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Cited by 14Abdominal vascular conditions and treatmentsSepsis Diagnosis and TreatmentInflammatory Biomarkers in Disease Prognosis

The Prognostic Value of C-Reactive Protein/Albumin Ratio in Acute Mesenteric Ischemia

Kaçer, İlker, Çağlar, Ahmet, Akıllı, Nazire Belgin·2023·The American Surgeon™
DOI 10.1177/00031348221074220
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Abstract

Background Diagnosis of acute mesenteric ischemia (AMI) in its early stages is important for reversing ischemic damage. The CRP to albumin (CRP/Alb) ratio has been defined as an inflammatory indicator and is associated with the severity of inflammation and mortality rates. However, the prognostic value of CRP/Alb has not been evaluated in patients with AMI. Here, we aimed to examine the prognostic significance of CRP/Alb and compare it with other inflammatory markers. Materials and Methods In this retrospective, case-control study, we included patients diagnosed with AMI at the emergency department between January 1, 2016, and December 31, 2020. In addition to demographic characteristics, lactate, D-dimer, white blood cell (WBC), CRP/Alb, and neutrophil/lymphocyte ratio (NLR) were recorded. Testing characteristics of CRP/Alb in predicting in-hospital mortality were studied. Results The mean age of 132 patients was 66.48 ± 15.95 years and 71 (53.8%) of them were male. The cut-off value obtained using the receiver operating characteristic (ROC) curve for in-hospital mortality was a CRP/Alb ratio of >1.32 (sensitivity, 93.65%; specificity, 69.57%; +LR, 3.08; −LR, .091; AUC, .782; 95% CI, .70-.85; P < .0001). The comparison of ROC curves between CRP/Alb and WBC, NLR, and lactate revealed a statistically significant difference ( P < .05), whereas there was not any statistically significant difference between the ROC curves of CRP/Alb and D-dimer ( P = .47). Conclusion C-reactive protein/albumin ratio is a powerful predictor of in-hospital mortality for AMI patients. It was superior to WBC, NLR, and lactate. It could be used to determine low-risk patients and help clinicians with treatment options.

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  • A CRP to albumin ratio is a powerful predictor of in-hospital mortality in acute mesenteric ischemia, surpassing white blood cell count, neutrophil to lymphocyte ratio, and lactate levels.

    “For instance, a CRP to albumin ratio has been identified as a powerful predictor of in-hospital mortality, surpassing white blood cell count, neutrophil to lymphocyte ratio, and lactate levels [20].”

    From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [20]

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Authors
Kaçer, İ., Çağlar, A., & Akıllı, N. B.
Affiliations
  • Aksaray University (TR)
  • Konya Eğitim ve Araştırma Hastanesi (TR)
Corresponding author
Kaçer, İlker
ORCID
Venue
The American Surgeon™
Publisher
SAGE Publications
Published
2022-01-25
Volume
89
Issue
5
Pages
1661-1667
ISSN
  • 0003-1348 (ISSN-L)
  • 1555-9823
DOI
10.1177/00031348221074220
OpenAlex
W4207016738
Cited by
14
References
23
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3
FWCI
2.64
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The American Surgeon (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
acute mesenteric ischemia, C-reactive protein to albumin ratio, prognostic factors, in-hospital mortality, neutrophil-to-lymphocyte ratio, lactate, D-dimer, white blood cell count, inflammatory markers, mortality prediction
MeSH terms
Aged, 80 and over, C-Reactive Protein, Female, Humans, Lactates, Male, Prognosis, Retrospective Studies, ROC Curve, Serum Albumin, Case-Control Studies, Mesenteric Ischemia

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