DepressionPsychology and Mental Health

The Phenomenology of Major Depression and the Representativeness and Nature of DSM Criteria.

Open access
Kendler, Kenneth S.·2016·American Journal of Psychiatry

Abstract

How should DSM criteria relate to the disorders they are designed to assess? To address this question empirically, the author examines how well DSM-5 symptomatic criteria for major depression capture the descriptions of clinical depression in the post-Kraepelin Western psychiatric tradition as described in textbooks published between 1900 and 1960. Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia. For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks. Five symptoms and signs (changes in volition/motivation, slowing of speech, anxiety, other physical symptoms, and depersonalization/derealization) are not present in the DSM criteria. Compared with the DSM criteria, these authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms. These results suggest that important features of major depression are not captured by DSM criteria. This is unproblematic as long as DSM criteria are understood to index rather than constitute psychiatric disorders. However, since DSM-III, our field has moved toward a reification of DSM that implicitly assumes that psychiatric disorders are actually just the DSM criteria. That is, we have taken an index of something for the thing itself. For example, good diagnostic criteria should be succinct and require minimal inference, but some critical clinical phenomena are subtle, difficult to assess, and experienced in widely varying ways. This conceptual error has contributed to the impoverishment of psychopathology and has affected our research, clinical work, and teaching in some undesirable ways.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.2016.15121509

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

1 of 10 cited sources checked · 1 supported · 0 flagged

  • Findingown data

    Eighteen symptoms and signs of depression were described in the textbooks, 10 of which are covered by the DSM criteria for major depression or melancholia.

    “Eighteen symptoms and signs of depression were described, 10 of which are covered by the DSM criteria for major depression or melancholia.”
    Quote in the paperSubstantial claim
  • Findingown data

    For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks.

    “For two symptoms (mood and cognitive content), DSM criteria are considerably narrower than those described in the textbooks.”
    Quote in the paperSubstantial claim
  • Findingreasoning

    The descriptive literature placed greater relative emphasis on cognitive and attitudinal changes associated with depression than do the DSM criteria, where these features constitute only one criterion characterized solely by worthlessness and guilt.

    “Second, the descriptive literature placed greater relative emphasis on the cognitive and attitudinal changes associated with depression than do the DSM criteria, where these features constitute only one criterion, characterized solely by worthlessness and guilt.”
    Quote in the paperSubstantial claim
  • Findingown data

    None of the textbook authors noted increased appetite and weight gain, which are also described in DSM criterion A3.

    “However, none of the authors noted increased appetite and weight gain, which are also described in this DSM criterion.”
    Quote in the paperSubstantial claim
  • Findingown data

    Fatigue, exhaustion, and feelings of being tired out, well captured by DSM criterion A6, were described by only eight textbook authors.

    “Fatigue, exhaustion, and feelings of being tired out, symptoms well captured by DSM criterion A6, were described by only eight authors.”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim. 24
  • May combine two claims. 26
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation

    There has been a diminution in psychopathological expertise and interest since the advent of DSM-III.

    “Second, it does not explain the diminution in psychopathological expertise and interest since the advent of DSM-III (4).”
    Quote in the paperNot a substantial claim1 of 1 sources checked
  • May combine two claims.

    Findingown data

    Compared with the DSM criteria, the textbook authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms.

    “Compared with the DSM criteria, these authors gave greater emphasis to cognitive, physical, and psychomotor changes, and less to neurovegetative symptoms.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Depression-associated depersonalization and derealization were noted in 12 textbooks, and no DSM-5 criteria for major depression describe this kind of depressive symptomatology.

    “Depression-associated depersonalization and derealization were noted in 12 of the textbooks.A number of descriptions were provided, including everything feeling changed or unreal, seeing the world through a mist, and perplexity.No DSM-5 criteria for major depression describe this kind of depressive symptomatology.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Lewis commented on all but two of the symptoms and signs developed from the textbook review, indicating a high degree of consilience between the two sources.

    “First, Lewis comments on all but two of the symptoms and signs that I developed from the textbook review, so there is a high degree of consilience between these two sources of information (Table 3).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [7] source
  • May combine two claims.

    Findingown data

    Psychomotor changes were reported by all but one textbook author; 12 described only psychomotor retardation and six also commented on agitation; these signs are well presented in DSM-5 criterion A5.

    “Psychomotor changes were reported by all but one author, 12 of whom described only aspects of psychomotor retardation and six of whom also commented on agitation.These signs are well presented in DSM-5 criterion A5.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Speech that was slow, hesitant, indistinct, and/or monosyllabic was described by all but two textbook authors and is not included in DSM-5.

