Cited by 57Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: a literature review and metaanalysis

Joffe, Russell T., Brimacombe, Michael, Levitt, Anthony J., Stagnaro-Green, Alex·2007·Psychosomatics

Abstract

Thyroxine is the standard replacement therapy for patients with clinical hypothyroidism. However, there has been recent interest in examining the potential advantages of combined thyroxine and triiodothyronine treatment for the treatment of hypothyroidism. The authors review the nine studies to-date and conclude that the variability and limitations in study design make definitive and clinically useful recommendations difficult. They therefore conducted a metaanalysis of the nine controlled studies examining the impact of combined thyroxine-plus-triiodothyronine versus thyroxine alone, with measures of psychiatric symptoms as the primary outcome. Their analysis reveals no significant difference in treatment effect on psychiatric symptoms in the nine controlled studies to date.

Integrity signals

Registry

Crossref · 10.1176/appi.psy.48.5.379

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24 of 24 references verified0 citation errors · 0 not checkable

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  • Four systematic reviews and meta-analyses based on RCTs failed to show any advantages in quality of life, mood states, or psychometric performance for patients receiving combination therapy.

    “Four systematic reviews and meta-analyses based on RCTs failed to show any advantages in quality of life, mood states, or psychometric performance for patients receiving combination therapy (160–163).”

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Authors
Joffe, R. T., Brimacombe, M., Levitt, A. J., & Stagnaro-Green, A.
Affiliations
University of Toronto (CA)
Corresponding author
Joffe, Russell T.
Venue
Psychosomatics
Publisher
Elsevier BV
Published
2007-09
Volume
48
Issue
5
Pages
379-384
ISSN
0033-3182 (ISSN-L)
OpenAlex
W2117756761
Cited by
57
References
24
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 11 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Locations
  • Psychosomatics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
overt hypothyroidism, thyroxine, triiodothyronine, thyroid hormone replacement, psychiatric symptoms, depression
MeSH terms
Drug Therapy, Combination, Humans, Hypothyroidism, Thyroxine, Triiodothyronine, Treatment Outcome

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