Cited by 31Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorAdrenal Hormones and Disorders

Neuroendocrine responses to methylphenidate and d-amphetamine: applications to attention-deficit disorder

S Lurie, Aglaia N. O'Quinn·1991·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

The authors reviewed the studies of the neuroendocrine secretion of growth hormone, prolactin, and cortisol as they relate to attention-deficit hyperactivity disorder (ADHD). Studies to date have focused on the hormonal responses to the stimulants (amphetamines and methylphenidate) in children and adults. The authors discuss the methodologic limitations of current studies, the implications of this research for an understanding of the pathophysiology of ADHD, as well as the mechanisms of action of the stimulants and the side effect of stimulant-related growth suppression. They also suggest directions for future research.

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Registry

Crossref · 10.1176/jnp.3.1.41

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Acute effects on growth hormone and prolactin have been observed, but do not yet explain persisting growth deficits.

    “Acute effects on growth hormone and prolactin have been observed, but do not yet explain persisting growth deficits [18, 37, 84].”

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Authors
Lurie, S., & O'Quinn, A. N.
Affiliations
Duke Medical Center (US)
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
1991-02-01
Volume
3
Issue
1
Pages
41-50
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W2432032963
Cited by
31
References
57
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2014: 1 · 2013: 2 · 2012: 2
FWCI
0.08
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
attention deficit hyperactivity disorder, methylphenidate, d-amphetamine, stimulants, neuroendocrine response, growth hormone, prolactin, cortisol, growth inhibition, stimulant side effects, pathophysiology
MeSH terms
Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dextroamphetamine, Growth Disorders, Humans, Methylphenidate, Neurosecretory Systems

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