Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: a literature review and metaanalysis
Abstract
Thyroxine is the standard replacement therapy for patients with clinical hypothyroidism. However, there has been recent interest in examining the potential advantages of combined thyroxine and triiodothyronine treatment for the treatment of hypothyroidism. The authors review the nine studies to-date and conclude that the variability and limitations in study design make definitive and clinically useful recommendations difficult. They therefore conducted a metaanalysis of the nine controlled studies examining the impact of combined thyroxine-plus-triiodothyronine versus thyroxine alone, with measures of psychiatric symptoms as the primary outcome. Their analysis reveals no significant difference in treatment effect on psychiatric symptoms in the nine controlled studies to date.
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Four systematic reviews and meta-analyses based on RCTs failed to show any advantages in quality of life, mood states, or psychometric performance for patients receiving combination therapy.
“Four systematic reviews and meta-analyses based on RCTs failed to show any advantages in quality of life, mood states, or psychometric performance for patients receiving combination therapy (160–163).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [162]
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- Authors
- Joffe, R. T., Brimacombe, M., Levitt, A. J., & Stagnaro-Green, A.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Joffe, Russell T.
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 48
- Issue
- 5
- Pages
- 379-384
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2117756761
- Cited by
- 57
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 11 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- overt hypothyroidism, thyroxine, triiodothyronine, thyroid hormone replacement, psychiatric symptoms, depression
- MeSH terms
- Drug Therapy, Combination, Humans, Hypothyroidism, Thyroxine, Triiodothyronine, Treatment Outcome
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