Neuroendocrine responses to methylphenidate and d-amphetamine: applications to attention-deficit disorder
Abstract
The authors reviewed the studies of the neuroendocrine secretion of growth hormone, prolactin, and cortisol as they relate to attention-deficit hyperactivity disorder (ADHD). Studies to date have focused on the hormonal responses to the stimulants (amphetamines and methylphenidate) in children and adults. The authors discuss the methodologic limitations of current studies, the implications of this research for an understanding of the pathophysiology of ADHD, as well as the mechanisms of action of the stimulants and the side effect of stimulant-related growth suppression. They also suggest directions for future research.
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Acute effects on growth hormone and prolactin have been observed, but do not yet explain persisting growth deficits.
“Acute effects on growth hormone and prolactin have been observed, but do not yet explain persisting growth deficits [18, 37, 84].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [84]
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European guidelines on managing adverse effects of medication for ADHD
(for the European Guidelines Group), Graham, J., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Döpfner, M., Hamilton, R., Hollis, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0140-6 · Cited by 374 · see citing works
- Authors
- Lurie, S., & O'Quinn, A. N.
- Affiliations
- Duke Medical Center (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 1991-02-01
- Volume
- 3
- Issue
- 1
- Pages
- 41-50
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2432032963
- Cited by
- 31
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- attention deficit hyperactivity disorder, methylphenidate, d-amphetamine, stimulants, neuroendocrine response, growth hormone, prolactin, cortisol, growth inhibition, stimulant side effects, pathophysiology
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Growth Disorders, Humans, Methylphenidate, Neurosecretory Systems
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