Effects of the Total Triterpenic Fraction of Centella Asiatica in Venous Hypertensive Microangiopathy: A Prospective, Placebo-Controlled, Randomized Trial
Abstract
The aim of this study was to demonstrate whether total triterpenic fraction of Centella asiatica (TTFCA), was effective in improving the microcirculation in venous hypertension and microangiopathy. Forty patients with severe venous hypertension, ankle swelling, lipodermatosclerosis were included. After informed consent, patients were randomized into a treatment and a placebo group: those in the treatment group received TTFCA (tablets, 60 mg, twice daily for 8 weeks). The two groups of subjects were comparable for age and sex distribution. The mean age was 48 years (SD 9; M:F= 11:11) in the treatment group (22 patients) and 47.6 (SD 7; M:F= 10:8) in the placebo group (18 patients). There were no differences between placebo and treatment group at inclusion; there was no change between inclusion and measurements at 8 weeks in the placebo group. A decrease (p < 0.05) in RF (flux at rest) and RAS (rate of ankle swelling) were observed in the treatment group. The decrease in capillary filtration was associated with improvement in signs and symptoms (p < 0.05). The difference in flux, signs and symptoms, and filtration was clinically important at 8 weeks. No side effects were observed. In conclusion venous microangiopathy was improved by TTFCA treatment.
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C. asiatica extracts positively influence wound healing by improving collagen synthesis and microcirculatory function.
“C. asiatica extracts have been shown to positively influence wound healing by improving collagen synthesis [18,21] and microcirculatory function [22,23].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [22]
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- Authors
- Cesarone, M. R., Belcaro, G., De Sanctis, M. T., Incandela, L., Cacchio, M., Bavera, P., Ippolito, E., Bucci, M., Griffin, M., Geroulakos, G., Dugall, M., Buccella, S., Kleyweght, S., & Cacchio, M.
- Affiliations
- University of Milan (IT)
- Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Vascular Surgery, University of Milan, Italy
- Venue
- Angiology
- Publisher
- SAGE Publications
- Published
- 2001-10
- Volume
- 52
- Issue
- 2_suppl
- Pages
- S15-S18
- ISSN
- 0003-3197 (ISSN-L)
- 1940-1574
- OpenAlex
- W2810688187
- Cited by
- 41
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2013: 7 · 2012: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Diagnosis and Treatment of Venous Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- Centella asiatica, venous hypertension, lipodermatosclerosis, ankle swelling, microcirculation, capillary filtration
- MeSH terms
- Administration, Oral, Female, Humans, Hypertension, Male, Microcirculation, Middle Aged, Plant Extracts, Prospective Studies, Severity of Illness Index, Triterpenes, Venous Insufficiency
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