    “Speech that was slow, hesitant, indistinct, and/ or monosyllabic was described by all but two authors.This symptom is not included in DSM-5.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Various aspects of anxiety, including panic attacks and obsessive fears, were noted by 14 textbook authors, but anxiety is not included in the DSM criteria for major depression.

    “Various aspects of anxiety, including panic attacks and obsessive fears, were noted by 14 authors, but anxiety is not included in the DSM criteria for major depression.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Lowered mood, impairment in cognitive function, and psychomotor changes are all well reflected in the DSM criteria for major depression.

    “All three of these are well reflected in the DSM criteria for major depression.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingcitation

    Compared with DSM-5 criteria, Muncie's 1939 criteria included symptoms of depersonalization and derealization and gave greater emphasis to physiological symptoms and changes in facial expression and posture.

    “Compared with the DSM-5 criteria, Muncie's criteria included symptoms of depersonalization and derealization and gave greater emphasis to physiological symptoms and changes in facial expression and posture.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [22] Muncie W, 1939 source
  • May combine two claims.

    Findingown data

    The next most common central symptom, volitional changes, was noted by only 20% of these authors and is not described in DSM-5 criteria.

    “The next most common central symptom, volitional changes, was noted by only 20% of these authors and is not described in DSM-5 criteria.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Other physical symptoms and signs were noted by 17 textbook authors, most commonly gastrointestinal complaints, diminished libido, amenorrhea, headaches, and changes in facial expression and posture; these are not captured by any part of the DSM-5 A criterion for major depression.

    “Other physical symptoms and signs, noted by 17 authors, was the most difficult symptom category to summarize.Most commonly described were gastrointestinal complaints, but diminished libido, amenorrhea, and headaches were also often noted.Also frequently described were changes in facial expression and posture.These phenomena are not captured by any part of the A criterion in DSM-5 major depression.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Ten of the 18 symptoms and signs were well described by the DSM A criteria for major depression and one by a criterion for melancholia.

    “As seen in Table 4, ten of the 18 symptoms and signs were well described by the DSM A criteria for major depression and one by a criterion for melancholia.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Poor appetite and weight loss were described by 10 and nine textbook authors respectively, consistent with DSM criterion A3.

    “Poor appetite and weight loss were described by, respectively, 10 and nine textbook authors, consistent with DSM criterion A3.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingnone given

    Nearly all textbook authors commented on changes in the speech of depressed patients, most typically describing it as slow, low in volume, with long pauses; this sign is not in DSM-5.

    “Eighth, nearly all authors commented on changes in the speech of depressed patients, most typically describing it as slow, low in volume, with long pauses.This sign is not in DSM-5.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The textbook authors gave less importance to the neurovegetative features of depression-changes in sleep, appetite, and weight-than the DSM criteria do, and no author noted them as key depressive symptoms.

    “Fifth, the textbook authors gave less importance to the neurovegetative features of depression-changes in sleep, appetite, and weight-than the DSM criteria do.No author noted them as key depressive symptoms.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    The nature of psychiatric practice changed during the 20th century, with outpatient care constituting a larger proportion of our work, especially after 1960.

    “First, the nature of psychiatric practice changed during the 20th century, with outpatient care constituting a larger proportion of our work, especially after 1960.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Findingreasoning

    By the time DSM-III was published in 1980, the majority of depressed patients were being seen in ambulatory settings and were often more mildly ill.

    “By the time DSM-III was published in 1980, the majority of depressed patients were being seen in ambulatory settings and were often more mildly ill.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    Many classical textbook authors believed that derealization was an important clinical feature of major depression.

    “But many of our classical textbook authors believed that derealization was an important clinical feature of major depression.”
    • Also stated in: § Illustrations of the Problems Associated With Our Category Mistake · plain
      “Yet, senior clinicians of earlier generations thought it was a critical feature of the depressive syndrome that reflected their patients' lived experiences.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
  • Probably not a substantial claim: may not pass S4 (based). May combine two claims.

    Findingnone given

    For the key major depression criteria A1 and A7, DSM-5 lists three and two descriptors, respectively.

    “For the key major depression criteria A1 and A7, DSM-5 lists three and two descriptors, respectively.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    Most textbook writers considered anxiety to be a prominent and clinically important part of the presentation of major depression.

    “Most of our textbook writers considered anxiety to be a prominent and clinically important part of the presentation of major depression.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.
  • Classified as probably not a substantial claim.

    Findingnone given

    Many classical textbook writers were seeing severely depressed patients in hospitals.

    “Many of the classical textbook writers were seeing severely depressed patients in hospitals.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given

    Many mental health clinicians have conflated clinical evaluation and assessment of DSM criteria in clinical work, research, and teaching.

