Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism

Singer, Peter A.

doi:10.1001/jama.1995.03520340064038

Cited by 427Thyroid Disorders and TreatmentsClinical practice guidelines implementationThyroid and Parathyroid Surgery

Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism

Singer, Peter A.·1995·JAMA: The Journal of the American Medical Association

DOI 10.1001/jama.1995.03520340064038

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Abstract

Objective To develop a set of minimum clinical guidelines for use by primary care physicians in the evaluation and management of patients with hyperthyroidism and hypothyroidism. Participants Guidelines were developed by a nine-member ad hoc Standards of Care Committee of the American Thyroid Association (the authors of this article). The participants were selected by the committee chair and the president of the American Thyroid Association on the basis of their clinical experience. The committee members represented different geographic areas within the United States, in order to take into account different practice styles. Evidence Guidelines were developed on the basis of expert opinion of the participants, as well as on available published information. Consensus process Input was obtained from all of the participants, each of whom wrote an initial section of the document. A complete draft document was then written by three participants (P.A.S., D.S.C., and E.G.L.) and resubmitted to the entire committee for revision. The revised document was then submitted to the entire membership of the American Thyroid Association for written comments, which were then reviewed (mainly by P.A.S., D.S.C., and E.G.L.). Many of the suggestions of the American Thyroid Association members were incorporated into the final draft, which was then approved by the Executive Council of the American Thyroid Association. The entire process, from initial drafts to final approval, took approximately 18 m…

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The options of treatment with L-T3 or the combination of L-T4 and L-T3 have largely been abandoned.
“The options of treatment with L-T3 or the combination of L-T4 and L-T3 therefore have largely been abandoned [2,3] .”
From 2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism (2012) · cites this paper as [2]

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Method
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Background
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Background
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“As serum half-lives of both agents are quite short, i.e. 4±6 h for MMI and 75 minutes for PTU, it is suggested that both agents should be administered in divided daily doses (Burman, 1995; McKenzie & Zakarija, 1995; Utiger, 1995; Reed Larsen et al., 1998; Cooper, 2000).”
Background
CLINICAL AND LABORATORY DIAGNOSIS OF THYROTOXICOSIS
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Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves’ hyperthyroidism
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Authors: Singer, P. A.
Affiliations: University of Southern California (US)
Corresponding author: Singer, Peter A.
Venue: JAMA: The Journal of the American Medical Association
Publisher: American Medical Association (AMA)
Published: 1995-03-08
Volume: 273
Issue: 10
Pages: 808
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.1995.03520340064038
OpenAlex: W2011275871
Cited by: 427
References: 0
Citations by year: 2026: 2 · 2025: 6 · 2024: 7 · 2023: 13 · 2022: 16 · 2021: 13 · 2020: 11 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 16 · 2013: 16 · 2012: 27
FWCI: 11.50
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords: hyperthyroidism, hypothyroidism, thyroid dysfunction, diagnosis, treatment, primary care, consensus recommendations, American Thyroid Association

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Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism

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