    “First, it fails to recognize the degree to which many mental health clinicians have conflated clinical evaluation and assessment of DSM criteria in our clinical work, research, and teaching.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationreasoning

    Meeting the DSM criteria for major depression is not the same thing as having major depression, and the DSM criteria do not constitute clinically significant depression.

    “But meeting the DSM criteria for major depression is not the same thing as having major depression.The DSM criteria do not constitute clinically significant depression.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    Increased eating and weight gain were introduced into the Research Diagnostic Criteria for major depression and carried over into all subsequent editions of DSM.

    “Increased eating and weight gain were introduced into the Research Diagnostic Criteria (35) for major depression and carried over into all subsequent editions of DSM.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [35] Spitzer RL, 1975

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S2 (checkable), S4 (based). May combine two claims.

    Interpretationreasoning

    This conceptual error has contributed to the impoverishment of psychopathology and has affected research, clinical work, and teaching in undesirable ways.

    “This conceptual error has contributed to the impoverishment of psychopathology and has affected our research, clinical work, and teaching in some undesirable ways.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S4 (based).

    Interpretationreasoning

    The critique does not address the underlying conceptual problems of diagnostic literalism and reification that arise directly from our category mistake of confusing our fallible diagnostic criteria with the categories they are designed to assess.

    “Third and most importantly, the critique does not address the underlying conceptual problems of diagnostic literalism and reification that arise directly from our category mistake of confusing our fallible diagnostic criteria with the categories they are designed to assess.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).

    Premisereasoning

    Developers of diagnostic criteria are appropriately concerned about specificity.

    “Second, developers of diagnostic criteria are also appropriately concerned about specificity.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    Many of us have become diagnostic literalists with respect to DSM, stymied by an excessive respect for our own creation.

    “Many of us have become diagnostic literalists with respect to DSM, stymied by an excessive respect for own creation.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.

    Premisereasoning

    Diagnostic criteria need only to identify true cases with sufficient sensitivity and specificity, and not to reflect complete catalogs of important symptoms and signs.

    “That is, criteria need only to identify true cases with sufficient sensitivity and specificity, and not to reflect complete catalogs of important symptoms and signs.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    It is problematic when we focus our teaching, our clinical work, and our research solely around DSM criteria.

    “But it is problematic when we focus our teaching, our clinical work, and our research solely around DSM criteria.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    The presence of such validators helps illustrate the difference between indexing and constituting a disorder.

    “The presence of such validators helps illustrate the difference between indexing and constituting a disorder.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Interpretationreasoning

    By losing sight of the indexical function of diagnostic criteria and confounding the criteria with the disorders themselves, we open the door to reification.

    “By losing sight of the indexical function of our diagnostic criteria and confounding the criteria with the disorders themselves, we open the door to reification.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Premisenone given

    The goals of those who develop diagnostic criteria are not the same as those of the textbook writers, with the former being much more concerned with brevity, reliability (and hence low inferential content), and specificity.

    “Third, as noted above, the goals of those who develop diagnostic criteria are not the same as those of the textbook writers, with the former being much more concerned with brevity, reliability (and hence low inferential content), and specificity.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationreasoning

    Derealization did not make it into DSM because it is a subtle concept, time-consuming to evaluate, and perhaps of limited reliability.

    “We can understand why this did not make it into DSM: It is a subtle concept, time-consuming to evaluate, and perhaps of limited reliability.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationcitation

    It is possible, although unlikely given modest symptomatic differences seen for depression in major depression as compared with bipolar illness, that some of the differences between the symptoms described and those listed in the DSM-5 criteria result from admixture of patients with bipolar illness.

    “It is possible, although unlikely given modest symptomatic differences seen for depression in major depression as compared with bipolar illness (37), that some of the differences between the symptoms described and those listed in the DSM-5 criteria result from admixture of patients with bipolar illness.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [37] source
  • Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.

    Interpretationreasoning

    DSM criteria are imperfect approximations created by a very human process that, although scientifically informed, could not be claimed by any knowledgeable individual to be infallible.

    “DSM criteria are imperfect approximations created by a very human process that, although scientifically informed, could not be claimed by any knowledgeable individual to be infallible.”
    Quote in the paperNot a substantial claim
  • Classified as probably not a substantial claim. May combine two claims.

    Interpretationreasoning

    The DSM-5 descriptor lists for criteria A1 and A7 are too short to capture adequately the range of human experience of the mood state of depression and the range of self-derogatory/pessimistic depressive cognitions.

    “As illustrated by our textbook writers, these lists are too short to capture adequately the range of human experience of the mood state of depression and the range of self-derogatory/pessimistic depressive cognitions.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Interpretationreasoning

    Given our pride in diagnosis and lack of definitive validators, our field has undergone a conceptual creep in which our criteria have mistakenly become our disorder.

    “Given our pride in our diagnosis and our lack of definitive validators, it is understandable that our field has had undergone a”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable).

    Premisereasoning

    A symptom could be clinically important, but if it is shared by many other syndromes, it would likely not make a good diagnostic criterion.

    “A symptom could be quite clinically important, but if it is shared by many other syndromes, it would likely not make a good diagnostic criterion.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).

    Premisenone given

    To be practical, diagnostic criteria need to be succinct.

    “Third, to be practical, diagnostic criteria need to be succinct.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.

    Interpretationnone given

    DSM criteria have been enshrined in diagnostic algorithms and structured interviews, and are so often required by journal and grant reviewers that they approach the tokens of an orthodox faith.

    “These criteria have been enshrined in our diagnostic algorithms and structured interviews, and are so often required by journal and grant reviewers that they approach the tokens of an orthodox faith.”
    Quote in the paperNot a substantial claim
41 of 41
  • The paper relies on this without support.

    Textbooks are the best place to obtain expert opinion about the important symptoms and signs of depression.

    “I focus initially on textbooks as the best place to obtain expert opinion about the important symptoms and signs of depression.”
  • The paper relies on this without support.

    The 19 selected textbooks are representative of the post-Kraepelinian Western psychiatric tradition circa 1900-1960.

    “In total, 19 textbooks, published from 1899 to 1956 from five countries (nine from the United States, seven from the United Kingdom, and one each from Germany, France, and Switzerland), met inclusion criteria.”
  • The paper relies on this without support.

    The textbook descriptions and Lewis's cases accurately reflect the phenomenology of depressive illness or major depression.

    “I next review the phenomenology of depression described by Aubrey Lewis in what is the most detailed survey of the phenomenology of depression written in the 20th century (7).”
  • The paper relies on this without support.

    Lewis's monograph is the most detailed survey of the phenomenology of depression written in the 20th century.

    “I next review the phenomenology of depression described by Aubrey Lewis in what is the most detailed survey of the phenomenology of depression written in the 20th century (7).”
  • The paper relies on this without support.

    The 19 textbooks examined are representative of the Western post-Kraepelinian psychiatric tradition.

    “The DSM symptomatic criteria for major depression do a reasonable but incomplete job of assessing the prominent clinical symptoms and signs of depressive illness as described in the Western post-Kraepelinian psychiatric tradition.”
5 of 5

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Abstract understates the number of symptoms covered by DSM criteria

    Minor

    The abstract says 10 symptoms or signs are covered by criteria for major depression or melancholia. The quantitative analysis counts 10 well covered by major-depression criteria plus one covered by a melancholia criterion, for a total of 11.

  • Dana textbook has two publication years

    Minor

    Table 1 dates Dana's textbook to 1907, while its bibliography entry gives 1904.

  • Conflicting counts of central neurovegetative symptoms

    Minor

    One section says one author considered a sleep, appetite, or weight change central to depression; a later section says no author considered those changes key symptoms.

3 of 3

Cites

Flagged first, then by citations

Research works printed but not linked: 4

  1. Burton R, 1893, The Anatomy of Melancholia
  2. White WA, 1913, Outlines of Psychiatry: Nervous and Mental Disease Monograph Series No 1
  3. Mayer-Gross W, 1954, Clinical Psychiatry
  4. Spitzer RL, 1975, Research Diagnostic Criteria for a Selected Group of Functional Disorders

Cited by

Sorted by citations

Authors
Kendler, K. S.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Kendler, Kenneth S.
Venue
American Journal of Psychiatry
Published
2016-08-01
Volume
173
Issue
8
Pages
771-780
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2346168897
Cited by
255
References
42
Citations by year
2026: 25 · 2025: 32 · 2024: 32 · 2023: 20 · 2022: 27 · 2021: 19 · 2020: 24 · 2019: 15 · 2018: 27 · 2017: 27 · 2016: 5 · 2013: 1
FWCI
153.04
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
Keywords
major depressive disorder, DSM-5 diagnostic criteria, melancholia, history of psychiatry, psychomotor symptoms, neurovegetative symptoms, depersonalization/derealization
MeSH terms
Attitude of Health Personnel, Curriculum, Major Depressive Disorder, Diagnosis, Differential, Education, Medical, Humans, Psychopathology, Research, Textbooks as Topic, United States, Diagnostic and Statistical Manual of Mental Disorders

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